Chiral methyl. Medical search. Frequent questions

In 2010, researchers at Merck & Co. and Codexis reported on the biocatalytic asymmetric synthesis of chiral amines from ketones in the manufacture of sitagliptin, the active ingredient in Merck's antidiabetes drug Januvia. (pharmtech.com)
Preparation of ß-chloro sulfinamides in a synthesis of chiral azridines. (sigmaaldrich.com)
This thesis discusses work aimed at the synthesis of chiral bis(pentaalkylcyclopentadienyl) and polyaza/oxo ligands for Ln(II) ions, and their subsequent application in asymmetric organic synthesis. (dur.ac.uk)

It is also employed as a reagent for synthesizing chiral amines. (guidechem.com)
Useful reagent for synthesizing chiral amines. (sigmaaldrich.com)

The main advantages of organocatalyzed stereoselective reactions include mild reaction conditions and the use of a sole catalyst without the need of other chiral ligands [4,5] . (beilstein-journals.org)
ADC ligands were built from chiral C_1-symmetric pyrrolidine subunits. (dissertation.com)
The location of the chiral substituents proximal to the oxygen atom of the carbonyl led to a reasonable hypothesis that these ADCs might be useful asymmetric ligands. (dissertation.com)
however steric crowding created by the phosphine ligands caused the chiral groups to orient themselves away from the metal center, as observed by X-ray analysis. (dissertation.com)
Synthesis of enantiomerically pure bis(pentaalkylcyclopentadienyl) ligands was attempted via a novel double Nazarov cyclisation of 5,6-di-(methyl)-decane-3,8-dione. (dur.ac.uk)

The following short review summarizes the results we achieved with the investigation of chiral silicon groups as auxiliaries for the enantioselective synthesis. (chimia.ch)
Although the use of Ln(^2+) species as one electron reducing agents has recently become popular, relatively few processes have focused on the control of stereochemistry by the incorporation of chiral auxiliaries at the metal centre. (dur.ac.uk)
S. Bienz, S. Bratovanov, A. Chapeaurouge, P. Huber, L. Fischer, M. Pietzsch, C. Syldatk: Chiral Silicon Groups as Auxiliaries for Enantioselective Synthesis: Access to Optically Active Silanes by Biotransformation and the Enantiospecific Preparation of (R)-(+)-1-Phenylethanol. (uzh.ch)

Highly selective asymmetric synthesis of 2-hydroxy fatty acids has been accomplished through chiral imide enolates. (usda.gov)

Our company specializes in API, Pharmaceutical Intermediates, Chiral Compounds and Amino Acids. (ruifuchem.com)
The launch of the selectAZyme line of biocatalysts follows Almac's $4-million investment in biocatalysis R&D. Research areas include new biocatalytic platforms for producing chiral intermediates, hyperactivation of biocatalysts for reducing enzyme loadings, developing drivers for cofactor recycling, and mitigating problems with equilibriums. (pharmtech.com)

Overall Retention of Methyl Stereochemistry during B12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis. (megazyme.com)

Alkoxy)methyl-substituted silicon compounds with 'Si-centered chirality', which were prepared in optically active form by application of a bioreduction, have been efficiently used as starting materials for a number of stereoselective reactions. (chimia.ch)
The respective α-hydroxysilanes could be stereospecifically desilylated to chiral secondary alcohols, or, depending on the substitution pattern, further used as starting compounds for stereocontrolled oxidation, Cope - or Claisen -type rearrangement reactions. (chimia.ch)
Interestingly, X-ray analysis of Rh-ADC complex 3-5 based on chiral C_1-symmetric pyrrolidine subunits demonstrated a change in conformational preference from the palladium compounds, as the methyl substituents were located proximal to the rhodium center. (dissertation.com)
Few organofluorine compounds exist naturally ( C&EN, May 22, page 12 ), meaning that almost all must be made. (acs.org)
M. Trzoss, S. Bienz: A Chiral Silyl Ether as Auxiliary for the Asymmetric Nucleophilic Addition to α- and β-Silyloxy Carbonyl Compounds. (uzh.ch)

Enantioselective hydroxylation of other fatty acids including elaidic acid, petroselinic acid, vaccenic acid, and linoleic acid were evaluated under the similar conditions using (4R,5S)-(+)-4-methyl-5- phenyl-2-oxazolidinone as a chiral auxiliary to give 98% ee values for all cases. (usda.gov)
Amino-functional silica-coated N-doped carbon dots (NH2-SiO2-CDs) were covalently modified by l-tryptophan (chiral selector) by producing an amide bond between carboxyl groups of L-try and amino groups of NH2-SiO2-CDs to develop a novel high throughput chiral nanoprobes (L-try-CONH-SiO2-CDs) for highly sensitive and enantioselective quantification of S-/R-mandelic acid (S-/R-Man). (bvsalud.org)

Chiral α-metallated vinylsilanes were converted to α-silyl-substituted allylic alcohols and to α-silyl-substituted α,β-unsaturated ketones. (chimia.ch)
2-Methyl-1-butanol is a component of many mixtures of commercial amyl alcohols. (wikipedia.org)
Alcohol dehydrogenases are used to synthesize chiral alcohols from ketones. (pharmtech.com)

In these reactions, stereoinduction in the products is achieved by the chiral environment present in the catalyst itself. (beilstein-journals.org)

The prior led to chiral allenes in a Peterson -type reaction - however, without stereoselectivity - the latter delivered stereoselectively β-chiral silicon-free ketones upon stereocontrolled conjugate cuprate addition followed by removal of the silicon auxiliary. (chimia.ch)

Thus, several PPA copolymers containing the ethynyl-4-benzamide of ( S )-phenylglycine methyl ester (M 1 ) to dictate the helical structure/sense of the copolymer, and the ethynyl-4-benzamide of the 11-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)undecane-1-thiol (M 2 ) to link the copolymer to the AuNPs are prepared. (rsc.org)
9~ yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2R, 5S, cis)-4-amino-5- fluoro-l-(2~ hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, EmtrivaTM, (-)-cis FTC) and their physiologically functional derivatives. (gc.ca)
L-Leucine methyl ester is a protected form of L-Leucine (L330110). (tsaminoacid.com)

Reaction of (R,R)- or (S,S)-bis(1-phenylethyl)amine with nBuLi in hexane solution gave the chiral amide [{PhC(H)Me}2NLi] 1. (strath.ac.uk)

2-Methyl-2-butanol Lide, David R. (1998), Handbook of Chemistry and Physics (87 ed. (wikipedia.org)
I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)

Emtricitabine or 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)- pyrimidinone has two chiral carbon atoms. (who.int)
SMILES describing only the labeled molecular graph (i.e. atoms and bonds, but no chiral or isotopic information) are known as generic SMILES. (daylight.com)

The specifications for TDF include description, clarity of solution, identification of TDF and fumaric acid, assay and fumaric acid content by HPLC, related substances by HPLC, heavy metals, residue on ignition, water content and residual solvents, chloro methyl isopropyl carbonate (by GC). (who.int)
Unrestricted use of solvents, a wide range of dissolution conditions, the use of any miscible solvent as a mobile phase, dissolved samples, chiral column regeneration. (thelabstore.co.uk)

2000. Placental transfer and pharmacokinetics of a single dermal dose of [14C] methyl parathion in rats. (cdc.gov)
2000. Monitoring methyl parathion residues in milk and yogurt, and fate of [14C] methyl parathion during milk processing. (cdc.gov)

IE solvent-resistant chiral column, the amylose-tris (3,5-dichlorophenylcarbamate) covalently bonded to the surface of the silica gel. (thelabstore.co.uk)

Methanolysis of the hydroxylated products with magnesium methoxide gave methyl 2-hydroxyoleate. (usda.gov)

Five chiral oleic acid imides were prepared by reaction of oleic acid with pivaloyl chloride followed by reaction with five different lithiated chiral oxazolidinones including (R)-(+)-4-benzyl-2-,(S)-(-)-4-benzyl-2-,(4R,5S)-(+)-4-methyl- 5-phenyl-2-, (4S,5R)-(-)-4-methyl-5-phenyl-2-, and (R)-(+)-4-isopropyl- 2-oxazolidinones in 88-92% yields. (usda.gov)
A systematic study of the interactions between water and alkyl methyl imidazolium chloride ionic liquids at 298.2 K, based on activity coefficients estimated from water activity measurements in the entire solubility range, is presented. (ua.pt)

In the Morita-Baylis-Hillman (MBH) reactions of arylaldehydes with methyl vinyl ketone, it was observed that in the presence of a catalytic amount of a chiral phosphine Lewis base (CPLB) bearing multiple phenol groups, such as CPLB1 (10 mol %), the corresponding MBH adducts could be obtained in moderate to good yields with low to moderate ee's (4-45% ee) at ambient temperature (10 degrees C) in THF. (unboundmedicine.com)

The Highlight deals with the catalytic desymmetrization by C-H functionalization to solve the chiral methyl problem (D. A. Nagib). (chemistryviews.org)

This chiral recognition probe was successfully synthesized through meticulous control of nano-ovals-shaped gold nanoparticles morphology and surface passivation. (bvsalud.org)

Enantioenriched, highly functionalized cyclopropane derivatives were prepared by a simple and green approach using monosaccharide‐based chiral crown ethers as phase transfer catalysts. (researchgate.net)

The related C2 symmetric molecule with both methyl groups directed towards the metal is 8.68 kcal mol-1 less stable than I. Therefore, in the absence of aggregation and external solvation, significant stabilisation is achieved through Li· · ·C(H) benzyl interactions. (strath.ac.uk)

This outcome is consistent with a double-inversion process, first in the S N 2 reaction of cob(I)alamin with SAM to form methylcobalamin and again in a radical transfer of the methyl group from methylcobalamin to the substrate. (megazyme.com)
Treatment of 2,3-dihydro-2-methyl-3-phenyl-1 H -pyrazino[3,4,5- cd ]indolizine 2-oxides ( 5 ) with trifluoroacetic anhydride gave new heterocyclic six-membered betaines ( 6 ) which underwnet 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate and maleimides in hot toluene to yield the corresponding cycloadducts ( 7 ) and ( 8 ). (heterocycles.jp)

The chiral imides were reacted with NaN(Me3Si)2 at -78C to give enolates, which subsequently reacted with 2- (phenylsulfonyl)-3-phenyloxaziridine to give hydroxylated products in 78-83% yields. (usda.gov)

All these nanocomposites show a dynamic chiral behaviour, it being possible to manipulate their helical sense by the action of external stimuli. (rsc.org)
As an example of biocatalysis at work, Almac carried out preliminary screening to show that a carbonyl reductase (CRED) bioreduction could replace a resolution for preparing a chiral alcohol. (pharmtech.com)

1975. [Effect of methyl parathion or zineb administration on the activity of some hepatic enzymes in rats]. (cdc.gov)

J. Fässler, P. Huber, S. Bratovanov, L. Bigler, N. Bild, S. Bienz: Neighboring Group Participation in the Gas Phase: Loss of Benzaldehyde from [(Benzyloxy)methyl]dialkylsilyl-Substituted 1,3-Dithianes. (uzh.ch)

The methods developed during this study allow high-yield in situ generation of labeled SAM and recombinant expression and purification of the malate synthase needed for chiral methyl analysis. (megazyme.com)

Chiral Studies Across the Spectrum of Polymer Science: From dilute solution to the glassy state, from liquid crystals to peptide nucleic acids, to viruses and most recently investigations of plant based method of control of arthropod disease vectors. (nyu.edu)
Moreover, it is possible to control the aggregation of these nanocomposites into macroscopically chiral nanospheres with low polydispersity by using Ba 2+ as a crosslinking agent. (rsc.org)

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SMILES denotes a molecular structure as a graph with optional chiral indications. (daylight.com)

Studies on adsorption and desorption of methyl parathion on humic substances. (cdc.gov)

Here we determine the stereochemical course of this process at the methyl group during the biosynthesis of the clinically used antibiotic fosfomycin. (megazyme.com)

Movement of methyl parathion, lindane and atrazine through lysimeters in field conditions. (cdc.gov)

What are the applications and synthesis of (S)-(-)-2-Methyl-2-propanesulfinamide? (guidechem.com)

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