• The PCR-based assay was extremely sensitive and did not need donor and recipient samples for the assessment of chimerism. (celljournal.org)
  • We used a genome-wide single nucleotide polymorphism (SNP) array to study patients with chromosome aneuploidy mosaicism, UPD and one individual with XX/XY chimerism to gain insight into the developmental mechanism and timing of these events. (nih.gov)
  • Chimerism monitoring using biallelic single nucleotide or insertion/deletion polymorphisms : how many markers to screen? (ugent.be)
  • In Mother 3, chimerism is one of main themes, with chimeric animals being introduced early on in the game. (wikipedia.org)
  • After 1 year, only 33% of chimeric individuals survived but they are 40% bigger than not chimeric ones, suggesting that chimerism could confer a competitive advantage linked to increased growth rate. (ekt.gr)
  • Researchers in Jun Wu's lab compare normal mouse embryos (left) to horse-mouse chimeric embryos (right) to identify barriers to interspecies chimerism. (the-scientist.com)
  • Mixed hematopoietic chimerism after marrow allografts. (northwestern.edu)
  • Dive into the research topics of 'Mixed hematopoietic chimerism after marrow allografts. (northwestern.edu)
  • Here we show that a novel, nondepleting CD40 monoclonal antibody, 3A8, can combine with combined CTLA4Ig and sirolimus in a well-established primate bone marrow chimerism-induction model. (usuhs.edu)
  • Human genetic chimerism, which can not only cause a wide range of illnesses but also lead to the same person having more than one profile in genetic fingerprinting, has served as a plot device in many works of fiction. (wikipedia.org)
  • Most known examples are subsequent to the 2004 book Free Culture, where author Lawrence Lessig digresses briefly to describe chimerism and suggest that it could, and had yet to, be well used as a television plot device (particularly for police procedurals involving genetic fingerprinting). (wikipedia.org)
  • Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. (asu.edu)
  • One of the key signs of chimerism is differences in pigmentation . (iflscience.com)
  • Deletion did not persist when chimerism was lost. (ca.gov)
  • Trogocytosis as a mechanistic link between chimerism and prenatal tolerance. (nature.com)
  • Is mixed chimerism really required in maintaining a skin allograft tolerance? (elsevierpure.com)
  • The aim of the present study was to evaluate the application of the amelogenin gene for assessment of chimerism in PBL and/or BM samples of patients who received sex-mismatched BMT. (celljournal.org)
  • OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
  • Determine whether mixed chimerism can be safely converted to full donor chimerism in patients treated with DLI. (knowcancer.com)
  • Eligible patients with mixed chimerism and no graft versus host disease (GVHD) receive the first donor lymphocyte infusion (DLI) on the same day that donor lymphocytes are collected. (knowcancer.com)
  • The phenomenon of chimerism in the Mediterranean red coral ( Corallium rubrum ) is reported and quantified in semi-natural conditions. (ekt.gr)
  • Soft-coral natural chimerism: A window in ontogeny allows the creation of entities comprised of incongruous parts. (ekt.gr)
  • In scleractinian corals, fusion among allogeneic juveniles is known to occur following aggregated larval settlement in some brooding species, but no studies have investigated chimerism in juveniles of broadcast spawning corals or in adult populations of any coral species. (edu.au)
  • The extent of chimerism was explored within two wild populations of a common coral, Acropora millepora, on the Great Barrier Reef, Australia, by using up to 12 polymorphic DNA microsatellite loci. (edu.au)
  • Finally, if the chimerism theory is true, exclusive homosexuality should be more common in populations with a higher incidence of twinning, such as sub-Saharan Africans. (blogspot.com)
  • For the type of chimerism mentioned in this blogpost (also known as 'tetragametic' chimerism ), the most common cause is a twin pregnancy that naturally reduces to a single baby. (vibrantgene.com)
  • An even more common form of chimerism is called microchimerism. (vibrantgene.com)
  • Case Report: Identification of Germline Chimerism in Monochorionic Dizygotic Twins. (cdc.gov)
  • Researchers terminated the pregnancies of three of them to test the fetuses for chimerism, and they found it. (livescience.com)
  • Steve Sailer has entered this debate with a post on the chimerism theory , i.e., the idea that male homosexuality arises when a male fetus absorbs cells from a female twin that has died during early fetal development. (blogspot.com)
  • These values are likely to be vast underestimates of the true extent of chimerism in wild populations, as the sampling protocol was restricted to a maximum of eight branches per colony, whereas most colonies consist of hundreds of branches. (edu.au)
  • Chimerism is a condition whereby a person has not one but two complete genomes (or sets of DNA) in their body. (vibrantgene.com)
  • These results, combined with cytotoxic single-cell transcriptional profiles of donor T cells in recipient BM, suggest that tissue-resident GvH-reactive donor T cells migrated into the recipient circulation and BM, where they destroyed recipient hematopoietic cells through cytolytic effector functions and promoted engraftment of graft-derived HSPCs that maintain chimerism. (columbia.edu)
  • Marmosets are obligate litter bearers with most pregnancies resulting in dizygotic twins that show chimerism in the blood and other cells from the hematopoietic lineage, as a result of in utero exchange of stem cells through placental anastomoses during early development, a process that leads to lifelong chimerism. (nih.gov)
  • However, recent quantitative studies indicate that chimerism is limited to cells of the hematopoietic lineage, and that previous observation of widespread tissue chimerism was likely due to blood or lymphocyte infiltration of those tissues, as fibroblast cell lines from chimeric individuals were not chimeric. (nih.gov)
  • The evolutionary and functional consequences of hematopoietic chimerism, which is unique to marmosets and other callitrichid primates, are currently unknown. (nih.gov)
  • Ultrasensitive Chimerism Enhances Measurable Residual Disease Testing Post-Allogeneic Hematopoietic Cell Transplantation. (astct.org)
  • A proof-of-concept test of an ultrasensitive assay validated the post-allogeneic hematopoietic cell transplantation (allo-HCT) measurement of chimerism to increase measurable residual disease (MRD) data. (astct.org)
  • Development of late over early full donor chimerism (FDC) results in improved progression-free and overall survival in patients with advanced malignant lymphomas receiving nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT). (fiu.edu)
  • Thirdly, the CRA assesses HSC activity based on overall hematopoietic chimerism, which might reflect poorly on the actual HSC activity given the vastly different turnover rates of different blood cells lineages 13 . (elifesciences.org)
  • Solid organ allograft tolerance can be achieved by establishing mixed hematopoietic chimerism in recipients through transplantation of bone marrow (BM) from donors. (nih.gov)
  • The data showed that relapse correlated with absolute recipient chimerism proportions and rates at which these quantities grew in bone marrow aspirate (BMA) in the first 540 days after transplantation. (astct.org)
  • An increase in recipient alleles is usually indicative of a relapse of the patient's malignant cells, and therefore, the likelihood of relapse can be predicted following two successive increases in recipient chimerism within post-transplant whole blood or bone marrow samples: a phenomenon known as mixed chimerism. (hee.nhs.uk)
  • Molecular and cellular effects of chimerism on immunological suppression/tolerance and reactivity including studies comparing immune responses elicited by a sibling twin to those of a third-party donor organ (e.g., kidney, heart, lung) or cellular (e.g., bone marrow or islet) transplant and mechanisms associated with transplant tolerance or rejection. (nih.gov)
  • Human cell chimerism in spleen and bone marrow was maintained over time. (nih.gov)
  • Notably, human cell chimerism in peripheral blood and spleen as well as bone marrow positively correlated with each other. (nih.gov)
  • Objectives: Allogeneic mesenchymal stem cells (MSCs) and bone marrow cells (BMCs) were cotransplanted in nonobese diabetic mice after none myeloablative preconditioning and the development of chimerism, insulitis, diabetes, and graft-versus-host disease (GVHD) were monitored. (fujita-hu.ac.jp)
  • The limited correlation between relapse and detectable MRD by flow cytometry in BMA was enhanced when paired with increased recipient chimerism in BMA. (astct.org)
  • Further, the incidence of myeloid malignancies is higher after graft failure and mixed donor/recipient chimerism. (nih.gov)
  • The NOSI encourages applications focused on the biological and physiological significance and mechanisms that are responsible for chimerism in marmosets and other callitrichid primates. (nih.gov)
  • In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. (columbia.edu)
  • Study of the relatively few patients who have developed tolerance reveals that a state of chimerism may develop following transplantation. (medscape.com)
  • Full donor myeloid chimerism was observed after HCT. (confex.com)
  • Pigs, paving the path for future interspecies chimerism experiments.Plasmid building and lentiviral vectors production. (axlinhibitor.com)
  • Cell Competition Constitutes a Barrier for Interspecies Chimerism. (stembook.org)
  • In mice, ~1% chimerism is the threshold required for donor-specific tolerance. (nih.gov)
  • They were born through in vitro fertilization, and confined blood chimerism was diagnosed by additional short tandem repeat study. (e-kmj.org)
  • The observation of chimerism after in vitro fertilization should therefore be taken seriously," they said. (lds-mormon.com)
  • Mice receiving 50 million allogeneic donor BM cells attained 1.28% chimerism 1 month post-transplant, whereas mice receiving 10-25 million donor cells attained (nih.gov)
  • Applications in response to this NOSI should be aligned with the overall purpose, which is to improve our understanding of the biological and physiological significance of chimerism in this NHP model. (nih.gov)
  • These GvH clones entered the circulation, where their peak levels were associated with declines in HvG clones early after transplant, suggesting that GvH reactions may contribute to chimerism and control HvG responses without causing GVHD. (columbia.edu)
  • Conclusions: Coinjection of MSCs and BMCs increased the success rate in inducing chimerism and preventing insulitis and overt diabetes with no incidence of GVHD. (fujita-hu.ac.jp)
  • Human cell chimerism and absolute human cell count decreased between week 16 and 24 in the peripheral blood of hu mice, but were stable thereafter as assessed up to 32 weeks. (nih.gov)
  • Thereafter, blood glucose and chimerism were monitored on peripheral blood samples. (fujita-hu.ac.jp)
  • Donor chimerism, transplant-related toxicities and clinical and laboratory measures of SCD were secondary endpoints obtained 1 year after HCT. (confex.com)
  • Laparoscopic gonadectomy in a dog with 78,XX/78,XY chimerism and underdeveloped reproductive organs. (ufl.edu)
  • The panel of qPCR assays developed incorporated TaqMan chemistry that could assess chimerism to a degree of 1 in a million - sensitive enough to identify risk of relapse, the researcher hypothesized. (astct.org)
  • These findings show chimerism used along with MRD assays could better identify patients at highest relapse risk as early intervention candidates. (astct.org)
  • With continuous training on analysis, chimerism monitoring assessments will be implemented and performed on a weekly basis in our department using the quantitative fluorescence-based STR-PCR with capillary electrophoresis for PCR product resolution presented herein. (hee.nhs.uk)
  • Thus, we conclude that endothelial chimerism combined with vascular sequestration of DSAs protects islet grafts from humoral rejection. (jci.org)
  • We conclude that AMD3100 may enhance mixed chimerism in non-irradiated mice receiving allogeneic BM transplants. (nih.gov)
  • I'm a supporter of Barry Schect's Innocence Project -- using DNA testing to prove convicted criminals are actually innocent -- but I hope the possibility of chimerism is being examined in cases where there's a lot of non-DNA evidence that an accused is guilty of the crime charged. (mu.nu)
  • This study investigated two patients with Rh chimerism: patient A, a healthy individual, and patient B with myelofibrosis. (who.int)
  • In this thesis, we have confirmed that the wide range of sensitivity, in addition to the flexibility of the protocol ensures that chimerism analysis in patient samples with minimal DNA material can be performed. (hee.nhs.uk)
  • Patient is S/P SCT, and is diagnosed with mixed haplo cord chimerism. (aapc.com)
  • Chimerism occurs in the embryo as one is devoloping -- two fraternal twins embryos grow, but then one absorbs the other, incorporating the other's DNA into different tissues and organs of its body. (mu.nu)
  • Authors report a case of MCDADZ twin who showed blood chimerism detected by karyotyping and chromosome microarray. (e-kmj.org)
  • 아주 드물게 선천성 키메라증이 있을 수 있는데, 전신의 세포가 모두 섞인 형태로 나타나는 전신키메라증(whole body chimerism)과 혈액만이 섞인 형태로 보이는 혈액한정키메라증(confined blood chimerism)이 있다. (e-kmj.org)
  • There may be more cases of chimerism than people realize, the Strain team speculated, because fusions between two male embryos or two female embryos would probably be missed since the baby would show no sex organ abnormalities. (lds-mormon.com)
  • The goal of the clinical HCT protocols is full donor chimerism and not mixed chimerism. (nih.gov)
  • Therefore, for this model to reach its full translational utility in furthering our understanding of human health and diseases, it is imperative that we achieve a better understanding of the functional consequences of chimerism and its contributions to health, behavior and diseases in New World primates. (nih.gov)
  • It is also not known if chimerism limits or enhances the use of these animals as models for human physiology, health and disorders. (nih.gov)
  • I mention this because Discovery Health is currently running a documentary about chimerism, called "I Am My Own Twin," about the same woman profiled in that (yes, Dave) old NPR report. (mu.nu)
  • Reference-based targeted assemblers yielded either highly fragmented assemblies or high levels of chimerism, so we employ the general-purpose genomic assembler SPAdes. (biorxiv.org)
  • Using the PowerPlex® 16 STR system, we sort to establish chimerism analysis on NEQAS, retrospective and WB, CD3+ and CD15+ cell subsets samples. (hee.nhs.uk)
  • Apply for funds to study the biological basis and functional implications of chimerism in common marmosets and other New World primates through the new Notice of Special Interest (NOSI): Chimerism in Marmosets and Other New World Primates . (nih.gov)
  • And the fact that chimerism is so infrequently checked for means that there might be a lot of false-negative paternity tests, and false-netative DNA criminological tests, too. (mu.nu)
  • The risk of chimerism has risen in recent years because more women are taking fertility drugs, which release multiple eggs for fertilization. (lds-mormon.com)
  • State prosecutors stumbled across the term "chimerism" in a medical journal and tipped her lawyer. (mu.nu)