• A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. (lookformedical.com)
  • Such a division is not absolute, since some disorders may have both hemorrhagic and thrombotic manifestations. (medscape.com)
  • Mortality is related to the severity of bleeding and/or to thrombotic complications at presentation. (medscape.com)
  • A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)
  • Disorders of nonplatelet hemostasis can be divided into 2 groups based on whether they increase or decrease coagulation. (medscape.com)
  • Etiologically, nonplatelet hemostatic disorders can be divided those involving coagulation factors and those involving vascular aspects of hemostasis. (medscape.com)
  • Fibrinogen disorders can be quantitative (afibrinogenemia) or qualitative (dysfibrinogenemia), and they may be congenital or acquired. (medscape.com)
  • Factor I (also called fibrinogen) deficiency is an inherited bleeding disorder that is caused by a problem with factor I. Because the body produces less fibrinogen than it should, or because the fibrinogen is not working properly, the clotting reaction is blocked prematurely and the blood clot does not form. (ucdavis.edu)
  • Excessive menstrual bleeding in women with factor I deficiency may be controlled with hormonal contraceptives (birth control pills), intra-uterine devices (IUDs), or antifibrinolytic drugs. (ucdavis.edu)
  • Factor II (also called prothrombin) deficiency is an inherited bleeding disorder that is caused by a problem with factor II. (ucdavis.edu)
  • Factor II deficiency is an autosomal recessive disorder, which means that both parents must carry the defective gene in order to pass it on to their child. (ucdavis.edu)
  • Factor II deficiency is very rare, but like all autosomal recessive disorders, it is found more frequently in areas of the world where marriage between close relatives is common. (ucdavis.edu)
  • Afibrinogenemia is defined as a deficiency or absence of fibrinogen (coagulation factor I) in the blood. (medscape.com)
  • While these disorders occur less often than Hemophilia A or B, patients with other bleeding disorders and their families can still benefit from the comprehensive service of UC Davis Hemostasis and Thrombosis Center. (ucdavis.edu)
  • Other people experience bleeding (similar to those seen in afibrinogenemia) and others show signs of thrombosis (abnormal blood clots in blood vessels) instead of bleeding. (ucdavis.edu)
  • A defect in the function of any other clotting factors may cause bleeding, and the severity may range from mild to severe depending on the mutation or particular defect. (ucdavis.edu)
  • Mortality is related to the severity of bleeding and/or to thrombotic complications at presentation. (medscape.com)
  • The condition appears to be rare, however, with only 400 families reported as of 2012. (medscape.com)