Emergent BioSolutions' CHIKV VLP vaccine candidate is being developed for the prevention of disease caused by a chikungunya virus infection, for which no vaccine or treatment is currently available. (precisionvaccinations.com)
Here, we investigated the effect of CHIKV infection on the whole bacterial community of Ae. (datadryad.org)
Taxonomic microarrays and quantitative PCR showed that members of Alpha-, and Gamma-proteobacteria phyla, as well as Bacteroidetes, responded to CHIKV infection. (datadryad.org)
The abundance of bacteria from the Enterobacteriaceae family increased with CHIKV infection whereas the abundance of known insect endosymbionts like Wolbachia and Blattabacterium decreased. (datadryad.org)
JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands. (pasteur.fr)
A probable case is a clinically compatible case with an infection, or 2) another cause in a patient with concurrent CHIKV infection. (cdc.gov)
A new study by researchers at the Washington University School of Medicine in St. Louis (WUSTL) has identified broadly neutralizing antibodies that protect against infection in mice from multiple, distantly related alphaviruses-including Chikungunya virus (CHIKV)-that cause fever and debilitating joint pain. (genengnews.com)
Dr. Streblow's lab has also generated a rhesus macaque (RM) chikungunya virus (CHIKV) infection animal model to identify correlates of CHIKV pathogenesis and to test novel antivirals and vaccines. (ohsu.edu)
Now, researchers writing in PLOS Neglected Tropical Diseases report that AGO traps successfully protected people from infection with chikungunya virus (CHIKV) in communities in Puerto Rico. (diwou.com)
Blood samples were collected from each participant to detect CHIKV infection and surveys recorded demographic information as well as data on mosquito repellant and bed net use and frequency of mosquito bites. (diwou.com)
CHIKV infection is characterized by an abrupt onset of fever, frequently accompanied by debilitating joint pain. (who.int)
Abstract INTRODUCTION: Chikungunya fever is a condition resulting from infection by chikungunya virus (CHIKV), an Aedes sp. (scielo.br)
The severe joint pain caused by CHIKV infection has a major impact on patients' quality of life, forcing them to reduce their daily activities and in some cases give up their jobs. (news-medical.net)
The project will use cutting-edge techniques to study the mechanisms leading to chronic CHIKV infection and enable research into effective treatments, specifically looking at changes in joints and their implications for joint inflammation and degradation. (news-medical.net)
Patients who suffer from this debilitating disease following a CHIKV infection not only have to deal with the painful physical consequences, but can also be forced to give up their jobs due to the pain and miss out on daily activities, severely impacting their quality of life. (news-medical.net)
Inovio's DNA vaccine and dMAb products show potential to offer immediate and long term protection to large populations from CHIKV infection. (drugtargetreview.com)
Common clinical symptoms of CHIKV infection include sudden onset of high fever and polyarthralgia. (cdc.gov)
Anti-CHIKV E2 pAb1
Rabbit anti-CHIKV E2 pAb, 100 ug - 1 kit is backordered and will ship as soon as it is back in stock. (phantome.org)
Dengue virus1
The lack of effective tools to control Aedes aegypti mosquito populations has resulted in the continued expansion of dengue virus, Zika virus and CHIKV. (diwou.com)
Aedes2
CHIKV is transmitted reported,ยงยง accounting for the highest case fatality rate (3.8%) primarily by Aedes aegypti and Aedes albopictus mosquitoes. (cdc.gov)
Chikungunya is a mosquito-borne viral disease caused by the chikungunya virus (CHIKV), a Togaviridae virus, transmitted by Aedes mosquitoes. (mvm.com)
DENV and CHIKV3
Eleven (17.46%) of the confirmed cases were DENV, 49 (77.77%) were CHIKV, and 3 (4.76%) were DENV and CHIKV co-infections. (who.int)
DENV and CHIKV infections are fast-growing mosquito-borne arboviral diseases. (who.int)
DENV and CHIKV are spreading across the country more rapidly than other arboviral diseases. (who.int)
Antibody titers1
The trial, involving 4,115 adults, aged 18 years and above, across 44 sites in the U.S., met its primary endpoint inducing protective CHIKV neutralizing antibody titers in 98.5% of participants 28 days after receiving a single shot (264 of 268 subjects from the per-protocol subgroup tested for immunogenicity, 95%CI: 96.2-99.6). (mvm.com)
Titers1
Data are CHIKV neutralization titers of serum. (cdc.gov)
Antibodies3
Chikungunya Virus (ChikV) IgG/IgM Rapid Test is a rapid immunochromatographic assay for the simultaneous detection of IgG and IgM antibodies to Chikungunya virus in human whole blood, serum or plasma. (hematologyanalyzerreagent.com)
A built-in control line will always appear in the test window when the test has performed properly, regardless of the presence or absence of anti- ChikV antibodies in the specimen. (hematologyanalyzerreagent.com)
In the current study, the researchers screened 60 neutralizing mouse and human antibodies against CHIKV and determined that 10 reacted against three or more different alphaviruses that cause arthritis-like symptoms. (genengnews.com)
Mosquito4
The medical and economic burden is expected to grow as the CHIKV primary mosquito vectors continue to spread geographically. (mvm.com)
VLA1553 is a live-attenuated, single-dose vaccine candidate against the chikungunya virus (CHIKV), a mosquito-borne virus that has spread to more than 110 countries 3 with the potential to rapidly expand further. (tmcnet.com)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disablingpolyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent[1]. (unl.pt)
In June 2014, the mosquito-borne chikungunya virus (CHIKV) emerged in the U.S. Virgin Islands (USVI), a location where tourists comprise the majority of the population during peak season (January–April). (cdc.gov)
ZIKV1
The first round of this global EQAP took rus (YFV) and Zika virus (ZIKV), and alphaviruses like place in 2016 as a continuation and global expansion chikungunya virus (CHIKV), are major threats to hu- of an EQAP initially developed in the WHO Western man health worldwide. (who.int)
The CHIKV RNA was detected in another seven samples that were positive by the ELISA method for DENV. (healthyguide.info)
No viral RNA was detected in the samples that were IgM positive against CHIKV by the ELISA method. (healthyguide.info)
Alphaviruses1
Currently, there is no vaccine or treatment for CHIKV or other alphaviruses. (genengnews.com)
Albopictus1
albopictus highlighting the co-ancestry of the different derived populations and the dissemination and transmission efficiencies for Chikungunya virus (CHIKV). (pasteur.fr)
Vaccine candidate4
A Maryland based life science company announced that its Chikungunya Virus virus-like particle (VLP) vaccine candidate, CHIKV VLP, was granted PRIority MEdicines, or PRIME, designation by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA). (precisionvaccinations.com)
Emergent is pleased to receive this important EMA designation and encouraged by the strength of our early data package, including results from the interim analysis of our Phase 2 safety and immunogenicity study for our CHIKV VLP vaccine candidate announced last April," said Abbey Jenkins, senior vice president, in a press release. (precisionvaccinations.com)
That phase 2 study found the CHIKV-VLP vaccine candidate produced 74 to 98 percent seroconversion across a series of dosing regimens. (precisionvaccinations.com)
The CHIKV VLP vaccine candidate is licensed from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. (precisionvaccinations.com)
20191
In 2018/2019, the Kassala area in eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, with a greater incidence of severe illness, fatality, and longer-term disability (8-10). (who.int)
Disease2
Broeckel R, Haese N,Messaoudi I, Streblow DN;Nonhuman Primate Models of Chikungunya VirusInfection and Disease (CHIKV NHP Model). (ohsu.edu)
However, CHIKV awareness was associated with using multiple prevention measures to reduce disease risk. (cdc.gov)
Symptoms1
Swelling of joints and severe arthralgia are the common symptoms in the case of CHIKV contamination, but was rare among the dual-infected patients. (healthyguide.info)
Chikungunya computer virus (CHIKV) and dengue computer virus (DENV) are circulating individually in the state of West Bengal, India. (healthyguide.info)
The term "Chikungunya" often refers to both the virus (CHIKV) and the illness or fever (CHIKF) caused by this virus. (medscape.com)
Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses, including Chikungunyavirus (CHIKV), encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. (fsu.edu)
Dr Anja Winter from Keele University's School of Life Sciences has received a prestigious Springboard grant from the Academy of Medical Sciences, to investigate severe joint pain in patients infected with Chikungunya virus (CHIKV). (news-medical.net)
Chikungunya Virus (CHIKV) was first detected in 1952, during a febrile outbreak on the Makonde Plateau, a border area between Mozambique and Tanzania [1]. (actascientific.com)
CHIKV is a small (60 - 70 nm) spherical enveloped virus with single- stranded positive sense RNA molecule and belongs to the genus Alphavirus, which included more than 30 species of arthropod borne viruses [1], and the family Togaviridae (Figure 1). (actascientific.com)
CHIKV is now included in the re-emerging virus group, particularly due to its recent expansion in the Americas. (actascientific.com)
Vector1
Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. (unl.pt)
Structural1
There are three structural (C, E1, E2) and four non structural proteins in CHIKV [2]. (actascientific.com)
Neurological1
Therefore, the objective was to review the literature to identify neurological manifestations of CHIKV. (intechopen.com)
Clinical1
Outbreaks of CHIKV in other areas highlighted its capability of undergoing mutation, resulting increased infectivity, and spread with variable clinical presentations in areas without any herd immunity [4]. (actascientific.com)
Rabbit1
The MSDS of Rabbit for anti-CHIKV is available from Karlan upon request. (phantome.org)
Participants2
A total of 114 participants (34.9%) were seropositive for CHIKV. (diwou.com)
Among all participants, including those who did not spend as much daylight time within the community, 26.1% were seropositive for CHIKV in the intervention communities and 43.8% were positive in communities without traps. (diwou.com)
Burden1
One approach to reduce the CHIKV burden is the development of a vaccine. (unl.pt)
Prevention1
CHIKV awareness and prevention measures. (cdc.gov)
Insect1
Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation. (unl.pt)
Patients1
The studies show that headaches were characterized as the most common symptom in adult patients affected by CHIKV, followed by meningeal involvement. (intechopen.com)
Infections1
For example, over the past several years CHIKV has caused millions of infections annually across the globe and so far in 2015, there have been 650 cases seen in U.S. residents, largely among travelers returning from the Caribbean, where they were infected. (genengnews.com)
Cases4
joints were common only in CHIKV-positive cases and abdominal pain was mainly associated with DENV contamination. (healthyguide.info)
Most of the cases with only DENV contamination were associated with abdominal pain, which was present in only one case with dual contamination by both CHIKV and DENV. (healthyguide.info)
CHIKV was first reported in sporadic cases in South Kordofan or rare cases in central and eastern Sudan (6,7), but outbreaks have dramatically increased. (who.int)
Generalized neuro-developmental delay was recorded in 51% of CHIKV infected children in La Reunion while only 15% of the control cases showed similar changes [3]. (actascientific.com)