• The term "Chikungunya" often refers to both the virus (CHIKV) and the illness or fever (CHIKF) caused by this virus. (medscape.com)
  • A new study by researchers at the Washington University School of Medicine in St. Louis (WUSTL) has identified broadly neutralizing antibodies that protect against infection in mice from multiple, distantly related alphaviruses-including Chikungunya virus (CHIKV)-that cause fever and debilitating joint pain. (genengnews.com)
  • Chikungunya (CHIKV) and Zika (ZIKV) viruses are two arboviruses which have recently broken their sylvatic isolation and gone into a rampant spreading among humans in some urban areas of the world, specially in Latin America. (biorxiv.org)
  • Given the huge burden that Chikungunya and Zika fevers impose to public health in the affected countries and the lack of effective interventions against them, the aim of this work was to evaluate the antiviral potential of bovine lactoferrin (bLf) - an iron-binding glycoprotein with broad-spectrum antimicrobial properties - in both CHIKV and ZIKV infections. (biorxiv.org)
  • Now, researchers writing in PLOS Neglected Tropical Diseases report that AGO traps successfully protected people from infection with chikungunya virus (CHIKV) in communities in Puerto Rico. (diwou.com)
  • The lack of effective tools to control Aedes aegypti mosquito populations has resulted in the continued expansion of dengue virus, Zika virus and CHIKV. (diwou.com)
  • albopictus highlighting the co-ancestry of the different derived populations and the dissemination and transmission efficiencies for Chikungunya virus (CHIKV). (pasteur.fr)
  • Seroprevalence of Chikungunya Virus (CHIKV) Infection on Lamu Island, Kenya, October 2004. (ajtmh.org)
  • Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). (datadryad.org)
  • Chikungunya virus (CHIKV) is an arthropod-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. (nbcsports.com)
  • In immunocompetent mice, CHIKV-EIG treatment reduced virus induced arthritis (including footpad swelling), arthralgia-associated cytokines, viremia, and tissue virus loads in a dose-dependent fashion. (usu.edu)
  • To estimate the cumulative incidence of persistent arthralgia at 6 months from acute Chikungunya virus (CHIKV) infection and to evaluate the association of clinical markers with the risk of long-term arthralgia. (paho.org)
  • Calcular a incidência acumulada de artralgia persistente após 6 meses de infecção aguda pelo vírus Chikungunya (CHIKV, sigla em inglês) e avaliar a associação de marcadores clínicos com o risco de artralgia a longo prazo. (paho.org)
  • Chikungunya virus (CHIKV) originated in a sylvatic cycle of transmission between non-human animal hosts and vector mosquitoes in the forests of Africa. (biomedcentral.com)
  • To mitigate such spillover, it is first necessary to delineate the distributions of the sylvatic mosquito vectors of CHIKV, to identify the environmental factors that shape these distributions, and to determine the association of mosquito presence with key drivers of virus spillover, including mosquito and CHIKV abundance. (biomedcentral.com)
  • Mosquito-borne chikungunya virus (CHIKV) was first identified in Tanzania in 1953. (biomedcentral.com)
  • Until 2004, CHIKV was considered a minor tropical pathogen responsible for a small number of cases of chikungunya fever, typified by high fevers and severe joint pain but not death [ 1 ]. (biomedcentral.com)
  • However, in 2005 and 2006 chikungunya disease incidence surged, with more than 272,000 CHIKV cases and up to 225 deaths in the Indian Ocean islands as well as 1.5 million cases in India [ 1 , 2 ]. (biomedcentral.com)
  • Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus , that is spread by Aedes mosquitoes. (chikungunyavirusnet.com)
  • Methodology and Principal Findings: Using a proteomics differential approach with two-Dimensional Differential in-Gel Electrophoresis (2D-DIGE), we defined the protein modulations in the midgut of Aedes aegypti that were triggered seven days after an oral infection (7 DPI) with dengue 2 (DENV-2) and chikungunya (CHIKV) viruses. (hal.science)
  • The team of researchers conducted a study on the Chikungunya Virus (CHIKV) outbreak on La Réunion Island between September 2005 and June 2006. (mirrordaily.com)
  • Mayaro (MAYV) and chikungunya viruses (CHIKV) are vector-borne arthritogenic alphaviruses that cause acute febrile illnesses. (ox.ac.uk)
  • Chikungunya Virus (ChikV) IgG/IgM Rapid Test is a rapid immunochromatographic assay for the simultaneous detection of IgG and IgM antibodies to Chikungunya virus in human whole blood, serum or plasma. (hematologyanalyzerreagent.com)
  • Initially identified in a rhesus monkey from Uganda's Zika forest in 1947 and subsequently isolated from humans in 1968 in Nigeria, 1 Zika virus (ZIKV) is a flavivirus transmitted by Aedes mosquitoes, the same vector transmitting other arboviruses of public health impact such as yellow fever virus, dengue virus (DENV) and chikungunya virus (CHIKV). (who.int)
  • There is currently no vaccine to prevent or medicine to treat chikungunya virus infection. (cdc.gov)
  • The recent re-emergence and travel-related spread of Chikungunya infection to Europe and the United States has drawn global attention. (medscape.com)
  • Chikungunya virus infection has a clinical presentation that overlaps with that of Ross River virus infection (fever, rash, polyarthritis) and dengue fever transmitted by the same mosquitoes. (medscape.com)
  • Both natural and Chikungunya virus infection-induced specific antibodies were essential for controlling Chikungunya virus infections. (medscape.com)
  • Chikungunya virus infection elicited strong innate immunity with an abundant production of proinflammatory markers and cytokines, including high levels of alpha interferon, interleukin (IL)-4, IL10, and gamma interferon. (medscape.com)
  • A 2017 study reported that Chikungunya infection activates toll-like receptors (TLR), triggering the innate immune system. (medscape.com)
  • This Health Advisory provides information on the current status of the chikungunya outbreak in Paraguay and advises on evaluating and testing travelers returning from Paraguay with signs and symptoms consistent with chikungunya virus infection. (cdc.gov)
  • For patients with suspected chikungunya disease, it is important to rule out dengue virus infection because proper clinical management of dengue can improve the outcome. (cdc.gov)
  • Paraguay has not reported any Zika cases in 2023 and although the risk of Zika virus infection is currently low, clinicians should consider Zika as part of the differential diagnosis for anyone who tests negative for these other pathogens. (cdc.gov)
  • Deaths linked to Chikungunya virus infection were estimated at 0.1% in La Réunion. (medscape.com)
  • Researchers have identified 'broadly neutralizing' antibodies that protect against infection by multiple, distantly related alphaviruses-including Chikungunya virus (above)-that cause fever and debilitating joint pain. (genengnews.com)
  • Our data show that bLf exerts a dose-dependent strong inhibitory effect on the infection of Vero cells by the aforementioned arboviruses, reducing their infection efficiency in up to nearly 80%, with no significant cytotoxicity, and such antiviral activity occurs at the levels of binding and replication of the virus particles. (biorxiv.org)
  • But a new study in the journal Neurology shows some people with chikungunya developed encephalitis, an infection of the brain that can lead to memory problems, dementia and even death. (wyso.org)
  • She says Gerardin's research highlights a big gap in knowledge about the virus - why some people have chronic complications and can develop a brain infection while others get off scot-free. (wyso.org)
  • 2019) Autocidal gravid ovitraps protect humans from chikungunya virus infection by reducing Aedes aegypti mosquito populations. (diwou.com)
  • Prospective studies are needed to fully assess the risk of dengue infection after exposure to Zika and chikungunya viruses and to determine whether the supposed cross-protection is long-lasting. (paho.org)
  • Dengue and chikungunya virus infection in man in Thailand, 1962-1964. (ajtmh.org)
  • Chikungunya infection-an emerging disease in Malaysia. (ajtmh.org)
  • Seroprevalence of Chikungunya Virus Infection on Grande Comore Island, Union of the Comoros, 2005. (ajtmh.org)
  • Is Chikungunya Infection Dangerous? (healthyms.com)
  • If you are sick with the symptoms of chikungunya, or you have been diagnosed with chikungunya infection, you can spread the disease to others through mosquito bites. (healthyms.com)
  • In her presentation, Dr. Friedlander said dermatologists should be aware of recent increases in cases of Zika virus infection, Chikungunya virus infection, and syphilis in newborns. (dermatologytimes.com)
  • The concern with Zika virus, which is a flavivirus related to dengue and transmitted by the same Aedes mosquito, relates to the potential association between maternal infection and infants born with microcephaly. (dermatologytimes.com)
  • The information is worrisome considering the consequences of microcephaly, which can range from mild developmental delay to severe motor and intellectual deficits, and the growing number of cases of Zika virus infection in countries outside Brazil, including the United States. (dermatologytimes.com)
  • Although a causal association between maternal Zika virus infection and congenital microcephaly is still under investigation, most everyone is convinced that it is real. (dermatologytimes.com)
  • Cases of Chikungunya virus infection have also been noted in the United States. (dermatologytimes.com)
  • Also transmitted through the bite of the Aedes mosquito, Chikungunya virus infection is sometimes referred to as "dengue light" because its symptoms tend to be milder than those of dengue virus infection. (dermatologytimes.com)
  • However, in newborn infants, Chikungunya virus infection has been associated with severe disease and fatalities. (dermatologytimes.com)
  • Recently as well, a report from Colombia has linked an epidemic of Chikungunya virus infection with cases of congenital infection and a high stillbirth rate, Dr. Friedlander said. (dermatologytimes.com)
  • Cutaneous findings of Chikungunya virus infection in neonates include a maculopapular and sometimes blistering rash, black streaks in the nails, and persistent hyperpigmentation after recovery from the acute disease. (dermatologytimes.com)
  • Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection" by Douglas Barker, Xiaobing Han et al. (usu.edu)
  • Current laboratory methods to diagnose chikungunya infection, such as virus isolation, RT-PCR and ELISA, are not readily available in many clinical settings. (scienceopen.com)
  • In order to provide a rapid and easy method for the diagnosis of chikungunya infection, rapid immunochromatographic tests to detect chikungunya IgM have recently become commercially available. (scienceopen.com)
  • Chikungunya infection causes fever and severe joint pain. (chikungunyavirusnet.com)
  • Only 20% of people with Zika virus infection show symptoms, which include mild fever, skin rash and conjunctivitis. (who.int)
  • A preceding viral infection was reported in 88% of these cases and retrospective analysis demonstrated that all 42 cases had serological tests suggesting prior dengue and Zika virus infections. (who.int)
  • Of these 42 confirmed cases, 26 had reported symptoms consistent with Zika virus infection. (who.int)
  • Prior to 2007, Zika virus infection had not been documented outside Asia or Africa. (who.int)
  • Some of these countries that are at risk for Zika virus infection are also either experiencing, or recovering from, complex emergencies, have fragile health systems, weak disease surveillance systems, poor response capacities, and a suboptimal level of public health preparedness. (who.int)
  • Zika virus infection further compounds the challenges as the majority of infected people do not display any symptoms and the population has no immunity to this new virus. (who.int)
  • The risk for chikungunya infection is highest in the tropical and subtropical regions of Africa, Southeast Asia, and parts of the Americas, where chikungunya virus-carrying mosquitos are endemic, according to the FDA. (medscape.com)
  • Infection with chikungunya virus can lead to severe disease and prolonged health problems, particularly for older adults and individuals with underlying medical conditions," Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research, said in a statement. (medscape.com)
  • bovine lactoferrin binds to the main zika protein that makes up the Zika virus tertiary amino lipid coating, regardless of pH, and locks these proteins into place, preventing the structural re-arangement changes required for the fusion step of infection. (ufg.br)
  • Without fusion of the virus to the 1st stage endosome, viral RNA' DNA is prevented from entering the golgi apparatus for reproduction, and infection is blocked. (ufg.br)
  • For example, until September 2015, there were 7,000 cases of Chikungunya Virus infection reported in Mexico, and 196 cases in Puerto Rico and Virgin Islands. (mirrordaily.com)
  • The assay is used as a screening test for Chikungunya viral infection. (hematologyanalyzerreagent.com)
  • Although the mice initially infected with Chikungunya had low levels of neutralizing antibodies in their bloodstream, these levels rose rapidly after secondary infection with Mayaro, inducing cross-protection against the latter. (azolifesciences.com)
  • Production of memory cells [ B and T lymphocytes ] takes time, but the mice first infected with Chikungunya already had them, so during secondary infection by Mayaro the immune response was faster, including a rise in levels of neutralizing antibodies,' Fumagalli explained. (azolifesciences.com)
  • This experiment served to demonstrate that antibodies produced in response to infection by Chikungunya also led to cross-protection against Mayaro. (azolifesciences.com)
  • Increased surveillance of the virus, including the requirement for laboratory confirmation of infection, was recommended. (who.int)
  • Chikungunya virus is a mosquito-borne alphavirus transmitted by infected mosquitoes, primarily Aedes aegypti and Aedes Albopictus [2]. (cdc.gov)
  • The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. (medscape.com)
  • Chikungunya, a tropical disease in poorer countries, is now becoming a major global health issue given the worldwide distribution of its mosquito vector ( Aedes albopictus and, to a less extent, Aedes aegypti ). (medscape.com)
  • Don't bite me: The female of a mosquito called Aedes aegypti can transmit yellow fever, dengue fever and chikungunya. (wyso.org)
  • Isolation of chikungunya virus from Aedes aegypti mosquitoes collected in the town of Yawat, Pune District, Maharashtra State, India. (ajtmh.org)
  • In recent years, mosquito species Aedes albopictus has expanded in the Indian Ocean region and was the principal vector of chikungunya outbreaks in La Reunion and neighbouring islands in 2005 and 2006. (datadryad.org)
  • Zika virus disease is caused by a RNA flavivirus transmitted to humans by the Aedes mosquito, the same type of mosquito that transmits dengue, chikungunya and yellow fever. (who.int)
  • Conclusion/Significance: Our study constitutes the first analysis of the protein response of Aedes aegypti's midgut infected with viruses belonging to different families. (hal.science)
  • Identificata in oltre 60 Paesi di Asia, Africa, Europa e delle Americhe, la chikungunya si trasmette da persona a persona attraverso la puntura di una zanzara femmina del genere Aedes, come Aedes aegypti ed Aedes albopictus (la zanzara tigre), ricorda l'Iss. (radiocolonna.it)
  • Chikungunya is transmitted by the bite of female mosquitoes of the species Aedes aegypti and A. albopictus . (azolifesciences.com)
  • Chikungunya disease is transmitted by the Aedes mosquito. (msdmanuals.com)
  • As of February 24, 2023, the Ministry of Health in Paraguay reported a total of 71,478 suspect chikungunya cases in Paraguay, with 29,362 of those being probable or confirmed cases since the outbreak began in October 2022 [1]. (cdc.gov)
  • The high tourism season in Costa Rica already has begun, and business owners are concerned reports of a chikungunya outbreak could cause a drop in visits. (ticotimes.net)
  • Several years after the Reunion Island outbreak, chikungunya was discovered in the Americas - first in the Caribbean in 2013 and then Mexico and Florida in 2014. (wyso.org)
  • Dr. Friedlander noted that accompanying the recent outbreak of Zika virus infections in Brazil there has been a tremendous uptick in the number of newborns with microcephaly - from 147 in 2014 to 2,782 in 2015, according to information from the Centers for Disease Control. (dermatologytimes.com)
  • The epidemic of Ebola virus disease in West Africa in 2014-2016 and the current Zika virus outbreak have highlighted the importance of having a clear road map for research and development in place before such an event occurs in order rapidly to activate and coordinate research and development and disburse the necessary funds as soon as the need arises. (who.int)
  • Yemen reported [cumulative No of cases (deaths), CFR %] two back-to-back outbreaks of outbreak ever reported from any chikungunya in 2011 and in 2012. (who.int)
  • In 2011, Yem- situation, one can only expect that en reported an explosive outbreak the situation will not worsen and the 60 countries and territories have reported transmission so far of chikungunya which was the first disease will not spread further. (who.int)
  • The design of a safe and efficient recombinant vaccine is in progress and has been shown to be protective in mouse and nonhuman primate models of Chikungunya. (medscape.com)
  • Yet, imagine if it were possible to generate a vaccine that would be protective for an entire class of viruses. (genengnews.com)
  • There is a lot of emphasis on identifying and understanding broadly neutralizing antibodies for other viruses-HIV, hepatitis C virus, dengue virus, influenza virus-but most of those antibodies neutralize different strains of the same virus," explained senior author Michael Diamond, M.D., Ph.D., a professor of medicine and director of the Division of Infectious Diseases and Vaccine Development in the Center for Human Immunology and Immunotherapy Programs at WUSTL. (genengnews.com)
  • There is no vaccine to protect against chikungunya. (medlineplus.gov)
  • There is currently no vaccine or treatment for chikungunya - but people who do contract the virus become immune to it. (wyso.org)
  • Scientists are evaluating the virus-like particles in clinical trials as a potential vaccine for chikungunya. (futurity.org)
  • The FDA approval is for Ixchiq - the first vaccine for the chikungunya virus, for those age 18 and older. (wuga.org)
  • Vienna, June 6, 2014 - A prophylactic vaccine candidate against Chikungunya fever, developed by the Austrian biotech company Themis Bioscience GmbH induces a significant neutralizing immune response and was also confirmed as safe. (omnescapital.com)
  • These are the major interim results of a phase 1 clinical study of the company's Chikungunya vaccine candidate that uses a standard anti-measles vaccine as a vector. (omnescapital.com)
  • The Chikungunya epidemic, currently raging through the Caribbean, illustrates the urgent necessity to develop an effective vaccine against the rapid spread of the disease in tropical regions, now also threatening the North American continent. (omnescapital.com)
  • The Vienna-based biotech company Themis Bioscience GmbH today received the interim results of a phase 1 clinical study of its Chikungunya fever prophylactic vaccine. (omnescapital.com)
  • Themis Bioscience GmbH develops prophylactic vaccines from the preclinical to the early clinical phase, focusing on emerging tropical infectious diseases, with initial vaccine candidates currently being developed against Dengue and Chikungunya. (omnescapital.com)
  • The first vaccine for chikungunya, an emerging mosquito-borne global health threat marked by fever and joint pain, has been granted accelerated approval by the US Food and Drug Administration (FDA). (medscape.com)
  • The new vaccine is approved for adults 18 years or older who are at increased risk for exposure to the virus. (medscape.com)
  • Some vaccine recipients had chikungunya-like reactions that lasted at least 30 days, the FDA adds. (medscape.com)
  • Cite this: World's First Chikungunya Vaccine Approved by FDA - Medscape - Nov 10, 2023. (medscape.com)
  • In late 2013, local transmission of chikungunya virus was first detected in Caribbean countries and then quickly spread, causing large outbreaks throughout the Americas over the next several years [4-5]. (cdc.gov)
  • Title : Countries with reported current or previous local transmission of chikungunya virus (as of February 10, 2014) Corporate Authors(s) : National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Division of Vector-Borne Diseases. (cdc.gov)
  • Chikungunya fever is a self-remitting febrile viral illness that has been associated with frequent outbreaks in tropical countries of Africa and Southeast Asia. (medscape.com)
  • These viruses are all spread to their hosts through mosquito vectors and typically cause sporadic outbreaks, although Chikungunya has begun to spread more globally leading to more persistent epidemics. (genengnews.com)
  • Dengue, zika, and chikungunya outbreaks in Central and South America countries have presented significant challenges related to their prevention and control. (paho.org)
  • A similar situation was observed in Colombia, where the decrease in dengue cases following the zika and chikungunya outbreaks went from 334.1 cases per 100 000 people in 2015 to 90.7 cases per 100 000 in 2017 and 173,1 cases per 100 000 in 2018 (5). (paho.org)
  • Chikungunya, once confined to Africa and Asia, has seen outbreaks in the Caribbean and bordering countries in South and Central America, including Haiti and the Honduras. (healthyms.com)
  • The current Zika virus outbreaks, and associated microcephaly and neurological disorders, have caused increasing alarm in countries across the world. (who.int)
  • 3 The virus has gone on to cause outbreaks in multiple Pacific island countries and has spread throughout the Americas. (who.int)
  • Using a murine model, Lum et al showed that anti-Chikungunya virus antibodies were elicited early in the course of the illness and were directed against the C-terminus of the viral E2 glycoprotein. (medscape.com)
  • Beginning in late 2022, Paraguay reported an increasing number of chikungunya cases, with more than 70,000 suspect and confirmed cases reported as of February 24, 2023 [1]. (cdc.gov)
  • The patients came here with fever and also with pain in their joints," says Dr. Susana Lloveras, an infectious disease physician at Hospital Muñiz in Buenos Aires, Argentina, one of several South American countries where the mosquito-borne virus has surged in 2023. (wuga.org)
  • Viruses 2023 , 15 , 1479. (usu.edu)
  • Viruses;15(7)2023 06 29. (bvsalud.org)
  • Furthermore, to confirm that the antibodies could protect animals from disease, the researchers infected mice with three different alphaviruses: Chikungunya, the closely related O'nyong'nyong virus, or the more distantly related Mayaro virus. (genengnews.com)
  • Employing the two most potent broadly neutralizing antibodies, the researchers treated the infected mice and saw markedly reduced joint disease caused by any of the viruses. (genengnews.com)
  • Typically, individuals who are infected with alphaviruses produce antibodies against many viral epitopes, some of which are not protective-setting up a weak immune response scenario that allows the virus time to replicate and exert its pathogenic effects. (genengnews.com)
  • Also, it is known that secondary DENV infections may be more severe than primary infections due to the antibody-dependent immune response (i.e., heterotypic sub-neutralizing antibodies that increase virus entry into poorly susceptible cells) (2,3). (paho.org)
  • That can be challenging because some people suffer from the joint pain for months or even years, even though their immune systems have created antibodies to clear the virus. (wuga.org)
  • But she tells her patients the disease just has to run its course, which can be challenging because some people suffer from the joint pain for months or years, even though their immune systems have created antibodies to clear the virus. (wpsu.org)
  • KIELIAN: That contact between the infected cell and the uninfected cell shields the virus from the antibodies, and that's how that cell gets infected. (wpsu.org)
  • As the test sample flows through the membrane within the test, the colored-chikungunya specific recombinant antigencolloidal gold conjugate complexes with specific antibodies (IgM and/or IgG) of chikungunya virus, if present in the sample. (hematologyanalyzerreagent.com)
  • When we tested neutralizing antibodies to one virus against the other, we found a low protective response to both. (azolifesciences.com)
  • In other words, Mayaro and Chikungunya trigger the production of different antibodies, but some of these antibodies are effective against both diseases,' Fumagalli said. (azolifesciences.com)
  • The mosquitoes that spread chikungunya are the same type that spread dengue fever , which has similar symptoms. (medlineplus.gov)
  • Call your health care provider if you develop symptoms of chikungunya. (medlineplus.gov)
  • A mosquito-borne virus that has made its way to the U.S. may be causing more serious symptoms than first thought. (wyso.org)
  • It can cause illness for 7 to 10 days, however, and those infected with chikungunya are more likely to develop symptoms. (healthyms.com)
  • Because it contains a live, weakened version of the chikungunya virus, it can cause chikungunya-like symptoms, the FDA notes. (medscape.com)
  • The symptoms of fever are common enough that it can be hard to pinpoint what is the cause without blood work, but the viruses do tend to show up when people are tested, especially in the summer. (myheronhome.com)
  • Serologic testing for virus specific IgM can be done for those presenting more than 7 days following onset of symptoms. (msdmanuals.com)
  • Other medically important alphaviruses found in the Americas include eastern equine encephalitis virus (neuroinvasive) and Mayaro virus (arthalgic). (cdc.gov)
  • Chikungunya and its cousins-Mayaro, Ross River, and O'nyong-nyong viruses-belong to a family of alphaviruses that mosquitoes spread and that cause joint pain. (futurity.org)
  • A study conducted at the University of São Paulo (USP) in Brazil suggests people previously infected by Chikungunya virus may develop partial immunity to Mayaro virus. (azolifesciences.com)
  • In the experiments, mice were infected first with Chikungunya and a month later with Mayaro. (azolifesciences.com)
  • Mayaro virus and Chikungunya virus both belong to the family Togaviridae. (azolifesciences.com)
  • Before 2013, the virus was found only in Africa, Asia, Europe, and lands in the Indian and Pacific oceans. (medlineplus.gov)
  • Chikungunya is a virus of the Togaviridae family which has affected different parts of the world on several occasions: 2004 in the Indian Ocean, 2007 in Africa, 2007 in Europe, 2011 in the Pacific region, and 2013 in the Americas. (pasteur.fr)
  • Besides South America, Chikungunya is a problem in other parts of the globe: India, China and numerous countries in Africa. (wuga.org)
  • There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. (chikungunyavirusnet.com)
  • As of April 2016, over 60 countries in the Americas, the Pacific Islands, South-east Asia and Africa have reported local transmission of Zika virus disease. (who.int)
  • In 2022, the number of chikungunya cases (n=273,685) reported to the Pan American Health Organization more than doubled the average annual number of cases reported during 2018-2021 [7]. (cdc.gov)
  • Nel 2022, il numero di casi e decessi dovuti alla chikungunya nella regione delle Americhe - riporta l'Oms sul proprio sito - è stato superiore a quello riportato negli anni precedenti. (radiocolonna.it)
  • The chikungunya virus is on the rise again, including in South America, where more than a quarter million new cases have already surfaced this year. (wpsu.org)
  • Chikungunya virus surges in South America. (onair.rs)
  • This information is essential to better estimate the risks of chikungunya emergence, specifying the strong genetic proximity of the mosquito in South-East France with that of La Reunion Island, where the largest chikungunya epidemic ever occurred in France, and more generally in Europe. (pasteur.fr)
  • An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. (ajtmh.org)
  • Tracking the re-emergence of epidemic chikungunya virus in Indonesia. (ajtmh.org)
  • Epidemic resurgence of Chikungunya virus in democratic Republic of the Congo: identification of a new central African strain. (ajtmh.org)
  • The Chikungunya epidemic, currently rampant in the Caribbean, shows that such a platform could be soon needed on a larger geographic scale. (omnescapital.com)
  • Several murine models with Chikungunya virus-related joint and neurological diseases are being investigated. (medscape.com)
  • Chikungunya starts with fevers and aches, like malaria and other mosquito-borne diseases. (wyso.org)
  • Mosquitoes that carry chikungunya virus are mainly active in the daytime, but mosquitoes that are active toward dawn and dusk can carry other diseases, such as West Nile virus. (healthyms.com)
  • Abstract Background: Arthropod borne virus infections cause several emerging and resurgent infectious diseases. (hal.science)
  • Among the diseases caused by arboviruses, dengue and chikungunya are responsible for a high rate of severe human diseases worldwide. (hal.science)
  • Diseases such as West Nile and Chikungunya spread so rapidly that it's almost impossible to contain them. (myheronhome.com)
  • Vectors of chikungunya virus in Senegal: current data and transmission cycles. (ajtmh.org)
  • In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. (chikungunyavirusnet.com)
  • In order to discuss this hypothesis it must be taken into account that Zika, dengue (DENV) and chikungunya viruses are closely related flaviviruses, with identical urban transmission and some immune interactions (1). (paho.org)
  • Although, dengue virus (DENV) complex humanitarian situation. (who.int)
  • Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. (medscape.com)
  • 3137 (345), 10.9% causing widespread epidemics with gue, Chikungunya and yellow fever. (who.int)
  • The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to notify clinicians and public health authorities of an increase in the number of cases of chikungunya reported in Paraguay. (cdc.gov)
  • For the most up-to-date information, please visit the Centers for Disease Control and Prevention's (CDC) website -- www.cdc.gov/chikungunya . (medlineplus.gov)
  • The Centers for Disease Control and Prevention, Atlanta, and the European Centre for Disease Control and Prevention,Stockholm, and other national public health agencies have also issued travel warnings, which include recommendations that pregnant women consider postponing travel to any area with ongoing Zika virus transmission. (who.int)
  • Dengue and Zika viruses are transmitted by the same mosquitoes and have similar clinical features as chikungunya disease and should be considered ( Centers for Disease Control and Prevention (CDC): Chikungunya Virus ). (msdmanuals.com)
  • On the other hand, we propose that the modulation of other proteins like transferrin, hsp60 and alpha glucosidase, may favour virus survival, replication and transmission, suggesting a subversion of the insect cell metabolism by the arboviruses. (hal.science)
  • There is a risk the virus will be spread to unaffected areas by infected travelers. (cdc.gov)
  • Chikungunya virus is a mosquito-borne disease especially prevalent in the Caribbean, where it can infect U.S. travelers. (healthyms.com)
  • Chikungunya can spread from person to person through the bite of a mosquito once travelers return home. (healthyms.com)
  • albopictus vector competence for chikungunya virus through an adaptive co-evolution process. (pasteur.fr)
  • A proteomic approach was undertaken to characterize the key virus/vector interactions and host protein modifications that happen in the midgut for viral transmission to eventually take place. (hal.science)
  • Now that we have these new structures, we can see how to disrupt the interaction between the virus and the protein it uses to get inside cells in the joints and other musculoskeletal tissues in order to block infections," adds co-senior author Daved Fremont, a professor of pathology and immunology, of biochemistry and molecular biophysics, and of molecular microbiology. (futurity.org)
  • They obtained the images using a chikungunya virus-like particle-which has shape of a virus but cannot cause infections because it carries no genetic material inside-as well as a fully infectious chikungunya virus. (futurity.org)
  • Although temporary associations do not prove causation, the strength and consistency of the observations suggest that infections with Zika virus and chikungunya virus could induce cross-protective immunity against dengue. (paho.org)
  • Other viral infections being seen more commonly in infants are Chikungunya and syphilis. (dermatologytimes.com)
  • It also highlights those at increased risk for severe disease and prevention measures to mitigate additional spread of the virus and potential importation into unaffected areas, including the United States. (cdc.gov)
  • We have more work to do but are encouraged that targeting this epitope could be a viable strategy for developing vaccines or treatments against Chikungunya and other related viruses that cause significant disease worldwide," Dr. Diamond concluded. (genengnews.com)
  • Dr. Susana Lloveras, an infectious disease physician at Hospital Muñiz in Buenos Aires, Argentina, says she used to see one or two cases of chikungunya a year. (wuga.org)
  • Having started in the Dominican Republic, it has already reached Haiti and fears are now growing that the disease could spread further to the USA, where isolated cases of Chikungunya have been observed in recent years. (omnescapital.com)
  • Chikungunya is an emerging viral disease, which is clinically difficult to distinguish from dengue. (scienceopen.com)
  • ARI DANIEL, BYLINE: Over the years, Dr. Susana Lloveras has seen cases of chikungunya in Buenos Aires, where she works as an infectious disease physician at Hospital Muniz. (wpsu.org)
  • On 1 February 2016, WHO announced that the recent cluster of neurological disorders and neonatal malformations reported in the Americas region constitute a Public Health Emergency of International Concern (PHEIC) and called for a global response to the spread of Zika virus disease. (who.int)
  • As of May 2016, no countries of the Region have reported importation of Zika virus disease or autochthonous transmission. (who.int)
  • prensa-latina.cu reported Nicaraguan authorities reported today on the detection of two new cases of chikungunya, which amounts to 35 the number of people affected by this disease. (latinamericacurrentevents.com)
  • Chikungunya disease usually presents with acute fever. (msdmanuals.com)
  • Chikungunya disease is an acute febrile illness followed by more chronic polyarthritis that can persist for months or years and be severe and disabling. (msdmanuals.com)
  • Chikungunya disease is suspected in patients who live in or have traveled to endemic areas if they develop sudden fever and arthralgias. (msdmanuals.com)
  • Prevention of chikungunya disease involves avoiding mosquito bites. (msdmanuals.com)
  • Chikungunya is a viral disease which an Region. (who.int)
  • Chikungunya virus causes fever, muscle and joint pain, and swelling of the joints. (healthyms.com)
  • Chikungunya virus, once confined to the Eastern Hemisphere, has infected more than 1 million people in the Americas since 2013, when mosquitoes carrying the virus showed up in the Caribbean. (futurity.org)
  • In addition, the recent introduction of Zika and chikungunya viruses in the Americas and the large-scale exposure of a uniformly unexposed population could affect subsequent transmission of dengue virus. (paho.org)
  • Epidemiological Alert:Chikungunya increase in the Region of the Americas. (msdmanuals.com)
  • Chikungunya and dengue viruses cocirculate in Paraguay and surrounding countries, are transmitted by the same species of mosquitoes, and have similar clinical presentations during acute illness. (cdc.gov)
  • In doing so, they likely provided breeding ground for the species of mosquito that can transmit the chikungunya virus. (wyso.org)
  • In 2018, Diamond, Fremont, and colleagues identified the protein Mxra8, found on the outer surface of cells in the joints, as the molecular handle that chikungunya and related viruses grasp to gain entry into cells of mice, humans, and other species. (futurity.org)
  • Since 2004, date of the well-known chikungunya emergence on La Reunion Island, the community of entomologists has focused a lot of efforts on the study of this species. (pasteur.fr)
  • Both viruses caused an increase of proteins involved in the generation of reactive oxygen species, energy production, and carbohydrate and lipid metabolism. (hal.science)
  • Most people infected with chikungunya virus become symptomatic. (cdc.gov)
  • Zika virus also has similar clinical features and transmission patterns as chikungunya and dengue viruses. (cdc.gov)
  • 181B potentially associated with Zika virus (ZIKV) has highlighted the urgent need to identify individuals infected with ZIKV. (who.int)
  • Preparedness for Zika virus testing in the World Health Organization Western Pacific Region Western Pacific Surveillance and Response Journal , 2016, 7(1):44-47. (who.int)
  • On 1 February 2016, the World Health Organization (WHO) declared that clusters of microcephaly cases and other neurological disorders occurring in Zika virus (ZIKV)-affected areas constituted a public health emergency of international concern. (who.int)
  • For years, scientists have been on the hunt to develop vaccines that would protect against all or most strains of particularly virulent viruses such as influenza. (genengnews.com)
  • As reported in Cell , the structures show in atomic-level detail how the virus and cell-surface protein fit together-data that promises to accelerate efforts to design drugs and vaccines to prevent or treat arthritis that chikungunya or related viruses cause. (futurity.org)
  • But to design effective drugs and vaccines that interfere with attachment, researchers needed a detailed picture of the molecular interactions between the virus and the protein.The researchers used a technique called cryo-electron microscopy (cryo-EM) to visualize the virus bound to the cell-surface protein. (futurity.org)
  • And always from people bringing the mosquito-borne virus with them from other countries. (wuga.org)
  • DANIEL: Each year, and always from people bringing the mosquito-borne virus with them from other countries. (wpsu.org)
  • Home Chikungunya blues Costa Rica registers 2 new cases of chikungunya virus, bringing total number. (ticotimes.net)
  • Costa Rican Health Ministry officials on Thursday confirmed two more cases of the chikungunya virus. (ticotimes.net)
  • Last month, officials issued a preventive alert prompted by a report of 300 confirmed cases of chikungunya in that country. (ticotimes.net)
  • We have 9 million visitors per year going to the Caribbean, and so we've seen lots and lots of imported cases of chikungunya," LaBeaud says. (wyso.org)
  • Over the years, Dr. Lloveras says she has seen cases of chikungunya in Buenos Aires "but it is not common for us. (wuga.org)
  • Mirror Daily, United States) - Researchers found that, in rare cases, mosquito-borne chikungunya virus causes brain damage which may lead to long-term effects. (mirrordaily.com)
  • Chikungunya is a virus passed to humans by the bite of infected mosquitoes. (medlineplus.gov)
  • This means that mosquitoes in those areas have the virus and are spreading it to humans. (medlineplus.gov)
  • Mosquitoes spread the virus to humans. (medlineplus.gov)
  • But in up to half of patients, the virus can cause severe arthritis that persists for months or years. (futurity.org)
  • When the virus is present in the blood of a pregnant person during delivery, chikungunya can be transmitted to the baby, as reported, and can cause severe, potentially fatal chikungunya in newborns. (medscape.com)
  • The sensitivity and specificity of the OnSite Chikungunya IgM Rapid Test-Cassette and the SD Bioline CHIK IgM rapid test were evaluated in comparison to a capture ELISA. (scienceopen.com)
  • The development of polyvalent immunoglobulins purified from human plasma samples of convalescent Chikungunya patients could benefit infected viremic mothers and newborns. (medscape.com)
  • But earlier this year, she says, "We receive every day patients with chikungunya, including some with no travel history. (wuga.org)
  • LLOVERAS: We receive everyday patients with chikungunya. (wpsu.org)
  • According to recent reports from the Ministry of health, the general condition of patients could indicate that Central America is facing a mild form of the virus. (latinamericacurrentevents.com)
  • The researchers also analyzed blood serum from patients infected by Chikungunya. (azolifesciences.com)
  • Chikungunya virus is spread to people by the bite of an infected mosquito. (cdc.gov)
  • They spread the virus when they bite other people. (medlineplus.gov)
  • The virus particles are enveloped icosahedral capsids and have a diameter of 60-70 nm. (cdc.gov)
  • To visualize how the virus interacts with the cell-surface protein, the researchers first flash-froze the viral particles attached to the protein. (futurity.org)
  • Characterization of reemerging chikungunya virus. (hal.science)