• He is most well known for his descriptions of phylogenetic trees, studies of radiolarians, and illustrations of vertebrate embryos to support his biogenetic law and Darwin's work with evolution. (asu.edu)
  • Moreover, it has recently been shown that mouse and human ES cells can develop into a three-dimentional (3D) optic cup in culture that remarkably resembles the embryonic vertebrate eye 20 , 21 . (nature.com)
  • [1] They are found in the vertebrate retina , which serve as support cells for the neurons, as all glial cells do. (iiab.me)
  • Müller glia have been further identified as fundamental to the transmission of light through the vertebrate retina due to their unique funnel shape, orientation within the retina and more favorable physical properties. (iiab.me)
  • During vertebrate development, the retina is originally derived from anterior neural plate. (oist.jp)
  • Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
  • A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
  • Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
  • Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)
  • 2001) had found amniotic epithelial cells conditioned medium showed neurotrophic effect on rat embryonic day 18 (E18) cortical neurons. (scielo.org.ar)
  • The earliest embryonic mammalian retinal waves are generated via gap junctions (Stage I), followed by Stage II, when they are driven by cholinergic amacrine cells [from late gestation until postnatal day 9 (P9) in mouse] ( Torborg and Feller, 2005 ). (jneurosci.org)
  • Haeckel aggressively argued that the development of an embryo repeats or recapitulates the progressive stages of lower life forms and that by studying embryonic development one could thus study the evolutionary history of life on earth. (asu.edu)
  • The present in vitro study suggests that the avian pineal organ is made up of multiple types of cells with different immunore-activity at the ontogenic state (from embryonic day 9 to day 14), before it acquires the final photoendocrinal nature of the mature state. (bioone.org)
  • The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis. (researchmap.jp)
  • Lateral and radial growth uncoupled in reaggregated retinospheroids of embryonic avian retina. (ehu.eus)
  • Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
  • During development, cells from diverse embryonic lineages interact to form the anterior segment. (biomedcentral.com)
  • Amniotic epithelial cells transplantation in Parkinson model of rats was found to reverse the condition and prevent death in neurons (Kakishita et al. (scielo.org.ar)
  • This includes regulation of the extracellular environment via uptake of neurotransmitters , removal of debris, regulation of K+ levels, storage of glycogen , electrical insulation of receptors and other neurons, and mechanical support of the neural retina. (iiab.me)
  • They are the only retinal glial cell that shares a common cell lineage with retinal neurons. (iiab.me)
  • [4] Müller glia have also been implicated to serve as guidepost cells for the developing axons of neurons in the chick retina. (iiab.me)
  • As glial cells, Müller glia serve a secondary but important role to neurons . (iiab.me)
  • In this region, six major classes of retinal neurons differentiate and form neural circuits responsible for vision. (oist.jp)
  • Although apoptosis is important for establishment of proper neural circuits by eliminating abnormally differentiated neurons, it is unclear how differentiating cells monitor their own abnormality, and how the threshold at which apoptosis is induced is determined. (oist.jp)
  • The retina has greater proliferative potential than the other two compartments by virtue of the presence of retinal progenitor cells (RPCs), which are capable of dividing repeatedly and generating retinal neurons and Müller glia on distinct developmental schedules. (molcells.org)
  • Of the six GPCs expressed in chick, only GPC1 was found in mature commissural neurons ( Figure S1 available online). (vegfr-3inhibitor.com)
  • Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)
  • In the US, where a portion of the population is opposed to destruction of human embryos to obtain stem cells, what avenues are open to scientists for obtaining pluripotent cells that do not offend the moral sensibilities of a significant number of citizens? (asu.edu)
  • Expression analysis of several Hox genes in human embryos. (cnr.it)
  • Next, by the intersect of the targeted genes with an increase in their expression in epithelial to mesenchymal transition (EMT) of RPE cells, we tried to build a microRNA-mRNA integrative network. (ac.ir)
  • Our study revealed that among the 3406 genes being upregulated over the course of EMT in RPE cells, adj p-value≤0.05, fold change≥1.5, 93 genes were miR-204-5p and miR 211-5p target genes. (ac.ir)
  • Expression of c-ets-1 and uPA genes is associated with mammary epithelial cell tubulogenesis or neoplastic scattering. (ehu.eus)
  • The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)
  • For example, mesoderm determinants are activated in the anterior third of the embryo, whereas neurogenic genes are expressed in central regions. (sdbonline.org)
  • This analysis indicates that each Otx class is characterized by highly specific and conserved expression features in the presumptive RPE, where Otx1 and Otx2, but not Otx5, are transcribed at optic vesicle stages, in the differentiating neural retina, where Otx2 and Otx5 show a conserved dynamic expression pattern, and in the forming ciliary process, a major site of Otx1 expression. (ox.ac.uk)
  • Conditional expression of Otx2 in these morphant embryos cell-autonomously rescues the formation of the ZLI at its correct location. (silverchair.com)
  • Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)
  • Otx2 cell-autonomous control of thalamic glutamatergic progenitors. (cnr.it)
  • Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2. (cnr.it)
  • Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. (biologists.com)
  • In addition to the cells originating from the OC, and thus the neural tube, neural crest-derived mesenchymal cells contribute to the formation of the ciliary folds, forming connective tissues and ciliary muscles( Beebe, 1986 ). (biologists.com)
  • These mesenchymal cells differentiate into the corneal endoderm, structures at the iridocorneal angle, and iris and ciliary body stroma. (biomedcentral.com)
  • It is specified in the anterior neural plate, and evaginates to form the OV, which in turn invaginates to form the OC. (biologists.com)
  • The ocular anterior segment is critical for focusing incoming light onto the neural retina and for regulating intraocular pressure. (biomedcentral.com)
  • Abnormal migration, proliferation, differentiation, or survival of these cells contribute to diseases of the anterior segment such as corneal dystrophy, lens cataract, and glaucoma. (biomedcentral.com)
  • With establishment of the lens vesicle, head mesoderm and neural crest cells migrate into a periocular location and eventually move into the anterior segment of the rudimentary eye between the surface ectoderm and the neural retina and lens. (biomedcentral.com)
  • A detailed understanding of the mechanisms of development of the anterior segment can provide general insights into questions such as tissue induction, cell type fate determination, and the regulation of cellular morphogenesis. (biomedcentral.com)
  • The primordial eye field in the anterior neural plate is specified immediately after gastrulation to form the optic vesicle (OV), a neuroepithelial evagination of the ventral-lateral diencephalic area. (molcells.org)
  • What are the consequences of expressing a constitutively activated form of the Toll receptor, Toll(10b), in anterior regions of the early embryo? (sdbonline.org)
  • Zebrafish represent a powerful model organism for investigating the genetics and cell biology of development and disease. (biomedcentral.com)
  • particular BiologyThe Life Sciences Institute asks an colourful retina, biology present interest. (cutechabeads.com)
  • [14] Studies in human models have demonstrated that Müller glia have the potential to serve as stem cells in the adult retina [15] and are efficient rod photoreceptor progenitors. (iiab.me)
  • Cell autonomous inhibition of Notch signal reception results in significantly increased endocrine differentiation demonstrating that these early progenitors are prevented from differentiating by ongoing Notch signaling. (biomedcentral.com)
  • Lineage tracing studies have revealed that both endocrine and exocrine cells are derived from Pdx1 -expressing progenitors [ 1 - 3 ]. (biomedcentral.com)
  • Chick in ovo electroporation is a technique which allows genetic manipulation of the avian embryo. (jove.com)
  • Little is known about the developmental origin, determination and differentiation of different pineal immunoreactive cells in the avian group, and an experimental establishment is then required to explain the differentiation of cell types (i.e. photosensory, neural and secretory types). (bioone.org)
  • 2001). In our previous report, we concluded the usefulness of amniotic epithelial cells transplantation in spinal cord injury repair research. (scielo.org.ar)
  • Cell adhesion molecules in early chicken embryogenesis. (academicinfluence.com)
  • At this juncture, through the present study it was found that, chicken neural retinal cells when grown alone failed to survive and contrarily when either co-cultured with chicken amniotic epithelial cells / cultured in amniotic epithelial cell conditioned medium not only survived but also showed extensive differentiation. (scielo.org.ar)
  • Fibroblast Growth Factor - 2 (FGF-2) plays a critical role in retinal development especially in chicken neural retinal development. (scielo.org.ar)
  • [7] Müller glia have also been shown to be important in the induction of the enzyme glutamine synthetase in chicken embryos, [8] which is an important actor in the regulation of glutamine and ammonia concentrations in the central nervous system . (iiab.me)
  • To further understand the mechanism by which Notch exerts this function, we have investigated pancreatic endocrine development in chicken embryos. (biomedcentral.com)
  • This lays the ground for further studies that take advantage of the ease at which chicken embryos can be manipulated. (biomedcentral.com)
  • Endocrine cells begin to appear soon after the first morphological signs of pancreas formation which occurs approximately at the 25-somite stage in the mouse and chicken [ 7 ]. (biomedcentral.com)
  • Such theories of preformation persisted well in the eighteenth century by which time (in 1759) the German investigator Caspar Friedrich Wolff (1733-1794) offered experimental evidence that no preformed embryo existed in the egg of the chicken. (biologydiscussion.com)
  • Students will learn about the evolution of the eye, and how the direction that evolution took led to an inside-out retina that resulted in light having to pass through several layers of cells before reaching the actual photoreceptors. (charlotteteachers.org)
  • They will learn about how vision occurs as light passes through the structures of the eye and is absorbed by photoreceptors in the retina, and how the brain interprets the signals in order to respond to what it is seeing. (charlotteteachers.org)
  • However, to fulfill this promise, a remaining challenge is to induce human iPSC to recreate in vitro key structural and functional features of the native retina, in particular the presence of photoreceptors with outer-segment discs and light sensitivity. (nature.com)
  • Further analysis of the obtained target gene list demonstrated that these two microRNAs are mostly involved in maintaining RPE cells from going through EMT via regulation of cell adhesion and secretion subnetworks and also MAPK and TGF-β1 signaling pathways while preserving cells from apoptosis and neuronal fates. (ac.ir)
  • Amniotic epithelial cells were known to express some of neuronal and glial cell markers (Sakuragawa et al. (scielo.org.ar)
  • The main objective of our group is to understand the cellular and molecular mechanisms of neural differentiation, from the early process of nervous sytem formation (known as neurulation), to neuronal differentiation. (fcien.edu.uy)
  • Here, via in-silico experiments based on biophysical modeling, we estimate water movement across astrocyte cell membranes, within astrocyte networks, and within the extracellular space (ECS) induced by neuronal activity, and quantify the relative role of different forces (osmotic, hydrostatic, and electrical) on transport and fluid flow under such conditions. (bvsalud.org)
  • Several types of immunoreactive cells from a neuronal line were suppressed with maturation of developing pineal glands, while other cell types such as photoreceptive and endocrinal lines became more prominent. (bioone.org)
  • These findings suggest that a reduced dosage of PHOX2B during development, through either a heterozygous deletion or dominant-negative mutation, imposes a block in the differentiation of sympathetic neuronal precursors, resulting in a cell population that is likely to be susceptible to secondary transforming events. (prolekarniky.cz)
  • Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. (lookformedical.com)
  • Placental stem cells. (scielo.org.ar)
  • Human pluripotent stem cells are valued for their potential to form numerous specialized cells and for their longevity. (asu.edu)
  • Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these diseases or as potential therapeutic agents. (nature.com)
  • Their embryos continue development until they attain a form resembling the adult. (biologydiscussion.com)
  • Developing retinal ganglion cells fire in correlated spontaneous bursts, resulting in propagating waves with robust spatiotemporal features preserved across development and species. (jneurosci.org)
  • Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
  • As the development of embryology grew in importance during the late 1800s, so did the need for models to show intricate details of embryos. (asu.edu)
  • Here we report that hiPSC can, in a highly autonomous manner, recapitulate spatiotemporally each of the main steps of retinal development observed in vivo and form three-dimensional retinal cups that contain all major retinal cell types arranged in their proper layers. (nature.com)
  • The results of the present study, a combined analysis of morphometry and RIA, open a new line for research into the pineal development and cell differentiation. (bioone.org)
  • [3] They are to be critical to the development of the retina in mice, serving as promoters of retinal growth and histogenesis via a non-specific esterase mediated mechanism. (iiab.me)
  • Isolation of a novel chick homolog of Serrate and its coexpression with C-Notch-1 in chick development. (ehu.eus)
  • This historic 1957 paper by Padget describes human cranial venous development using a number 0f Carnegie Collection embryos. (edu.au)
  • The present communication is the logical outcome of the author's companion study of the development of the cranial arteries in the human embryo (Padget, 1948, 1954). (edu.au)
  • Wnt signaling orchestrates multiple aspects of central nervous system development, including cell proliferation and cell fate choices. (biologists.com)
  • Several studies have demonstrated that Notch signaling is involved in the development of endocrine cells in the pancreas. (biomedcentral.com)
  • Embryogenesis or embryogeny may be defined as the formation and development of embryos. (biologydiscussion.com)
  • In some lower animals the amount of yolk is less in egg, so that the embryo hatches in earlier stages of development, called a larva. (biologydiscussion.com)
  • Aristotle (384-322 B.C.) was the first Greek philosopher who described the ontogenetic development of chick and many other forms. (biologydiscussion.com)
  • William Harvey (1578- 1657) and Marcello Malpighi (1628-1694) contributed information on the various stages of the development of chick on the basis of their studies with the help of simple lens. (biologydiscussion.com)
  • This method of progressive development from the simpler to the more complex, through the utilisation of building units (globules or cells) is called epigenesis. (biologydiscussion.com)
  • In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues. (molcells.org)
  • Development of the organs and tissues that make up multicellular organism is mediated by a series of compartmentalizations from unspecified germ layers of the post-gastrula embryo. (molcells.org)
  • By substituting the Arg/Lys residues in cationic cell-penetrating peptides (CPPs) with histidine, we obtained peptides with pH-dependent membrane-perturbation activity. (bvsalud.org)
  • The apoplast is the plant compartment present between the plasma membrane and the cuticle, comprised of the cell wall and the extracellular spaces where the "secretomes" are released and where the apoplastic fluid circulates. (bvsalud.org)
  • Better coupling between the tissue and the electrodes was achieved by placing a small piece of polyester membrane filter (5 μm pores) (Sterlitech) on the retina followed by a slice anchor holder (Warner Instruments). (jneurosci.org)
  • The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis. (ehu.eus)
  • An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
  • The subcellular localization of LPA 1 in LPA 1- overexpressing cells was mainly located in the plasma membrane and endogenously located in the perinuclear area. (molcells.org)
  • These results raise the possibility that Toll signaling components diffuse in the plasma membrane or syncytial cytoplasm of the early embryo (Huang, 1997). (sdbonline.org)
  • Influence on the Cells Membrane Permeability and Integrity Cell membrane integrity is crucial for cell features and success. (forgetmenotinitiative.org)
  • 2003). Similarly, when transplanted into ischemic cortical areas, they were found to differentiate into 'neuron-like' cells (Okawa et al. (scielo.org.ar)
  • The progenitor cell can then divide and differentiate into a number of retinal cell types, including photoreceptor cells , that may have been damaged during injury. (iiab.me)
  • Lens epithelial cells differentiate into lens fiber cells, each of which are integrated in a stereotyped geometric pattern to form spherical lens fiber core. (oist.jp)
  • This study indicated that miR-204-5p and miR 211-5p are involved in protecting RPE cells from EMT and reinforce their epithelial cell identity. (ac.ir)
  • Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)
  • The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)
  • Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
  • Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. (ac.ir)
  • Apoptosis is observed in developing tissues and is believed to remove abnormal cells. (oist.jp)
  • In addition, Wnt signal activation in the central retina was sufficient to induce the expression of markers of the ciliary body and iris, two tissues derived from the peripheral optic cup (OC). (biologists.com)
  • Cell adhesion molecules: implications for a molecular histology. (academicinfluence.com)
  • Cell adhesion and the molecular processes of morphogenesis. (academicinfluence.com)
  • However, it is still unclear to what extent hiPSC may be capable of recapitulating in vitro the cellular and molecular features of the native retina, especially regarding photoreceptor differentiation and functional maturation. (nature.com)
  • Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
  • Only gradually did these "globules" organise into rudiments (germ layers) which, in turn, took on the characteristics of the various organs of the embryo. (biologydiscussion.com)
  • The dynamics of aqueous humor have been best characterized in mammals where ciliary epithelial cells produce the clear ocular fluid while the trabecular meshwork, which is situated at the iridocorneal angle overlying Schlemm's canal, regulates drainage. (biomedcentral.com)
  • Neuroblastoma is an embryonal malignancy of the peripheral sympathetic nervous system (PSNS) that arises from the developing neural crest and manifests as neoplasms in sympathetic ganglia or adrenal medulla. (prolekarniky.cz)
  • Two-day old chick embryo section, showing the optic cup and the invaginating lens placode, labeled to show the presence of MARCKS protein (green) and actin filaments (red). (fcien.edu.uy)
  • Lenses consist of two cell-types: lens epithelial cells and lens fiber cells. (oist.jp)
  • Mühleisen TW, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. (arizona.edu)
  • To determine whether Notch in fact does act in Ngn3-expressing cells in vivo will require further studies relying on conditional mutagenesis. (biomedcentral.com)
  • Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
  • Previously, we have reported neurotrophism exhibited by human amniotic epithelial cells when transplanted after spinal cord injury in bonnet monkeys. (scielo.org.ar)
  • Recently, our conclusion of usefulness of amniotic epithelial cells transplantation to treat spinal cord injuries has been confirmed in rodent models of spinal cord injury (Zhi-yuan et al. (scielo.org.ar)
  • Ascending spinal tract formation in chick embryo originating from different spinal regions. (researchmap.jp)
  • It is interesting to note that while factor secreted by amniotic epithelial cells resembles EGF and/or FGF-2 in its biological action, known isoforms of them were not detected. (scielo.org.ar)
  • A defining feature of neuroblastic tumors is their broad spectrum of cellular differentiation, ranging from undifferentiated cells that indicate a poor prognosis to those showing greater differentiation and predicting a generally favorable outcome [2] . (prolekarniky.cz)
  • En: Cellular and Animal Models in Human Genomics Research (Translational and Applied Genomics Series). (fcien.edu.uy)
  • These peptides do not randomly penetrate cells like CPPs, but imitate the endosomal escape of CPPs following cellular uptake. (bvsalud.org)
  • New insights into cell-specific and compartmental ATP and GTP production, as well as utilization and buffering strategies and their relationship with known retinal and cellular functions, are discussed. (molvis.org)
  • A genuine variety of allelochemicals appear to alter place cell membranes. (forgetmenotinitiative.org)
  • Because of lipophilic nature from the cell membranes, monoterpenes could cause their devastation by raising permeability or inhibiting enzymes [18]. (forgetmenotinitiative.org)
  • Finally, it remains to be determined whether iPSC can recreate the 3D histo-architecture of the neural retina (NR) in vitro beyond a rudimentary stratification 22 . (nature.com)
  • Ephs and ephrins during early stages of chick embryogenesis Dev Dyn. (arizona.edu)
  • Using simulations we show that interplay between progenitor density, cell shape and changes in differentiation rate could naturally result in negative-feedback control on progenitor cell number. (biologists.com)
  • Extracellular NAMPT (eNAMPT, also called visfatin or pre-B-cell colony enhancing factor) has been shown to possess adipocytokine, pro-inflammatory, and pro-angiogenic activities. (bvsalud.org)
  • Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube. (ehu.eus)
  • This enhancer contains a cluster of low-affinity Dl binding sites that restrict expression to the ventral-most regions of early embryos. (sdbonline.org)
  • There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)
  • Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. (ac.ir)
  • First, we will investigate mechanisms that regulate cell differentiation and neural circuit formation. (oist.jp)
  • They are the most common type of glial cell found in the retina. (iiab.me)
  • Optical section of a 3 days-old zebrafish embryo retina, where retinal ganglion cells )magenta), actin filaments (yellow) and DNA (cyan) were labeled. (fcien.edu.uy)
  • Retinal ganglion cells were labeled both using a specific antibody (blue) and by transient transgenic GFP expression (yellow). (fcien.edu.uy)
  • Experiments were performed at P4-P6, when GABA A signaling is depolarizing in ganglion cells, and at P7-P10, when GABA A signaling is hyperpolarizing. (jneurosci.org)
  • Examination of ganglion cells had which these four groups of different parts. (solo-predictions.com)
  • Allelic deficiency, modeled by phox2b morpholino knockdown, led to a decrease in the terminal differentiation markers th and dbh in sympathetic ganglion cells. (prolekarniky.cz)