Chest ischemia onset ischemia time. Medical search. FAQ

symptom
Methods and Results- A total of 534 ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with thrombus aspiration within 12 hours of symptom onset were randomized to either an intracoronary or an intravenous bolus of abciximab (0.25 mg/kg). (ahajournals.org)
Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. (blogspot.com)
Intraspinal or intracranial hemorrhage comment most common symptom dull ache may resemble enteroviral infection include fever malaise and anorexia typically precede the onset. (visitmayberry.com)
showed that Q-waves on the baseline ECG are an independent marker of worse clinical outcome and, importantly, "after multivariable adjustment, baseline Q-wave but not time from symptom onset was significantly associated with a 78% relative increase in the hazard of 90-day mortality and a 90% relative increase in the hazard of death, shock, and CHF. (blogspot.fr)
Thus, another study shows that the ECG is a better marker of "acuteness" of the ECG than is time of symptom onset. (blogspot.fr)
Evaluation of chest discomfort in women must be tempered by a lower pretest likelihood of CAD and the atypical symptom presentation. (docplayer.net)
The use of a negative initial troponin I together with a symptom onset of ≥8 hours defines a population with a very low incidence of a hospital diagnosis of NSTEMI. (hindawi.com)
This serum protein of cardiac cell necrosis appears 4 to 12 hours after symptom onset and remains abnormal for 4 to 10 days [ 4 , 5 ]. (hindawi.com)
A strategy of measuring cardiac markers within 6 hours of symptom onset with repeat measurements occurring 8 to 12 hours after symptom onset is recommended by the American College of Cardiology/American Heart Association (ACC/AHA) and is thought to approach 100% sensitivity for excluding the diagnosis of AMI [ 3 ]. (hindawi.com)
The American College of Emergency Physicians (ACEP) has published a clinical policy that supports the use of a single negative TnI obtained 8 to 12 hours after symptom onset for the exclusion of non-ST-segment elevation myocardial infarction (NSTEMI). (hindawi.com)
This study involves a retrospective analysis of data collected from patients that present with an acute focal neurological deficit, suspected cerebral ischemia, or suspected intracranial hemorrhage within 24 hours of symptom onset or last known well time will be enrolled into the study. (clinicaltrials.gov)
The outcome of this treatment highly depends on the time from symptom onset to the administration of thrombolytic agent. (clinicaltrials.gov)
Last known normal time is widely used as the standard to determine the symptom onset. (clinicaltrials.gov)
The symptom of myocardial infarction usually contains chest pain, and it is easy to identify the exact time of onset. (clinicaltrials.gov)
First the history of symptom onset will be re-taken once more, focusing on the presentation of each neurological symptom. (clinicaltrials.gov)
The symptom onset judged by the neurologist first assessed at the emergency department will be compared to that of the stroke neurologist re-interviewed after admission. (clinicaltrials.gov)
The onset time and the sequence will be investigated by each symptom. (clinicaltrials.gov)

ischemic
A retrospective analysis of 1031 patients with STEMI referred for primary percutaneous coronary intervention with known ischemic times between 1 and 6 hours identified 165 patients with occluded arteries on presentation without evidence of preinfarction angina or collateral blood flow. (ahajournals.org)
Both ischemic duration and angiographic area at risk were not dependent on time of infarct onset. (ahajournals.org)
The ischemic region was mapped with bipolar electrodes and, after the chest was rapidly closed, signal-averaged recordings were made from the body surface. (physiology.org)
In each dog, delayed and fractionated electrograms were recorded directly from the ischemic epicardium that lasted a maximum of 118 +/- 18 ms after QRS onset. (physiology.org)
In dogs, demand ischemia triggers both stunning (reversible contractile dysfunction despite the return of normal myocardial perfusion) and ischemic preconditioning (protection against infarction caused by subsequent coronary occlusion) (1,2) . (onlinejacc.org)
Systolic dysfunction during exercise is a physiologically meaningful marker of ischemia that might bear closer comparison with ischemic preconditioning. (onlinejacc.org)
To avoid missing early myocardial damage in patients with normal or nondiagnostic electrocardiograms, physicians routinely employ the use of serial troponin measurements initially on arrival to the emergency department (ED) and subsequently at a time frame of 6 to 12 hours after the onset of ischemic symptoms. (hindawi.com)
The precise timing of serum marker measurement, however, must take into account the uncertainties often present with the exact timing of onset of ischemic symptoms and the sensitivity, precision, and institutional norms of the assay being utilized. (hindawi.com)
This clinical trial will determine an acceptable dose of reteplase in combination with a fixed dose of abciximab for ischemic stroke 3-24 hours from onset in patients screened with brain CT rather than MRI (as required by the ROSIE protocol). (clinicaltrials.gov)
Many features of this patient population have remained constant with successive reports over time: a female predominance, onset of symptoms commonly between 40 and 50 years of age, pain that is severe and disabling, and inconsistent responses to conventional anti-ischemic therapy. (onlinejacc.org)

myocardial infarction
Serious causes for chest pain include: Acute Coronary Syndromes (ACS): New onset angina, accelerating or crescendo angina and prolonged angina or coronary insufficiency, non ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI). (docplayer.net)
H-FABP is recommended to be tested in conjunction with troponin to identify myocardial infarction and Acute Coronary Syndrome in patients presenting with chest pain. (biopanda.co.uk)

cerebral
Aortic dissection (sudden, tearing chest or interscapular back pain with weakness, dizziness, diaphoresis, pallor, new aortic regurgitation, cerebral ischaemia or pulse deficits) Pulmonary embolism (sudden pleuritic chest discomfort with dyspnea, hypoxemia) Pericarditis (sharp, retrosternal chest discomfort. (docplayer.net)
Cerebral ischemia or intracranial hemorrhage suspected. (clinicaltrials.gov)
Therefore, it may be much unclear and uncertain to determine the onset time of cerebral infarction. (clinicaltrials.gov)
Despite the importance of onset time in therapeutic decision making, there was no study focusing on the certainty of onset time in cerebral infarction patients. (clinicaltrials.gov)
In this study, we will investigate the subjective certainty of patient about the onset time in clear-onset cerebral ischemia. (clinicaltrials.gov)

reperfusion
The effects of CHD are usually attributable to the detrimental effects of acute myocardial ischemia-reperfusion injury (IRI). (jci.org)
In rodents, infarct size after ischemia/reperfusion exhibits a circadian dependence on the time of coronary occlusion. (ahajournals.org)
The greatest myocardial injury occurred at 1:00 am onset of ischemia and 5:00 am onset of reperfusion, with the peak creatine kinase measured at the peak of the curve being 82% higher than that recorded at the trough. (ahajournals.org)
9 Recently, Durgan et al 10 demonstrated that ischemia/reperfusion tolerance is dependent on the time of day of coronary occlusion. (ahajournals.org)
Using a mouse ischemia/reperfusion model, they demonstrated a 3.5-fold variation in infarct size that was dependent on the time of day onset of coronary occlusion. (ahajournals.org)

electrocardiographic
Patients may also develop less anginal pain and electrocardiographic (ECG) evidence of ischemia during sequential exercise testing: the "warm-up" phenomenon (6) . (onlinejacc.org)
4 ) reported on 15 women ranging in age from 30 to 53 years with chest pain despite normal coronary angiograms (CPNCA), but with electrocardiographic (ECG) abnormalities at rest (ST-segment depression or T-wave inversion) that were accentuated by exercise. (onlinejacc.org)

duration
The score was derived using discriminant function analysis, by weighting and combining depth and configuration of ST depression (downsloping, horizontal or slowly upsloping), timing onset and duration of ischemia, grading ventricular arrhythmias, heart rate and blood pressure change, coexistence of exercise-induced chest pain and sex. (ahajournals.org)
The duration of the ventricular electrograms varied with time. (physiology.org)

abnormal
And influenza usually type b hib and pcv vaccines at the time of routine daily portable chest radiograph suggest, patients with abnormal lfts or it may be given orally or by stress testing with glucose control even before the age of onset and offset and may have a significant risk factors for infantile spasms or the caregiver that is produced by mucosal contact with human parvovirus. (visitmayberry.com)
Because patients may have had abnormal noninvasive testing that led to performance of coronary angiography, investigators have sought to show an association of this syndrome with myocardial ischemia. (onlinejacc.org)
Abnormalities in coronary flow and metabolic responses to stress have been reported by several groups, findings consistent with a microvascular etiology for ischemia and symptoms, but others have questioned the presence of ischemia, even in patients selected for abnormal noninvasive testing. (onlinejacc.org)

infarct
As the myocardium infarcts (Q-waves), rather than being "injured," (as manifested by ST elevation and hyperacute T-waves), the size of the T-wave diminishes, and also the ST elevation diminishes and Q-waves begin to form (although in anterior STEMI Q-waves may form very early due to ischemia of the conducting system, not infarct! (blogspot.com)
The time of onset of chest pain is not a good determinant of the time of onset of irreversible ischemia (infarct). (blogspot.com)
The results of this study demonstrate for the first time in humans that myocardial infarct size and left ventricular function after STEMI have a circadian dependence on the time of day onset of ischemia. (ahajournals.org)
There has been a sustained drive for earlier treatment of patients with a vascular event, and in most countries paramedics now give aspirin immediately on first contact with a patient who is experiencing severe chest pain and is judged to have possibly had a myocardial infarct or ischaemia. (bjcardio.co.uk)

ventricular
This study describes a noninvasive method for detecting delayed ventricular activation, caused by ischemia, on the body surface. (physiology.org)

STEMI
Acute occlusion of the coronary artery in the STEMI patient subjects the myocardium supplied by that vessel to acute myocardial ischemia, thereby demarcating the area at risk (AAR) of potential MI, should the acute coronary occlusion be sustained or permanent. (jci.org)
The GISSI and the LATE trial both established that late thrombolysis, up to 12 hours after onset of chest pain, is beneficial for STEMI. (blogspot.fr)
There are many STEMI, however, which will benefit beyond 12 hours of chest pain: the time onset of chest pain is not necessarily the time of onset of irreversible ischemia. (blogspot.fr)
Acute chest pain is best evaluated in the ER to rule out ACS, NSTEMI, STEMI or other serious causes. (docplayer.net)

marker
Thus we conclude that IMA assay is a sensitive but not very specific marker for early detection of myocardial ischemia. (alliedacademies.org)

angina
One hour after a high carbohydrate meal, the onset of angina during exercise occurs earlier than in the fasted state. (onlinejacc.org)
Relief by rest or nitroglycerin If all three features are present the chest pain or discomfort is classified as TYPICAL ANGINA. (docplayer.net)
If two of three features are present the chest discomfort is classified as ATYPICAL ANGINA. (docplayer.net)
Since initial reports over 4 decades ago, cases of patients with angina-like chest pain whose coronary angiograms show no evidence of obstructive coronary artery disease and who have no structural heart disease continue to be a common occurrence for cardiologists. (onlinejacc.org)

Evaluation
Evaluation of patients presenting with chest pain in the emergency department is difficult and challenging [ 1 , 2 ]. (alliedacademies.org)
1 CHEST PAIN EVALUATION TOOL Chest pain or discomfort is one of the commonest causes for presentation to the Emergency Room (ER) or physicians office. (docplayer.net)
A biomarker panel approach, similar to that used for the evaluation of chest pain patients (troponin I, CK-MB, and myoglobin) enhances diagnostic accuracy, particularly when the panel includes protein markers associated with various components of the disease pathophysiology. (clinicaltrials.gov)
Several published series, including the National Heart, Lung, and Blood Institute-sponsored CASS (Coronary Artery Surgery Study) and the WISE (Women's Ischemia Syndrome Evaluation) study, have reported that up to one-half of patients undergoing coronary angiography are found to have normal or nonobstructed epicardial coronary arteries ( 1-3 ). (onlinejacc.org)

discomfort
There are many causes for chest discomfort. (docplayer.net)
Less serious causes include: Chest wall pain (costochondritis, pleurodynia) Referred pain from cervical disc disease, brachial plexus (neuritis, scalenus anticus syndrome, cervical rib) Gastro-esophageal reflux disease (reflux esophagitis or esophageal spasm) Referred abdominal pain (biliary colic, gastritis, perforated ulcer or other viscus) Zoster or shingles Causes of chest pain or discomfort are best identified by a careful medical history. (docplayer.net)
Ischaemic chest pain or discomfort may present with typical or atypical features. (docplayer.net)
If only one of three features are present the chest discomfort is classified as NON ANGINAL CHEST PAIN. (docplayer.net)
Only 30% of women report chest discomfort prior to heart attack. (docplayer.net)

detrimental effects
However, whereas more recent studies have assessed the effect of meals of different composition on exercise tolerance and onset of ischemia ( [5, ), they did not assess the time course of any detrimental effects and furthermore used liquid meals rather than the warm solid foods that patients would usually consume. (onlinejacc.org)

hours
Existing biochemical markers are not suitable for assessing early myocardial ischemia particularly in first 2-6 hours of ischemia i.e. before setting in of irreparable myocardial damage. (alliedacademies.org)
Dr. Smith's ECG Blog: 5 hours of chest pain. (blogspot.com)
5 hours of chest pain. (blogspot.com)
A male is his 30's with h/o HTN presented after 6 hours of chest pain. (blogspot.com)
It is well known that thrombolytics work best with fresh thrombus, within 2 hours of onset of occlusion (Steg et al. (blogspot.com)
But this patient has had 5 hours of chest pain. (blogspot.com)
9 Hours of Chest Pain and Deep Q-waves: Is it too late for Thrombolytics? (blogspot.fr)
A 50 year old hypertensive presented with 9 hours of central crushing chest pain. (blogspot.fr)
Moreover, the chest pain is less than 12 hours. (blogspot.fr)
Dr. Smith's ECG Blog: 9 Hours of Chest Pain and Deep Q-waves: Is it too late for Thrombolytics? (blogspot.com)
It is effective only if begun within 3 to 4.5 hours of onset of the stroke because of potential deleterious side effects including life threatening symptomatic intracranial hemorrhage (sICH) when the drug is administered outside of this time window. (clinicaltrials.gov)
H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3-6 hours following chest pain onset. (biopanda.co.uk)
This treatment is effective only if begun within 3 hours of onset of the stroke, however, and most patients do not get to the hospital early enough to benefit from it. (clinicaltrials.gov)

noncardiac
This time of day dependence mainly has been attributed to noncardiac factors such as changes in sympathetic tone 6 and circadian variation in coagulation factors. (ahajournals.org)

arrhythmia
Mitral valve prolapse: Mitral valve prolapse is more common in women, and while often is assymptomatic it can manifests as fatigue, chest pain, shortness of breath, arrhythmia and a heart murmur. (drtorihudson.com)

thrombolytics
How long after onset of chest pain are thrombolytics effective (how long is the time window)? (blogspot.fr)

limiting chest pain
1-mm ST segment depression and limiting chest pain were recorded. (onlinejacc.org)

markers
The former involves protection against indirect markers of ischemia (chest pain and ECG changes), whereas the latter represents protection against irreversible myocardial necrosis. (onlinejacc.org)

acuteness
1. The ECG is a better indicator of acuteness than the time since onset of chest pain. (blogspot.com)

indicator
The Q-waves are the only indicator of prolonged ischemia. (blogspot.fr)

depression
Onset of chest pain or 1 mm ST depression was delayed and occurred at a higher rate-pressure product during the second exercise test. (onlinejacc.org)

humans
There is increasing evidence that transient ischemia in humans can affect myocardial function in similar patterns to those described in experimental animal models. (onlinejacc.org)

exercise
Despite similar hemodynamic adjustments, a high fat meal does not affect exercise time. (onlinejacc.org)
On a subsequent day, the exercise plus ischemia test was repeated after HMR 1402 (3.0 mg/kg i.v., n = 4, infusion 4 μg/kg/min for 1 h before exercise, n = 4). (aspetjournals.org)

reduction
Time to thrombolysis and mortality reduction. (blogspot.fr)

minutes
Conditions necessary for altering the metal binding site of HSA are known to occur in vivo and probably occur within minutes after the onset of myocardial ischemia [ 10 - 12 ]. (alliedacademies.org)
The Door (small hospital) to Balloon (PCI hospital) time will be 90 minutes. (blogspot.com)
H-FABP is a sensitive and highly specific biomarker of myocardial ischemia and can be detected in the blood as early as thirty minutes from the onset of chest pain. (biopanda.co.uk)

angiographic
The angiographic likelihood of significant CAD can be derived from these three cardinal features as well as the AGE and GENDER of the patient as presented in the table at the top of the chest pain algorithm on the next page. (docplayer.net)

severe
A 49-year-old male had felt severe chest pain accompanied by a cold sweat during his evening work of garbage collection. (hindawi.com)

artery
The SCAD had occurred in the distal right coronary artery (RCA), the mid left anterior descending artery (LAD), and the distal LAD at the same time. (hindawi.com)
Eleven dogs were studied before and during acute ischemia induced by coronary artery ligation and latex embolization. (physiology.org)

clinical
Though there are clinical, biochemical and other laboratory tests which help in diagnosis but there is no rapid and definitive test which can be termed as gold standard to rule out myocardial ischemia. (alliedacademies.org)

However
10 There is, however, relatively little evidence on the time between the onset of symptoms and the first medical contact (FMC). (bjcardio.co.uk)

Heart
When the blood and oxygen to the heart are decreased, the heart muscle suffers from ischemia and results in a squeezing or pressure pain in the chest. (drtorihudson.com)

effects
Multiple clock proteins appear to be regulated in a time-dependent manner in cardiomyocytes that may have profound effects on myocardial metabolism, function, and response to injury. (ahajournals.org)
A. Pathogenesisit is unlikely to be useful in the emergency department after a meal and at risk for the common benign entities as well as some cases intensive visual retraining may allow enough time to manifes- tation of effects. (visitmayberry.com)
Edwards and Weston, 1993 ), as during ischemia, drugs that block this channel would have minimal effects on the nonischemic myocardium, and therefore should be free of the proarrhythmic effects noted for many antiarrhythmic drugs. (aspetjournals.org)