Chemotherapy with cisplatin studies protected from chemotherapy induced. Medical search. Frequent questions

AIMS: This study aimed to evaluate the ability of compound 13d to induce autophagy and to promote apoptosis of tumor cells and its interaction mechanism. (bvsalud.org)
KEY FINDINGS: The results indicated that compound 13d could induce autophagy and apoptosis of gastric cancer cells. (bvsalud.org)
Furthermore, inhibition of PTEN activity increased cell apoptosis in the kidneys of mice induced by cisplatin. (oncotarget.com)
In summary, our study has demonstrated that inhibiting PTEN activity aggravates cisplatin-induced AKI via apoptosis, inflammatory reaction, and p53 signaling pathway. (oncotarget.com)
Conversely, wildtype αB-Crystallin and αB-Crystallin pseudophosphorylation mutants that alter its chaperone activity will be overexpressed in the OVCAR8 cells to determine the role of this protein in conferring resistance to WA-induced apoptosis. (bridgew.edu)
Furthermore, constitutively active and inactive forms of PKCδ respectively enhanced and suppressed cisplatin-induced apoptosis in cultured cells. (elsevierpure.com)
however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future. (hindawi.com)
One scientific study went further and suggested that turmeric can induce "apoptosis" that is cell death in fat cells. (herbs-for-health.com)
Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
In addition, ERW induces apoptosis together with glutathione in human leukemia HL60 cells (Tsai et al. (h2hubb.com)
These findings indicate that hydrogen-rich saline protects heart and liver from injury by inhibiting cell apoptosis. (h2hubb.com)
These findings demonstrate that hydrogen-rich saline could decrease DOX-induced cell apoptosis. (h2hubb.com)
have reported that GADD45α interacts with MEKK4/MTK1 and activates the JNK/p38 signaling pathway that induces apoptosis and introduction of the GADD45α expression vector into tumor cells via transient transfection induces apoptosis [43]. (thrombininhibitors.com)
GADD45α-mediated JNK/p38 activation is required for BRCA1-induced apoptosis [44] and UVB radiation-induced apoptosis is deficient in GADD45α-/- mouse epidermis MM-102 research buy [17]. (thrombininhibitors.com)
In this study, our results showed that depletion of GADD45α by RNAi inhibited ESCC cells proliferation and promoted apoptosis, which suggested that GADD45α may be a novel and effective target for ESCC therapy. (thrombininhibitors.com)
Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Cisplatin (cis-Diamminedichloroplatinum II) can lead to AKI because of its kidney toxicity [ 2 ]. (oncotarget.com)
From a clinical perspective, the well-known toxicity of chemotherapy often remains a serious barrier to successful treatment and even enrollment in clinical trials. (genengnews.com)
Taiwanese researchers found that si jun zi decoction can alleviate toxicity induced by cisplatin , a chemotherapy medication. (preventcancer.news)
2 Chemotherapy is associated with several adverse effects and signs of immediate and delayed toxicity. (asjo.in)
Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. (dogcancerblog.com)
Key words: advanced gastric cancer, chemotherapy, oxaliplatin, pemetrexed, phase II trial addition, cisplatin-based combinations are difficult toadminister in this often-debilitated population and have the Patients suffering from advanced gastric cancer (AGC) remain potential for severe toxicity. (aboutdrugspdf.com)
Despite regimens with acceptable toxicity profiles are needed, with increasing evidence that the appropriate management of fit increasing attention toward patient convenience and quality patients should be with systemic chemotherapy, nocombination has yet emerged as the standard of care. (aboutdrugspdf.com)
To date, chemotherapy relies heavily upon 5-fluorouracil (5-FU) and/or Oxaliplatin is a third-generation platinum derivative with cisplatin, with 5-FU-cisplatin (CF) and epirubicin-cisplatin- a more favorable toxicity profile than cisplatin [4]. (aboutdrugspdf.com)
Also cisplatin accumulation shows toxicity to normal tissues. (biomedcentral.com)
HemoHIM may be a beneficial supplement during cisplatin chemotherapy for enhancing the anti-tumor efficacy and reducing the toxicity of cisplatin. (biomedcentral.com)

Cisplatin (cis-Diamminedichloroplatinum II) has been widely and effectively used in chemotherapy against tumors. (oncotarget.com)
For example, one minute, ovarian granulosa cell tumors and other stromal malignancies are being successfully destroyed with a cisplatin and etoposide combination chemotherapy. (fieldofscience.com)
Eric Kmiec, PhD, director of ChristianaCare's Gene Editing Insitute and principal author of the study, and his team investigated the feasibility of using CRISPR-directed gene editing in combination with standard of care treatment of solid tumors, including NSCLC. (genengnews.com)
The trial would test whether using CRISPR to knock out the NRF2 gene in squamous cell carcinoma lung cancer tumors improves the efficacy of conventional chemotherapy and radiation treatments. (genengnews.com)
The cancers produce tumors that are frequently protected by the NRF2 gene. (genengnews.com)
Since the majority of ovarian tumors eventually recur in a drug-resistant form leaving patients few treatment options, the goal of this study is to explore the molecular mechanism induced by WA in a cisplatin-resistant ovarian cancer cell line (OVCAR8R) as compared to its cisplatin-sensitive syngeneic counterpart (OVCAR8). (bridgew.edu)
Research suggests that it can be used to treat malignant tumors in the digestive tract and to improve the immune function and quality of life of patients after chemotherapy. (preventcancer.news)
11 In one study with mice bearing breast cancer tumors, complete remission was confirmed on four out of ten fed with maitake, while the remaining six showed a 90 percent suppression rate. (earthsfirstfoods.com)
However, in many cases, chemotherapy or radiotherapy alone cannot achieve a satisfactory therapeutic outcome, namely the complete remission of tumors, and induces severe side effects at therapeutically effective doses. (biomedcentral.com)
Cisplatin (cis-diaminedichloroplatinum (II) or CDDP), a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors. (biomedcentral.com)
Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)

While healthy cells are protected from DNA damage induced by reactive oxygen species, malignant cells are protected against chemo- or radiotherapy. (genengnews.com)
Conventional medical treatment could include surgery, radiotherapy, immunotherapy and chemotherapy. (asjo.in)
The experiential arm consisted of patients treated with cisplatin 40 mg/m2 and gemcitabine 125 mg/m2 weekly instead of 6 weeks with concurrent external ray radiotherapy (50. (daubnet.com)
A inject II scan of bevaci- zumab in confederation with absolute radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma: preceding results of RTOG 0417. (daubnet.com)

Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
In 2011 World Journal of Urology published an animal study in which the kidney damage in rats caused by the chemotherapy drug, cisplatin was partially reversed by treatment with royal jelly. (healthbuff.com)
In 2015 the Journal of Ginseng Research published an animal study which showed that Korean red ginseng protected mice against damage to the male reproductive system caused by the chemotherapy drug, busulfan. (healthbuff.com)

Palonosetron did not inhibit the antitumor activity of cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C in murine tumor models. (com.bd)
Methods: A PK/PD study was performed in 27 early breast cancer patients treated with doxorubicin and cyclophosphamide for 4 cycles followed by 4 cycles of docetaxel 75-100 mg/m2 infused every 21 days. (unav.edu)
Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

Kidney issues and damage are fairly common in cancer patients undergoing some types of chemotherapy. (theamazingflower.com)
In earlier work, while studying the biology of the cognitive difficulties that linger in some people being treated for cancer, Noble and colleagues discovered that 5-fluorouracil, (cisplatin, cytarabine, carmustine), and multiple other types of chemotherapy, damages populations of stem cells in the CNS. (rochester.edu)

Examples of chemotherapy treatments that can lead to dysgeusia are cyclophosphamide, cisplatin, vismodegib, and etoposide. (wikipedia.org)
In 2012 Cell Journal published an animal study which showed that 6 weeks of supplementation with American ginseng protected rats from toxic effects of the chemotherapy drug cyclophosphamide on sperm quality. (healthbuff.com)

This study used the chemotherapy drug Cisplatin to induce compromised kidney function in mice. (theamazingflower.com)
Compared with vehicle mice, mice treated with bpV(pic) (specific inhibitor of PTEN) had exacerbated renal damage due to cisplatin-induced AKI. (oncotarget.com)
More inflammatory cytokines were activated after cisplatin treatment in mice of the bpV(pic)-treated group compared with vehicle mice, and these inflammatory cytokines may be partially derived from bone marrow cells. (oncotarget.com)
An alcohol-free fermented blueberry and blackberry beverage extract attenuates diet-induced obesity and blood glucose in mice. (greenmedinfo.com)
Here, we show that cisplatin induced rapid activation of autophagy in cultured kidney tubular cells and in the kidneys of injected mice. (elsevierpure.com)
Finally, administration of the PKCδ inhibitor rottlerin with cisplatin protected against cisplatin nephrotoxicity in wild-typemice, but not in renal autophagy-deficient mice. (elsevierpure.com)
Using mice transplanted with human colorectal cancer cells, they studied the anti-metastasis activities of the modified si jun zi decoction and compared it to the anti-cancer drug, 5-fluorouracil. (preventcancer.news)
Studies with diabetic mice have found that maitake exhibits anti-diabetic activity. (earthsfirstfoods.com)
By studying tamoxifen's impact on central nervous system cell populations and then screening a library of 1,040 compounds already in clinical use or clinical trials, his team identified a substance known as AZD6244, and showed that it essentially eliminated tamoxifen-induced killing of brain cells in mice. (rochester.edu)
Brandhorst walked through an example that used mice receiving chemotherapy treatment. (integrativepractitioner.com)
While fasting sensitized cancer cells in mice, fasting also reduced the severity of symptoms in patients that have received chemotherapy. (integrativepractitioner.com)
In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin and to reduce the side effects of cisplatin in melanoma-bearing mice. (biomedcentral.com)
Anticancer effects of HemoHIM with cisplatin were evaluated in melanoma-bearing mice. (biomedcentral.com)
In melanoma-bearing mice treated with cisplatin, HemoHIM administration also increased the activity of NK cells and Tc cells and the IL-2 and IFN-γ secretion from splenocytes, which seemed to contribute to the enhanced efficacy of cisplatin by HemoHIM. (biomedcentral.com)
Studies on mice show that even at astronomical doses of 300 mg per day for two years, there were no side effects. (innovativemedicine.org)

CBGA also strongly suppressed mRNA of inflammatory cytokines in cisplatin-induced nephropathy, whereas CBD treatment was only partially effective. (theamazingflower.com)

The majority of NK-1 receptor antagonist doses are administered intravenously in the United States, and with the introduction of Varubi IV, we now offer healthcare providers a unique, easy-to-use option that fits well into standard operating practices of a chemotherapy clinic or hospital," Mary Lynne Hedley, PhD, president and COO of Tesaro, said in a press release. (pharmacytimes.com)
Morphological studies show WA-induced cytotoxicity in both cell lines, however the OVCAR8R cells remain viable at 5.0 and 7.5μM WA while few OVCAR8 cells remain viable at these doses. (bridgew.edu)
In 2012 Support Care Cancer published a double-blind trial which tested the effects of a placebo vs three different doses of ginger in 744 cancer patients undergoing chemotherapy. (healthbuff.com)
In our case, my son initially encountered moderate-to-severe, high frequency hearing loss after his first dose of cisplatin, so all additional cisplatin doses were replaced with carboplatin to be a bit gentler on his auditory system. (cac2.org)
In a review of 6493 children on Pediatric Oncology Group studies, the risk of developing CHF was 5 times higher with cumulative doses higher than 550 mg/m 2 than with lower doses. (medscape.com)
2008). Patients receiving chemotherapy with a goal of cure must receive full doses of standard chemotherapy on schedule to achieve optimal outcomes (Bonadonna et al. (medscape.com)

Previously, we discovered that successful functional knockout (KO) of the NRF2 gene in chemo-resistant lung cancer cells significantly increased the anticancer activity of cisplatin, carboplatin, and vinorelbine in both cell culture and mouse models. (genengnews.com)
In addition, a 2016 clinical trial published in BMC cancer showed that 72 hours of fasting is associated with reduced DNA damage and reversal of lympthocutopenia in patients receiving gemcitabine/cisplatin, carboplatin/taxol. (integrativepractitioner.com)

Varubi indicated for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting in adults. (pharmacytimes.com)
The FDA has approved intravenous (IV) rolapitant (Varubi) for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting (CINV) in adults, according to Tesaro, the manufacturer of the agent. (pharmacytimes.com)
Delayed nausea and vomiting occurs between 25 and 120 hours after chemotherapy. (pharmacytimes.com)
We will continue our efforts to expand awareness of delayed chemotherapy-induced nausea and vomiting, and plan to make this important medicine available next month. (pharmacytimes.com)
Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial in maximizing patients' quality of life and optimizing outcomes of cancer therapy, and can be done more effectively than ever before. (medscape.com)
Similar to realtors' mantra of "location, location, location," oncology nurses should have the mantra "prevention, prevention, prevention" foremost on their minds when assessing and developing a plan of care for controlling chemotherapy-induced nausea and vomiting (CINV). (medscape.com)
Poorly controlled nausea or vomiting associated with chemotherapy increases risk of developing anticipatory nausea and vomiting, which ranges from 18%-57% in incidence (NCCN, 2012a). (medscape.com)
A study of patients with breast cancer who received aggressive antiemetics demonstrated improved appetite, better control of nausea and vomiting, and subsequent improved quality of life (Roldán et al. (medscape.com)

The CRISPR-directed gene editing strategy could advance as an effective augmentative therapy to approach patients with locally advanced lung cancer, especially where the current standard of care has failed and there may be resistance to standard chemotherapy. (genengnews.com)
Conclusions: Pharmacokinetically-guided dose adjustment of standard chemotherapy treatments might improve survival outcomes in patients with pancreatic ductal adenocarcinoma. (unav.edu)

However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment. (dogcancerblog.com)
However, the DCF regimen induced treatment of patients with AGC [5-9]. (aboutdrugspdf.com)
When cisplatin is part of the chemotherapeutic regimen, high frequency hearing loss is common. (cac2.org)

Common causes of dysgeusia include chemotherapy, asthma treatment with albuterol, and zinc deficiency. (wikipedia.org)
After treatment with LicA, reactive oxygen species, glutathione, and superoxide dismutase levels in cells all were significantly decreased, which indicated that LicA has an antioxidative effect on Aß25-35-induced oxidative injury. (bvsalud.org)
MCP-1 potently induced macrophage migration across the endothelial monolayer and adropin treatment effectively reduced this phenomenon. (bvsalud.org)
In a comment of previous clincial studies with human subjects, reported in the Forschung Komplementmedicine in 2008, the writers concluded that milk thistle is a positive option as a general supportive supplement for the liver and in treatment of cirrhosis. (superfoods-scientific-research.com)
The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity. (greenmedinfo.com)
ROCHESTER, MN-Stating that cancer cells are now "laughing in our fucking faces," a new Mayo Clinic study with widespread implications for the treatment and potential cure of the disease has found that the malignant growths have begun cruelly mocking researchers. (fieldofscience.com)
Following WA treatment for 24h, the endogenous level of αB-Crystallin is upregulated in a dose dependent manner in the cisplatin-resistant OVCAR8R cells, while the cisplatin-sensitive OVCAR8 cells upregulate αB-Crystallin and Hsp-27 at 2.5and 5.0μM WA. (bridgew.edu)
In vitro, pharmacologic inhibition of mTOR, directly or through inhibition of AKT, enhanced autophagy after cisplatin treatment. (elsevierpure.com)
A total of 31 patients were enrolled in the trial, with 20 patients in the treatment group receiving ONCOS-102 plus SoC chemotherapy, and 11 patients in the control group receiving SoC only. (prnewswire.com)
Previous MPM clinical trials have reported mOS in the range of 12-16 months for patients receiving the same SoC chemotherapy treatment [1] . (prnewswire.com)
Recently, the double checkpoint inhibitor (CPI) combination of Opdivo and Yervoy (nivolumab and ipilimumab) was approved by the U.S. Food and Drug Administration ( October 2020 ) and the European Medicines Agency ( April 2021 ) for the first-line treatment of MPM, based on a phase 3 trial showing mOS of 18.1 months compared with 14.1 months in the SoC control group (pemetrexed/cisplatin). (prnewswire.com)
Introduction A retrospective clinical study was performed to identify the characteristics of patients with lung cancer treated with integrative cancer treatment in addition to conventional medicine. (asjo.in)
A growing body of research supports the idea that fasting and fasting-mimicking diets support cancer treatment, induce stem cell activation, and can be an integral component in addressing autoimmune disease. (integrativepractitioner.com)
Chemotherapy has been one of the major therapeutic modalities commonly used for the treatment for a variety of cancer patients. (biomedcentral.com)
Resistance to chemotherapy, especially to DDP, has presented itself as a major obstacle in treatment of advanced ESCC. (thrombininhibitors.com)
In 2010 Chinese Acupuncture and Moxibustion published a study in which 64 patients with chemotherapy-induced peripheral neuropathy were divided into two treatment groups - acupuncture or cobamamide (vitamin B12) injections. (healthbuff.com)
In 2014 the Asian Pacific Journal of Cancer Prevention published a 45-patient study which showed that acupuncture administered the day prior, the day of, and the day after a chemotherapy treatment was able to reduce pain, nausea, vomiting, insomnia and anxiety. (healthbuff.com)
Studies from Emory University reveal how treatment with chemotherapy may awaken breast cancer cells from dormancy and trigger renewed growth. (insideprecisionmedicine.com)
Background: Despite a potentially curative treatment, the prognosis after upfront surgery and adjuvant chemotherapy for patients with resectable pancreatic ductal adenocarcinoma (PDAC) is poor. (unav.edu)
Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
Long-term studies of this population have brought to light specific adverse effects of treatment, which are often present years after treatment and thus are termed late effects. (medscape.com)
The aggressive nature of ATC makes treatment studies difficult to perform. (medscape.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
This column reviews the history and pathophysiology of treatments for CINV, as well as patient- and chemotherapy-specific risk factors that should be considered to optimize treatment outcomes in patients with CINV. (medscape.com)
Patients with cancer often approach chemotherapy treatment with preconceived ideas about what their experience will entail. (medscape.com)

TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
This study tested the effects of CBD and CBGA on reducing kidney damage and their anti-fibrosis effects in acute kidney disease mouse models. (theamazingflower.com)
In different study, 106 patients with mild acute and subacute liver illness characterized by elevated serum transaminase levels were randomized to receive silymarin or placebo. (superfoods-scientific-research.com)
Nephrotoxicity due to cisplatin is one of the most common clinical causes of acute kidney injury (AKI), which has a poor prognosis and high mortality. (oncotarget.com)

The small Hsps, αB-Crystallin and Hsp27, confer resistance to chemotherapy in several cancer cell lines, however, the role of WA on αB-Crystallin and Hsp27 expression in drug resistance remains unknown. (bridgew.edu)
Importantly, I found that αB-Crystallin and Hsp27 are constitutively expressed in the OVCAR8R cells, while OVCAR8 cells do not endogenously express these Hsps, suggestingthat overexpression of Hsps may confer resistance to chemotherapy and promote a more aggressive tumor type. (bridgew.edu)

Our results prompted further exploration of the feasibility of innovative therapeutic approaches aimed at reducing the clinical side effects of chemotherapy," noted the researchers. (genengnews.com)
15 Maitake has also been shown to help lessen the side effects of chemotherapy, including hair loss, nausea, and loss of appetite. (earthsfirstfoods.com)

New drug compounds have greater value if they do not compromise the effects of existing treatments, and in this case, Noble said, the experiments in his laboratory agreed with studies by other research groups, who found that the combined use of AZD6244 and chemotherapy enhances targeting of cancer cells. (rochester.edu)
In 2004 the Journal of Clinical Oncology published a study in which 31 patients with severe chemotherapy-related-fatigue saw an average 31 percent improvement in fatigue levels following 6-8 acupuncture treatments. (healthbuff.com)
A groundbreaking study conducted at Northwestern Medicine suggests that an artificial intelligence (AI) tool could spare breast cancer patients unnecessary chemotherapy treatments by more accurately predicting patient outcomes. (insideprecisionmedicine.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)

Patients with node-positive breast cancer that becomes node-negative after neoadjuvant chemotherapy can omit regional nodal irradiation (RNI) without increasing their risk for recurrence, suggests data presented at the 2023 San Antonio Breast Cancer Symposium. (insideprecisionmedicine.com)

Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)
Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. (biomedcentral.com)

But the next minute, those shit-eaters are overexpressing the BRCA1 locus protein and triggering the expression of the antiapoptotic protein survivin, thus protecting ovarian cells from cisplatin-induced survivin down-regulation and making them completely chemo-resistant. (fieldofscience.com)

Many healthcare providers tend to believe that CINV is no longer an unmet need but the reality is that more than half of patients treated with emetogenic chemotherapy experience delayed CINV, even when prescribed standard preventative therapies, such as a 5-HT3 receptor antagonist and dexamethasone," Lee Schwartzberg, MD, professor of Medicine at University of Tennessee Health Science Center, said in a statement. (pharmacytimes.com)

Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
Taurine has been shown to be depleted in people taking chemotherapy. (peacehealth.org)
It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)

In 2012 the Iranian Journal of Nursing and Midwifery Research published a double-blind clinical trial in which 80 women with breast cancer undergoing chemotherapy were given 1 gram of ginger or a placebo daily for 6 days, beginning 3 days before the start of chemotherapy. (healthbuff.com)
Adult tablet dosage: 0.5 mg administered approximately 1 hour prior to the start of chemotherapy. (com.bd)
Adult IV dosage: A single IV dose of 0.25 mg should be administered over 30 seconds approximately 30 minutes before the start of chemotherapy. (com.bd)

LicA could also significantly reduce Aß25-35-induced autophagy in SH-SY5Y cells. (bvsalud.org)
CONCLUSIONS: LicA protects SH-SY5Y cells against Aß25-35-induced injury, wherein suppressed autophagy and activated PI3K/Akt/mTOR signaling pathway are involved, and mTOR-dependent autophagy at least plays some role. (bvsalud.org)
Cisplatin also induced the phosphorylation of mammalian target of rapamycin (mTOR), p70S6 kinase downstream of mTOR, and serine/threonine-protein kinase ULK1, a component of the autophagy initiating complex. (elsevierpure.com)
Notably, in both cells and kidneys, blockade of PKCδ suppressed the cisplatin-induced phosphorylation of AKT, mTOR, p70S6 kinase, and ULK1 resulting in upregulation of autophagy. (elsevierpure.com)
Together, these results reveal a pathway consisting of PKCδ, AKT, mTOR, and ULK1 that inhibits autophagy in cisplatin nephrotoxicity. (elsevierpure.com)
PKCδ mediates cisplatin nephrotoxicity at least in part by suppressing autophagy, and accordingly, PKCδ inhibition protects kidneys by upregulating autophagy. (elsevierpure.com)
During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)

In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
Earlier studies showed that one microtubule drug, paclitaxel, works by interfering with mitosis to kill cancer cells though it does not stop the mitotic process entirely. (insideprecisionmedicine.com)

In the 1970's, two German research group proved through clinical studies that 70 percent of people suffering from chronic liver diseases had a vastly improved chance of recovery when given between 210 - 420 milligrams of silymarin daily over periods ranging from 6 weeks to 2 years. (superfoods-scientific-research.com)
The study is an open-label, exploratory phase 1/2 trial adding ONCOS-102 to SoC chemotherapy (pemetrexed/cisplatin) in first- and second- (or later) line MPM to assess safety, immune activation and clinical efficacy compared with SoC alone. (prnewswire.com)
The turmeric herb is quite effective at preventing and even treating various diseases that there are currently over 9,000 clinical and medical scientific studies that have been conducted on this " Queen of Spices . (herbs-for-health.com)
In one clinical study a specific beta-glucan found in maitake, known as D-fraction, administered to cancer patients increased NK cell activity and effectively repressed cancer progression in all ten subjects. (earthsfirstfoods.com)
Maitake's hepoprotective effects have been shown in clinical studies as well. (earthsfirstfoods.com)
In 2016 the Iranian Journal of Pharmaceutical Research published a double-blind, placebo-controlled clinical trial involving 107 AML patients who underwent chemotherapy, which found that a combination of 50 grams of honey and 150 grams of tahini consumed 3 timer per day reduced white blood cell count, fever duration and gastrointestinal complications compared to a control group. (healthbuff.com)
We present a 4-year retrospective study that evaluated the clinical impact of the acceptance of the recommendations made by a meropenem-focused ASP. (unav.edu)

In mechanistic studies, we showed coimmunoprecipitation of PKCδ and AKT from lysates of cisplatin-treated cells and direct phosphorylation of AKT at serine-473 by PKCδ in vitro. (elsevierpure.com)
HemoHIM itself did not inhibit melanoma cell growth in vitro , and did not disturb the effects of cisplatin in vitro . (biomedcentral.com)
In vitro studies indicated that palonosetron is not inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1 & CYP3A4/5 (CYP2C19 was not investigated) nor does it induce the activity of CYP1A2, CYP2D6 or CYP3A4/5. (com.bd)

A major cause of dysgeusia is chemotherapy for cancer. (wikipedia.org)
Silymarin may protect the liver from toxic chemicals and have been tested for their potential to make chemotherapy more effective or less toxic as well as to slow or stop the growth of cancer cells. (superfoods-scientific-research.com)
Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
According to the study, researchers now have a much better sense of the molecular and cellular basis of tumor growth, including the ingrained sense of entitlement that reportedly drives cancer cells to grow irregularly until they become one big fuck-you to scientists. (fieldofscience.com)
Their study is published in Molecular Cancer Research in an article titled, " Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells . (genengnews.com)
In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
In their study, the researchers investigated the effectiveness of si jun zi in inhibiting the metastasis of colorectal cancer cells to the liver. (preventcancer.news)
Traditional Chinese medicine has always been a goldmine for cancer researchers, and this new study proves why. (preventcancer.news)
In a study using maitake MD-fraction (similar to the beta-glucan D-fraction) from maitake, cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. (earthsfirstfoods.com)
The National Cancer Institute has studied maitake for its potential anti-HIV activity. (earthsfirstfoods.com)
As far as I know, no one else has discovered an agent that singles out and protects brain and central nervous system cells while also not protecting cancer cells," said Noble, who also collaborates with researchers at the UR's James P. Wilmot Cancer Center . (rochester.edu)
Researchers were also optimistic about finding that while AZD6244 protected brain cells, it did not also protect cancer cells. (rochester.edu)
There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide . (dogcancerblog.com)
Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
Let's examine the research and bring to light the possible therapeutic effects and advantages molecular hydrogen or hydrogen water has demonstrated in scientific studies to have against cancer. (h2hubb.com)
In 2012 the Journal of Ginseng Research published a study involving 30 children who were treated for leukemia and solid cancer with chemotherapy or stem cell transplantation. (healthbuff.com)
Adding immunotherapy to chemotherapy almost doubled survival in patients with an advanced type of bladder cancer, in the first of its kind trial reported in The New England Journal of Medicine and at the annual meeting of the European Society for Medical Oncology (ESMO). (insideprecisionmedicine.com)
An international trial funded by Cancer Research UK and UCL Cancer Trials Centre has shown that adding a short course of chemotherapy prior to chemoradiation therapy (CRT) improves outcomes by substantially reducing the risk for relapse and death among patients with locally advanced cervical cancer. (insideprecisionmedicine.com)
Chemotherapy has at least two shortcomings: It can harm healthy cells as well as cancerous ones, and it can have difficulty reaching therapeutic targets that hide within cancer cells. (insideprecisionmedicine.com)
Aims: We aimed to study the relation between pharmacokinetics (PK) and pharmacodynamics (PD) of docetaxel in early breast cancer and recommend a target exposure. (unav.edu)
In many countries, vaccines against some human papillomavirus (HPV) types are now administered to girls and young women with the goal of protecting them against HPV-induced cervical cancer ( 1 , 2 ). (cdc.gov)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells. (dogcancerblog.com)

In 2016, the Journal of Neuroscience published a study on the effects of Ramadan fasting on fatigue and quality of life in patients with multiple sclerosis (MS). During the summer of 2014, 218 study participants completed a 14 hour fasting period, measuring 20 health factors before and after fasting. (integrativepractitioner.com)
Specific to autoimmune disease, a fasting-mimicking diet reduced immune cell infiltration and demyelination, according to a 2016 study in Cell Reports. (integrativepractitioner.com)

19 One study theorizes maitake's anti-diabetic activity may be due to its effect on insulin receptors, increasing insulin sensitivity and ameliorating insulin resistance. (earthsfirstfoods.com)

Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)

The exact mechanism of chemotherapy-induced dysgeusia is unknown. (wikipedia.org)
Although its mechanism remains unclear, WA has been shown to upregulate heat shock proteins (Hsps) which protect against diverse cellular insults. (bridgew.edu)
Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)

SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase). (weeksmd.com)

This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)

The tumor tissue analyses revealed broad and powerful ONCOS-102-induced remodeling of the tumor microenvironment with increased T-cell infiltration and a shift towards pro-inflammatory immune cells, far beyond what was observed for the SoC-only control group. (prnewswire.com)
Furthermore, medical mushrooms and other substances were used to improve the immune system and to reduce chemotherapy side effects. (asjo.in)
13 When maitake was combined with chemotherapy, immune cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone 14 . (earthsfirstfoods.com)

OBJECTIVE: To assess effect of licochalcone A (LicA) on amyloid-ß (Aß) peptide fragment 25-35-induced nerve injury and reveal the potential molecular mechanisms involved. (bvsalud.org)
mRNA and culture media were collected for molecular studies. (bvsalud.org)
Despite improvements in the understanding of the diverse aspects related to cisplatin-induced AKI, the cellular and molecular mechanisms are not fully understood. (oncotarget.com)
Molecular studies demonstrated that Ulk1 together with another mammalian ATG1 homolog, Ulk2, form complex with mATG13 and FIP200 (mammalian homologues of ATG13 and ATG17) and regulate the autophagic machinery [ 5 , 6 ]. (oncotarget.com)
Molecular hydrogen is a new medical gas that can be dissolved in water and administered through drinking, inhalation, baths, intravenous drip (IV), etc. 5 Molecular hydrogen through these administration methods has more than 600 studies, showing therapeutic benefits in more than 170 human disease models, and it is still in its infancy. (h2hubb.com)
Molecular hydrogen in numerous studies has demonstrated an anti-apoptotic effect in health or injured cells. (h2hubb.com)

We find that CBGA, but not CBD, protects the kidney from cisplatin-induced nephrotoxicity . (theamazingflower.com)
The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)

2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)

The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes. (weeksmd.com)
Nephrotoxicity is a major adverse effect in cisplatin chemotherapy, and renoprotective approaches are unavailable. (elsevierpure.com)

It is used as an antineoplastic agent and to induce diabetes in experimental animals. (cancerindex.org)

In 2014 the Iranian Journal of Reproductive Medicine published an animal study which tested the effects of royal jelly on rats treated with the chemotherapy drug, bleomycin. (healthbuff.com)

Chemotherapy often induces damage to the oral cavity, resulting in oral mucositis, oral infection, and salivary gland dysfunction. (wikipedia.org)
In 2013 the Journal of Pharmacological Sciences published an animal study which found that the anti-inflammatory and anti-oxidative stress properties of royal jelly were effective in healing oral mucositis (ulcers of the mouth caused by chemotherapy) in hamsters. (healthbuff.com)
The royal jelly group saw a significant reduction in chemotherapy-induced mucositis compared to the control group. (healthbuff.com)

The findings of the study, reported in the March 30, 2010 issue of the Proceedings of the National Academy of Sciences of the USA, show that silymarin inhibit the development of the hepatitis virus by way of their anti-inflammatory and antioxidant effects. (superfoods-scientific-research.com)

Our finding supports PDL-1 in CAFs as a chemotherapy response biomarker and as a drug delivery and therapeutic target for chemoresistant NSCLC. (cdc.gov)

Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
Even though there are limitations, the study suggests that integrative therapy could improve nutritional status and quality of life, with possible positive effect on overall survival. (asjo.in)
RR, TTP, and survival were comparable to those achieved in studies using different 5-fluorouracil (5-FU)-oxaliplatin combinations, without the inconvenience of prolonged 5-FU schedules. (aboutdrugspdf.com)
DCF) to the reference arm of CF showed that DCF improved Several phase II studies have demonstrated that oxaliplatin in survival significantly compared with that seen in the cohort combination with 5-FU may be an effective and well-tolerated treated with CF alone [2]. (aboutdrugspdf.com)
A study by Wong et al examined oncocytic adrenocortical neoplasms (OANs), which are believed to have a more favorable overall median survival than conventional adrenocortical carcinomas. (medscape.com)

Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. (weeksmd.com)
In 2011 Oxidative Medicine and Cellular Longevity published an animal study in which royal jelly was effective in reducing oxidative stress and increasing glutathione (antioxidant) levels in the livers of rats treated with the chemotherapy drug, cisplatin. (healthbuff.com)

Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
RESULTS: LicA improved cell viability and decreased lactate dehydrogenase leakage remarkably in Aß25-35-induced injury in SH-SY5Y cells. (bvsalud.org)
Treating cells with synthetic adropin protects against the increased permeability observed during the natural injury progression. (bvsalud.org)
Preincubation of LLC-PK1 cells with 0.5-5 microM SFN by 24 h was able to prevent, in a concentration-dependent way, CDDP-induced cell death. (weeksmd.com)
Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
In this study we investigated whether SWCNT-transformed lung epithelial cells present CSC traits. (cdc.gov)
RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)

Some studies have shown that DHEA improves learning and memory in those with low DHEA levels, but other studies have failed to detect any significant cognitive effects from DHEA supplementation. (healthyplace.com)
Further studies are needed to determine whether DHEA supplementation helps prevent or slow medical conditions associated with the aging process. (healthyplace.com)
Studies suggest that DHEA supplementation may help impotent men have and sustain an erection. (healthyplace.com)

Further studies with pharmacological and genetic approaches revealed that TIGAR regulated the phosphorylation of ATM, a key protein in DDR, through Cdk5. (nature.com)

In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)

however, chemotherapy can permit these typically non-pathogenic agents to cause serious infection, which may result in a decrease in saliva. (wikipedia.org)
Of the 97 patients who completed the 4-week study, there was a statistically considerable greater decrease in transaminase levels in the silymarin group. (superfoods-scientific-research.com)

Mushroom researcher Hiroaki Nanba reports that maitake has the strongest tumor growth inhibition properties of all mushrooms studied. (earthsfirstfoods.com)

In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
Echinacea may help protect white blood cell (WBC) counts in chemotherapy-induced myelosuppression. (interactionsguide.com)
Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)

While there, he ran into an animal study showing that melatonin had an extremely curious effect on active cancers. (innovativemedicine.org)
This study was cancers is mostly derived from case reports or small series approved by our institutional review board. (cdc.gov)

Results demonstrated that morbidity was consistent among both study groups , therefore proving that Pedmark did not shield the tumor while protecting the patient . (cac2.org)

Anatomy4

Organisms1

Diseases83

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Phenomena and Processes14

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science2

Health Care26

Apoptosis17

Toxicity10

Tumors12

Radiotherapy4

Caused by the chemotherapy drug3

Doxorubicin4

Types of chemotherapy2

Cyclophosphamide2

Mice15

Cytokines1

Doses6

Carboplatin2

Nausea and Vomiting9

Standard chemotherapy2

Regimen4

Treatment27

Acute4

Confer resistance to chemotherapy2

Side effects of c2

Treatments4

20231

Chemotherapeutic agents2

Ovarian1

CINV1

People taking chemo4

Start of chemotherapy3

Autophagy7

Paclitaxel2

Clinical7

Vitro3

Cancer23

Mediates1

20162

Resistance1

Malignant1

Mechanism3

Renal1

Tumor cells1

Immune3

Molecular6

Kidney3

Neoadjuvant1

Renoprotective2

Antineoplastic1

Bleomycin1

Mucositis3

Inflammatory1

Therapeutic1

Survival5

Oxidative2

Cells7

Supplementation3

Regulated the phosphorylation1

Antioxidants2

Decrease2

Inhibition1

Cell3

Cancers2

Morbidity1