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Hematopoietic Stem Cell TransplantationStem Cell TransplantationBone MarrowTransplantation, HomologousBone Marrow TransplantationBone Marrow CellsTransplantation, AutologousStem CellsPeripheral Blood Stem Cell TransplantationTransplantation ConditioningGraft vs Host DiseaseAntineoplastic Combined Chemotherapy ProtocolsHematopoietic Stem CellsBone and BonesHematologic NeoplasmsTreatment OutcomeLiver TransplantationTransplantation ChimeraCombined Modality TherapyMesenchymal Stem Cell TransplantationGraft SurvivalTissue DonorsCord Blood Stem Cell TransplantationWhole-Body IrradiationCyclophosphamideMultiple MyelomaCell TransplantationBusulfanCell DifferentiationRecurrenceKidney TransplantationEmbryonic Stem CellsBone Marrow DiseasesMyeloablative AgonistsHistocompatibility TestingLeukemiaDisease-Free SurvivalMelphalanTime FactorsSurvival AnalysisAdult Stem CellsHematopoietic Stem Cell MobilizationSurvival RateRemission InductionHematopoiesisHistocompatibilityChemotherapy, AdjuvantAntigens, CD34Retrospective StudiesImmunosuppressive AgentsLeukemia, Myeloid, AcuteBone Marrow ExaminationBone RemodelingBone Marrow PurgingAntineoplastic AgentsMesenchymal Stromal CellsBone Marrow NeoplasmsGraft vs Leukemia EffectGranulocyte Colony-Stimulating FactorSalvage TherapyMice, Inbred C57BLPrognosisCells, CulturedMyelodysplastic SyndromesLymphoma, Non-HodgkinFollow-Up StudiesStem Cell NicheTransplantation ImmunologyHeart TransplantationHematologic DiseasesEtoposidePluripotent Stem CellsAnemia, AplasticPrecursor Cell Lymphoblastic Leukemia-LymphomaVidarabineFlow CytometryTransplantation, IsogeneicGraft RejectionCytarabineHepatic Veno-Occlusive DiseaseLung TransplantationNeural Stem CellsCell LineageChimerismColony-Forming Units AssayBone DensityLeukemia, Myelogenous, Chronic, BCR-ABL PositiveGraft vs Tumor EffectLymphocyte TransfusionHodgkin DiseaseHLA AntigensDoxorubicinOrgan TransplantationMultipotent Stem CellsImmunosuppressionT-LymphocytesAcute DiseaseInduced Pluripotent Stem CellsBone NeoplasmsLymphocyte Depletion
TransplantTransplantsFollowed by autologous stem cell transRegimensRemissionBiopsyUndergoSalvage chemotherapyPatient's own bone marrowHigh-dose chemotherapy or radiationCyclophosphamideAllogeneic stem cellRadiotherapyTreatmentsClinicalProgenitor cellsDose chemotherapyCancersSpleenProcedureAcuteRefractoryHSCTTypicallyDonor cellsLymphomaCombination of chemotherapy drugsUmbilical cordDosesMobilizationMultiple myelomaASCTReceived from a person'sBlood stem cellsAplasticPerson'sSingle-agent chemotherapyRespond to chemotherapyImmatureHematologyBiopsiesTreatmentMalignanciesCompletion of chemotherapySurvivalClonalLeukemiaImmuneInfection
Transplant36
  • Options include chemotherapy using bortezomib, autologous stem cell transplantation, immunomodulatory drugs, and kidney transplant. (wikipedia.org)
  • Learn more about bone marrow transplant for AML. (medicalnewstoday.com)
  • Pediatric Hematology/Oncology and bone marrow transplant patients are admitted to Doernbecher Children's Hospital state-of-the-art 21-bed unit, known as 10-South. (ohsu.edu)
  • The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
  • Then, in 2013, I joined the adult bone marrow transplant team as a newly graduated physician assistant. (mskcc.org)
  • As a member of the transplant team, I work closely with doctors, other physician assistants, nurse practitioners, nurses, and support staff to care for patients undergoing stem cell transplantation. (mskcc.org)
  • Some patients may benefit from a bone marrow transplant. (rxwiki.com)
  • Bone marrow or peripheral blood stem cell transplantation includes mobilization, harvesting and transplant of bone marrow or peripheral blood stem cells, and the administration of high dose chemotherapy or radiotherapy before the actual transplant. (hinshawlaw.com)
  • A bone marrow or stem cell transplant in which stem cells from a donor (called allogeneic ) are transplanted into a patient is often the best chance for a cure for patients with recurrent or resistant cancers such as leukemia and lymphoma. (autm.net)
  • However, of the roughly 25,000 patients who receive a stem cell transplant each year worldwide , only about half survive, according to the Worldwide Network for Blood & Marrow Transplantation . (autm.net)
  • The researcher behind the assay is Wing Leung, M.D., Ph.D., chair of St. Jude's Department of Bone Marrow Transplant and Cellular Therapy . (autm.net)
  • Stem cells, which live in the spongy center (called marrow) of certain bones in the body, produce the body's blood cells - including NK cells - that play a critical role in the immune system to fight off invading germs and cancer cells.A stem cell transplant essentially recruits a whole new defense against the disease by infusing stem cells from a well-matched donor into the patient to attack the cancer. (autm.net)
  • The stem cell transplantation procedure (also called a bone marrow or cord blood transplant ) is typically preceded by chemotherapy and radiation therapy to eliminate as much of the cancer as possible. (autm.net)
  • Using the test to retrospectively analyze the outcomes of previous transplant procedures, Leung's research team determined that NK cells expressing the stronger version of KIR2DL1 destroy cancer cells more effectively than cells expressing the weaker version of KIR2DL1. (autm.net)
  • In a study by Leung and his colleagues published in the Journal of Clinical Oncology , the researchers demonstrated that children with leukemia were much more likely to survive their transplant and their disease was significantly less likely to progress when bone marrow transplants came from donors whose NK cells expressed the stronger form of KIR2DL1. (autm.net)
  • Access to the largest and oldest Bone Marrow and Blood Stem Cell Transplant program in Georgia. (emory.edu)
  • A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
  • In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
  • When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
  • When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
  • Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
  • However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
  • The finding, which was published in the June 25th issue of Bone Marrow Transplantation on-line, was made by researchers from the Stem Cell Transplant Program and the Amyloid Treatment and Research Program at Boston University Medical Center (BUMC). (cellmedicine.com)
  • This approach appears to be associated with an improvement in overall survival as it increases the proportion of patients who ultimately achieve a complete response stated lead researcher, Vaishali Sanchorawala, MD, who is the clinical director of the Stem Cell Transplant Program, section of hematology/oncology at BUMC and associate professor of medicine at Boston University School of Medicine. (cellmedicine.com)
  • Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
  • This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. (mdanderson.org)
  • Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
  • 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
  • Their recent research aims to help more patients find a cure through expanded bone marrow transplant treatment and gene therapy. (medlineplus.gov)
  • In a more traditional bone marrow transplant, a patient is first treated with chemotherapy. (medlineplus.gov)
  • Then, he or she receives a bone marrow transplant from a healthy donor. (medlineplus.gov)
Transplants10
  • Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
  • bone marrow or stem cell transplants. (hinshawlaw.com)
  • Insight Genetics hopes to reduce that uncertainty - and increase the success rate of stem cell transplants - by offering a new test to help identify the optimal stem cell donor. (autm.net)
  • This test helps take the guesswork out of donor-patient matching for allogeneic stem cell transplants,' says JonEric Pettersson, manager of commercial development at Insight Genetics. (autm.net)
  • The use of the new test will change the choice of stem cell donors in as many as 20,000 of the 25,000 transplants performed each year. (autm.net)
  • The majority of stem cell transplants are performed on patients with cancers that originate in blood cells, including leukemia, multiple myeloma and some lymphomas, that are highly resistant to standard treatments. (autm.net)
  • To better understand the molecular mechanisms that influence GVT in bone marrow transplants, Leung and his colleagues began studying the genetic makeup of NK cells in 2004. (autm.net)
  • Unfortunately, the way the transplants are currently performed, with toxic treatments to prepare the children to accept the donor cells and the side effects caused by lymphocytes that contaminate standard blood cell grafts reduces the likelihood of successful cure. (ca.gov)
  • But bone marrow transplants are often expensive, time consuming, and hard to get. (medlineplus.gov)
  • One problem with bone marrow transplants is that you need to have a family member whose genes match,' says Dr. Rodgers. (medlineplus.gov)
Followed by autologous stem cell trans2
Regimens8
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
  • Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
  • In a systematic review that compared the effectiveness of these regimens, Amarasena et al concluded that platinum-based chemotherapy regimens did not provide a statistically significant benefit over non-platinum-based agents in survival or overall tumor response. (medscape.com)
  • The investigators suggested that non-platinum-based chemotherapy regimens may have a better risk-benefit profile. (medscape.com)
  • Their disease had been refractory (defined as less than partial response) to one (18 patients) or two (24 patients) regimens of neoadjuvant chemotherapy. (elsevierpure.com)
  • Single-agent chemotherapy improved the average survival to four months and the development of combination chemotherapy regimens has further increased the average survival to approximately nine months with some patients surviving two years or longer. (yourcancercare.com)
  • Clinical trials continue to evaluate new drugs and new combinations of drugs in an effort to improve upon the treatment results achieved with standard chemotherapy regimens. (yourcancercare.com)
Remission5
Biopsy6
  • A bone marrow biopsy will be done in order to rule out multiple myeloma. (wikipedia.org)
  • If the biopsy shows that there is cancer, it is important that certain tests (called estrogen and progesterone receptor tests) be done on the cancer cells. (stopgettingsick.com)
  • Tissue from the tumor needs to be taken to the laboratory for estrogen and progesterone tests at the time of biopsy because it may be hard to get enough cancer cells later, although newer techniques can be used on tissue that is not fresh. (stopgettingsick.com)
  • A biopsy of an enlarged lymph node or bone marrow will be taken and examined to figure out the specific type of cancer based on several tissue biological markers as well as cell structure. (rxwiki.com)
  • Diagnosis of lymphoma is done with a biopsy, which involves examination by a pathologist of tissue or cells obtained by removing all or part of a lymph node. (emory.edu)
  • A complete staging workup may include a physical exam, blood work, CT and/or PET scans, bone marrow biopsy, and sometimes a lumbar puncture. (emory.edu)
Undergo9
  • Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)
  • Doctors may also recommend this treatment to those with relapsed or resistant AML after they undergo re-induction chemotherapy. (medicalnewstoday.com)
  • People who undergo intensive chemotherapy may need to stay in the hospital for 3-5 weeks . (medicalnewstoday.com)
  • Omisirge is indicated for patients scheduled to undergo umbilical cord blood transplantation after myeloablative conditioning treatments such as chemotherapy or radiotherapy. (pharmalive.com)
  • Typically, patients receiving stem cell transplantation for hematologic cancers need to undergo an aggressive regimen of chemotherapy or radiotherapy to remove existing stem cells. (pharmalive.com)
  • Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
  • Currently, recipients that undergo BMT are treated with toxic agents such as radiation and chemotherapy in order to in order to eliminate their own blood forming stem cells and permit the donor cells to take and develop. (ca.gov)
Salvage chemotherapy1
Patient's own bone marrow2
High-dose chemotherapy or radiation3
  • The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
  • For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
  • Treatment of various cancers increasingly involves cytoreductive therapy, including high dose chemotherapy or radiation therapy. (justia.com)
Cyclophosphamide3
  • Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
  • Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)
  • Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mdanderson.org)
Allogeneic stem cell19
Radiotherapy3
  • This treatment consists of destroying cancerous bone marrow cells using higher doses of chemotherapy and in some cases, radiotherapy, and then replacing them with healthy stem cells to help patients regain a new and healthy immune system. (emory.edu)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
Treatments8
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Additionally, many new treatments called monoclonal antibodies have been successfully used ( rituximab ( Rituxan ) for B-cell lymphomas, ofatumumab (Arzerra) for NHL, Ocrelizumab is in clinical trials). (rxwiki.com)
  • Healthcare providers typically recommend stem cell transplantation if initial treatments don't work or if conditions have come back. (clevelandclinic.org)
  • Some medical treatments may affect transplantation. (clevelandclinic.org)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • The progress that has been made in the treatment of small cell lung cancer has resulted from the development of multi-modality treatments, new anti-cancer agents and participation in clinical trials. (yourcancercare.com)
  • Cancer surgery may be your only treatment, or it may be supplemented with other treatments, such as radiation, chemotherapy, hormone therapy and biological therapy. (wecareindia.com)
  • Surgery is often combined with other cancer treatments, such as chemotherapy and radiation. (wecareindia.com)
Clinical8
  • To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca. (karger.com)
  • The clinical training exposes fellows to all domains of our subspecialty including general oncology, hematology, bone marrow transplantation, palliative care, and neuro-oncology. (ohsu.edu)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. (biomedcentral.com)
  • Future progress in the treatment of small cell lung cancer will result from continued participation in appropriate clinical trials. (yourcancercare.com)
  • We have brought together world experts in transplantation, protein development and clinical study design who have the shared objective of bringing the technology of antibody targeting stem cells to patients. (ca.gov)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
Progenitor cells8
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • The cells are processed using Gamida's proprietary nicotinamide technology, which enriches the hematopoietic progenitor cells, preserves their stemness and promotes their migration to the bone marrow. (pharmalive.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Dose chemotherapy7
Cancers6
  • Leukemia is an umbrella term for cancers affecting the blood-forming cells in the body. (medicalnewstoday.com)
  • In general, cancers result from mutations in cells. (medicalnewstoday.com)
  • Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment. (news-medical.net)
  • The FDA has approved Gamida Cell 's omidubicel-onlv, now to be marketed as Omisirge , in patients over 12 years of age with blood cancers, the company announced Monday. (pharmalive.com)
  • Radiation therapy and some types of chemotherapy have the strongest links to second cancers. (cancer.net)
  • These diseases include, but are not limited to sickle cell and Fanconi's anemia, autoimmune diseases like diabetes and multiple sclerosis, and cancers that originate from the blood system such as leukemias and lymphomas. (ca.gov)
Spleen3
  • They can affect multiple parts of the the lymphoid tissue, including the lymph nodes, spleen, and the bone marrow and are further classified into fast-growing or slow-growing. (rxwiki.com)
  • Lymphoma can affect any part of your lymphatic system, which is made up of lymphocytes, lymph nodes and vessels, the spleen and bone marrow. (emory.edu)
  • Involvement of other organs, such as spleen, liver, or bone marrow is an indication of advanced disease. (vin.com)
Procedure6
  • Omisirge also facilitates the recovery of white blood cells, leading to an overall safer transplantation procedure. (pharmalive.com)
  • The patients in the small phase I/II trial continued to improve for up to 24 months after the transplantation procedure and then stabilized. (scienceblog.com)
  • In the procedure, Burt and colleagues treated patients with chemotherapy to destroy their immune system. (scienceblog.com)
  • The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion. (scienceblog.com)
  • We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy for cancer," Burt said. (scienceblog.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Acute7
Refractory4
  • CAR T-cell therapy is currently being used at Winship for patients with relapsed or refractory B-cell lymphomas, including diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma. (emory.edu)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
HSCT7
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Typically3
  • These cells have not yet wholly matured, but they typically develop into white blood cells. (medicalnewstoday.com)
  • For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
  • Currently the standard treatment for extensive small cell lung cancer is chemotherapy using a combination of chemotherapy drugs, typically cisplatin or carboplatin combined with etoposide or irinotecan. (yourcancercare.com)
Donor cells5
  • In a successful transplantation, the donor cells seek out the latent cancer cells, eradicate them, and you have the potential for a cure. (autm.net)
  • This desired characteristic of the donor cells is called the graft-versus-tumor (GVT) reaction. (autm.net)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • This antibody can safely target a recipient's stem cells making room for the donor cells. (ca.gov)
  • Based on the animal studies we expect that this antibody will markedly increase the levels of donor cells as compared to current standards. (ca.gov)
Lymphoma21
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • We report a case of primary large B cell-type pituitary lymphoma in a 47-year-old immunocompetent female who presented with headache and cranial nerve palsy. (karger.com)
  • Liu JK, Sayama C, Chin SS, Couldwell WT: Extranodal NK/T-cell lymphoma presenting as a pituitary mass. (karger.com)
  • Aho R, Ecfor T: Pathogenesis of primary central nervous lymphoma: invasion of malignant lymphoid cells into and within the brain parenchyma. (karger.com)
  • Fleming WH, Murphy PR, Murphy LJ, Hatton TW, Matusik RJ, Friesen NG: Human growth hormone induces and maintains cmyc gene expression in Nb2 lymphoma cells. (karger.com)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • It is used for Leukaemia/Lymphoma/Myeloma and B-MRD panels along with the CD34 counts, T-cell subset analysis and PNH. (jaslokhospital.net)
  • The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
  • These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
  • Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
  • Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
  • Hodgkin lymphoma is distinguished from other diseases classified as lymphoma primarily because of the presence of Reed-Sternberg cells, which are large, cancerous cells found in Hodgkin lymphoma tissues. (rxwiki.com)
  • Lymphoma is a cancer that occurs when your body's white blood cells, called lymphocytes, begin behaving abnormally. (emory.edu)
  • Each type of lymphoma is sensitive to different combinations of chemotherapy, which may involve one or a combination of anticancer drugs that destroy cancer cells. (emory.edu)
  • Lymphoma is the most common haematopoietic malignancy in dogs, and is the most responsive to chemotherapy. (vin.com)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
Combination of chemotherapy drugs1
Umbilical cord3
Doses3
  • This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)
  • When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
  • Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
Mobilization5
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
  • The stem cell mobilization result was poor. (cdc.gov)
Multiple myeloma4
  • About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's macroglobulinemia, and the monoclonal gammopathy of undetermined significance premalignant stages of these two diseases. (wikipedia.org)
  • Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
  • blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
ASCT1
Received from a person's1
  • The genes in cells carry the hereditary information that is received from a person's parents. (stopgettingsick.com)
Blood stem cells2
Aplastic1
  • It has also been used as a therapy for disorders like aplastic anemia, which are associated with bone marrow failure. (ucsfhealth.org)
Person's1
  • Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry. (news-medical.net)
Single-agent chemotherapy2
  • A number of randomized trials have tried to answer questions concerning the superiority of combination over single-agent chemotherapy, the number of drugs to be used in combination, and dose intensity. (medscape.com)
  • Nonrandomized trials of combination chemotherapy have shown superior response rates and survival compared with single-agent chemotherapy. (medscape.com)
Respond to chemotherapy2
Immature4
Hematology1
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Biopsies1
  • My role includes seeing and examining inpatients on a daily basis, prescribing chemotherapy and other medications, performing bone marrow biopsies and aspirates, and participating in stem cell infusions. (mskcc.org)
Treatment29
  • In this regard, the essential hematopoietic stem cells are removed, whilst treatment with the chemotherapeutic agent, the dose of which is elevated by three to five times, takes place. (leading-medicine-guide.com)
  • This complex treatment offers a huge benefit for patients: even more resistant cancer cells are killed by the more intensive treatment process. (leading-medicine-guide.com)
  • The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
  • One treatment option is induction chemotherapy, which involves several drugs. (medicalnewstoday.com)
  • Doctors use this treatment regimen to eliminate leukemia cells and bring blood counts back to normal. (medicalnewstoday.com)
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • See Small Cell Lung Cancer Treatment Protocols for summarized information. (medscape.com)
  • Nausea and vomiting (N/V) is a common complication of cancer treatment and a common cause of anxiety and distress in patients, in some cases even prior to their first chemotherapy session. (medscape.com)
  • During treatment, a patient's white blood cells are removed from the body and genetically changed to recognize and kill cancerous cells. (emory.edu)
  • Prognostic factors include stage and substage of disease, histologic type, immunophenotype (B-cell versus T-cell), presence of hypercalcemia, response to therapy, pre-treatment steroid therapy, and possibly gender. (vin.com)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
  • After treatment, the bone marrow is replaced via a vein. (epnet.com)
  • They are removed from circulating blood before chemotherapy or radiation treatment. (epnet.com)
  • These cells are then replaced after treatment. (epnet.com)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • It is important to keep a record of the cancer treatment, including a list of specific chemotherapy drugs or other medications, you or your child received. (cancer.net)
  • The following is a general overview of the treatment of extensive small cell lung cancer. (yourcancercare.com)
  • Patients with extensive disease small cell lung cancer are rarely curable with currently available standard treatment strategies although many patients experience a response to treatment. (yourcancercare.com)
  • This preventive treatment-called prophylactic cranial irradiation-is usually reserved for patients who have had a good response to chemotherapy. (yourcancercare.com)
  • While some progress has been made in the treatment of small cell lung cancer, better treatment strategies are clearly needed, as the majority of patients still experience disease recurrence. (yourcancercare.com)
  • There are several areas of active exploration aimed at improving the treatment of small cell lung cancer. (yourcancercare.com)
  • If the antibody treatment results a stronger blood system originating from a donor in SCID patients, this result would prove that the antibody could be used to optimize engraftment of gene-therapy modified cells and could be applied to the treatment the many other diseases that need a BMT. (ca.gov)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
  • The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
  • Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
  • 5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
  • Ultimately, Dr. Rodgers and Dr. Tisdale hope to work towards more affordable, accessible treatment options-such as bone marrow repair. (medlineplus.gov)
Malignancies1
  • Patients with malignancies and those undergoing chemotherapy are often immunocompromised and are at high risk of acquiring bacterial and viral infections that can cause hemorrhagic cystitis. (medscape.com)
Completion of chemotherapy1
  • At 1 and 6 months after completion of chemotherapy, she presented with anasarca and was diagnosed with relapse exclusively in the bone marrow twice. (karger.com)
Survival3
  • They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
  • Although applying multi-modal therapies (radiation, chemotherapy, and surgery) has increased 5-year survival amongst standard-risk MB patients, overall survival (OS) rates seem to have plateaued. (biomedcentral.com)
  • Targeted therapies are anticancer drugs that interfere with specific pathways involved in cancer cell growth or survival. (yourcancercare.com)
Clonal1
Leukemia10
Immune12
  • Reduced neutrophils, a white blood cell that acts as the immune system's first line of defense, can lead to infections. (medicalnewstoday.com)
  • The assay, developed by researchers at St. Jude Children's Research Hospital , provides information on both the patient's cancer cells and the makeup of receptors on specialized immune cells called natural killer (NK) cells from donor candidates. (autm.net)
  • What's more, he found that this variation in the NK cell's gene content, as well as the matching between the donor KIR and recipient HLA, affects the strength of the cells' immune response and its cancer-killing ability following transplantation. (autm.net)
  • This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
  • It functions by slowing or blocking cell growth and compromising the immune system's response. (ijbs.com)
  • Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)
  • They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)
  • After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system. (scienceblog.com)
  • In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. (scienceblog.com)
  • and still others stimulate the immune system to recognize and attack the cancer cell. (yourcancercare.com)
  • Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). (mdanderson.org)
  • Once the donated stem cells begin working, the patient's immune system may see the remaining cancer cells as not belonging in the patient's body and destroy them. (mdanderson.org)
Infection5
  • Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins, called light chains (LCs), in the body. (wikipedia.org)
  • These abnormal cells reproduce very quickly and do not function as healthy white blood cells to help fight infection. (texaschildrens.org)
  • Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, director of the FDA's Center for Biologics Evaluation and Research, said in a statement. (pharmalive.com)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • infection with axillary temperature, bone pain, and headache. (cdc.gov)