Allogeneic hematopoietic cell transplantationHematopoietic stem cell transReversed by autologous stem cell transRegimensAcuteOrganRadiation TherapyFecal microbiota transplantationRegimenHigh-doseRadiotherapyDuration of neutropeniaConventional chemotherapyDoses of chemotherapy drugsNeutropeniaMarrowCurative therapyCell TransplantationComplete remissionConsolidationInfectionPatientsInduction chemotherapyCyclophosphamideGranulocyte colonyCancerSystemicTreatmentPeripheralLeast 24Drug TherapyDonorsDrugsComplications
Allogeneic hematopoietic cell transplantation4
- Introduction: In the United States, autologous hematopoietic cell transplantation (autoHCT) has fallen out of favor over chemotherapy consolidation for non-high-risk acute myeloid leukemia (AML) when allogeneic hematopoietic cell transplantation (alloHCT) is unfeasible, which is common in racial minorities because of donor registry under-representation and socioeconomic challenges. (elsevierpure.com)
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
- Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
- In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
Hematopoietic stem cell trans2
- Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). (johnshopkins.edu)
- Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
Reversed by autologous stem cell trans1
- Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
Regimens6
- A variety of chemotherapy regimens are used in CLL. (medscape.com)
- See Chemotherapy Regimens, below, and Chronic Lymphocytic Leukemia Treatment Protocols . (medscape.com)
- It should be noted that many clinical trials in CLL represent a younger population, which can tolerate aggressive chemotherapy regimens to show impressive results. (medscape.com)
- For example, George Canellos, one of the original members of the NCI, had noticed that a long-term side effect of megadose chemotherapy regimens was myelodysplasia, a condition that tended to progress to leukemia. (wikipedia.org)
- These guidelines provide a comprehensive assessment of eligibility criteria, stem cell collection and mobilisation strategies and regimens, risk-adapted melphalan dosing, role for induction and consolidation therapies, specific supportive care management, long-term outcome with respect to survival, haematologic response and relapse and organ responses following stem cell transplantation. (medthority.com)
- Their disease had been refractory (defined as less than partial response) to one (18 patients) or two (24 patients) regimens of neoadjuvant chemotherapy. (elsevierpure.com)
Acute4
- Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
- Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
- Autologous transplantation consolidation for non-high-risk acute myeloid leukemia is less frequently used, yet not fully abandoned. (elsevierpure.com)
- METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
Organ4
- Treatment of post-transplant lymphoproliferative disease (PTLD) following solid organ transplantation with low-dose chemotherapy. (qxmd.com)
- 14. In the absence of effective antibiotics, some of the most advanced interventions available to modern medicine, like organ transplantations, hip and joint replacements, cancer chemotherapy, and care of pre-term infants, could become too dangerous to perform. (who.int)
- Other patients at greater risk because of decreased responsiveness to polysaccharide antigens or more rapid decline in serum antibody include those with functional or anatomic asplenia (e.g., sickle cell disease or splenectomy), Hodgkin's disease, lymphoma, multiple myeloma, chronic renal failure, nephrotic syndrome, and organ transplantation. (cdc.gov)
- Assessment of five-year experience with abdominal organ cluster transplantation. (cancercentrum.se)
Radiation Therapy3
- The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
- Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
- High doses of chemotherapy drugs or radiation therapy can kill cancer cells but often also kills the person's stem cells, which prevents the bone marrow from producing normal blood cells. (msdmanuals.com)
Fecal microbiota transplantation3
- Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient's intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). (hindawi.com)
- Currently, as a means of intestinal microecological regulation in addition to microecological preparations, fecal microbiota transplantation (FMT) has become popular in recent years. (hindawi.com)
- Fecal Microbiota Transplantation for Dysbiosis - Predictable Risks. (cdc.gov)
Regimen4
- High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant (HDC/ABMT or just ABMT), was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. (wikipedia.org)
- Randomized clinical trials reported treatment-mortality rates from 0% to 7% for women who received the HDC/BMT treatment, versus no such deaths within the control groups that received the typical chemotherapy regimen. (wikipedia.org)
- Scholars@Duke publication: Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. (duke.edu)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
High-dose14
- High-dose chemotherapy with autologous stem-cell rescue (HDC/ASCT) is the best salvage therapy for patients with aggressive B-cell lymphomas. (cun.es)
- The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
- High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
- All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
- 3 The idea for high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) originated in the 1950s as a leukemia treatment, when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person. (wikipedia.org)
- The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. (wikipedia.org)
- To belabour the point further Hortobagyi, using data from the University of Texas M. D. Anderson Cancer Center in Houston, reported in May 1995 that those eligible for high-dose chemotherapy survived 65% longer on conventional chemotherapy than those who would not have been eligible for the protocol. (wikipedia.org)
- Guidelines for high dose chemotherapy and stem cel. (medthority.com)
- High dose intravenous melphalan and autologous stem cell transplantation was developed for the treatment of AL amyloidosis in the early 1990s and was prompted by its success in multiple myeloma. (medthority.com)
- Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation. (blogspot.com)
- Background/Aim: High-dose chemotherapy (HDCT) and stem cell transplantation (SCT) have been established as the standard of care in patients with relapsed germ cell tumours (GCTs). (herts.ac.uk)
- The role of high-dose chemotherapy (HDCT) in patients with refractory breast cancer is not well established. (elsevierpure.com)
- High-dose chemotherapy with autologous stem cell transplantation is infrequently also used. (sciencedaily.com)
- The aim of this population-based study was to describe the magnitude and panorama of late effects among patients treated with or without high-dose chemotherapy with autologous stem cell transplantation (HD-ASCT). (lu.se)
Radiotherapy2
- TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
- Aetiology of cancer, influence of nutrition on cancer development, nutrition of oncology patients Pharmacotherapy of malignant diseases and adverse effects of these drugs- Radiotherapy of malignant diseases, adverse effects of radiotherapy Basic information's about most frequent cancer diseases Urological cancer Digestive tract cancer Lung cancer Gynaecologic cancer Bone marrow transplantation, indication, methods, results. (muni.cz)
Duration of neutropenia1
- Growth factors may be used to decrease the duration of neutropenia following chemotherapy. (medscape.com)
Conventional chemotherapy5
- Most studies that have attempted to define the value of BMT have been subject to varying degrees of bias because of the problems of identifying a "conventional chemotherapy" control group with which the outcome of patients who have received BMTs can be compared. (ox.ac.uk)
- A randomized controlled trial, incorporating a GA and comparing age-adapted HCT-ASCT treatment with conventional chemotherapy is needed. (biomedcentral.com)
- The primary objective is to demonstrate that intensified chemotherapy followed by consolidating HCT-ASCT is superior to conventional chemotherapy with rituximab, MTX, procarbazine (R-MP) followed by maintenance with procarbazine in terms of progression free survival (PFS). (biomedcentral.com)
- They then believed that STAMP produced more durable remissions than those by conventional chemotherapy, and so Peters left to set up a randomized clinical trial at Duke University. (wikipedia.org)
- However, only women who were healthier and responded better to conventional chemotherapy were eligible for the Phase II studies. (wikipedia.org)
Doses of chemotherapy drugs1
- With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. (wikipedia.org)
Neutropenia2
- After transplantation, most febrile episodes require in-patient treatment and observation until profound neutropenia and clinically significant infection resolves. (medscape.com)
- Nivestym (filgrastim-aafi) is a recombinant human granulocyte colony-stimulating factor biosimilar to Neupogen indicated for the treatment of neutropenia associated with chemotherapy and related conditions. (drugs.com)
Marrow17
- Evaluate the feasibility and outcome of bone marrow transplantation using family or unrelated donors in infants with the 11q23 abnormality. (knowcancer.com)
- Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
- Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
- Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
- How to avoid bias when comparing bone marrow transplantation with chemotherapy. (ox.ac.uk)
- Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)
- Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
- In HDC, the bone marrow transplantation was used to maximise chemotherapeutic dosage. (wikipedia.org)
- Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
- Bone marrow transplantation , 37 (10), 929-935. (elsevierpure.com)
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
- Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
- Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)
Curative therapy1
- Allogeneic stem cell transplantation is the only known curative therapy. (medscape.com)
Cell Transplantation9
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
- Prophylactic platelet transfusion for haemorrhage after chemotherapy and stem cell transplantation. (ox.ac.uk)
- OBJECTIVES: To determine the optimal use of platelet transfusion for the prevention of haemorrhage (prophylactic platelet transfusion) in patients with haematological malignancies undergoing chemotherapy or stem cell transplantation. (ox.ac.uk)
- SELECTION CRITERIA: Randomised controlled trials involving transfusions of platelet concentrates, prepared either from individual units of whole blood or by apheresis, and given prophylactically to prevent bleeding in patients with haematological malignancies and receiving treatment with chemotherapy and/or stem cell transplantation. (ox.ac.uk)
- These are sometimes added when patients require additional therapy, such as stem cell transplantation, or when a temporary access situation develops (as when an indwelling central line is removed because of infection). (medscape.com)
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
Complete remission1
- Patients and Methods: We identified adults with favorable or intermediate cytogenetic risk AML in first complete remission after induction at Montefiore Medical Center from 1999 to 2015, and analyzed 81 patients who received consolidation with ≥2 cycles of chemotherapy, of whom 28 received autoHCT. (elsevierpure.com)
Consolidation3
- We compared autoHCT consolidation outcomes with chemotherapy alone in a minority-rich cohort in the Bronx. (elsevierpure.com)
- We compared outcomes of consolidation strategies in a minority-rich cohort in the Bronx with limited access to allogeneic transplantation. (elsevierpure.com)
- Autologous transplantation conferred relapse-free and overall survival benefit over chemotherapy consolidation alone, the current standard in the United States, and it might constitute a valuable option for ethnic/racial minorities. (elsevierpure.com)
Infection2
- Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
- In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
Patients11
- One is delayed or impaired wound healing, which frequently occurs in the patients undergoing surgery due to long-term chemotherapy ( 1 ). (ijbs.com)
- Previous studies reported that old patients had high risks in chemotherapy ( 9 ) and the wound healing was compromised with the increase of age ( 10 ). (ijbs.com)
- For patients with suitable donors, transfer to a center capable of performing stem cell transplantations is usually necessary. (medscape.com)
- ASt/AJT Journal Club on "Simultaneous pancreas-kidney transplantation in Caucasian versus African American patients. (healthytransplant.com)
- I also care for patients who need to be readmitted for health issues and complications that can arise following transplantation. (mskcc.org)
- Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
- Both OS and PFS were better in patients whose disease became operable after chemotherapy than in those whose disease remained inoperable. (elsevierpure.com)
- At the final analysis of the study, KEYTRUDA plus chemotherapy showed a statistically significant and clinically meaningful improvement in OS compared to chemotherapy alone in these patients. (merck.com)
- Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
- The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)
- The proposed study is designed to examine the effects of AZD0171 and durvalumab in combination with standard-of-care chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC). (uclahealth.org)
Induction chemotherapy1
- Doctors may also recommend this treatment to those with relapsed or resistant AML after they undergo re-induction chemotherapy. (medicalnewstoday.com)
Cyclophosphamide1
- Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)
Granulocyte colony1
- We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions. (johnshopkins.edu)
Cancer5
- Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
- For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
- Chemotherapy and you: support for people with cancer. (medlineplus.gov)
- Chemotherapy uses anticancer drugs to kill cancer cells. (hopkinsmedicine.org)
- Chemotherapy involves the use of drugs to kill cancer cells. (epnet.com)
Systemic4
- Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
- Systemic Chemotherapy. (knowcancer.com)
- Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
- 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
Treatment1
- They are removed from circulating blood before chemotherapy or radiation treatment. (epnet.com)
Peripheral1
- Peripheral blood lymphocytes were analysed by flow cytometry, ELISA, and T-cell-receptor spectratyping before and after transplantation. (northwestern.edu)
Least 241
- If you are receiving Nivestym because you are also receiving chemotherapy, your dose of Nivestym should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. (drugs.com)
Drug Therapy2
- Targeted drug therapy may also be suitable if AML does not respond to chemotherapy. (medicalnewstoday.com)
- At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
Donors2
- Early failures are then automatically assigned to the chemotherapy group even if they have donors and so would have gone on to a BMT had they not relapsed or died. (ox.ac.uk)
- FMT refers to the transplantation of functional bacteria in the feces of healthy donors into the gastrointestinal tract of the patient to restore the balance of the intestinal microecology, which subsequently treats diseases associated with disorders of intestinal microorganisms. (hindawi.com)
Drugs3
- Doctors may use a combination of chemotherapy drugs, such as cytarabine, and an anthracycline drug, such as daunorubicin. (medicalnewstoday.com)
- This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)
- Doctors may give targeted drugs along with chemotherapy. (medicalnewstoday.com)
Complications1
- Oral complications of chemotherapy and head/neck radiation. (medlineplus.gov)