Chemotherapy resistance protected from chemotherapy induced. Medical search. Frequent questions

In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. (oncotarget.com)
The BH3-mimetic Obatoclax induces apoptosis and decreases MCL1 expression in androgen-sensitive PCa cells, while castration-resistant PCa cells are less sensitive and react with an upregulation of MCL1 expression. (oncotarget.com)
In cisplatin-resistant cell lines, BT potentiated cisplatin-induced cytotoxicity at most drug ratios via enhanced ROS generation and modulation of key regulators of apoptosis. (biomedcentral.com)
Experiments are underway to systematically determine the role of αB-crystallin in conferring resistance of ovarian cancer cells to apoptosis. (bridgew.edu)
Conversely, wildtype αB-Crystallin and αB-Crystallin pseudophosphorylation mutants that alter its chaperone activity will be overexpressed in the OVCAR8 cells to determine the role of this protein in conferring resistance to WA-induced apoptosis. (bridgew.edu)
Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
Additionally, ivermectin has been shown to induce apoptosis and autophagy in a mutually regulated manner. (healththoroughfare.com)
Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
As ARRY334543 (Varlitinib) a consequence patients not only suffer from immediate side effects such as nausea hair loss diarrhea and neutropenia but will also be subjected to an increased risk of developing resistance to treatment and/or second tumors later on in existence. (immune-source.com)
It may provide novel insight into the role of Mrp1 in oxidative stress regulation, and thereby give us critical information regarding the potential adverse sequelae of introduction of MRP1 inhibitors as adjuncts to clinical chemotherapy of multidrug resistant tumors. (uky.edu)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
Since the majority of ovarian tumors eventually recur in a drug-resistant form leaving patients few treatment options, the goal of this study is to explore the molecular mechanism induced by WA in a cisplatin-resistant ovarian cancer cell line (OVCAR8R) as compared to its cisplatin-sensitive syngeneic counterpart (OVCAR8). (bridgew.edu)
While treatments directed against this receptor have successfully lowered mortality rates, many primary tumors initially or later exhibit resistance. (biomedcentral.com)
We examined a panel of prolactin-induced tumors for characteristics relevant to clinical tumors: histotype, ERα/progesterone receptor (PR) expression and estrogen responsiveness, Activating Protein 1 (AP-1) components, and phosphorylation of signal transducer and activator of transcription 5 (Stat5), extracellular signal regulated kinase (ERK) 1/2 and AKT. (biomedcentral.com)
Finally, we used microarray analyses to compare prolactin-induced ERα+ and ERα- tumors, and examined responsiveness to estrogen and the anti-estrogen, Faslodex, in vivo . (biomedcentral.com)
Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
The trial would test whether using CRISPR to knock out the NRF2 gene in squamous cell carcinoma lung cancer tumors improves the efficacy of conventional chemotherapy and radiation treatments. (genengnews.com)
The cancers produce tumors that are frequently protected by the NRF2 gene. (genengnews.com)
Not only that, but when the body starts growing tumors it's actually trying to protect itself. (healththoroughfare.com)
Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
Despite aggressive treatment with surgery, irradiation and sometimes chemotherapy, tumors invariably recur as incurable lesions. (lu.se)
Tumor cells with stem cell characteristics are thought to be responsible for therapeutic resistance in brain tumors. (lu.se)
Using mouse models of glioma and primary human glioma cultures, we aim to characterize phenotypic intratumoral heterogeneity specifically with regards to radiation resistant stem-like tumor cells, the molecular signaling pathways underlying therapeutic resistance, and microenvironmental control over tumor cell phenotypes with the overall goal of developing novel therapeutic strategies targeting therapy-resistant cells in malignant brain tumors. (lu.se)

While healthy cells are protected from DNA damage induced by reactive oxygen species, malignant cells are protected against chemo- or radiotherapy. (genengnews.com)
The standard of care therapy for GBM consists in surgical resection of the tumor, followed by radiotherapy and adjuvant plus concomitant chemotherapy with Temozolomide (TMZ) (Stupp protocol) ( 3 ). (frontiersin.org)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
In addition, a significant proportion of cancers can be cured, by surgery, radiotherapy or chemotherapy, especially if they are detected early. (who.int)

It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
This suggests that the bone marrow microenvironment induces a redox adaptation in ALL subclones that protects against cytotoxic stress and potentially gives rise to minimal residual disease. (bioskinrevive.com)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)

Pharmacological activation of wild-type p53 has been found to protect normal cells in culture from cytotoxicity and nuclear aberrations caused by standard cancer therapeutics. (immune-source.com)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
Morphological studies show WA-induced cytotoxicity in both cell lines, however the OVCAR8R cells remain viable at 5.0 and 7.5μM WA while few OVCAR8 cells remain viable at these doses. (bridgew.edu)
If cellular ferritin is even further increased through 1 h incubation (24 h prior to H2O2 exposure) of both cell types with hemin, FeSO4, or exogenous spleen apoferritin itself (24 h), marked resistance to H2O2-mediated cytotoxicity is manifest. (mtak.hu)
Data analogous to those with H2O2-mediated cytotoxicity were obtained in studies of bleomycin-engendered DNA strand breakage and cell damage, i.e., brief treatment of BT-20 cells with both hemin or FeSO4 significantly increases their sensitivity to bleomycin (100 micrograms/ml), whereas treatment followed by 24 h incubation with media alone significantly protects against bleomycin toxicity. (mtak.hu)
CR protects against asbestos-induced acute cytotoxicity mediated by the AKT/PI3K pathway and furthermore, SV40 early region genes are able to up-regulate CR in mesothelial cells. (unifr.ch)

The small Hsps, αB-Crystallin and Hsp27, confer resistance to chemotherapy in several cancer cell lines, however, the role of WA on αB-Crystallin and Hsp27 expression in drug resistance remains unknown. (bridgew.edu)
Importantly, I found that αB-Crystallin and Hsp27 are constitutively expressed in the OVCAR8R cells, while OVCAR8 cells do not endogenously express these Hsps, suggestingthat overexpression of Hsps may confer resistance to chemotherapy and promote a more aggressive tumor type. (bridgew.edu)

Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
As an adjunct therapy, they are widely used to protect the immune system from the toxic effects of chemo- and radiation therapy in the treatment of cancer [3,7]. (healthcaremarts.com)
The management of advanced HNSCC consists of multiple-modality therapy with surgery, radiation, and chemotherapy. (medscape.com)
The current conventional modalities (surgery, radiation, chemotherapy) are nonselective and can cause damage to normal tissue. (medscape.com)
Despite the crucial role of radiation resistance in patient mortality, few viable therapeutic strategies have been identified to target these resistant cells. (lu.se)

Knocking down (KD) hypoxia-induced factor 1α (HIF-1α), a key regulator of the cellular response to hypoxia, antagonized the effects observed in hypoxic T-ALL and restored chemosensitivity. (bvsalud.org)
Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion. (mpg.de)

We will also study the mitochondrial damage induced by DOX and the role of Mrp1 during this process. (uky.edu)
Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)

Our experimental studies have shown that MMWT when used in combination with chemotherapy protects the immune system from the toxicity of chemotherapy without introducing any additional toxicity of its own. (healthcaremarts.com)
From a clinical perspective, the well-known toxicity of chemotherapy often remains a serious barrier to successful treatment and even enrollment in clinical trials. (genengnews.com)

Several small-molecule activators of the p53 tumor suppressor have been shown to induce a slight cytostatic response in normal cells in tradition. (immune-source.com)

By using integrated genomics, we identified a small number of overexpressed and amplified genes from chromosome 8q22 that were associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
Using integrated genomics, we identified a small number of over-expressed and amplified genes from chromosome 8q22 significantly associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)

Its power intensity needs to be within the safety limit and its penetration depth should be sufficient to induce deep and localized hyperthermia and achieve tumor destruction. (frontiersin.org)

Cyclotherapy strategies purpose at improving the therapeutic windows of standard chemotherapy by protecting healthy cells.1-3 For instance if transient cell cycle arrest ARRY334543 (Varlitinib) in G1 or G2 was induced in normal tissues only their level of sensitivity to S- and M-phase poisons would be decreased while leaving the tumor vulnerable to the treatment. (immune-source.com)
The CRISPR-directed gene editing strategy could advance as an effective augmentative therapy to approach patients with locally advanced lung cancer, especially where the current standard of care has failed and there may be resistance to standard chemotherapy. (genengnews.com)

Adjuvant chemotherapy for breast cancer after surgery has effectively lowered metastatic recurrence rates. (bioseek.eu)

Also, they were postulating that chlorogenic acid that was found in coffee in the caffeine may actually upregulate tumor suppressor genes , which protect a body against cancer developing and also help with DNA repair. (keranews.org)
Deletions in the gene coding for the tumor suppressor PTEN also induce the persistent activation of PKB/cAkt since it is the negative regulator of this enzyme. (justia.com)

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. (thermofisher.com)
Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy. (mtak.hu)
Metformin enhances the sensitivity of drug-resistant ovarian cancer cells to chemotherapy. (oncotarget.com)
The Gene Editing Institute has done multiple tests in animals to establish that disabling NRF2 with CRISPR increases sensitivity to chemotherapy. (genengnews.com)

Our focus is translational research that advances the understanding of cancer treatment resistance mechanisms through the development of novel targeted therapies in order to improve patient survival. (massgeneral.org)
Immunology research to investigate the mechanisms of a new aerosol treatment, which induces an innate immune response to protect against pathogens that cause pneumonia, asthma, and other lung diseases, has earned major funding from the National Heart, Lung, and Blood Institute. (mdanderson.org)
Therefore, to understand the self-regulation and defense mechanisms of heart tissue under the oxidative stress may provide us new approaches to alleviate the clinical cardiotoxicity of chemotherapy. (uky.edu)
Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. (frontiersin.org)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)

With this line it has been demonstrated that pre-incubation with LD doxorubicin (LDDOX) protects normal cells against tubulin poisons.4 5 Similarly a LD of actinomycin?D (LDactD) another clinically approved anticancer drug has been used like a chemoprotectant in combination with the Aurora kinase inhibitor VX680.6 Unfortunately both LDDOX and LDactD also protected p53-deficient malignancy cell lines to a small degree. (immune-source.com)
Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)

Drug resistance to currently used chemotherapies is the fundamental cause of recurrence and poor overall survival in ovarian cancer patients [ 1 - 3 ]. (biomedcentral.com)
Resistance to chemotherapy, a major therapeutic challenge in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), can be driven by interactions between leukemic cells and the microenvironment that promote survival of leukemic cells. (bvsalud.org)
Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)
Through patient-derived AML xenograft (PDX) models and single cell proteomics, we have elucidated the roles of E-sel in AML survival and drug resistance. (confex.com)

The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)
At the same time, a subpopulation of highly tumorigenic glioma stem cells (GSCs) with high plasticity and self-renewal properties contribute to tumor malignancy through their sustained proliferation, invasion, stimulation of angiogenesis, suppression of anti-tumor immune responses and chemo-resistance ( 12 ). (frontiersin.org)
It might also help stimulate the immune system and protect organs. (medlineplus.gov)

Secondly, the central nervous system (CNS) has a unique microenvironment and is protected by the blood-brain barrier (BBB), which limits the access of systemically delivered drugs to the brain reducing the therapeutic options available for GBM. (frontiersin.org)

Isoproterenol has been reported to cause insulin resistance leading to diabetic ketoacidosis. (wikipedia.org)
Scientists have not come up with a particular explanation, but one thing mentioned was insulin resistance pathways . (keranews.org)
Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)

Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. (bmbreports.org)

With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
In order to mitigate the side effects and resistance resulting from cisplatin-based chemotherapy, it is essential to investigate new drugs which are non-toxic and work in alternative/similar pathways to cisplatin, thus providing additional therapeutic options in ovarian cancer. (biomedcentral.com)

In the asthma studies, the aerosol not only protects against acute virus-induced injury, but also has long-term immunomodulatory effects that prevent allergic asthma. (mdanderson.org)
TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)

Resistance to the conventional anti-cancer therapies is a characteristic of CSCs which is most important from a clinical point of view. (bmbreports.org)
Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)

Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)

In order to investigate the effectiveness of HePC ointment as a topical anti-leishmanial preparation, we tested its efficacy on experimentally induced lesions in hamsters. (who.int)

Cutaneous lesions were experimentally induced by inoculation with leishmania promastigotes in 60 golden hamsters. (who.int)
During the last 2 decades, many attempts have been made to develop effective new compounds for treating cutaneous leishmaniasis (CL) that would be economical, that could be applied topically to lesions and that would avoid the development of resistance. (who.int)

It also has severe limitations on the dosage of chemotherapeutic agents that can be administered to a patient, thus, limiting the effective range of chemotherapy. (justia.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
Furthermore, our studies have shown that the combined millimeter wave- and chemotherapy can reduce the tumor metastasis, and tumor resistance to chemotherapeutic drugs. (healthcaremarts.com)

The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates. (thermofisher.com)
Inhibition of HIF-1α and activation of the mTORC1 pathway may help suppress the drug resistance of T-ALL in hypoxic niches. (bvsalud.org)
The live supporting benefits of Astragalus include stimulation of hepatic DNA synthesis, simulation of superoxide dismutase and glutathione reductase to support healthy oxidation enhancing levels of antioxidants, suppression of ethanol-induced lipid accumulation, inhibition of nucleic acid polymerases to downregulate management of healthy cell production and translation, free radical scavenging and joint health by transforming growth factor beta-1, and collagen synthesis in hepatic cells [12]. (biotanicahealth.com)
The cell inhibition rate was used to evaluate the inhibitory effect of drugs on the tumor and the effect of adaptation for drug resistance. (oncotarget.com)
eNOS phosphorylation was subsequently decreased in EC, suggesting that inhibition of E-sel may protect BM vasculature by blocking the production of NO. In addition, targeting E-sel showed signaling alterations in AML MSC. (confex.com)

Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells. (mpg.de)

Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulating the tumor cell-intrinsic PD-1 remains to be further elucidated. (jcancer.org)

Dr. Cusack organized the Mass General Peritoneal Surface Malignancy Program in 2011 and treated his first patient with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in October 2011. (massgeneral.org)

Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
Our results prompted further exploration of the feasibility of innovative therapeutic approaches aimed at reducing the clinical side effects of chemotherapy," noted the researchers. (genengnews.com)

This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)

English Malignant mesothelioma (MM) are highly aggressive asbestos-related neoplasms, which show strong chemotherapy-resistance and there is no effective cure for MM so far. (unifr.ch)
Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)

Targeting metabolic remodeling by inhibiting antioxidant production and antiapoptosis was able to overcome drug resistance. (bioskinrevive.com)

This study was designed to investigate the association of gene polymorphisms in the p53 gene and mitochondrial genome D-loop region with metformin-induced sensitization and prognosis of ovarian cancer. (oncotarget.com)
Subsequently, we revealed that PDL-1 expression is upregulated in chemotherapy-treated CAFs and is associated with poor prognosis. (cdc.gov)

SiRNA-mediated knockdown of either of two of these genes, the antiapoptotic gene YWHAZ and a lysosomal gene LAPTM4B, sensitized tumor cells to anthracyclines, and overexpression of either of the genes induced anthracycline resistance. (bioseek.eu)
Two of these genes, the anti-apoptotic gene YWHAZ , and LAPTM4B , a novel lysosomal gene, sensitized tumor cells to anthracyclines when either was depleted by siRNA knockdown and induced drug resistance when either was over-expressed. (bioseek.eu)
Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)

Isoprenaline can also ameliorate the impairment of intestinal stem cells mediated by β2-adrenoreceptors after chemotherapy. (wikipedia.org)
Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Keywords: actinomycin D chemoprotection cyclotherapy leptomycin B Nutlin-3 p53 tenovin-6 Launch Chemotherapy approaches purpose at developing remedies that eradicate cancers cells effectively and selectively. (immune-source.com)
This compound has been shown to selectively shield normal cells against S-phase poisons 8 tubulin poisons 9 10 a Polo-like kinase 1 inhibitor (PLK1I)12 and an Aurora kinase inhibitor.7 Most importantly oral administration of nutlin-3 protects mice against PLK1I-induced neutropenia.12 Table?1. (immune-source.com)
Activation of the mammalian target of rapamycin (mTOR) was diminished in hypoxic leukemic cells, and treatment of T-ALL with the mTOR inhibitor rapamycin in normoxia mimicked the hypoxia effects, namely decreased cell growth and increased quiescence and drug resistance. (bvsalud.org)
HIF-1α KD also restored mTOR activation in low O2 concentrations, and inhibiting mTOR in HIF1α KD T-ALL protected leukemic cells from chemotherapy. (bvsalud.org)
Together, this research aims to elucidate the effectiveness of WA as a potential therapy for ovarian cancer cells that acquire resistance to platinum-based therapies. (bridgew.edu)
This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
Associated with Caco-2 resistance, these cells were found to be enriched in the endogenous iron chelator, ferritin. (mtak.hu)
Then, the inhibitory rate on cells in the experimental group was observed by CCK8 assay, in order to study the sensitization effect of metformin in different chemotherapies of ovarian cancer. (oncotarget.com)
It's also interesting to note that ivermectin can inhibit tumor stem cells and reverse multidrug resistance, and is most effective when used alongside other chemotherapy drugs. (healththoroughfare.com)
It has an archaic metabolism similar to yeast, growing rapidly in low oxygen environments, and making only two ATP energy molecules from a molecule of sugar, then throwing off waste which creates a moat of toxicity and protects the cancer cells from the body's defenses. (dunphynunley.com)
RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)

increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. (bmbreports.org)

Our investigations are ongoing in biomarkers of resistance and potential new targets for therapeutic intervention in colorectal cancer, melanoma and Merkel cell carcinoma. (massgeneral.org)
The standard treatment for Stage 3 colon cancer is about six months of chemotherapy, but chemotherapy by itself is not a guarantee. (keranews.org)
Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. (biomedcentral.com)
Platinum-based chemotherapy is still an effective treatment for ovarian cancer in spite of severe side effects and development of resistance associated with its use [ 10 ]. (biomedcentral.com)
Proglumide treatment also protected the mice from the development of excessive fibrous tissue (fibrosis) that can be associated with cancer metastases and resistance to chemotherapy. (takethehealth.com)
This research will help protect patients who are most vulnerable to pneumonia, especially patients with cancer," said Scott Evans, M.D. , the principal investigator for this research program and an associate professor of Pulmonary Medicine at The University of Texas MD Anderson Cancer Center. (mdanderson.org)
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. (bioseek.eu)
Overexpression of these two genes was associated with poor tumor response to anthracycline treatment in a neoadjuvant chemotherapy trial in women with primary breast cancer. (bioseek.eu)
Direct correlation between resistance to chemotherapy and activation of PKB was shown in several prostate cancer cell lines and in human tumorogenic tissues, and elevation of PKB levels in prostate tumor tissues, is clinically associated with HRPC (Yongde et al. (justia.com)
This study aims to investigate the association of p53 and D-loop gene with drug resistance and sensitization induced by metformin in ovarian cancer. (oncotarget.com)

Although its mechanism remains unclear, WA has been shown to upregulate heat shock proteins (Hsps) which protect against diverse cellular insults. (bridgew.edu)

MRP1 (multidrug resistance associated protein 1) is a member of the C subfamily of the ATP binding cassette (ABC) transport proteins. (uky.edu)

A recent publication has demonstrated that introduction of NOS blockers in combination with chemotherapy led to slower leukemia progression and longer remissions in contrast to chemotherapy alone (Passaro et al, 2017). (confex.com)

He calls this process inducible resistance. (mdanderson.org)

Prolactin-induced carcinomas were markedly diverse with respect to histotype, ERα/PR expression, and activated signaling cascades. (biomedcentral.com)

Subsequent treatment with second-line or third-line agents (after interim non-platinum therapy) results in less than 33% response rate due to the increase of resistance to these drugs [ 6 - 9 ]. (biomedcentral.com)
Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
Combination treatment induced higher Ki67 positivity, and hyperactivation of pRb and p-S6 in MSC in vivo. (confex.com)
The major drawback associated with the treatment is that it is painful and costly, relapses occur and above all, resistance develops. (who.int)
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. (who.int)

Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)

Examples of this level of eradication are the use of chemotherapy with ivermectin to eliminate blindness resulting from onchocerciasis and of vitamin A to eliminate xerophthalmia. (cdc.gov)

It is safe, clean and contains antibodies which help protect against many common childhood illnesses. (who.int)

Bacterial adaptation makes antibacterial drug resistance from the 1918 Pandemic Virus inevitable. (cdc.gov)
A/Swine/Iowa/30 were protected against death and major a new drug that kills bacteria without disturbing the human weight loss and had undetectable virus in respiratory tis- host. (cdc.gov)
Our finding supports PDL-1 in CAFs as a chemotherapy response biomarker and as a drug delivery and therapeutic target for chemoresistant NSCLC. (cdc.gov)

The main recipients of STZ chemotherapy were middle-aged patients with pancreatic NET and unresectable liver metastases. (cancerindex.org)

Evans and his team designed a synthetic aerosol, a combination of two synthetic ligands that bind Toll-like receptors, to stimulate these mucosal responses to protect against respiratory pathogens, such as bacteria, viruses, or fungi, before they are well-established in the lungs. (mdanderson.org)

Specific Aim 1: Characterize the role of Mrp1 in protecting the heart from DOX-induced injury in vivo. (uky.edu)

CRC cell growth induced by C. tropicalis is partially offset in the presence of PD-1 overexpression. (jcancer.org)
The 1st studies used low doses (LD) of DNA damaging providers to induce p53-dependent cell cycle arrest. (immune-source.com)
Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
Such activity would result in increased cell death of tumor tissue where PKB is elevated, and in decreased resistance to chemotherapy agents. (justia.com)

Even in immunocompromised mice with leukemia, the aerosol protects against pneumonia. (mdanderson.org)

The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. (cancerindex.org)

Anatomy4

Organisms2

Diseases66

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Phenomena and Processes33

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science4

Health Care25

Apoptosis10

Tumors16

Radiotherapy4

Cytotoxic4

Cytotoxicity6

Confer resistance to chemotherapy2

Radiation5

Hypoxia-induced2

Damage induced2

Toxicity of chemotherapy2

Shown to induce1

Anthracycline-based3

Sufficient to induce1

Standard chemotherapy2

Adjuvant1

Tumor suppressor2

Sensitivity4

Mechanisms5

Doxorubicin2

Survival4

Immune4

Microenvironment1

Insulin resistance3

Tumorigenesis1

Pathways2

Acute2

CSCs2

Diabetic ketoacidosis1

Efficacy1

Lesions2

Chemotherapeutic3

Inhibition5

Bone marrow1

Immunotherapy1

Cytoreductive surgery1

Clinical2

Methods4

Malignant2

Metabolic1

Prognosis2

Knockdown3

Cells13

Therapies1

Cancer10

Mechanism1

Multidrug1

Progression1

Inducible1

Carcinomas1

Treatment6

Angiogenesis1

Ivermectin1

Antibodies1

Drug3

Metastases1

Combination1

Vivo1

Cell4

Mice1

Effectiveness1