Chemotherapy precursor b cell lymphoblastic leukemia lymphoma. Medical search. Frequent questions

Daratumumab has been successfully used with other targeted agents or standard chemotherapy with minimal additional toxicity in multiple myeloma studies. (pediatricsnationwide.org)
An open-label phase I, multi-center study to determine the recommended dose of the chimeric antigen receptor T-cell treatment CYAD-211 after a non-myeloablative preconditioning chemotherapy in multiple myeloma patients with relapsed or refractory disease. (biosafety.be)
Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
For examples include acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphomas and multiple myeloma. (medgadget.com)
The most commonly diagnosed blood cancers are non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma. (medgadget.com)
Hematologic Malignancie market report is segmented on the basis of type, therapy and by regional & country level.Based upontype, Hematologic Malignancie market is classified intoLeukemia, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Lymphoma,Multiple Myeloma and Others. (medgadget.com)

Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
Children with Down syndrome have an increased risk for developing both acute myeloid as well as lymphoblastic leukemia. (ox.ac.uk)
Myeloid leukemia in children with Down syndrome is preceded by a preleukemic clone (transient leukemia or transient myeloproliferative disorder), which may disappear spontaneously, but may also need treatment in case of severe symptoms. (ox.ac.uk)
Twenty percent of children with transient leukemia subsequently develop myeloid leukemia. (ox.ac.uk)
American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults. (rochester.edu)
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
According to the case study, an acute myeloid leukemia patient has remained cancer free for 9 months following treatment with the chimeric antigen receptor (CAR) T-cell treatment, CYAD-01, and a bone marrow transplant. (pharmacytimes.com)
researchers are investigating Celyad's new CAR T therapy CYAD-01 in the treatment of acute myeloid leukemia (AML). (pharmacytimes.com)
[ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
Of these 20 patients, 7 patients had acute lymphoblastic leukemia, and 13 had acute myeloid leukemia. (bvsalud.org)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
And, malignancy in the myeloid lineage that includes precursor cells to red blood cells, platelets and white blood cells such as granulocytes. (medgadget.com)
Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia. (incliva.es)
Outcomes after intensive chemotherapy for secondary and myeloidrelated changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry. (incliva.es)
Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
Similar to acute myeloid leukemia, acute lymphoblastic leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)

The prognosis for infants with acute lymphoblastic leukemia (ALL), particularly those with KMT2A gene rearrangement (KMT2A-r), is dismal. (nih.gov)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
The prognosis of children with KMT2A -rearranged ( KMT2A -r) acute lymphoblastic leukemia (ALL) remains dismal. (bvsalud.org)
The prognosis of relapsed/refractory (R/R) pediatric acute leukemia is extremely poor. (bvsalud.org)
Although BPDCN is initially sensitive to conventional chemotherapy regimens, this response is relatively short and long-term prognosis is poor. (elsevierpure.com)
Genomic signatures and prognosis of advanced stage Chinese pediatric T cell lymphoblastic lymphoma by whole exome sequencing. (cdc.gov)

Patients were randomized in a 2:1 ratio to receive blinatumomab (n = 271) or one treatment with investigator's choice out of 4 types of SOC chemotherapy regimens (n = 134). (astellas.com)
The purpose of this study is to determine the safety and tolerability of SNDX-5613 when given in combination with 2 different chemotherapy regimens in participants with relapsed/refractory acute leukemias harboring KMT2A rearrangement, KMT2A amplification, NPM1c, or NUP98r. (ucsf.edu)
This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (ucsf.edu)
Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (ucsf.edu)
The overall response rate with aggressive acute lymphoblastic leukemia-type induction regimens was as high as 90%, but the durability of response was short. (elsevierpure.com)
Therapy of lymphoblastic lymphoma (LL) has evolved with use of chemotherapy regimens modeled after those for acute lymphocytic leukemia (ALL). (ashpublications.org)
We treated 33 patients with LL with the intensive chemotherapy regimens hyper-CVAD (fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone) or modified hyper-CVAD used for ALL at our institution. (ashpublications.org)
Patients with Burkitt leukemia/lymphoma are treated with regimens specific for this diagnosis. (medscape.com)

These cells normally occupy the follicles (nodular swirls of various types of lymphocytes) in the germinal centers of lymphoid tissues such as lymph nodes. (wikipedia.org)
They may then circulate in the blood to cause an asymptomatic condition termed in situ lymphoid neoplasia of the follicular lymphoma type (i.e. (wikipedia.org)
In situ follicular lymphoma is an accumulation of monoclonal B cells (i.e. cells descendent from a single ancestral cell) in the germinal centers of lymphoid tissue. (wikipedia.org)
This translocation is proposed to occur during the early development of immature bone marrow B-cells (i.e. pre-B-cells/pro-B-cells) after which these cells circulate freely and in rare cases accumulate and mature to centrocytes and/or centroblasts in the germinal centers of lymphoid follicles to form ISFL. (wikipedia.org)
This lymphoid population reacted with PAX-5 and TdT immunohistochemical antibodies in a diffuse manner confirming precursor B-cell origin. (bvsalud.org)
A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
In ALL the lymphoid cells of the white blood cells are affected. (bhaskarhealth.com)
There is a cancerous transformation of a clone of cells from lymphoid progenitor cells. (bhaskarhealth.com)

OBJECTIVES: I. Assess the feasibility and outcome of intensified induction/consolidation followed by intensified re-induction/re-intensification in infants less than 1 year of age with newly diagnosed acute lymphocytic leukemia (ALL). (knowcancer.com)
FL accounts for 10-20% of non-Hodgkin's lymphomas with ~15,000 new cases of it being newly diagnosed each year in the US and Europe. (wikipedia.org)
The abiraterone acetate plus prednisone combination was previously approved for metastatic castration-resistant prostate cancer (CRPC) after chemotherapy and for newly diagnosed metastatic CRPC. (ahdbonline.com)
CMH is now one of only a handful of children's hospitals treating patients on a clinical trail for newly diagnosed patients with B-cell ALL with a slower than expected response to treatment. (childrensmercy.org)
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (ucsf.edu)
BOSULIF (bosutinib) has been granted a positive opinion for the treatment of adults with newly diagnosed chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML). (medgadget.com)

BACKGROUND: Although reinduction rates are good for children with relapsed acute lymphoblastic leukaemia there is no consensus on whether bone marrow transplantation (BMT) is the most effective treatment to prolong second remission. (ox.ac.uk)
She underwent chemotherapy according to the L2 protocol, followed by autologous bone marrow transplantation, which produced complete remission. (unipg.it)
In the blinatumomab arm, this included 35% of patients that had relapsed post-allogenic hematopoietic stem cell transplant (alloHSCT), and excluded those with late first relapse (≥ 12 months after initial remission). (astellas.com)
The overall remission rate was 81%, with 50% of patients remaining leukemia free 1 year after treatment. (childrensmercy.org)
While more than half of patients with AML go into remission after treatment with chemotherapy, many relapse due to residual leukemia cells evading both chemotherapy and the immune system. (pharmacytimes.com)
The Japan Adult Leukemia Study Group conducted the ALL-87 study to determine whether response-oriented induction therapy and intensive consolidation and maintenance/intensification therapies could increase complete remission (CR) rate and survival in adult acute lymphoblastic leukemia (ALL). (elsevierpure.com)
The results seen with the recently approved novel agent blinatumomab ( Blincyto , Amgen Inc) are "notable," say authors reporting a trial in which monotherapy produced complete remission in almost half of patients with relapses or refractory B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
After achieving the second remission, the patient received a killer cell immunoglobulin-like receptor ligand-mismatched CBT with a reduced-intensity conditioning regimen and has been in remission for 52 months. (bvsalud.org)
For patients with chronic myelomonocytic leukemia, the overall response rate was higher for azacitidine plus lenalidomide vs azacitidine alone (68% vs 28%, P = .02) but similar for all arms across cytogenetic subgroups, as was remission duration and overall survival. (ascopost.com)
The main aims of this study are to confirm the highest dose of ponatinib tablets and minitablet capsules that can be given to participants with acceptable side effects, and to evaluate if participant's leukemia achieves remission. (ucsf.edu)
Allogeneic hematopoietic stem cell transplantation, particularly when performed during the first remission, may produce durable remissions in selected adults. (elsevierpure.com)
Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)
TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia. (cancercentrum.se)

To compare drug sensitivity of ALL cells from diagnosis to relapse in vitro and in vivo and determine if acquired resistance to specific agents is related to specific somatic genome variants that are not detected or found in only a minor clone at initial diagnosis. (centerwatch.com)
At $475,000, Novartis' Kymriah (tisagenlecleucel) is approved by FDA for patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia that's refractory or in second or later relapse. (managedhealthcareexecutive.com)
Thus, killer cell immunoglobulin-like receptor ligand-mismatched CBT with reduced-intensity conditioning might be a treatment option for patients with KMT2A- r ALL who relapsed after transplantation, even with extramedullary relapse. (bvsalud.org)
Relapse risk following truncation of PEG-asparaginase in childhood acute lymphoblastic leukemia. (cancercentrum.se)
ÓG, Vaitkeviciene G, Lepik K, Forslund A, Heyman M, Harila-Saari A. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. (cancercentrum.se)

Scholars@Duke publication: Sex-Specific Associations Between Chemotherapy, Chronic Conditions, and Neurocognitive Impairment in Acute Lymphoblastic Leukemia Survivors: A Report From the Childhood Cancer Survivor Study. (duke.edu)
Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997. (ox.ac.uk)
Results of three consecutive completed UK trials (1980-1997) for childhood lymphoblastic leukaemia are presented. (ox.ac.uk)
Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALL R1 trial. (ox.ac.uk)
DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship? (regionh.dk)
Vitamin D and bone minerals status in the long term survivors of childhood acute lymphoblastic leuke. (ac.ir)
in a case control cross sectional study calcium (Ca), magnesium (Mg), phosphorus (P) and also alkaline phospatse (AlK P), and compared in two groups of childhood ALL survivors: groups A (who were treated wtih chemotherapy alone) and group B (who received chemotherapy plus 1800-2400 rads cranial radiation therapy). (ac.ir)
T-lymphoblastic lymphoma (T-LBL) accounts for 25-30% of childhood NHL and is closely related to T-lymphoblastic leukemia (T-ALL). (medscape.com)
Population-based attributes for Social Exclusion Index (SEI) and household size may be useful surrogate markers of early exposure to childhood infections, which has been found to decrease the risk of acute lymphoblastic leukemia (ALL). (medscape.com)
The spectrum of acute central nervous system symptoms during the treatment of childhood acute lymphoblastic leukaemia. (cancercentrum.se)
Gene-environment analyses reveal novel genetic candidates with prenatal tobacco exposure in relation to risk for childhood acute lymphoblastic leukemia. (cdc.gov)
Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15?000 leukemia cases and 46?000 controls from the Childhood Cancer and Leukemia International Consortium. (cdc.gov)
Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population. (cdc.gov)
Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil. (cdc.gov)
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. (lu.se)

In November 2015, the EU granted conditional marketing authorization for blinatumomab for the treatment of adults with Philadelphia chromosome-negative (Ph-) relapsed or refractory B-cell precursor ALL. (astellas.com)
Patient-Reported Quality of Life After Tisagenlecleucel Infusion in Children and Young Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia: A Global, Single-Arm, Phase 2 Trial. (childrensmercy.org)
Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common in children and young adults. (medscape.com)
The European Commission approved Inotuzumab ozogamicin [14] as a monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) on June 30, 2017 under the trade name Besponsa® (Pfizer/Wyeth), [15] followed on August 17, 2017 by the FDA. (wikipedia.org)
Ibrutinib is a small molecule drug currently approved for use in adults to treat B-cell cancers such as mantle cell lymphoma, chronic lymphocytic leukemia and others. (pediatricsnationwide.org)
This study is about an anticancer drug called ponatinib which is a tyrosine kinase inhibitor given with chemotherapy to children, teenagers, and young adults up to 21 years of age with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia who have relapsed or are resistant to other treatment. (ucsf.edu)
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). (ucsf.edu)
Results from the analysis showed a median overall survival (OS) of 26 months and demonstrated that responses remained durable in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with a consistent safety profile observed since the two-year analysis. (gilead.com)
In adults, B-cell precursor ALL is the most common form, accounting for 75% of cases. (gilead.com)
Additionally,Leukemia is diagnosed 10 times more often in adults than children.New cases of leukemia, lymphoma and myeloma are expected to account for 10 percent of the estimated 1,762,450 new cancer cases diagnosed in the US in 2019. (medgadget.com)
It's FDA-approved to treat a certain type of acute lymphoblastic leukemia (ALL) in adults and in children. (medicalnewstoday.com)

Continuous efforts have been made in Japan to investigate the role of hematopoietic stem cell transplantation (HSCT) for infants with KMT2A-r ALL, but improvement in outcome was modest. (nih.gov)
A third of these patients subsequently underwent allogeneic hemopoietic stem cell transplantation. (medscape.com)
We retrospectively reviewed 20 consecutive pediatric patients with R/R acute leukemia who underwent a first HLA-haploidentical peripheral blood stem cell transplantation following reduced-intensity conditioning (haplo-RIC-PBSCT) with very low-dose antithymocyte globulin (ATG) between 2012 and 2019. (bvsalud.org)
ZUMA-3 is an ongoing international multicenter (US, Canada, Europe), single arm, open label, registrational Phase 1/2 study of Tecartus in adult patients (≥18 years old) with ALL whose disease is refractory to or has relapsed following standard systemic therapy or hematopoietic stem cell transplantation. (gilead.com)
No consolidation with autologous or allogeneic stem cell transplantation was performed. (ashpublications.org)

To determine the tolerability of combination therapy with ruxolitinib and Early Intensification therapy in patients with activation of JAK-STAT signaling that can be inhibited by ruxolitinib and Day 15 or Day 22 MRD ≥5%, Day 42 MRD ≥1%, or LLy patients without complete response at the End of Induction and all patients with early T cell precursor leukemia. (centerwatch.com)
Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)

We will establish two prospective groups of patients with Acute Lymphoclastic Leukemia (ALL): "Cohort A" will be enrolled on the study at the time of diagnosis while "Cohort B" will be enrolled during maintenance chemotherapy. (rochester.edu)
The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
Acute Leukemia Diagnosis - A Practical Morphologic, Immunophenotypic, and Cytogenetic Approach. (llu.edu)
20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
As with chronic myelogenous leukemia (CML) , the myeloproliferative aspect of SCLL has a chronic phase that transforms into a myeloblastic phase, typically within 1 year of diagnosis. (medscape.com)
The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. (elsevierpure.com)
At diagnosis, 80% were T-cell immunophenotype, 70% were stages III to IV, 70% had mediastinal involvement, and 9% had central nervous system (CNS) disease. (ashpublications.org)

Arm I (closed to accrual as of 4/2006): Patients receive same induction, consolidation, and interim maintenance therapy schedule as localized lymphoblastic lymphoma patients. (knowcancer.com)
Maintenance (84 day course): Patients receive same therapy as localized lymphoblastic lymphoma patients, except methotrexate IT is administered on day 0 and 28 (for first 4 courses). (knowcancer.com)
Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
Several types of adoptive cell transfer are under investigation, but CAR T-cell therapy is the first to enter clinical practice. (medscape.com)
The first report of CAR T-cell therapy was in 2010, in a patient with advanced follicular lymphoma. (medscape.com)
Blinatumomab was granted breakthrough therapy and priority review designations by the U.S. Food and Drug Administration, and is now approved in the U.S. for the treatment of relapsed or refractory Bcell precursor ALL in adult and pediatric patients. (astellas.com)
in this study the effects of chemotherapy and chemotherpy plus radiation therapy on this complication were compared in ALL survivors. (ac.ir)
CAR T-cell therapy and other immunotherapies may cure patients who have endured multiple rounds of treatment. (managedhealthcareexecutive.com)
Gilead's Yescarta (axicabtagene ciloleucel), at $373,000, is approved for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. (managedhealthcareexecutive.com)
Patients were randomly allocated either to receive or not, intrathecal chemotherapy on day 8 of the induction therapy. (elsevierpure.com)
Response-oriented induction therapy produced a high CR rate, but fairly intensive consolidation and maintenance/intensification chemotherapies resulted in only a marginal effect on DFS in adult ALL. (elsevierpure.com)
Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. (ucsf.edu)
The process for administering CAR T-cell therapy is complex, with multiple steps including CAR T-cell manufacturing, lymphodepleting chemotherapy, cellular therapy infusion, and management of short-term and long-term toxicities. (ajmc.com)
Pharmacists are intricately involved in the process of providing CAR T-cell therapy both at the organizational level of budgeting and coordinating therapy and in direct patient care roles providing counseling and support for adverse effect management. (ajmc.com)
Research in CAR T-cell therapy is expected to improve tolerability and expand indications to more types of malignancies and earlier phases of disease. (ajmc.com)
Managed care professionals should have an understanding of the clinical trial data and place in therapy in lymphoma, myeloma, and acute lymphoblastic leukemia as well as guideline recommendations for adverse effect management associated with CAR T-cell therapies. (ajmc.com)
Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)
1 CAR T-cell therapy pivotal trials demonstrated unprecedented overall response rates (ORRs) and complete responses (CRs) that led to the FDA approval of 5 CAR T-cell products: tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axi-cel), lisocabtagene maraleucel (liso-cel), brexucabtagene autoleucel (brexu-cel), and idecabtagene vicleucel (ide-cel). (ajmc.com)
In addition, challenges related to manufacturing a patient-specific product, need for inpatient administration in a tertiary care setting, high costs and inadequate reimbursement have limited access to CAR T-cell therapy. (ajmc.com)
2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)
SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), today announced the three-year follow-up results from the pivotal ZUMA-3 study of the CAR T-cell therapy Tecartus ® (brexucabtagene autoleucel). (gilead.com)
Induction consolidation was administered with 8 or 9 alternating cycles of chemotherapy over 5 to 6 months with intrathecal chemotherapy prophylaxis, followed by maintenance therapy. (ashpublications.org)
Food and Drug Administration granted accelerated approval to rucaparib (RUBRACA, Clovis Oncology, Inc.) for patients with deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy. (blogspot.com)
Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy. (cancercentrum.se)

TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
ALL is usually treated with a combination of chemotherapy and radiotherapy. (bhaskarhealth.com)

Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)

Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
There was no significant difference in CR rates and DFS between the two randomized groups according to the intrathecal chemotherapy on day 8. (elsevierpure.com)

Methods: The Leukemia and Lymphoma Committee of the Japanese Society of Pediatric Hematology and Oncology (JSPHO) sent out questionnaires to 110 JSPHO affiliated hospitals and collected cases of MNPKL diagnosed during the period 2000-2013. (confex.com)
Children's Oncology Group AALL0631 modified chemotherapy with the addition of high-dose cytarabine in early intensification was introduced to KMT2A-r patients, and the option of HSCT was restricted to HR patients only. (nih.gov)
Chemotherapy- and immunotherapy-related side effects can send patients to the emergency room-that is, if oncology practices don't proactively manage patients and provide timely triage. (managedhealthcareexecutive.com)

OUTLINE: Patients are stratified by disease characteristics (disseminated lymphoblastic lymphoma vs localized lymphoblastic lymphoma [localized lymphoblastic lymphoma is closed to accrual as of 10/2005]) and age. (knowcancer.com)
Patients with localized lymphoblastic lymphoma (closed to accrual as of 10/2005) are not randomized. (knowcancer.com)
PATIENTS AND METHODS: Analyses comparing the outcome of related donor allogeneic BMT (related allograft) with chemotherapy are unreliable because of selection biases. (ox.ac.uk)
Analysis by treatment received gave similar results, with BMT patients having a 5% (P = 0.8) eight-year EFS advantage over patients who received chemotherapy. (ox.ac.uk)
Compared to Regimen B (i.e. additional doxorubicin during induction and additional cyclophosphamide and cytarabine during consolidation chemotherapy), patients receiving Regimen A had fewer problems with pain and nausea. (ox.ac.uk)
This phase II trial studies how well OBI-3424 works in treating patients with T-cell acute lymphoblastic leukemia that has come back (relapsed) or does not response to treatment (refractory). (rochester.edu)
In the TOWER study, blinatumomab was shown to extend overall survival compared to standard-of-care (SOC) chemotherapy in adult patients with relapsed or refractory ALL. (astellas.com)
The TOWER study was a Phase 3 randomized study investigating the efficacy of blinatumomab versus SOC chemotherapy in 405 adult patients with Ph- relapsed or refractory B-cell precursor ALL. (astellas.com)
Afatinib was previously approved for patients with metastatic NSCLC and EGFR exon 19 deletions or exon 21 ( L858R ) substitution mutations, and for patients with metastatic squamous NSCLC that progressed with platinum-based chemotherapy. (ahdbonline.com)
An international phase 2 study treated 75 patients with relapsed or refractory B-cell ALL with Kymriah. (childrensmercy.org)
however, Kymriah holds an additional indication to treat B-cell precursor acute lymphoblastic leukemia in certain pediatric and young adult patients. (pharmacytimes.com)
CYAD-01 genetically modifies the patients' immune cells to express a natural killer receptor that targets leukemia cells. (pharmacytimes.com)
Lymphoblastic lymphoma is aggressive and progresses rapidly, presenting as stage IV disease in more than 70% of patients (see Staging). (medscape.com)
Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
Postchemotherapy disease-free survival was very low and many patients died during chemotherapy. (ijmpo.org)
The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)
Patients with primary lymphoma or leukemic involvement of the biliary tract and liver often present with symptoms and signs of biliary tract obstruction or inflammation. (bvsalud.org)
In an open label, multicenter phase 2 study, researchers are investigating the efficacy and safety of daratumumab, a targeted immunotherapy that attacks cells which overexpress CD38, in patients with relapsed or refractory precursor B- or T-cell acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL). (pediatricsnationwide.org)
Our primary question is to determine the percentage of patients with complete response for B- and T-cell ALL/LL," says Susan Colace, MD , pediatric oncologist at Nationwide Children's, one of the participating sites for the study. (pediatricsnationwide.org)
Thus, daratumumab has the potential to provide therapeutic benefit for patients with relapsed/refractory B-cell or T-cell ALL/LL. (pediatricsnationwide.org)
We are currently enrolling only patients with T-cell ALL/LL," says Dr. Colace. (pediatricsnationwide.org)
In a multisite study, researchers are examining the safety and efficacy of ibrutinib in combination with multiagent chemotherapy in pediatric patients with relapsed/refractory mature B-cell leukemia and non-Hodgkin lymphoma (NHL). (pediatricsnationwide.org)
Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (ucsf.edu)
Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. (ucsf.edu)
The goals of this study are to help make chemotherapy more effective in treating the patient's leukemia as demonstrated by fewer patients with leukemia minimal residual disease (MRD) while also trying to reduce the amount of body fat that chemotherapy causes the patient to gain in the first month. (ucsf.edu)
The continued durable response and significant improvement in survival indicated by these new data can potentially establish a new standard of care for adult patients living with this aggressive form of leukemia. (gilead.com)
Findings consistent with chronic myelomonocytic leukemia have been noted in at least several patients. (medscape.com)
Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4+CD56+ hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. (oncotarget.com)
Food and Drug Administration approved the combination of nivolumab (OPDIVO, Bristol-Myers Squibb Co.) plus ipilimumab (YERVOY, Bristol-Myers Squibb Co.) and 2 cycles of platinum-doublet chemotherapy as first-line treatment for patients with metastatic or recurrent non-small cell lung cancer (NSCLC), with no epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) genomic tumor aberrations. (blogspot.com)
Food and Drug Administration approved brigatinib (ALUNBRIG, ARIAD Pharmaceuticals Inc.) for adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test. (blogspot.com)
Food and Drug Administration approved the combination of nivolumab (OPDIVO, Bristol-Myers Squibb Co.) plus ipilimumab (YERVOY, Bristol-Myers Squibb Co.) as first-line treatment for patients with metastatic non-small cell lung cancer whose tumors express PD-L1(≥1%), as determined by an FDA-approved test, with no epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) genomic tumor aberrations. (blogspot.com)
Food and Drug Administration granted accelerated approval to capmatinib (TABRECTA, Novartis) for adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test. (blogspot.com)
The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
Patients with Philadelphia chromosome-positive ALL receive a tyrosine kinase inhibitor (TKI) in combination with chemotherapy. (medscape.com)
Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia. (cancercentrum.se)
Posttransplant cyclophosphamide versus antithymocyte globulin in patients with acute lymphoblastic leukemia treated with allogeneic hematopoietic cell transplantation from matched unrelated donors. (cdc.gov)
G308A) polymorphisms in Egyptian patients with acute lymphoblastic leukemia: A single-center study. (cdc.gov)

This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. (rochester.edu)
The study aims to determine the safety and feasibility of complete outpatient blinatumomab administration for subjects with minimal/measurable residual disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL). (rochester.edu)
President and CEO Yoshihiko Hatanaka "Astellas") today announced that an application was submitted in Japan for the marketing authorization for bispecific CD19-directed CD3 T cell engager (BiTE ® ) antibody construct blinatumomab (Genetically Recombination) (generic name, development code: AMG 103, "blinatumomab") to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). (astellas.com)
Blinatumomab (genetically recombinant antibody) is a bispecific CD19-directed CD3 T cell engager (BiTE ® ) antibody construct that binds specifically to CD19 expressed on the surface of cells of B-lineage origin and CD3 expressed on the surface of T cells. (astellas.com)
Blinatumomab is the first of a novel class of drugs known as bispecific T-cell engagers and is designed to direct cytotoxic T cells to CD19-expressing cancer cells. (medscape.com)
As reported with other monoclonal antibodies, life-threatening reactions can potentially result from massive release of cytokines, and blinatumomab also causes B-cell depletion, leading to further decreases in immunoglobulin levels, and thus increasing the risk for infections, he writes. (medscape.com)
The incorporation of blinatumomab into conventional chemotherapy backbones, potentially including other monoclonal antibodies, should produce opportunities to assess the feasibility of such combinations and to increase treatment efficacy," he writes. (medscape.com)
It seems more likely that we should use blinatumomab sequentially with chemotherapy instead of concurrently. (medscape.com)
Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. (ucsf.edu)

A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)

VSV-GP128 is a recombinant live-attenuated Vesicular Stomatitis Virus (VSV), modified to minimize the potential of neurotoxicity for humans and skin disease in animals, and engineered to contain cancer antigens, which help it induce an immune response against colorectal tumour cells. (biosafety.be)

The acute leukemia is resistant to conventional chemotherapy. (medscape.com)

Systemic Chemotherapy. (knowcancer.com)

However, recent advancements in the treatment of t-FL (e.g. the addition to standard chemotherapy of agents such as rituximab) have improved overall survival times. (wikipedia.org)
For example, can it improve long-term outcomes compared with standard chemotherapy, and can it be used earlier in the course of the disease and in combination with other treatment approaches? (medscape.com)

the tumor derives from the precursors of plasmacytoid dendritic cells (ie, plasmacytoid monocytes). (medscape.com)
Results: BPDCN is derived from precursor plasmacytoid dendritic cells. (elsevierpure.com)

In consequence, multiple B-cell clones that exhibit increasing genomic alterations and malignant behaviors populate the disorder. (wikipedia.org)
The overexpression of Bcl2 in the B-cells of ISFL is thought to be a critical factor in their pathological accumulation and subsequent malignant progression. (wikipedia.org)
Given that no other signs and symptoms of malignant lymphoma were present, the mediastinal tumor was surgically removed. (unipg.it)
it recognizes a specific protein on the surface of malignant cells (eg, CD19 on B-cells). (medscape.com)
Many investigators have suggested that both lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) may be part of one clinical spectrum of a single malignant lymphoproliferative disorder . (medscape.com)
This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
Загальні відомості про лейкоз Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

Overall CR rate (CR + CRi), CR, and subsequent allogeneic stem cell transplant (alloSCT) rates remained unchanged since the prior data cut at 71%, 56%, and 20%, respectively. (gilead.com)

vitamin D and bone mninerals abnormalities are one of the nonapparent late effects of acute lymphoblastic leukemia (ALL). (ac.ir)
Among bone marrows studied a case of T-LL developed pancytopenia, during chemotherapy showed giant pronormoblast (Parvovirus infection). (ijmpo.org)
This patient was found to have B-lymphoblastic leukemia involving his bone marrow on further clinical and diagnostic workup. (bvsalud.org)
It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
Normally the blood cells are produced by bone marrow. (bhaskarhealth.com)
There are stem cells within the bone marrow that mature to form the blood cells. (bhaskarhealth.com)
The bone marrow produces mature forms of each of these types of cells. (bhaskarhealth.com)
In leukemia, the affected bone marrow fails to release adult and mature cells and releases a large number of immature white blood cells that are known as blast cells. (bhaskarhealth.com)

Acute leukemias in children with Down syndrome. (ox.ac.uk)
ALL accounts for about 20% of adult acute leukemias. (msdmanuals.com)

In the US and Europe, this disease is the second most common form of non-Hodgkin's lymphomas, exceeded only by diffuse large B-cell lymphoma. (wikipedia.org)
However, each year 2-3% of FL cases progress to a highly aggressive form often termed stage 3B FL, to an aggressive diffuse large B-cell lymphoma, or to another type of aggressive B-cell cancer. (wikipedia.org)
T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)

Diffuse large cell lymphomas and their mimics. (llu.edu)

The serial progressions of in situ FL to FL and FL to t-FL appear to involve the accumulation of increasing numbers of genomic alterations (i.e. chromosome abnormalities and gene mutations) in the formative B-cell precursors to these disorders. (wikipedia.org)
At least some of these alterations appear to cause the over-expression or under-expression of the products of genes that regulate these cells' susceptibility to develop further genomic alterations, to survive, to proliferate, and/or to spread to other tissues. (wikipedia.org)
These cells commonly bear a pathological genomic abnormality, i.e. a translocation between position 32 on the long (i.e. "q") arm of chromosome 14 and position 21 on chromosome 18's q arm. (wikipedia.org)
The overarching objective of this study is to use novel precision medicine strategies based on inherited and acquired leukemia-specific genomic features and targeted treatment approaches to improve the cure rate and quality of life of children with acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). (centerwatch.com)
To assess clonal diversity and evolution of pre-leukemic and leukemic populations using DNA variant detection and single-cell genomic analyses in a non-clinical, research setting. (centerwatch.com)
To identify germline or somatic genomic variants associated with drug resistance of ALL cells to conventional and newer targeted anti-leukemic agents in a non-clinical, research setting. (centerwatch.com)

Importantly, it appears that orexigenic neuropeptide Y agouti connected protein neurons come to be lively inside a low ROS situation, which can be the opposite of anorexigenic VEGFR tyrosine kinase inhibitor pro opiomelanocortin cocaine and amphetamine regulated transcript cells, which appear to rely a lot more on glucose and are much more lively at increased ROS levels. (wnt-signaling.com)
Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia. (cancercentrum.se)

They must be in their first occurrence of relapsed/refractory BL, Burkitt-like lymphoma, Burkitt leukemia, DLBCL, DLBCL not otherwise specified, or other pediatric mature B-cell NHL. (pediatricsnationwide.org)

BACKGROUND: The purpose was to examine associations between treatment and chronic health conditions with neurocognitive impairment survivors of acute lymphoblastic leukemia (ALL) treated with chemotherapy only. (duke.edu)
The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)
For examples, acute myelogenous leukemia and chronic myelogenous leukemia. (medgadget.com)
MYLOTARG (gemtuzumabozogamicin) together with daunorubicin and cytarabine has been granted a positive opinion for the treatment of patient's age 15 years and above with previously untreated, de novo, CD33-positive acute chronic myelocytic leukemia (AML), except acute promyelocytic leukemia (APL). (medgadget.com)
In acute leukemia the condition progresses rapidly unlike in chronic leukemia. (bhaskarhealth.com)

In August of 2017, tisagenlecleucel (Kymriah) was approved for the treatment of children and adolescents with B-cell acute lymphoblastic leukemia (ALL) who have relapsed or not responded to chemotherapy. (childrensmercy.org)
Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia. (childrensmercy.org)

Follicular lymphoma (FL) is a cancer that involves certain types of white blood cells known as lymphocytes. (wikipedia.org)

Kymriah is a novel cellular immunotherapy that reprograms a patient's own immune system to identify and kill leukemia cells. (childrensmercy.org)

Participants will take ponatinib for 10 weeks in combination with chemotherapy (reinduction and consolidation blocks) and will be followed up for at least 3 years. (ucsf.edu)

The genetically modified autologous T cells are expanded in vitro at a production facility and then reinfused into the patient. (medscape.com)

Risk stratification and introduction of intensive chemotherapy in this study were effective and were able to eliminate HSCT for a subset of infants with KMT2A-r ALL. (nih.gov)

Rome/NCI criteria accurately predict standard and high-risk groups for B cell lineage, but not consistently for T cell disease. (ox.ac.uk)

Anatomy13

Organisms6

Diseases38

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes18

Information Science4

Health Care6

Multiple myeloma6

Myeloid19

Prognosis6

Regimens8

Lymphoid8

Newly diagnosed6

Remission14

Relapse5

Childhood15

Adults11

Stem cell transplant5

Early T cell precursor2

Diagnosis7

Therapy25

Radiotherapy2

Neoplasms1

Intrathecal Chemotherapy4

Oncology3

Patients38

Blinatumomab9

TRANSPLANTATION1

Humans1

Conventional chemotherapy1

Systemic Chemotherapy1

Standard chemotherapy2

Plasmacytoid dendr2

Malignant10

Allogeneic1

Bone8

Acute leukemias2

Large B-cell lym3

Diffuse1

Genomic6

Tyrosine2

Burkitt1

Chronic5

Tisagenlecleucel2

Follicular lymphoma1

Immunotherapy1

Combination with chemotherapy1

Autologous1

Intensive1

Lineage1