Chemotherapy plus peripheral stem cell transplantation harvest autologous peripheral blood stem cell transplantation. Medical search. Frequent questions

p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (issca.us)

The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
OBJECTIVE: To evaluate the use of high-dose sequential chemotherapy in a Brazilian population. (bvsalud.org)
Chemotherapy consisted of the sequential administration of high-dose cyclophosphamide (4 or 7 g/m²) and granulocyte-colony stimulating factor (300 µg/day), followed by peripheral blood progenitor cell harvesting, administration of etoposide (2g/m²) and methotrexate (8 g/m² only for Hodgkin's lymphoma) and autologous hematopoietic stem cell transplantation. (bvsalud.org)
Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
The presence of inflammatory cytokines after high-dose chemotherapy leads to proliferation and activation of MDSCs originating from autologous hematopoietic progenitors at the time of engraftment. (biomedcentral.com)
Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. (shengsci.com)
Bone marrow or stem cells that have been removed from a donor are carefully frozen and stored while the patient receives high-dose chemotherapy and sometimes whole-body radiation treatment. (lymphoma.ca)
This means that they receive stem cells (either their own stem cells that were stored prior to myeloablative therapy or stem cells from a donor) to replenish their bone marrow which had previously been destroyed by the high-dose therapy. (lymphoma.ca)
High-dose chemotherapy, with or without myeloablative radiation therapy, is then administered to the patient to destroy the cancerous cells, as well as the healthy cells in the bone marrow. (lymphoma.ca)
The patient first receives a high dose of chemotherapy and/ or radiotherapy to eliminate the remaining cancer cells in the body. (parkwaycancercentre.com)
The damaged bone marrow will then be replenished with new stem cells to alleviate the side effects of the high-dose therapy. (parkwaycancercentre.com)
Although there was evidence of a response to CTD (M-protein 34 g/L), bortezomib and dexamethasone treatment was initiated as an alternative, but this was discontinued after three cycles due to progressive disease (M-protein 49 g/L). The patient was then treated with lenalidomide and dexamethasone with the aim of reducing disease burden prior to high-dose therapy and autologous stem cell transplantation. (bmj.com)
UCB may also be used to reconstitute the bone marrow after high-dose chemotherapy or radiotherapy. (sajbl.org.za)

Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
Autologous transplants have the advantage of lower risk of infection during the immune-compromised portion of the treatment, since the recovery of immune function is rapid. (wikipedia.org)
In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
At the time they performed the first transplants surprisingly little was known about hematopoietic stem cells, immune responses to transplants or the complex human leucocyte antigen system. (revistadehematologia.org.mx)
Data from the United Network of Organ Sharing ( UNOS ) and the Organ Procurement and Transplantation Network ( OPTN ) catalog over 175,000 transplants between the years 2000 and 2015 (Optn.transplant.hrsa.gov 2016 ). (pocketdentistry.com)
There are two types of stem cell transplants, namely. (stemcelline.com)
How do Stem-cell Transplants Work? (lymphoma.ca)
There are two different types of transplants: bone marrow transplants and peripheral blood stem-cell transplants (PBSCTs). (lymphoma.ca)
In bone marrow transplants, the stem cells are taken from the bone marrow. (lymphoma.ca)
PBSCTs are now more commonly performed than bone marrow transplants, as the procedure is easier and the body is able to regenerate new stem cells faster. (lymphoma.ca)
The number of stem cell transplants (SCT) being done is more than 40,000 across the world. (bloodcancercure.com)
India is slowly contributing toward this huge number of stem cell transplants (SCT) done every year. (bloodcancercure.com)
This method is used for several diseases like many aggressive lymphomas, leukemias, and even in failed cases of autologous transplants. (bloodcancercure.com)
Frequently, stem cells are taken from the pelvic bone, filtered, and stored under special conditions for future transplants. (parkwaycancercentre.com)
Additionally, stem cell transplants can also be categorised based on who donates the stem cells. (parkwaycancercentre.com)

It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
The high doses of therapy lead to destruction of patient's marrow and immune system, which is then replaced by healthy marrow from self (autologous) or donor (allogeneic) hematopoietic stem cells that have been harvested from bone marrow or peripheral blood before therapy. (lovesorghum.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
The drying and scarring effects of the attack by the donor cells can affect the inside of the mouth and the esophagus (from the throat to the stomach), causing them to become excessively dry and damaged. (drcremers.com)
However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
The article covers the following topic:- leukemia introduction, Stem cell transplant for treatment of Leukemia, benefits of transplant, types of transplant, complications, and how to be a stem cell donor. (stemcelline.com)
Topics:- Leukemia therapy with stem cell transplant, advantages of transplant, different types of transplant, side effects, and how to become a stem cell donor. (stemcelline.com)
Allogeneic transplant- The transplantation involves infusing stem cells, extracted from a donor who is genetically matched with the patient. (stemcelline.com)
Usually, the donor may be a sibling or any blood-related person, just in case no one is available then, the nearest genetically equivalent person can also donate to the patient. (stemcelline.com)
Are you interested in being a stem cell donor? (stemcelline.com)
Stem cells or bone marrow derived from a donor (allogeneic transplant) are usually collected immediately before use and not stored for any length of time. (lymphoma.ca)
The harvested stem cells or bone marrow (obtained from either the patient's own healthy cells or from a donor) are then transplanted intravenously into the bloodstream of the patient. (lymphoma.ca)
In this type of transplant , a mandatory requirement is a donor from whom stem cells can be obtained. (bloodcancercure.com)
Allogeneic stem cell (stem cells from a donor) transplant is used to help patients recover from the effects of chemotherapy and/or radiotherapy as well as to eradicate the remaining cancer cells in the patient after chemotherapy and/or radiotherapy. (parkwaycancercentre.com)
In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
The donor immune cells can kill the leftover cancer cells and will exert a "graft-versus-cancer" effect, keeping the cancer cells in check. (parkwaycancercentre.com)
A donor, either related or unrelated to the patient, who donates the stem cells for transplant. (parkwaycancercentre.com)
Finding a donor with suitable stem cells is critical to avoid graft rejection or graft-versus-host syndrome. (parkwaycancercentre.com)
Many factors dictate whether the donor stem cells are suitable for the recipient but the most important one is the human leukocyte antigen (HLA) system. (parkwaycancercentre.com)
UCB's advantages over other sources of stem cells such as adult bone marrow and embryonic stem cells include easy procurement, minimal risk to the donor, excellent proliferation and differentiation, immediate availability, and autologous use. (sajbl.org.za)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
Allogeneic-donor-derived cells can be genetically modified to eliminate expression of HLA-A. (ashpublications.org)
HLA-A disruption from donor cells is a step toward generating allogeneic cells as an off-the-shelf therapeutic. (ashpublications.org)
Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. (ashpublications.org)

It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). (biomedcentral.com)
Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. (shengsci.com)
Three significant kinds of blood cancers are as leukemia, lymphoma, and multiple myeloma. (bloodcancercure.com)
A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. (lookformedical.com)

Non-myeloablative, so-called mini transplant (microtransplantation) procedures, have been developed requiring smaller doses of preparative chemotherapy and radiation therapy, allowing HSCT to be conducted in the elderly and other patients who would otherwise be considered too weak to withstand a conventional treatment regimen. (wikipedia.org)
The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
What is an autologous stem cell transplant? (leukaemia.org.au)
Most people have a single autologous transplant. (leukaemia.org.au)
It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
A stem cell transplant is a procedure in which a person receives blood stem cells, which make any type of blood cell. (scdstudies.com)
Since the first successful organ transplant in 1954, advancements in medical technology, immunology, and pharmacology have increased the success rate of solid organ transplantation. (pocketdentistry.com)
To avoid relapsing and declination of the immune system, Stem Cell transplant is reported to be encouraged. (stemcelline.com)
The result of Stem Cell transplant shows that the success rate hits up to 60.7% while only 39.3% remain in relapsed cases. (stemcelline.com)
The world is bestowed with a profound technique, namely, Stem Cell therapy or Stem Cell Transplant which helps in restoring your immune system and curing the disease at once. (stemcelline.com)
Autologous transplant - This transplant involves the extraction of stem cells from the patient's blood or bone marrow during the most stable condition of the patient. (stemcelline.com)
The average cost of an Autologous transplant is $10,000 to $39,796 and for an Allogenic transplant, it lies between $10,832 to $44,701. (stemcelline.com)
At times, very advanced and nonresponsive lymphomas may be treated using a bone marrow transplant (marrow is the soft tissue in the centre of large bones that produces white and red blood cells and platelets) or stem-cell transplantation (the cells that develop blood). (lymphoma.ca)
A syngeneic transplant is when the cells are donated by an identical twin. (lymphoma.ca)
To combat this problem, the patient receives a bone marrow or a stem-cell transplant. (lymphoma.ca)
What is the Difference Between a Bone Marrow Transplant and a Stem-cell Transplant? (lymphoma.ca)
Harvesting is the procedure by which the bone marrow or stem cells are obtained in preparation for the transplant. (lymphoma.ca)
In a bone marrow transplant, the stem cells are withdrawn from the bone marrow under general anesthesia by inserting a needle into a bone in the pelvic region, called the iliac crest. (lymphoma.ca)
Stem cells or bone marrow harvested from the patient (autologous transplant) are generally preserved and stored in a freezer until ready for use. (lymphoma.ca)
Stem cell transplant (SCT) is a cure available for several diseases and all of these treatments are done at economical prices in India. (bloodcancercure.com)
But survival and success rate of stem cell transplant (SCT) procedure has its dependency on several factors like the stage of the disease, type of disease, an age of the patient, and health condition of the patient etc. (bloodcancercure.com)
Stem cell transplant (SCT) turns out to be a life-saving procedure for several malignant and non-malignant diseases. (bloodcancercure.com)
Over the past few years, India has become equipped with facilities in its hospitals to be able to handle all sort of complicated cases requiring a stem cell transplant (SCT). (bloodcancercure.com)
Learn More About Stem Cell Transplant. (bloodcancercure.com)
What are the types of Stem Cell Transplant (SCT)? (bloodcancercure.com)
There are several types of stem cell transplant (SCT) available which are used to treat different malignant and non-malignant diseases. (bloodcancercure.com)
Every disease cannot be treated with one particular type of stem cell transplant (SCT) and neither can evert SCT be applicable in every case. (bloodcancercure.com)
This type of transplant uses the stem cells of the patient to carry out the transplant successfully. (bloodcancercure.com)
In this case, some of the healthy stem cells of the patient are extracted and preserved to be used during transplant. (bloodcancercure.com)
But this stem cell transplant (SCT) method has a limitation that at times, some of the cancer cells might remain, even after the complete procedure. (bloodcancercure.com)
This also reboots the immune system once again and even the cancer killing effect continues after the stem cell transplant (SCT). (bloodcancercure.com)
But the main disadvantage allogeneic stem cell transplant (SCT) holds is a rejection or denial of the transplanted stem cells, slow engraftment, and more complications like GVHD etc. (bloodcancercure.com)
What is the Success rate of Stem Cell Transplant (SCT) in India? (bloodcancercure.com)
Stem cell therapy, or stem cell transplant, is a procedure that aims to restore blood-forming stem cells in patients who have undergone chemotherapy or radiotherapy . (parkwaycancercentre.com)
Autologous stem cell (patient's own stem cells) transplant is used to help patients recover from the effects of chemotherapy. (parkwaycancercentre.com)
Stem cell transplant is often a part of the treatment plan for blood cancers. (parkwaycancercentre.com)
The stem cells originate from the patient who will receive the transplant. (parkwaycancercentre.com)
Other uses of cytostatic chemotherapy agents (including the ones mentioned below) are the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and the suppression of transplant rejections (see immunosuppression and DMARDs ). (wikidoc.org)

Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. (wikipedia.org)
Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma. (wikipedia.org)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
Patient will undergo autologous HSCT next month. (pocketdentistry.com)
Explained to patient the oral complications of HSCT, chemotherapy, and radiation. (pocketdentistry.com)

Autologous is when the patient's own stem cells are removed from his or her bone marrow or bloodstream. (lymphoma.ca)

Over a thousand new patients are given chemotherapy every year. (mediescapes.com)
Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)
We examined the clinical outcome of three autologous PDLP-treated patients in an effort to provide primary knowledge on the effectiveness of this treatment approach and preliminary clinical evidence for randomized controlled trial in the future. (ca.gov)
For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. (scdstudies.com)
It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
Patients treated with isatuximab-RVd (six cycles) had lower numbers of collected stem cells compared to those receiving RVd (six cycles) induction (8.8 × 10 6 /kg bw versus 9.7 × 10 6 /kg bw, p = 0.801), without experiencing significant delays in LP or increased numbers of LP sessions in a multivariable logistic regression analysis. (biomedcentral.com)
We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients. (cttjournal.com)
The 30 patients who had no marrow metastases at the time of PSC harvesting had an actuarial event-free survival of 47%, while those 26 patients with marrow metastases had a significantly different actuarial event-free survival of 27% (P = .02). (shengsci.com)
CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
Patients with lymphomas that are difficult to treat or resistant to standard therapy may benefit from chemotherapy or radiation therapy given in very high doses (myeloablative therapy). (lymphoma.ca)
Many patients brought back to their healthy lives and stretched their life-span by strengthening the body cells against the blood cancer cells. (bloodcancercure.com)
Similar expansions could also be obtained from the peripheral blood of patients with acute leukemia undergoing therapy ( n = 11). (aacrjournals.org)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
Ninety eligible patients will be randomly assigned at a ratio 1:1:1 to one of the following: control group (n = 30), low-cell dose treatment group (n = 30), and high-cell dose treatment group (n = 30). (unav.edu)
Objectives: To evaluate the safety and feasibility of endobronchial administration of bone marrow autologous MSCs (BM-MSC) in patients with mild-to-moderate IPF. (unav.edu)
Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
In a first escalating-dose phase, three patients were included sequentially in three dose cohorts (10×106, 50×106 and 100×106 cells). (unav.edu)
In 2014, the CBS Provincial Territorial Blood Liaison Committee (CBS-PTBLC) requested that the NAC develop recommendations and guidelines for the use of irradiated blood components for Canadian patients. (nacblood.ca)
Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of Neupogen therapy. (medicines.org.uk)
Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)

During this time you are likely to be experiencing some of the common side effects of chemotherapy and radiotherapy which may include nausea, vomiting, mucositis (sore mouth) and bowel problems (diarrhoea). (leukaemia.org.au)

Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)
These stem cells may come from a family member, from someone you don't know or from umbilical cord blood. (clevelandclinic.org)
Umbilical cord blood is blood collected from the umbilical cord and placenta after a baby is born. (clevelandclinic.org)
peripheral blood, or placental/umbilical cord blood). (cdc.gov)
1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
The blood that is left behind in the placenta and umbilical cord after a baby is delivered contains stem cells, and these can be carefully collected and stored. (parkwaycancercentre.com)
Recent medical advances in the field of regenerative medicine and tissue transplantation have highlighted the importance of umbilical cord blood (UCB) as a valuable alternative source of haematopoietic stem cells, which are potentially life-saving in a vast array of clinical applications. (sajbl.org.za)
What is umbilical cord blood banking and why is it important? (sajbl.org.za)
In the novel and exciting field of regenerative medicine, umbilical cord blood (UCB), also known as placental blood, is no longer considered biological waste. (sajbl.org.za)
1 , 2 UCB is the blood in the cut umbilical cord and placenta after delivery. (sajbl.org.za)

3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)

In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
1. Definition: GVHD develops when the donor's immune cells mistakenly attack the patient's normal cells. (drcremers.com)
This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
MDSCs are characterized by myeloid origin, immature state, and most importantly by their potent ability to suppress different aspects of immune responses, especially T cell proliferation and cytokine production [ 7 ]. (biomedcentral.com)
Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells. (shengsci.com)
Tolerance Tolerance Pharmacokinetics and Pharmacodynamics of the transplanted organ by the immune system Immune system The body's defense mechanism against foreign organisms or substances and deviant native cells. (lecturio.com)
It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
These treatments require further medication to improve the immune system deteriorated during the period and sometimes even end up with destroying the healthy blood cells. (stemcelline.com)
First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)
2 UCB is at the forefront of research exploring gene therapy, prenatal diagnosis, immune cell therapy, antibiotic efficacy and identification of new proteins. (sajbl.org.za)
Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)

The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)

In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
It is more common these days to collect bone marrow stem cells from the bloodstream. (leukaemia.org.au)
Stem cells normally live in the bone marrow, but they can be encouraged to move out of the bone marrow and into the bloodstream. (leukaemia.org.au)
G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
From here the stem cells make their way to your bone marrow where they become re-established and start making new blood cells. (leukaemia.org.au)
Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
Hematopoietic stem cell transplantation is a procedure that involves the infusion of stem cells to treat patient malignancies or to repair diseased or defective bone marrow. (lovesorghum.com)
2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
It helps make room in the patient's bone marrow for new blood stem cells to grow, and helps prevent the patient's body from rejecting the transplanted cells. (scdstudies.com)
Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lecturio.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lecturio.com)
They are found primarily in the bone marrow and also in small numbers in the peripheral blood. (lecturio.com)
Leukemia is a cancer of blood cells and bone marrow, which means it results in excessive growth of white blood cells. (stemcelline.com)
The mutation in the bone marrow cells causes dysfunctionality and under-development of the body. (stemcelline.com)
Stem cell therapy stimulates the growth of new bone marrow cells which results in the repopulation of healthy blood cells and replenishing the body's self-defense. (stemcelline.com)
If extraction from bone marrow is to be avoided then stem cells from the bone marrow are pushed out to the bloodstream. (stemcelline.com)
With types of NHL that have spread to the bloodstream or bone marrow, it may be difficult to obtain uncontaminated cells or cells that can be used, even after treating them in a laboratory to remove or kill the NHL cells. (lymphoma.ca)
Marrow or cell transplantation is done to replace healthy cells that have been destroyed by cancer treatment. (lymphoma.ca)
This process kills all or most normal stem and bone marrow, while destroying cancer cells. (lymphoma.ca)
After therapy, the frozen marrow or cells are thawed and put back in the body. (lymphoma.ca)
However, this can potentially destroy all the stem-cells in the bone marrow and leave the patient at very high risk for infection. (lymphoma.ca)
Blood Cancer Cure is a common type of cancer majorly attacks the blood, bone marrow, or lymphatic system. (bloodcancercure.com)
HSCs mostly stay in the bone marrow and mature into blood cells as they grow. (parkwaycancercentre.com)
Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
Stem cells are collected from the bone marrow - the spongy soft tissues in the bones. (parkwaycancercentre.com)
Myeloma is a B-cell malignancy that is characterised by the monoclonal expansion and accumulation of abnormal plasma cells within the bone marrow. (bmj.com)
In view of the fact that UCB has become a valuable, non-invasive source of stem cells for regenerative therapy, establishment of a public cord blood bank (CBB) in South Africa would vastly improve the availability of haematopoietic stem cells for research and therapeutic uses, and increase the tissue genetic diversity that currently impedes the South African bone marrow registry. (sajbl.org.za)
These progenitor cells have greater clonal expansion and proliferative capacity than normal bone marrow cells. (sajbl.org.za)
2 , 3 Normally, the bone marrow serves as the source for replenishing the cellular components of peripheral blood including red and white blood cells and platelets. (sajbl.org.za)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (issca.us)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)
However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
If a person experiences serious blood loss, yellow bone marrow can be activated and transformed into red bone marrow. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)

What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
Deficiency or malfunction of these blood cells occurs in disease conditions prevalent in Africa, including cancers like leukaemia and haemoglobinopathies like thalassaemia or sickle-cell disease. (sajbl.org.za)

During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
p>Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). (nemours.org)
The treatment helps to restore damaged blood cells such as red blood cells, white blood cells, and platelets. (parkwaycancercentre.com)
White blood cells last anywhere from a few hours to a few days, platelets for about 10 days, and red blood cells for about 120 days. (medscape.com)

Cord Blood, rich in stem cells, is now in use. (mediescapes.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)
The baby will not be harmed in any way during the cord blood collection. (parkwaycancercentre.com)

This procedure starts with the patient receiving intensive chemotherapy with or without total body irradiation in an attempt to kill all cancerous cells. (lovesorghum.com)
The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. (biomedcentral.com)
The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)
The NAC assembled an Irradiation Working Group to review current standards, published guidelines, and recent literature on the indications for irradiated components and the quality of irradiated red blood cell (RBC) components to facilitate recommendations for best practices. (nacblood.ca)
and recent publications on the quality of stored RBC post irradiation and practices involving irradiation of autologous blood collected by intraoperative cell salvage were consulted. (nacblood.ca)

This BMT unit is at par with the best in the world, and performs both Allogenic, and Autologous BMT's. (mediescapes.com)
Facilities for both autologous and Allogenic transplantation are available at the hospital, using a cell separator for stem cell harvest procedures and a freezing system to cryo-preserve the cells for future use. (mediescapes.com)

Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
The stem cells are collected by passing all the blood through an apheresis machine that draws out stem cells from the blood and returns the rest of the blood. (stemcelline.com)
The stem cells are separated from other components of the blood in a process called apheresis, with the rest of the blood being returned to the patient. (lymphoma.ca)
The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
In- duced pluripotent stem cells have been used to create active T cells to support cancer immunotherapy. (bmrat.org)
Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. (aacrjournals.org)

Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)

For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Transplanted tissue may be cells (e.g., hematopoietic stem cells Hematopoietic stem cells Progenitor cells from which all blood cells derived. (lecturio.com)
Derived from the fetal allantois, it provides a rich source of multipotent stem cells, including CD34+ and CD38- haematopoietic progenitor cells. (sajbl.org.za)
Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)

Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)
However, during stem cell mobilization and -collection, no study-specific therapeutic intervention was performed. (biomedcentral.com)
Organ transplantations have become the therapeutic option of choice for many individuals with end-stage organ failure. (lecturio.com)
Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)
As a source of non-embryonic stem cells, UCB has found potential uses as a therapeutic modality in more than 80 clinical applications, both haematological and non-haematological. (sajbl.org.za)
In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (issca.us)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)

Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
The source of the stem cells is either from Adult body tissues or Embryo cells. (stemcelline.com)
This environment raises ethical questions about consent and ownership of tissues, the cost-effectiveness of harvesting and storage of UCB, undue influence on donors, and issues of distributive justice such as the fact that UCB, which is potentially life-saving and could be easily obtained, may become a resource unfairly restricted only to the wealthy. (sajbl.org.za)

Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)

Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Malignancies with slower growth rates, such as indolent lymphomas, tend to respond to chemotherapy much more modestly. (wikidoc.org)

BACKGROUND: Pregnancy represents a challenge for women with sickle cell disease (SCD), with higher rates of both maternal and fetal complications. (bvsalud.org)

After 4 cycles of chemotherapy with topotecan and etoposide, 131 I-MIBG treatment was performed at a dose of 18 mCi/kg. (biomedcentral.com)

Graft-versus-host disease (GVHD) is a complication that may occur after hematopoietic cell transplantation (HCT) in which donated cells view the recipient's cells as foreign and attack them. (scdstudies.com)
The originally produced document was published in 2017 and was informed by the published guidelines on the use of irradiated blood components by the British Committee for Standards in Haematology, 2010, and the guidelines for prevention of transfusion-associated graft-versus-host disease (TA-GVHD) by the Australian and New Zealand Society of Blood Transfusion, 2011. (nacblood.ca)

Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
One to two days before your stem cell infusion, you'll take a regimen of drugs to help prevent GVHD. (drcremers.com)

This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
PBSC mobilization should be performed after induction therapy to ensure collection of a sufficient number of cells. (biomedcentral.com)

We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)
Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)

For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
A blastocyst contains an inner cell mass including a clump of around 150 cells that eventually will generate the entire body of the adult animal. (bmrat.org)
This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)

Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)

In Section II, Dr. James Griffin reviews the mechanisms that lead to activation of tyrosine kinases by mutations in AML, the consequences of that activation for the cell, and the opportunities for targeted therapy and discusses some examples of developing novel drugs (tyrosine kinase inhibitors) and their effectiveness in AML (FLT3). (ashpublications.org)
The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire body. (scdstudies.com)
This study demonstrates that stem cell collection is feasible after prolonged induction with isatuximab-RVd without collection failures and might be further explored as induction therapy. (biomedcentral.com)
Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)
The general treatments for leukemia are surgery, chemotherapy, radiation therapy, or a set of these based on the type and stage of cancer. (stemcelline.com)
Stem cells, because they divide rapidly, can be killed off by chemotherapy and radiation therapy. (lymphoma.ca)
Therefore, the doses of chemotherapy and radiation therapy used to treat lymphoma are limited due to the risk of damaging these stem cells. (lymphoma.ca)
After that chemotherapy or radiation therapy is initiated to kill and destroy the malignant stem cells of the body. (bloodcancercure.com)
A small number of stem cells can be found in the blood, and these can be collected for stem cell therapy. (parkwaycancercentre.com)
The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. (unav.edu)
The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. (wikidoc.org)
Collectively, although scientists are increasingly aware of mitochondria's dynamic and transferable capabilities of mitochondria, the unclear mechanism and effectiveness of mitochondrial transfer/transplantation therapy limit its widespread application in diseases. (biomedcentral.com)

The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)

Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (issca.us)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)

Blood cancer can be very treatable in some cases, because of the revolution in the traditional treatment methods. (bloodcancercure.com)
The development of clinically applicable methods to produce large numbers of fully functional NK cells is a critical step to maximize the potential of this approach. (aacrjournals.org)
Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. (biomedcentral.com)
WO 2013/002880 describes compositions and methods comprising bio-energetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures. (justia.com)
US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)

As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)

We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
The safety and efficacy of Neupogen are similar in adults and children receiving cytotoxic chemotherapy. (medicines.org.uk)
The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)
Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)

It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)

Conventional and intensive chemotherapy is routinely performed at the hospital. (mediescapes.com)
For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)

6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
Alemtuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. (scdstudies.com)
Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)

In allogeneic stem cell transplantation, healthcare providers replace unhealthy stem cells with donated healthy stem cells. (clevelandclinic.org)

We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)

Both MDSC phenotypes pre-ASCT but not post-ASCT similarly suppressed in vitro autologous T and natural killer T cell proliferation. (biomedcentral.com)

This process is called stem cell mobilisation and usually involves the use of chemotherapy in combination with colony stimulating growth factor injections - usually G-CSF. (leukaemia.org.au)
Transplantation is a procedure that involves the removal of an organ or living tissue and placing it into a different part of the body or into a different person. (lecturio.com)
The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)

This breakthrough, for which Dausset was awarded the Nobel Prize in Physiology or Medicine in 1980, opened the door to safer and more successful organ and stem cell transplantation. (revistadehematologia.org.mx)
Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)

indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)

Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
The patient was viremic with CMV detected in blood and CSF by PCR. (frontiersin.org)
Conditioning regimens are treatments used to prepare a patient for stem cell transplantation. (scdstudies.com)
In 2001, at age 21, the patient experienced an episode of severe pain and vomiting and was taken to the emergency room for a complete blood work up. (pocketdentistry.com)
At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)
These cells can self-renew and the patient can enjoy a long-term cure from blood cancer. (parkwaycancercentre.com)
However, after a week, the patient was admitted with idiosyncratic syndrome including hyponatraemia, a fall in albumin and worsening of blood counts. (bmj.com)

Treatment was frequently interrupted and dose adjusted to account for neutropenia and despite a minor response after six cycles (starting M-protein 47 g/L, finishing M-protein 34 g/L), in October 2009, she proceeded with stem cell mobilisation. (bmj.com)

After you have finished this treatment, your stem cells are thawed and reinfused through a vein into your bloodstream. (leukaemia.org.au)
The long-term goal of this proposal is to develop stem cell-based treatment for major defects in the orofacial regions. (ca.gov)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
Cancer vaccines based on the knowledge of cancer stem cells have been studied and applied for cancer treatment. (bmrat.org)
This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
Transplantation can offer the individual a definitive treatment for a given disease entity. (lecturio.com)
Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)

With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
A cell line derived from cultured tumor cells. (lookformedical.com)

Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)

Acute GVHD can occur soon after the transplanted cells begin to appear in the recipient. (drcremers.com)
Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
The expanded NK cells were significantly more potent than unstimulated or IL-2-stimulated NK cells against acute myeloid leukemia cells in vitro . (aacrjournals.org)
In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)

Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (issca.us)
Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (issca.us)
In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (issca.us)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (issca.us)
and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (issca.us)

Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)

In a PBSCT, stem cells are taken from the bloodstream, a far easier and more commonly used procedure. (lymphoma.ca)

Anatomy32

Organisms5

Diseases51

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Psychiatry and Psychology2

Phenomena and Processes28

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups5

Health Care20

Bone marrow transpla5

High-dose17

Transplants17

Donor36

Multiple myeloma7

Transplant45

HSCT13

Patient's own stem cells1

Patients30

Effects of chemotherapy1

Umbilical12

Granulocyte colony1

Immune15

Destroyed tissue and resum1

Marrow55

Cancers3

Platelets4

Cord-blood5

Irradiation5

Allogenic2

Apheresis6

Immunotherapy3

Solid organ transplantation1

Progenitor cells5

Therapeutic9

Tissues9

Genetically2

Respond to chemotherapy2

Sickle cell di1

Etoposide1

Graft-versus-2

Infusion2

Mobilization4

Myeloma5

Adult3

Mesenchymal stem1

Therapy14

Kidney transplantation1

Stromal cells3

Methods5

Hodgkin's1

Cytotoxic6

Tissue transplantation1

Intensive chemotherapy2

Monoclonal5

Unhealthy stem cells1

Multipotent1

Suppressed in vitro1

Involves3

Organ2

Proliferation and activation1

Patient9

Mobilisation1

Treatment11

Tumor cells2

Donors1

Acute4

MSCs5

Clinical1

PBSCT1