• In newly diagnosed myeloma patients, upfront autologous transplant (ASCT) prolongs progression-free survival 1 (PFS1) compared with chemotherapy plus lenalidomide (CC+R). Salvage ASCT at first relapse may still effectively rescue patients who did not receive upfront ASCT. (nih.gov)
  • Options include chemotherapy using bortezomib, autologous stem cell transplantation, immunomodulatory drugs, and kidney transplant. (wikipedia.org)
  • Using a retrospective approach in DLBCL patients undergoing autologous stem cell transplant (AHSCT), we evaluated the association of hypomagnesemia with survival. (nature.com)
  • And it compared using that same regimen to giving it with ibrutinib added to the R-CHOP portion of the chemotherapy, followed by ibrutinib maintenance after the stem cell transplant or another experimental arm that added ibrutinib to the R-CHOP portion of the chemotherapy and gave 2 years of ibrutinib maintenance without stem cell transplantation. (cancer.net)
  • I think, importantly, this arm compared to each of those 2 experimental arms versus the standard of care and showed graphically that both of the arms that contained ibrutinib, the BTK inhibitor, looked to have improved failure-free survival compared to the standard stem cell transplant arm. (cancer.net)
  • Overall, pulmonary complications, both infectious and non-infectious, occur in 40-60% of patients after stem cell transplantation [ 3 ], and are usually classified as early or late onset, depending on whether they occur within 100 days of the transplant [ 4 ]. (ersjournals.com)
  • The standard management of these patients includes high-dose chemotherapy followed by autologous stem cell transplant. (hindawi.com)
  • A significant number of patients who relapse after stem cell transplant do so in previously involved sites and may present with disease that could be encompassed in a radiation field. (hindawi.com)
  • Post-transplant lymphoproliferative disorder (PTLD) is a common and serious complication of solid organ transplantation. (cancernetwork.com)
  • they include younger age and pre-transplant EBV naivety, as well as the degree and type of immune suppression, type of organ transplantation, and time from transplantation. (cancernetwork.com)
  • Post-transplant lymphoproliferative disorders (PTLDs) are a relatively common and significant complication following solid organ transplantation, occurring in up to 10% of adult patients. (cancernetwork.com)
  • Transplant Cell Ther. (stembook.org)
  • MONJUVI is a CD19-directed cytolytic antibody indicated in combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant (ASCT). (nih.gov)
  • Haematopoeitic stem cell transplant (HSCT) recipients - from day of admission (~day -7) to day +35. (who.int)
  • A stem cell transplant (SCT) is not a common treatment for Waldenstrom macroglobulinemia (WM), but it might be an option in younger patients for whom other treatments are no longer working. (cancer.org)
  • Blood-forming stem cells used for a transplant come either from the blood or from the bone marrow. (cancer.org)
  • In an allogeneic SCT, the stem cells for the transplant come from someone else (a donor). (cancer.org)
  • The survival data of pediatric and young adult patients with metastatic/recurrent Ewing's sarcoma treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) suggest the treatment may beneficial, according to a study. (medjournal360.com)
  • In this single institution study, 47 patients with metastatic disease at diagnosis or recurrent Ewing's sarcoma were treated with high-dose chemotherapy followed by tandem (n = 20) or single (n = 27) ASCT. (medjournal360.com)
  • Autologous stem cell transplantation (ASCT) is the standard of care for multiple myeloma patients eligible for high-dose therapy, lymphoma patients undergoing second-line treatments and for acute myelogenous leukaemia (AML) [ 1 ]. (ersjournals.com)
  • Many reports focus on allogenic transplantation alone [ 5 ], but the only report dealing with ASCT displayed a 25% prevalence of pulmonary complications within the first year post-ASCT and a severe associated risk of death [ 6 ]. (ersjournals.com)
  • Autologous stem cell transplantation (ASCT) is the standard of care for patients with relapsed HL [ 3 ]. (hindawi.com)
  • About half of all patients undergoing ASCT are rescued and definitely cured by such an approach, but the outcome of patients relapsing or refractory to second-line chemotherapy and ASCT is dismal, with a median survival of less than three years [ 4 ]. (hindawi.com)
  • One of the most important and widely accepted prognostic factors for patients undergoing ASCT appears to be chemosensitivity at relapse, with patients responding to second-line chemotherapy and having a much better outcome than patients with refractory disease, whose relapse rate approaches 80% in some published series [ 5 , 6 ]. (hindawi.com)
  • An open-label phase 2 combination trial (L-MIND study) is investigating the safety and efficacy of tafasitamab in combination with lenalidomide in patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) who are not eligible for high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT). (pharmiweb.com)
  • Purpose: Our aim was to capture the biology of classical Hodgkin lymphoma (cHL) at the time of relapse and discover novel and robust biomarkers that predict outcomes after autologous stem-cell transplantation (ASCT). (rug.nl)
  • Nevertheless, despite the controversy, autologous SCT (ASCT) is frequently used based on the encouraging results from the Nordic Lymphoma Group prospective phase 2 clinical trial and data from multiple retrospective or registry studies 5-7 . (ebmt.org)
  • ASCT results were best in patients achieving complete remission (CR) after frontline chemotherapy 6 . (ebmt.org)
  • PFS included all patients peripheral blood progenitor cell (PBPC) harvesting, HDS and and was calculated from HDCY date until the date of ASCT.9 progression, relapse, last follow-up or death due to any cause. (bvsalud.org)
  • Hematopoietic stem cells (HSCs) were collected by both peripheral blood apheresis and bone marrow harvest after mobilization with a single dose of cyclophosphamide (4 g/m 2 ) and daily filgrastim therapy (10 μg/kg/day). (nebraska.edu)
  • 6. Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer. (nih.gov)
  • 12. High-dose cyclophosphamide + carboplatin and interleukin-2 (IL-2) activated autologous stem cell transplantation followed by maintenance IL-2 therapy in metastatic breast carcinoma - a phase II study. (nih.gov)
  • First-line treatment with immunomodulatory drugs, proteasome inhibitors and dexamethasone for multiple myeloma, and anthracycline-based protocols for lymphomas, followed by mobilisation therapy (favouring stem cell release into peripheral blood) with a high dose of cyclophosphamide was carried out. (ersjournals.com)
  • Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
  • Human leucocyte antigen-matched related haematopoietic stem cell transplantation using low-dose cyclophosphamide, fludarabine and thymoglobulin in children with severe aplastic anaemia. (amedeo.com)
  • On the basis of clinical behavior and morphologic features, two predominant and clinically significant types of therapy-related myeloid neoplasms (t-MNs) have been defined, distinguished principally on the basis of the nature of cytotoxic therapy: those arising after treatment with alkylating chemotherapy (eg, cyclophosphamide, chlorambucil, cisplatin) and/or ionizing radiation therapy and those arising after therapy with topoisomerase II inhibitors. (medscape.com)
  • Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer. (unmc.edu)
  • About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's macroglobulinemia, and the monoclonal gammopathy of undetermined significance premalignant stages of these two diseases. (wikipedia.org)
  • 7. [High dosage chemotherapy with autologous stem cell transplantation in multiple myeloma]. (nih.gov)
  • Multiple myeloma arises when the cancer cells travel through the body and form tumors in several different bones. (cancerquest.org)
  • Multiple myeloma is a cancer of B lymphocytes, a type of immune cell. (cancerquest.org)
  • In multiple myeloma a plasma B cell becomes genetically damaged and reproduces (proliferates) uncontrollably. (cancerquest.org)
  • Multiple myeloma results in the overproduction of antibodies by B cells in the tumors. (cancerquest.org)
  • Another protein present on the surface of B cells (β-2 microglobulin) is frequently elevated in multiple myeloma. (cancerquest.org)
  • A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. (stembook.org)
  • Brain glucose metabolism in patients with newly diagnosed multiple myeloma significantly decreases after high-dose chemotherapy followed by autologous stem cell transplantation. (stembook.org)
  • Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase III trial. (stembook.org)
  • Multiple myeloma (MM) is a cancer of blood where a specific white blood cell starts mimicking itself and create more and more clones with a high rate of proliferation. (ukbiobank.ac.uk)
  • Reported positive results from a pre-planned interim analysis of GENESIS Phase 3 trial of motixafortide for stem cell mobilization (SCM) in multiple myeloma patients. (prnewswire.com)
  • Few studies have reported whether a serum magnesium level below the reference range (RR) is associated with prognosis in patients with diffuse large B cell lymphoma (DLBCL). (nature.com)
  • Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) 1 . (nature.com)
  • On 15 January 2015, orphan designation (EU/3/14/1424) was granted by the European Commission to MorphoSys AG, Germany, for humanised Fc engineered monoclonal antibody against CD19 for the treatment of diffuse large B-cell lymphoma. (europa.eu)
  • What is diffuse large B-cell lymphoma? (europa.eu)
  • Diffuse large B-cell lymphoma is the most common cancer of the lymphatic system, a network of vessels that transport fluid (lymph) from tissues through the lymph nodes and into the bloodstream. (europa.eu)
  • Patients with diffuse large B-cell lymphoma may also have fever, tiredness, night sweats or weight loss that have no obvious cause. (europa.eu)
  • Although some people with diffuse large B-cell lymphoma can be cured, it remains a serious and life-threatening disease, particularly when the disease is diagnosed late or has come back after initial treatment. (europa.eu)
  • At the time of designation, diffuse large B-cell lymphoma affected approximately 2.5 in 10,000 people in the European Union (EU). (europa.eu)
  • At the time of designation, several medicines were authorised for the treatment of diffuse large B-cell lymphoma in the EU. (europa.eu)
  • The sponsor has provided sufficient information to show that the medicine might be of significant benefit for patients with diffuse large B-cell lymphoma because early studies show a positive response in patients whose disease has come back after, or who have not responded to, previous treatment. (europa.eu)
  • At the time of submission of the application for orphan designation , clinical trials with the medicine in patients with diffuse large B-cell lymphoma were ongoing. (europa.eu)
  • At the time of submission, the medicine was not authorised anywhere in the EU for diffuse large B-cell lymphoma or designated as an orphan medicinal product elsewhere for this condition. (europa.eu)
  • Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. (haematologica.org)
  • Background Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic syndromes in complete remission, but post-remission chemotherapy and autologous stem cell transplantation are potential alternatives, especially in patients over 45 years old. (haematologica.org)
  • For the minority of patients younger than 60 years with advanced stages of MDS, allogeneic stem cell transplantation (SCT) is usually considered the treatment of choice. (haematologica.org)
  • 6 - 8 However, the outcome of autologous peripheral blood SCT for patients lacking a suitable donor, appeared, in some studies, comparable to that of allogeneic SCT. (haematologica.org)
  • This study addressed the issue of whether the existence of an HLA-identical sibling donor and the intention to perform an allogeneic SCT after the first consolidation course of chemotherapy results in a favorable outcome. (haematologica.org)
  • Allogeneic stem cell transplantation offers the only chance of cure in these patients. (hindawi.com)
  • The achieved remission was consolidated using allogeneic bone marrow transplantation after FLAMSA reduced density conditioning without amsacrine. (muni.cz)
  • Four months after allogeneic transplantation the patient is free of relapse. (muni.cz)
  • Consolidative SCT (autologous or allogeneic) was allowed at the investigator's discretion, but their intent had to be declared before starting treatment. (ebmt.org)
  • In the A+CHP arm, 114 patients with either ALK negative sALCL (n=76) or non-sALCL (n=38) were in a CR at the end of treatment, of whom 38 patients received consolidative SCT (36 autologous and 2 allogeneic). (ebmt.org)
  • The blood-forming stem cells can come either from the patient (called an autologous SCT) or from a donor (called an allogeneic SCT). (cancer.org)
  • The stem cells for an allogeneic SCT are usually collected from a donor's bone marrow or blood on several occasions. (cancer.org)
  • Despite advances in treatment regimens for angioimmunoblastic T cell lymphoma, prognosis remains poor with an overall 5-year median survival of 32% 3 . (radiopaedia.org)
  • Treatment for people with cHL after auto-HSCT fails or after at least two prior multi-agent chemotherapy regimens fails in those not candidates for auto-HSCT. (tumejorcelular.com)
  • This study evaluated the use of a standard regimen of giving R-CHOP chemotherapy alternating with R-DHAP chemotherapy. (cancer.net)
  • So a chemotherapy regimen that includes Ara-C as their component followed by autologous stem cell transplantation. (cancer.net)
  • After at least one prior multi-agent chemotherapy regimen has died, patients with systemic anaplastic extensive cell lymphoma are feasted. (tumejorcelular.com)
  • Design and Methods We evaluated, after intensive anti-leukemic remission-induction chemotherapy, the impact of the availability of an HLA-identical sibling donor on an intention-to treat basis. (haematologica.org)
  • 3 years old), tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. (e-crt.org)
  • 3 years old), RT including reduced-dose craniospinal RT (23.4 or 30.6 Gy) was administered either after two cycles of induction chemotherapy or after surgery, and tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. (e-crt.org)
  • 11. A short course of induction chemotherapy followed by two cycles of high-dose chemotherapy with stem cell rescue for chemotherapy naive metastatic breast cancer. (nih.gov)
  • It is an anti-neoplastic implication in the therapy of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. (tumejorcelular.com)
  • Therapy of patients with CD30-expressing mycosis fungoides or primary cutaneous anaplastic large cell lymphoma. (tumejorcelular.com)
  • They included newly diagnosed patients with ALK negative systemic anaplastic large cell lymphoma (sALCL) or non-sALCL CD30+ PTCL. (ebmt.org)
  • The cancer affects a type of white blood cell called B lymphocytes, or B cells. (europa.eu)
  • These cytokines are produced by activated T lymphocytes, mast cells, and tissue stroma cells. (ispub.com)
  • Differential WBC showed 69% eosinophil, (37.8 cells x103/uL), 26% neutrophils and 3.5% lymphocytes. (ispub.com)
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • Ikhula kwiiseli ezimhlophe zegazi ezibizwa ngokuba zii-T-cells (lymphocytes). (lymphoma.org.au)
  • Inokura kubva kumasero machena eropa anonzi T-cells (lymphocytes). (lymphoma.org.au)
  • Nabubuo ito mula sa mga puting selula ng dugo na tinatawag na T-cells (lymphocytes). (lymphoma.org.au)
  • Ọ na-etolite site na mkpụrụ ndụ ọbara ọcha a na-akpọ T-cell (lymphocytes). (lymphoma.org.au)
  • Amachokera ku maselo oyera a magazi otchedwa T-cell (lymphocytes). (lymphoma.org.au)
  • Naugmad kini gikan sa puti nga mga selula sa dugo nga gitawag ug T-cells (lymphocytes). (lymphoma.org.au)
  • E hlaha ho tsoa liseleng tse tšoeu tsa mali tse bitsoang T-cells (lymphocytes). (lymphoma.org.au)
  • There have also been improvements in the therapy of those patients who relapse after AHSCT with the recent approval of CAR-T cell therapy 14 . (nature.com)
  • Despite a high clinical success, relapse in Hodgkin lymphoma occurs in 10-30% of cases and 5-10% patients are nonresponsive to initial chemotherapy. (hindawi.com)
  • It is one of the more common subtypes of mature T-cell lymphomas. (radiopaedia.org)
  • Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation. (ebmt.org)
  • Uhlobo lwe-Enteropathy lwamathumbu e-T-cell lymphomas luchaphazela abantu abadala, ngaphezulu kweminyaka engama-60. (lymphoma.org.au)
  • Enteropathy type intestinal T-cell lymphomas inowanzobata vanhu vakuru, pamusoro pemakore makumi matanhatu. (lymphoma.org.au)
  • Ang enteropathy type intestinal T-cell lymphomas ay karaniwang nakakaapekto sa mga matatandang tao, higit sa edad na 60 taon. (lymphoma.org.au)
  • Enteropathy type intestinal T-cell lymphomas e masani ona a'afia ai tagata matutua, i luga atu o le 60 tausaga. (lymphoma.org.au)
  • Ụdị enteropathy nke eriri afọ T-cell lymphomas na-emetụtakarị ndị agadi, karịa afọ 60. (lymphoma.org.au)
  • Enteropathy Type intestinal T-cell lymphomas nthawi zambiri imakhudza anthu okalamba, opitilira zaka 60. (lymphoma.org.au)
  • Ang enteropathy type intestinal T-cell lymphomas kasagarang makaapekto sa mga tigulang, kapin sa 60 anyos. (lymphoma.org.au)
  • Enteropathy mofuta oa intestinal T-cell lymphomas hangata e ama batho ba baholo, ho feta lilemo tse 60. (lymphoma.org.au)
  • The 4-year survival of the 65 patients randomized to autologous peripheral blood stem cell transplantation or a second consolidation course of high-dose cytarabine was 37% and 27%, respectively. (haematologica.org)
  • Autologous peripheral blood stem cell transplantation does not provide longer survival than intensive chemotherapy. (haematologica.org)
  • We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). (e-crt.org)
  • 8. Complete response after high-dose chemotherapy and autologous hemopoietic stem cell transplatation in metastatic breast cancer results in survival benefit. (nih.gov)
  • The reported five-year event-free survival ranges between 80 and 90% with combined modality chemotherapy and radiotherapy [ 1 ]. (hindawi.com)
  • Additionally, they have for the first time developed a predictive score to assess event free survival following stem cell transplantation. (bu.edu)
  • Event-free survival is defined as the time between stem cell transplantation and initiation of next line of therapy or death, whichever occurs first. (bu.edu)
  • The researcher also developed a prognostic score for event free survival which incorporated measuring the patients' light chain levels and bone marrow plasma cell percentage. (bu.edu)
  • Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. (radiopaedia.org)
  • We previously shared preliminary positive overall response rate and disease control rate data, on approximately half of the patients enrolled in this study arm, at last year's ESMO IO conference, and we remain optimistic that the combination of motixafortide and KEYTRUDA ® , together with chemotherapy, will prove beneficial to survival as well. (prnewswire.com)
  • PROCEDURE: We compared 5-year overall survival (OS) and event-free survival (EFS) between the upfront surgery (n = 26) and neoadjuvant chemotherapy (n = 104) groups at three oncology centers in Beijing, China. (bvsalud.org)
  • We conducted a clinical gene therapy study to determine whether retroviral-mediated transfer of MDR1 in human hematopoietic cells would result in stable engraftment, and possibly expansion, of cells containing this gene after treatment with myelosuppressive doses of paclitaxel. (nebraska.edu)
  • One patient remained positive for the MDR1 transgene throughout all six cycles of paclitaxel therapy, whereas the other 2 patients showed a decrease in the number of cells containing the transgene to undetectable levels. (nebraska.edu)
  • Despite the low level of engraftment of MDR1-marked cells, a correlation was observed between the relative number of granulocytes containing the MDR1 transgene and the granulocyte nadir after paclitaxel therapy. (nebraska.edu)
  • High-dose Therapy followed by Autologous Haematopoietic Stem Cell Transplantation in Multiple. (annals.edu.sg)
  • 1. [High dosage therapy and autologous peripheral stem cell transplantation in breast carcinoma]. (nih.gov)
  • It's a kind of lymphoma that can be quite aggressive, and particularly for younger patients who are suitable for aggressive therapy, the role of autologous stem cell transplantation has been something that's been important for the first-line therapy for mantle cell lymphoma. (cancer.net)
  • however, the risk of developing secondary myeloid neoplasms following alkylating chemotherapy or radiation therapy seems to increase with age. (medscape.com)
  • Approximately 30% of therapy-related myeloid neoplasm (t-MN) cases involve patients treated for nonneoplastic disorders, and those treated with high-dose chemotherapy followed by autologous stem cell transplantation. (medscape.com)
  • Adenovirus expressing wild type P53 induces apoptosis in drug resistant human breast cancer cells: a potential in vivo and ex vivo gene therapy approach for Drug Resistant Tumors. (unmc.edu)
  • Immune reconstitution following high-dose chemotherapy and autologous stem cell transplantation with and without pembrolizumab maintenance therapy in patients with lymphoma. (stembook.org)
  • However, after a stem cell therapy treatment , she has had her life changed , she is looking into the future and excited to see her children grow up and is currently planning to run a marathon. (bioeden.com)
  • Treatment is curative in most cases and consists of chemotherapy with or without other treatment modalities, including antibody-drug conjugates, immunotherapy, and radiation therapy. (msdmanuals.com)
  • Hagop Kantarjian, MD, of The University of Texas MD Anderson Cancer Center, offers his thoughts on abstract 794, "Inotuzumab Ozogamicin in Combination With Low-Intensity Chemotherapy (Mini-Hyper-CVD) as Front-Line Therapy for Older Patients (≥ 60 years) With Acute Lymphoblastic Leukemia," presented by Elias Jabbour, MD. (ascopost.com)
  • Opdivo is also indicated for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy. (pharmaceutical-technology.com)
  • Angioimmunoblastic T-cell lymphoma (AITL) (previously known as angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) ) is a rare, aggressive (fast-growing) form of peripheral T-cell lymphoma. (radiopaedia.org)
  • Peripheral T-cell lymphoma: spectrum of imaging findings with clinical and pathologic features. (radiopaedia.org)
  • There is no consensus on the role of consolidative stem cell transplantation (SCT) following frontline chemotherapy in patients with peripheral T cell lymphoma (PTCL), mainly due to the lack of large prospective randomized trials in that setting 1-4 . (ebmt.org)
  • The main treatment was chemotherapy (medicines to treat cancer), sometimes in combination with radiotherapy (treatment with radiation). (europa.eu)
  • Radiation-Induced Oral Mucositis worden onderstaand genoemde aanpak in deze grafiek besproken en vertaal ik maar niet. (kanker-actueel.nl)
  • The doses of chemotherapy (chemo) drugs (and radiation) doctors can give are limited by the side effects they can cause. (cancer.org)
  • Then the patient is given high doses of chemo (and sometimes radiation) to kill the WM cells. (cancer.org)
  • Additionally, all patients without a sibling donor in complete remission after the first consolidation course were randomized to either autologous peripheral blood stem cell transplantation or a second consolidation course consisting of high-dose cytarabine. (haematologica.org)
  • Patients with metastatic breast cancer who achieved a complete or partial remission after standard chemotherapy were eligible for the study. (nebraska.edu)
  • The total of 11 cycles of this chemotherapy resulted, according to a follow up PET-CT, in complete remission. (muni.cz)
  • Chemotherapy combines treating adult patients with stage III or stage IV classical Hodgkin lymphoma that has not previously received treatment. (tumejorcelular.com)
  • It is represented on the surface of systemic anaplastic giant cell lymphoma cells and Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma. (tumejorcelular.com)
  • Opdivo in combination with Cabometyx is indicated for the treatment of unresectable or metastatic renal cell carcinoma (RCC) in adults, also indicated for the treatment of relapsed or refractory classical Hodgkin lymphoma in children. (pharmaceutical-technology.com)
  • 5. [High-dosage chemotherapy and the autologous transplantation of peripheral hematopoietic progenitor cells in breast cancer: the initial results, analysis of toxicity and the necessary support means]. (nih.gov)
  • The purpose of this initiative is to encourage research aimed at providing a better understanding of the differences between stem/progenitor cells from different sources such as bone marrow, peripheral circulation of children and adults and placental/cord blood. (nih.gov)
  • Important studies to be pursued entail the characterization of stem/progenitor cells for self-renewal, proliferation, and expansion and the mechanisms involved in these processes. (nih.gov)
  • The required dose of craniospinal RT might be reduced in older patients if the intensity of chemotherapy is increased. (e-crt.org)
  • For older children, a few studies have suggested that outcome might be improved with standard-dose craniospinal RT (CSRT) and high-dose alkylator-based chemotherapy [ 2 ]. (e-crt.org)
  • 13. [High-dose chemotherapy with four drugs and peripheral blood progenitor cell autologous transplantation in disseminated breast cancer]. (nih.gov)
  • 14. Induction, mobilization of peripheral blood stem cells (PBSC), high-dose chemotherapy and PBSC infusion in patients with untreated stage IV breast cancer: outcomes by intent to treat analyses. (nih.gov)
  • 15. Prognostic significance of the immunocytochemical detection of contaminating tumor cells (CTC) in apheresis products of patients with high-risk breast cancer treated with high-dose chemotherapy and stem cell transplantation. (nih.gov)
  • Twenty-nine percent of patients had received high-dose chemotherapy with BEAM and undergone autologous stem cell transplantation. (onclive.com)
  • However, the disease relapsed again in lymph nodes, lungs, skin and bones 5 months after the high dose chemotherapy. (muni.cz)
  • Over low dose laser als manier om orale mucositis aan te pakken staat ook een en ander op onze website en in de literatuurlijsten . (kanker-actueel.nl)
  • High-dose chemotherapy, autologous stem cell transplantation , and immunotherapy are also being used. (medlineplus.gov)
  • This stem cell treatment uses donor stem cells that are taken from bone marrow, following a course of chemotherapy. (bioeden.com)
  • Ms Jackson explained that the processes was "incredibly tough", with the course of chemotherapy causing her to suffer severe hallucinations, nausea, burning pain and "excruciating" mouth ulcers. (bioeden.com)
  • The use of chemotherapy for the treatment of cancer began at the start of the 20th century in an attempt to narrow the universe of chemicals that affect the disease. (uwi.edu)
  • Reversible transcriptional activation of mdr 1 by sodium butyrate treatment of human colon cancer cells. (unmc.edu)
  • Details regarding initial treatment options, including stem cell transplantation, are provided in this review. (karger.com)
  • The treatment uses chemotherapy to kill the disease before carrying out the stem cell treatment. (bioeden.com)
  • Now six months after the stem cell treatment, Ms Jackson has seen a huge improvement in all her symptoms and is living a normal life. (bioeden.com)
  • There are certain treatments of MM including chemotherapy, imuunomodulatory drugs and autologous stem cell transplantation which has rendered the treatment very effective but it still is a very much fatal condition. (ukbiobank.ac.uk)
  • Opdivo is indicated for the treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy. (pharmaceutical-technology.com)
  • It is indicated for treatment of recurrent or metastatic squamous cell carcinoma of head and neck. (pharmaceutical-technology.com)
  • Gut distress determined by the Mucositis Daily Questionnaire (MDQ) for up to 3 cycles of chemotherapy and calculated as area under the curve and adjusted per cycle (AUC MDQ/cycle) [The MDQ is assessed daily for the duration of each treatment cycle up to a maximum of 3 full cycles. (who.int)
  • Doctors can try to get around this problem by giving an infusion of blood-forming stem cells after treatment. (cancer.org)
  • We believe the best stem cells to use in emerging treatments will be the patient's own stem cells as this doesn't require a search for a suitable donor and in turn, eliminates chances of the transplanted cells being rejected. (bioeden.com)
  • If there are no siblings with a good match, the cells may come from an HLA-matched, unrelated donor - a stranger who has volunteered to donate cells. (cancer.org)
  • 6 , 9 , 10 Moreover, a retrospective study comparing intensive chemotherapy alone against chemotherapy followed by transplantation did not show a clear benefit for chemotherapy followed by SCT. (haematologica.org)
  • We explored whether preoperative chemotherapy affected surgical outcomes and identified the risk factors for events and death, including resection margin status, PRETreatment EXTent of disease stages, age, sex, pathology classification, and α-fetoprotein levels. (bvsalud.org)
  • Metastatic testicular cancer has always been sensitive to chemotherapy. (uwi.edu)
  • Opdivo is also indicated to treat patients with advanced (metastatic) non-small cell lung cancer whose disease progressed during or after platinum-based chemotherapy. (pharmaceutical-technology.com)
  • Tafasitamab is being clinically investigated as a therapeutic option in B cell malignancies in a number of ongoing combination trials. (pharmiweb.com)
  • The hormone levels affected due to chemotherapy were differentiated from the effects of the tumour itself by comparing the hormone levels before the onset of chemotherapy to levels measured during and after completion of chemotherapy. (uwi.edu)
  • Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
  • AUC for solid tumour patients will be assessed over the 3rd full cycle of chemotherapy after starting medicinal cannabis. (who.int)
  • Three of the four patients demonstrated engraftment of cells containing the MDR1 transgene. (nebraska.edu)
  • olu didi lungaphantsi lubalelwa malunga ne-20% yazo zonke iimeko ze-intestinal T-cell lymphoma. (lymphoma.org.au)
  • I-Intestinal T-cell lymphoma ingaba khona kwiindawo ezininzi ezahlukeneyo kwi-bowel ayiyi kusasazeka kwezinye iindawo zomzimba. (lymphoma.org.au)
  • Kune marudzi maviri e intestinal T-cell lymphoma. (lymphoma.org.au)
  • Zvakakosha kuziva kuti vanhu vazhinji vane chirwere chechiliac HAVAITAI enteropathy type intestinal T-cell lymphoma. (lymphoma.org.au)
  • A biopsy inodiwa kuongorora intestinal type T-cell lymphoma uye inogona kuoma kuongorora nokuti zviratidzo zvakafanana nemamwe mamiriro ezvinhu, kusanganisira chirwere chechiliac. (lymphoma.org.au)
  • Intestinal T-cell lymphoma inogona kunge iripo munzvimbo dzakasiyana siyana mudumbu haiwanzo kupararira kune dzimwe nhengo dzemuviri. (lymphoma.org.au)
  • Vanhu vazhinji vanoonekwa kuti vane intestinal T-cell lymphoma vanova vasina kunaka nezviratidzo zvavo uye vanoda kurapwa. (lymphoma.org.au)
  • Intestinal T-cell lymphoma inonetsa kurapa sezvo ichiwanzoonekwa pane imwe nguva uye varwere vanowanzotadza kurwara zvakanyanya panguva yainoongororwa. (lymphoma.org.au)
  • Mayroong dalawang uri ng intestinal T-cell lymphoma. (lymphoma.org.au)
  • Mahalagang malaman na karamihan sa mga taong may celiac disease ay HINDI nagkakaroon ng enteropathy type intestinal T-cell lymphoma. (lymphoma.org.au)
  • E lua ituaiga ole intestinal T-cell lymphoma. (lymphoma.org.au)
  • o lenei vaega laiti e tusa ma le 80% o mataupu uma o le intestinal T-cell lymphoma. (lymphoma.org.au)
  • E taua le iloa o le toʻatele o tagata e maua i le maʻi celiac e LĒ atiaʻe le enteropathy type intestinal T-cell lymphoma. (lymphoma.org.au)
  • A biopsy e manaʻomia e suʻesuʻeina le intestinal type T-cell lymphoma ma e mafai ona faigata ona faʻamaonia ona o faʻamaoniga e tutusa ma isi tulaga, e aofia ai maʻi celiac. (lymphoma.org.au)
  • Intestinal T-cell lymphoma e mafai ona i ai i le tele o nofoaga eseese i totonu o le manava e le masani ona sosolo atu i isi vaega o le tino. (lymphoma.org.au)
  • O le to'atele o tagata e maua i le intestinal T-cell lymphoma e fa'aletonu o latou auga ma e mana'omia ona togafitia. (lymphoma.org.au)
  • Intestinal T-cell lymphoma e faigata ona togafitia ona e masani ona maua i se taimi mulimuli ane ma e masani ona le lelei tagata gasegase i le taimi e maua ai. (lymphoma.org.au)
  • subtype a bụ ihe dị ka 80% nke ikpe niile nke lymphoma T-cell intestinal. (lymphoma.org.au)
  • Ọtụtụ ndị mmadụ na-achọpụta na ha nwere lymphoma T-cell intestinal adịghị enwe ahụ ike na mgbaàmà ha na ọ ga-adị mkpa ka a gwọọ ha. (lymphoma.org.au)
  • Pali mitundu iwiri ya intestinal T-cell lymphoma. (lymphoma.org.au)
  • Ndikofunika kudziwa kuti anthu ambiri omwe ali ndi matenda a celiac SAMAKHALA ndi mtundu wa intestinal T-cell lymphoma. (lymphoma.org.au)
  • Adunay duha ka matang sa intestinal T-cell lymphoma. (lymphoma.org.au)
  • Kini nga subtype nag-asoy sa hapit 80% sa tanan nga mga kaso sa intestinal T-cell lymphoma. (lymphoma.org.au)
  • Importante nga mahibal-an nga kadaghanan sa mga tawo nga adunay sakit nga celiac DILI makapalambo sa enteropathy type intestinal T-cell lymphoma. (lymphoma.org.au)
  • A biopsy gikinahanglan sa pagdayagnos sa intestinal type T-cell lymphoma ug mahimong lisod madayagnos tungod kay ang mga simtomas susama sa ubang mga kondisyon, lakip na ang celiac disease. (lymphoma.org.au)
  • Ang intestinal T-cell lymphoma mahimong anaa sa daghang lain-laing mga dapit sa tinai nga dili kasagaran mokaylap sa ubang mga bahin sa lawas. (lymphoma.org.au)
  • Daghang mga tawo nga nadayagnos nga adunay intestinal T-cell lymphoma ang dili maayo sa ilang mga sintomas ug kinahanglan nga matambalan. (lymphoma.org.au)
  • Ang intestinal T-cell lymphoma lisod matambalan tungod kay kini kasagarang madayagnos sa ulahing yugto ug ang mga pasyente sagad dili maayo sa panahon nga kini madayagnos. (lymphoma.org.au)
  • A biopsy hoa hlokahala ho hlahloba intestinal mofuta oa T-cell lymphoma 'me ho ka ba thata ho lemoha hobane matšoao a tšoana le maemo a mang, ho akarelletsa le lefu la celiac. (lymphoma.org.au)
  • Intestinal T-cell lymphoma e ka ba teng libakeng tse ngata tse fapaneng ka har'a mala a ke keng a hasana likarolong tse ling tsa 'mele. (lymphoma.org.au)
  • Batho ba bangata ba fumanoang ba e-na le intestinal T-cell lymphoma ha ba phele hantle ka matšoao a bona 'me ba tla hloka ho phekoloa. (lymphoma.org.au)
  • Bertrand Coiffier, MD, PhD, of Centre Hospitalier Lyon-Sud, offers his thoughts on abstract 146, " Rituximab Maintenance vs Wait and Watch After Four Courses of R-DHAP Followed By Autologous Stem Cell Transplantation in Previously Untreated Young Patients With Mantle Cell Lymphoma: First Interim Analysis of the Phase III Prospective LyMa Trial, a Lysa Study," presented by Steven Le Gouill, MD, PhD. (ascopost.com)
  • Biopsy findings were consistent with small noncleaved cell non-Hodgkin lymphoma. (medscape.com)
  • Bone marrow biopsy, serum, and urine protein electrophoresis were consistent with IgG MM. Bone marrow flow cytometry revealed plasma cells and eosinophil predominant cell lineage. (ispub.com)
  • A biopsy iyadingeka ukufumanisa uhlobo lwamathumbu e-T-cell lymphoma kwaye kunokuba nzima ukuxilonga ngenxa yokuba iimpawu zifana nezinye iimeko, kuquka nesifo se-celiac. (lymphoma.org.au)
  • A biopsy ay kinakailangan upang masuri ang uri ng bituka na T-cell lymphoma at maaaring mahirap i-diagnose dahil ang mga sintomas ay katulad ng iba pang mga kondisyon, kabilang ang celiac disease. (lymphoma.org.au)
  • A biopsy dị mkpa iji chọpụta ụdị eriri afọ T-cell lymphoma na ọ nwere ike isi ike ịchọpụta n'ihi na mgbaàmà ndị ahụ yiri ọnọdụ ndị ọzọ, gụnyere ọrịa celiac. (lymphoma.org.au)
  • A biopsy ndikofunikira kuti muzindikire matumbo amtundu wa T-cell lymphoma ndipo zimakhala zovuta kuzizindikira chifukwa zizindikiro zake zimafanana ndi matenda ena, kuphatikiza matenda a celiac. (lymphoma.org.au)
  • 75% after the first two cycles of neoadjuvant chemotherapy had better EFS and OS. (bvsalud.org)
  • 3 Department of Bone Marrow Transplantation and Oncohematology, Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland. (nih.gov)
  • 11 Hematology and Bone Marrow Transplantation Unit, IRCCS San Martino-Ist, Genova, Italy. (nih.gov)
  • This is a complex procedure where patients receive their own stem cells to help restore the bone marrow. (europa.eu)
  • Vertebral fractures and low lean mass in young men with sickle cell disease: Lack of association with bone mineral density and clinical characteristics. (amedeo.com)
  • In adults, B cells form and mature in the bone marrow. (cancerquest.org)
  • The cancerous cells over-produce antibodies that may accumulate in the bone marrow. (cancerquest.org)
  • The plasma cell burden is usually small, with a median of 5-7% bone marrow plasma cells (BMPCs) [ 8 ]. (karger.com)
  • It disrupts the inner-workings of the blood serum, compromises immune system of the body and finally lets end-organ damage manifest in bone in the process, interfering with the process of red-blood cell generation it reeks havoc. (ukbiobank.ac.uk)
  • Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
  • Higher doses can't be used, even if they might kill more cancer cells, because they would severely damage the bone marrow, where new blood cells are made. (cancer.org)
  • These stem cells settle in the bone marrow, where they can create new blood cells. (cancer.org)
  • Bone marrow transplants were more common in the past, but they have largely been replaced by stem cells taken from the blood. (cancer.org)
  • The high doses of chemo kill the normal bone marrow cells as well as the cancer cells. (cancer.org)
  • The patient's own blood-forming stem cells are removed from their bloodstream and stored to use later. (cancer.org)
  • Immune system impairment and chemotherapies significantly increase the risk of infections, particularly pneumonia [ 2 ]. (ersjournals.com)
  • Enhanced IgG immune response to COVID-19 vaccination in patients with sickle cell disease. (amedeo.com)
  • When activated, B cells produce Y-shaped proteins (antibodies) that are part of the immune response. (cancerquest.org)
  • Also to be studied are the immune cells present in the different tissue sources, and the mechanisms of their action in graft vs. host disease, and in graft vs. leukemia effect. (nih.gov)
  • So the TRIANGLE study was a randomized controlled clinical trial, meaning that the trial was performed in a randomized fashion to be able to test 3 particular strategies for patients with mantle cell lymphoma. (cancer.net)
  • Mantle cell lymphoma, as many of you may know, is a relatively uncommon form of non-Hodgkin lymphoma. (cancer.net)
  • The combination of ibrutinib and bortezomib elicited durable responses in patients with relapsed or refractory mantle cell lymphoma and high-risk features such as a Ki-67 over 30%, blastoid or pleomorphic variant, p53 overexpression, and TP53 mutations and/or deletions. (onclive.com)
  • The combination of ibrutinib (Imbruvica) and bortezomib (Velcade) elicited durable responses in patients with relapsed or refractory mantle cell lymphoma (MCL) and high-risk features such as a Ki-67 over 30%, blastoid or pleomorphic variant, p53 overexpression, and TP53 mutations and/or deletions, according to data from a phase 1/2 trial (NCT02356458) published in eClinicalMedicine . (onclive.com)