• To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
  • Preclinical data shows improvements in response for the combination of imatinib mesylate (IM, Gleevec) and gemcitabine (GEM) therapy compared with GEM alone. (aacrjournals.org)
  • Tasigna demonstrated that significantly fewer patients progressed to more advanced stages of the disease than the standard of care Gleevec (imatinib mesylate) tablets* at 12 months. (salesandmarketingnetwork.com)
  • All filings are based on data showing superior efficacy for Tasigna in the first head-to-head comparison of the drug against the standard of care Gleevec in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
  • If approved for the first-line indication, Tasigna will be the first drug for newly diagnosed patients to become available since the approval of Gleevec in 2002. (salesandmarketingnetwork.com)
  • This randomized, open-label, multicenter trial compared the efficacy and safety of Tasigna versus Gleevec in adult patients with newly diagnosed Ph+ CML in chronic phase(1). (salesandmarketingnetwork.com)
  • In the ENESTnd clinical trial significantly fewer patients at 12 months progressed to accelerated or blastic phase on Tasigna 300 mg twice daily than on Gleevec 400 mg once daily (2 patients vs. 11 patients)(1), demonstrating a significant improvement in disease control. (salesandmarketingnetwork.com)
  • Fewer patients discontinued due to adverse events from the Tasigna 300 mg twice daily arm of the study compared to the Gleevec 400 mg once daily arm. (salesandmarketingnetwork.com)
  • Tasigna has been approved in more than 80 countries for the treatment of chronic phase and accelerated phase Ph+ CML in adult patients resistant or intolerant to at least one prior therapy, including Gleevec. (salesandmarketingnetwork.com)
  • Participants will take ponatinib tablets with chemotherapy. (ucsf.edu)
  • For participants who cannot swallow tablets or who are receiving less than a 10 mg dose, a capsule with small ponatinib minitablets inside will be provided. (ucsf.edu)
  • Taj Pharmaceuticals manufactures a wide range of pharmaceuticals formulation involving Tablets / Capsules / Injections and Orals. (tajgenerics.com)
  • Taj Pharma India team has an excellent expertise in manufacturing and export of Imatinib Mesylate Tablets 400mg. (tajgenerics.com)
  • Taj Pharmaceuticals has performed these business activities related to exports of Imatinib Mesylate Tablets 400mg for major foreign-affiliated pharmaceutical import companies, ministry of health, tenders etc. and have enjoyed the full confidence of these companies, instructions and governments. (tajgenerics.com)
  • best quality suppliers and exporter of Imatinib Mesylate Tablets 400mg. (tajgenerics.com)
  • Taj Pharmaceuticals is manufactures Imatinib Mesylate Tablets 400mg under WHO-cGMP Plant. (tajgenerics.com)
  • Taj Pharma is licenced to manufacture Imatinib Mesylate Tablets 400mg formulation from Food and Drug Administration of Indian authorities as the rules and regulations with all compliances for international markets. (tajgenerics.com)
  • Letrozole Tablets USP is used to treat breast cancer in women who are post-menopausal - that is, women who no longer have periods, either naturally due to their age or after surgery or chemotherapy.Letroz is available in tablets containing 2.5 mg of the active ingredient, letrozole. (onlinemeds24x7.com)
  • Locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. (nih.gov)
  • 8-13 Tyrosine kinase inhibitors (TKI) (imatinib, sunitinib, and regorafenib) have dramatically changed the treatment landscape and outcomes for gastrointestinal stromal tumour (GIST), one of the most common STS subtypes. (emjreviews.com)
  • Patients usually present with the skin eruption 1-2 weeks after use of the cytotoxic drug. (wikipedia.org)
  • The overwhelming majority of neutrophilic eccrine hidradenitis (NEH) is seen in people with cancer, especially leukaemia, who receive chemotherapy with a cytotoxic drug. (wikipedia.org)
  • In patients receiving chemotherapy, it has been postulated that a high concentration of the cytotoxic drug in sweat has a direct toxic effect on the eccrine glands. (wikipedia.org)
  • However, if the patient developed NEH after chemotherapy, the offending cytotoxic drug has to be discontinued, and the patient must avoid this particular cytotoxic drug in the future, because NEH usually re occurs upon re exposure to the same cytotoxic drug. (wikipedia.org)
  • As per the Cairo-Bishop criteria, laboratory and clinical TLS is typically diagnosed within 3 days before and 7 days after cytotoxic chemotherapy is started. (touchoncology.com)
  • By comparison, TLS in patients with solid organ tumours treated with cytotoxic chemotherapy occurs within 3 days (95% CI 2.9-4.4). (touchoncology.com)
  • As opposed to cytotoxic chemotherapy, TKIs target specific mutated kinases that promote tumour angiogenesis and neoplastic cells growth, proliferation, and resistance to apoptosis. (touchoncology.com)
  • However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
  • Although the mechanisms of gene activation are still unclear, ceramide's role as a messenger of cytotoxic response to chemotherapy might be linked to the MDR pathway. (sphingolipidclub.com)
  • The purpose of this study is to determine the safety and tolerability of SNDX-5613 when given in combination with 2 different chemotherapy regimens in participants with relapsed/refractory acute leukemias harboring KMT2A rearrangement, KMT2A amplification, NPM1c, or NUP98r. (ucsf.edu)
  • This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (ucsf.edu)
  • Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (ucsf.edu)
  • Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. (medscape.org)
  • 4 Aside from doxorubicin-based regimens, novel chemotherapy agents, eribulin and trabectedin, have demonstrated efficacy in the L-sarcomas, liposarcoma (LPS), and leiomyosarcoma (LMS), highlighting the role of histology-directed therapy for these malignancies. (emjreviews.com)
  • We planned to perform adjuvant chemotherapy, but the patient declined it because of anorexia. (bvsalud.org)
  • Inhibition of Growth Cancer chemotherapy has often been seen as a last resort after surgery and irradiation have failed but there has been growing use of adjuvant chemotherapy in combined modality treatments. (present5.com)
  • 9. When cancer is treated with surgery followed by chemotherapy it is referred to as adjuvant therapy. (studylib.net)
  • Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)
  • 10. When chemotherapy is given to shrink a tumor it is referred to as neoadjuvant, 11. (studylib.net)
  • Various therapeutic options, including imatinib, are available to treat desmoid tumor. (e-crt.org)
  • Imatinib was effective and well tolerated for advanced desmoid tumor treatment. (e-crt.org)
  • Our results show that HES1 , regulated by NOTCH2 , as an indicator of sensitivity to imatinib, and an important therapeutic consideration for desmoid tumor. (e-crt.org)
  • During the physical examination the patient presented a normal physical status (Height 173 cm, Weight 64 kg, BMI 21) with the exception of a mobile painless solid tumor formation palpable in the middle left quadrant of the abdomen with approximate size 10 cm. (ommegaonline.org)
  • Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (ucsf.edu)
  • In contrast to microbial chemotherapy, there has been much greater emphasis on combination chemotherapy against cancer. (present5.com)
  • The objectives in combination chemotherapy have been to limit the toxicity of individual agents and to evade drug resistance by exposing the cancer cell to drugs with different modes of action simultaneously. (present5.com)
  • This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
  • Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia. (mayo.edu)
  • NEH was first described in 1982 in a patient with acute myeloid leukaemia (AML) who had received cytarabine as chemotherapy. (wikipedia.org)
  • EA9181, A Phase III Randomized Trial of Steroids+Tyrosine Kinase Inhibitor Induction With Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults Rochester, Minn. This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. (mayo.edu)
  • This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (ucsf.edu)
  • METHODS: 14 patients who underwent salvage esophagectomy for residual or recurrent esophageal cancer after PDT between April 2006 and November 2022 at our institution, were enrolled. (bvsalud.org)
  • Selumetinib in paediatric patients with BRAF -aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicenter, phase 2 trial. (medscape.org)
  • The treatment of adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery. (tajgenerics.com)
  • With gene-wise functional analyses, we detected a significant correlation between recurrent NOTCH2 noncoding mutations and clinical response to imatinib. (e-crt.org)
  • Systemic treatments travel throughout your body and are typically drug therapies such as targeted therapy, immunotherapy or chemotherapy. (patientresource.com)
  • This review describes advances in chemotherapy, molecularly targeted, and immunotherapy agents for STS. (emjreviews.com)
  • In this article, we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. (cancernetwork.com)
  • Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs. (cancernetwork.com)
  • We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs. (cancernetwork.com)
  • A study of the drugs selumetinib verus carboplatin/vincristine in patients with neurofibromatosis and low-grade glioma. (medscape.org)
  • Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
  • When patients develop resistance, multiple drugs with different pathways of entry and different cellular targets are used. (savedelicious.com)
  • this introduces a resource that should gain relevance considering the increasing number of oral anticancer drugs. (ons.org)
  • Multidrug resistance (MDR) in cancer cells leads to synchronous resistance of cancer cells to structurally unrelated anticancer drugs, which is one of the most important factors that are responsible for the failure of cancer chemotherapy [1, 2]. (cp-456773inhibitor.com)
  • Some targeted therapy drugs are oral medications given in pill form, and others are given intravenously (IV). (patientresource.com)
  • Determining which mutations are targetable is not simple for a variety of reasons including (i) the identified mutations may not be drivers in that patient, (ii) more than one driver mutation may be present, (iii) genetic and spatial heterogeneity within the tumour make it difficult to be reasonably certain that the truncal/clonal mutations that could be targeted have been properly identified, which is the main focus of our work here. (biomedcentral.com)
  • For example, mutations present in the first tumour initiating cancer cell should, in principle, be clonal and consequently found in every cancer cell of the particular patient. (biomedcentral.com)
  • While for most LCH-patients efficient therapies are available, patients with BRAF mutations may benefit from the BRAF inhibitor vemurafenib. (oncotarget.com)
  • Some are specifically approved for newly diagnosed patients, while others are approved for use after other therapies have failed due to resistance, changes in mutations or intolerance. (patientresource.com)
  • Multicenter phase I/II study of nivolumab combined with paclitaxel plus ramucirumab as the second-line treatment in patients with advanced gastric cancer. (postersessiononline.eu)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • Paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment. (tajgenerics.com)
  • Paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase. (tajgenerics.com)
  • Adult and paediatric patients with Ph+ CML in blast crisis. (tajgenerics.com)
  • Adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy. (tajgenerics.com)
  • In adult and paediatric patients, the effectiveness of imatinib is based on overall haematological and cytogenetic response rates and progression-free survival in CML, on haematological and cytogenetic response rates in Ph+ ALL, MDS/MPD, on haematological response rates in HES/CEL and on objective response rates in adult patients with unresectable and/or metastatic DFSP. (tajgenerics.com)
  • In this report, we describe a case of TLS in a patient with gastrointestinal stromal tumour (GIST) that occurred 15 days after commencement of imatinib. (touchoncology.com)
  • 5 Against this background, we report a case of delayed TLS in a patient with advanced GIST treated with imatinib. (touchoncology.com)
  • 5 It is noteworthy that in high-risk patients with haematological malignancies, targeted therapy including TKIs, monoclonal antibodies, chimeric antigen receptors and proteasome inhibitors are often associated with TLS. (touchoncology.com)
  • NEH has been reported in patients with cancer who have not received any form of chemotherapy (i.e., as a paraneoplastic syndrome), in patients with HIV and/or AIDS, and after the use of paracetamol (acetaminophen). (wikipedia.org)
  • In patients with clinically localized prostate cancer, the National Comprehensive Cancer Network (NCCN) strongly discourages the use of NADT before RP outside of a clinical trial. (medscape.com)
  • Available data indicate that cancer patients use these products (along with standard treatments) more often than the general population. (cancernetwork.com)
  • 1] Compared with healthy populations, cancer patients appear to be more frequent users of these supplements. (cancernetwork.com)
  • 2,3] The majority employ them as adjuncts to chemotherapy or other cancer treatments to alleviate symptoms and to prevent recurrence. (cancernetwork.com)
  • 8] In this article, we focus on "herbs" used by cancer patients and survivors. (cancernetwork.com)
  • Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. (ucsf.edu)
  • Patients who underwent colon interposition after esophagectomy for cancer between 2010 and 2020 were analyzed. (bvsalud.org)
  • The cancer was judged to be cT4a, N2M1(H1 LYM: No. 16), cStage â £ and thus was considered suitable for chemotherapy. (bvsalud.org)
  • However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
  • This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes (MSH1, MSH2, MSH6) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
  • Cancer Chemotherapy - Lecture Outline 1. (present5.com)
  • Targets for cancer chemotherapy 2. (present5.com)
  • This variability together with the cellular heterogeneity are complications for cancer chemotherapy. (present5.com)
  • Unlike microbial chemotherapy in which there are marked differences in chemistry from the host cells, the cancer cell provides relatively limited changes from the normal cells and does not offer clear targets for chemotherapeutic attack. (present5.com)
  • Inhibition of Growth Experimental cancer chemotherapy has been largely directed at the inhibition of cellular proliferation with little attention being directed to more difficult models which would detect effects on the invasive and metastatic potential of cancer cells. (present5.com)
  • Metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type, an anti-EGFR therapy. (nih.gov)
  • Cancer treatment to relive symptoms of advanced disease is referred to as palliative chemotherapy. (studylib.net)
  • Preliminary results in colorectal cancer (CRC) patients enrolled in the GATTO study, a phase I study of Tomuzotuximab in combination with Gatipotuzumab in patients with EGFR positive solid tumors. (postersessiononline.eu)
  • Travelers with a history of cancer who received their last chemotherapy treatment ≥3 months previously and whose malignancy is in remission. (unboundmedicine.com)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • FDA-approved for use in combination with prednisone for the treatment of patients with metastatic, castration-resistant prostate cancer who have received prior chemotherapy containing docetaxel. (com.bd)
  • Ponatinib in pediatric patients with Philadelphia chromosome-positive leukemia: a retrospective survey of the Japan Children's Cancer Group (Kodama Y et al. (cml-foundation.org)
  • Imat (Imatinib) tablet is used to treat certain types of cancer of the blood cells, stomach, intestine, bone marrow, and skin. (magicinepharma.com)
  • I. To determine the levels of expression of c-KIT and its ligand, stem cell factor (SCF) in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
  • To determine the levels of expression of AKT2 and its activated form, phospho-AKT2, in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
  • The purpose of this study was to clarify the frequency and clinical features of patients who underwent colon interposition in thoracic esophagectomy and to investigate the postoperative complications and survival. (bvsalud.org)
  • The regulatory submissions are based on data from the ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials of Newly Diagnosed Ph+ CML Patients) Phase III clinical trial. (salesandmarketingnetwork.com)
  • The first clinical trials of Tasigna began 21 months after its discovery, with the drug receiving its first regulatory approval in the second-line indication in 2007(3). (salesandmarketingnetwork.com)
  • Here, we describe potential roles of NOTCH2 and HES1 in clinical response to imatinib at genome and transcriptome levels. (e-crt.org)
  • The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)
  • However, the NCCN notes that androgen deprivation therapy before, during, and/or after radiation prolongs survival in selected patients who are receiving radiation therapy only. (medscape.com)
  • Tyrosine kinase inhibitors (TKI) such as Imatinib can inhibit the critical gene driving the disease leading to long lasting remissions, improved survival and perhaps even cure in some patients [ 7 - 10 ]. (biomedcentral.com)
  • Children with chronic myeloid leukemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicentre experience in Taiwan (Liu HC et al. (cml-foundation.org)
  • Most patients with chronic GVHD experience skin problems that may start with a rash and itching. (drcremers.com)
  • EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)
  • Now this priority review designation brings us one step closer to offering patients who are newly diagnosed with Ph+ CML in the chronic phase a promising new treatment option. (salesandmarketingnetwork.com)
  • however, some patients in the chronic phase can receive targeted therapy and remain in remission for many years. (patientresource.com)
  • Patient-reported long-term outcome following allogeneic hematopoietic stem cell transplantation in pediatric chronic myeloid leukemia (Schleicher O et al. (cml-foundation.org)
  • Imatinib is an antineoplastic agent and a 2-phenylaminopyrimidine derivative that is used to treat chronic myelogenous leukemia. (magicinepharma.com)
  • Eight patients (57.1%) had postoperative complications of Clavien-Dindo grade II or more. (bvsalud.org)
  • A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL Rochester, Minn., Jacksonville, Fla. (mayo.edu)
  • The goals of this study are to help make chemotherapy more effective in treating the patient's leukemia as demonstrated by fewer patients with leukemia minimal residual disease (MRD) while also trying to reduce the amount of body fat that chemotherapy causes the patient to gain in the first month. (ucsf.edu)
  • However, the efficacy of oral dapsone as prevention has not been demonstrated very clearly until now. (wikipedia.org)
  • Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas. (medscape.org)
  • This study is about an anticancer drug called ponatinib which is a tyrosine kinase inhibitor given with chemotherapy to children, teenagers, and young adults up to 21 years of age with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia who have relapsed or are resistant to other treatment. (ucsf.edu)
  • This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy can make the patient's ALL more sensitive to chemotherapy and also reduce the amount of body fat gained during treatment. (ucsf.edu)
  • 53.2% received preoperative treatment and 52.3% underwent thoracoscopic surgery. (bvsalud.org)
  • Nursing Interventions/Patient Teaching Evaluation Monitor labs (CBC, blood urea nitrogen [BUN], creatinine, liver panel, and electrolytes) before drug administration and during treatment. (studylib.net)
  • Standard of care refers to a diagnostic and treatment process that a clinician is recommended to follow for a certain type of patient and illness. (patientresource.com)
  • She started receiving treatment with corticosteroids, successively with Cyclophophamide (Endoxan®), cyclosporine (Sandimmune), one year of hemodialysis and in October 2006 she received a kidney transplant from a cadaveric donor. (ommegaonline.org)
  • The purpose of this study is to evaluate the rate of complete MRD response by flow cytometry after 4 weekly doses of daratumumab-hyaluronidase (Day 29) among patients with MRD positive T-ALL in hematologic morphologic complete remission or complete remission with incomplete hematologic recovery. (mayo.edu)
  • A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor. (medscape.org)
  • Trametinib in pediatric patients with neurofibromatosis type 1-associated plexiform neurofibroma: a phase I/II study. (medscape.org)
  • No patients in the study had a prolongation of the QT interval >500 milliseconds(1). (salesandmarketingnetwork.com)
  • Here we present a retrospective genotyping study and a prospective observational study of a patient treated with a BRAF inhibitor. (oncotarget.com)
  • Neutrophilic eccrine hidradenitis (NEH) usually is a cutaneous complication of chemotherapy, but it can also occur for other reasons. (wikipedia.org)
  • Adult patients with relapsed or refractory Ph+ ALL as monotherapy. (tajgenerics.com)
  • Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. (ucsf.edu)
  • 2011). Even for patients showing resistance to first-line therapy, their life expectancy may improve because of modern TKI alternatives (Kantarjian et al. (ons.org)
  • BCRP substrates: Monitor patients closely for symptoms of increased exposure to BCRP substrates. (nih.gov)
  • The effect of imatinib on the outcome of bone marrow transplantation has not been determined. (tajgenerics.com)
  • today, life spans of responding patients are considered comparable to the general population in contrast to the previously often lethal outcome (Gambacorti-Passerini et al. (ons.org)
  • Besides the toxic effects of chemotherapy, another major problem is chemoresistance [5]. (savedelicious.com)
  • A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/ITD AML (BMT CTN 1506) Rochester, Minn., Scottsdale/Phoenix, Ariz. (mayo.edu)
  • The use of two or more chemotherapy agents is referred to as combination therapy 6. (studylib.net)
  • We do not know yet how to select patients for this therapy and how to move it from life extension to cure. (aacrjournals.org)
  • Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
  • Withhold STIVARGA in patients with worsening or severe infections. (nih.gov)
  • Among 20 patients, four (20%) had a partial response and 14 (66.7%) had stable disease, 11 of which continued for ≥ 1 year. (e-crt.org)