Chemotherapy oligodendroglioma. Medical search. Frequent questions

People with oligodendrogliomas have a higher survival rate than most other brain tumors. (healthline.com)
The outlook for oligodendroglioma tumors depends on the grading scale of the tumor, the overall health of the person who is diagnosed, and how early the tumor has been diagnosed. (healthline.com)
Their good prognosis relative to other parenchymal tumors probably stems from inherently less aggressive biological behavior and a favorable response to radiation and chemotherapy. (medscape.com)
The incidence of oligodendrogliomas is around 5% of all central nervous system neuroepithelial tumors. (medscape.com)
Conclusions: In isocitrate dehydrogenase-mutant and 1p/19q-codeleted oligodendrogliomas, most of the tumors that demonstrated early progression appeared as local, nonlethal lesions, which have been well-controlled by salvage treatments. (elsevierpure.com)
In the World Health Organization (WHO) classification of brain tumors, anaplastic oligodendrogliomas are classified as grade III. (wikipedia.org)
A recent long-term study does affirm that radiation combined with adjuvant chemotherapy is significantly more efficacious for anaplastic oligodendroglioma patients with 1p 19q co-deleted tumors and has become the new standard of care. (wikipedia.org)
Adding procarbazine, lomustine and vincristine chemotherapy to radiotherapy increases PFS and OS in patients with anaplastic oligodendroglial tumors and represents a new standard of care in those with 1p/19q co-deletions, according to data presented at the 2012 American Society of Clinical Oncology Annual Meeting. (cancertherapyadvisor.com)
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group study 26951. (thieme-connect.de)
It has also been hypothesized that other genetic alterations may be responsible for a small subset of patients whose glial brain tumors are chemotherapy-resistant. (mayoclinic.org)
The 1p/19q deletion is a diagnostic marker to differentiate between astrocytoma and oligodendroglioma and a positive prognostic marker for patients with oligodendroglial tumors. (kockro.com)
A Phase III study conducted by the European Organisation for Research and Treatment of Cancer (EORTC) has shown that giving combination chemotherapy after standard radiation therapy delayed tumour growth and extended the lives of patients with anaplastic oligodendroglial tumors, a form of brain cancer. (ecancer.org)
A sub-analysis of the study showed the survival benefit of combination chemotherapy-radiation treatment may be limited to patients whose tumors contained specific deletions of genetic material in chromosomes 1 and 19 (1p/19q co-deletions). (ecancer.org)
Treatment for malignant brain tumors also includes chemotherapy with nitrosoureas, which cross the blood-brain barrier and allow other chemotherapeutic drugs to go through as well. (online-family-doctor.com)
Well-differentiated oligodendrogliomas are slow-growing tumors that look very much like normal cells. (cancer.org)
These deletions are diagnostic for oligodendroglial tumors, predict longer survival, and predict a better response to radiation therapy and chemotherapy. (msdmanuals.com)
Oligodendrogliomas account for 15-20% of primary tumors, and occur in two peaks, around the ages of 35 and 55. (ufl.edu)
A test for "1p-19q chromosomal co-deletion" is a test that can be done on the chromosomes within tumors of oligodendroglioma origin. (ufl.edu)
On average, oligodendroglioma tumors with 1p-19q co-deletions tend to have a better response to therapy (radiation or chemotherapy) as well as a better overall outcome, regardless of treatment. (ufl.edu)

Gliomas are tumours of the central nervous system (brain tumours) and are subdivided into astrocytomas and oligodendrogliomas. (sciencedaily.com)
The results of this study really suggest that in selected patients with IDH mutant low-grade gliomas we can potentially delay the use of these toxic chemotherapies and radiation, maybe for years if not many years, and as a result delay the long-term toxicities of those therapies in a group of patients who typically are experiencing long-term survival," Lesser added. (medscape.com)
Depending on the individual cell of origin, gliomas can be further categorised as e.g. astrocytoma, oligodendroglioma or ependymoma. (kockro.com)
Low-grade gliomas include pilocytic astrocytomas (WHO grade I), which grow very slowly and occur almost only in childhood, as well as diffuse astrocytomas (WHO grade II) and oligodendrogliomas (grade II). (kockro.com)
This is particularly valuable for the differential diagnosis of slow-growing and diffuse gliomas as well as recurrent lesions, especially having undergone radiation therapy or chemotherapy. (kockro.com)
Conventional therapy for malignant gliomas consists primarily of surgical debulking followed by radiation therapy and possibly chemotherapy. (jnccn.org)
In this article, we summarize these trials and discuss ongoing clinical trials involving implantable chemotherapy-containing polymers in the treatment of patients with malignant gliomas. (jnccn.org)
Gliomas classified as grade II by the World Health Organization (WHO) include astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. (johnshopkins.edu)
Palliative measures for gliomas, astrocytomas, oligodendrogliomas, and ependymomas include dexamethasone for cerebral edema and antacids and histamine receptor antagonists for stress ulcers. (online-family-doctor.com)
They are histological y are classified as WHO grade II gliomas: diffuse astrocytoma, diagnosed as the third most common primary tumor of the oligodendroglioma, pilomyxoid astrocytoma, pleomorphic xanthoastrocytoma, and ependymoma [3]. (bvsalud.org)
3 months earlier) with grade 2 or 3 gliomas are eligible if the patient has not received prior radiation or prior chemotherapy. (sncrf.org)
Oligodendrogliomas (WHO grade II) are among the slowest-growing gliomas. (msdmanuals.com)
Johnson, DR & Jaeckle, KA 2012, Low Grade Gliomas and Oligodendrogliomas in Adulthood . (elsevierpure.com)
Weller M. Chemotherapy for low-grade gliomas: when? (medscape.com)

The trial compared outcomes in patients who received radiation therapy alone versus radiation therapy (RT) plus chemotherapy with procarbazine, CCNU, and vincristine (PCV). (medscape.com)
For further treatment, radiation or chemotherapy with temozolomide or a chemotherapy with Procarbazine, CCNU and Vincristine (PCV) has been shown to be effective and was the most commonly used chemotherapy regimen used for treating anaplastic oligodendrogliomas. (wikipedia.org)
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (thieme-connect.de)
Adjuvant chemotherapy with PCV (procarbazine [Matulane], lomustine [CeeNU], and vincristine) following standard radiation therapy delayed disease progression and increased survival in patients with a relatively rare type of brain tumor called anaplastic oligodendroglioma. (ascopost.com)
Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. (hemonc.org)
Radiotherapy with procarbazine, lomustine, and vincristine improves overall survival (OS) in patients with 1p19q co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma. (cambridge.org)

Medicine, 81 Irwon-ro, Gangnam-gu, astrocytoma and oligodendroglioma of brain in adults. (bvsalud.org)
Rarely, astrocytomas contain astrocytoma and oligodendroglioma cells. (msdmanuals.com)

The benefit of adjuvant chemotherapy and radiotherapy (RT), given as single modalities or sequentially, is still unclear. (cochrane.org)
high-risk patients should be treated with fractionated external-beam radiation therapy (EBRT) or adjuvant chemotherapy. (medscape.com)

To compare postoperative sequential RT and chemotherapy to RT alone in adults with newly diagnosed AO or mixed AOA. (cochrane.org)
In general, for newly diagnosed CNS lymphoma, HD-MTX based chemotherapy forms the backbone of treatment. (dana-farber.org)
This is a single-arm, non-randomized, open-label Phase 2 therapeutic study that will assess the effects of adding BPM31510 onto a conventional treatment framework of RT and concurrent TMZ chemotherapy for subjects with newly diagnosed glioblastoma. (stanford.edu)

More recently, trials have shown that high-dose chemotherapy followed by autologous stem cell transplant is very effective not only in increasing progression-free survival and overall survival rates, but also with a reduced risk of neurotoxicity, which is quite common with whole brain radiation, especially as age advances. (dana-farber.org)
Our early results, reported at a median patient follow-up of 5.9 years, showed that radiation therapy plus PCV chemotherapy was associated with a statistically significant prolongation of median progression-free survival, but not with overall survival. (mayoclinic.org)
Median progression- free survival time for patients receiving radiation therapy plus PCV chemotherapy versus radiation therapy alone was 10.4 years and 4.0 years, respectively. (mayoclinic.org)
Ten-year, progression-free survival and overall survival rates for patients in the radiation therapy plus PCV chemotherapy arm versus those in the radiation therapy alone arm were 51 percent versus 21 percent and 60 percent versus 40 percent, respectively. (mayoclinic.org)

Does giving chemotherapy, radiotherapy or both improve survival in people with rare (anaplastic oligodendrogliomas and oligoastrocytomas) brain tumours? (cochrane.org)
One study was able to demonstrate a significant survival benefit for the addition of chemotherapy to radiotherapy after surgery, compared with radiotherapy alone. (cochrane.org)
Despite a high incidence of adverse events, adding aflibercept to FOLFIRI chemotherapy is associated with "a consistent trend" of increased survival among metastatic colorectal cancer patients, regardless of patients' previous bevacizumab treatment status, according to a study presented at the 2012 American Society of Clinical Oncology Annual Meeting. (cancertherapyadvisor.com)
Furthermore, several randomised trials have shown that the addition of alkylating chemotherapy, either temozolomide or nitrosourea-based regimens, to radiotherapy results in prolonged survival. (smw.ch)
The favorable prognostic variables researchers identified for progression-free and overall survival included the radiation plus PCV chemotherapy arm and oligodendroglioma histology. (mayoclinic.org)
What we show is that, despite a crossover that we had in our study, we see a significant clinically relevant increase in survival if we give chemotherapy early on. (ecancer.org)

Traditionally, the standard of care for people with rare anaplastic oligodendrogliomas and anaplastic oligoastrocytomas (brain tumours) has been surgery followed by radiotherapy. (cochrane.org)
We searched the scientific literature up to March 2014 for studies of adults over 18 years of age with a diagnosis of anaplastic oligodendrogliomas, anaplastic oligoastrocytomas or anaplastic astrocytomas. (cochrane.org)
Standard care of adjuvant treatment for anaplastic oligodendrogliomas (AO) and anaplastic oligoastrocytomas (AOA) is not yet well defined. (cochrane.org)

We excluded no specific chemotherapy regimens. (cochrane.org)
As expected, treatment toxicity was greater in the PCV chemotherapy arm and consistent with patients receiving multiagent chemotherapy regimens. (mayoclinic.org)
Radiation and chemotherapy regimens may vary among institutions. (medscape.com)

However, the benefit of adjuvant (post-surgery) chemotherapy and radiotherapy is still unclear. (cochrane.org)
After surgery, the participants had to have received radiotherapy alone, chemotherapy alone or radiotherapy plus chemotherapy. (cochrane.org)
Furthermore, in one study, these specific chromosome deletions and mutations predicted which group of participants derived benefit from the addition of chemotherapy to radiotherapy after surgery. (cochrane.org)
Surgery is typically used for treating oligodendrogliomas, particularly if the tumor is low grade. (healthline.com)
The goal of surgery is to remove as much of the oligodendroglioma as possible. (mayoclinic.org)
Chemotherapy is often used after surgery to kill any tumor cells that might remain. (mayoclinic.org)
Radiation therapy is sometimes used after surgery and may be combined with chemotherapy. (mayoclinic.org)
Palliative care can be used at the same time as other treatments, such as surgery, chemotherapy or radiation therapy. (mayoclinic.org)
IDH1 R132H in anaplastic oligodendroglioma Surgery can help reduce symptoms caused by the tumor. (wikipedia.org)
She went through surgery, chemotherapy and radiotherapy and her treatment is still ongoing. (braintumourresearch.org)
My original prognosis was extremely poor, but I'm doing much better after surgery in June 2016, intensive whole-brain radiotherapy in August 2016, targeted radiotherapy in November 2016 and I've now had 3 out of 6 rounds of PCV chemotherapy since January 2017. (braintumourresearch.org)
High-grade glioma (HGG) are optimally treated with maximum safe surgery, followed by radiotherapy (RT) and/or systemic chemotherapy (CT). (surgicalneurologyint.com)
This is triple therapy so you've got the surgery, you've got the radiotherapy, you're now saying add the chemotherapy with, in this case, it's PCV chemotherapy. (ecancer.org)
Since then, his days have been filled with radiation, chemotherapy and surgery. (denverite.com)
Nevertheless, treatment options such as surgery , chemotherapy , and radiation have side effects that can impact quality of life. (aaroncohen-gadol.com)
This last January, I had brain surgery to remove the tumor, and my final diagnosis was oligodendroglioma grade 3. (dearjackfoundation.org)
Julianne is given a choice between surgery to excise the tumour or radiation and chemotherapy. (youmakememore.net)
While treatable with surgery, radiation, and chemotherapy, LGG are not curable and carry a poorer prognosis than is generally recognized. (elsevierpure.com)
For people who can't have surgery, radiation therapy and chemotherapy may be the main treatment. (mayoclinic.org)
A chemotherapy medicine taken as a pill is often used after surgery and during and after radiation therapy. (mayoclinic.org)
Sometimes thin, circular wafers containing chemotherapy medicine might be put in the brain during surgery. (mayoclinic.org)
This extra layer of support goes with other treatments, such as surgery, chemotherapy or radiation therapy. (mayoclinic.org)

Oligodendroglioma is a rare tumor that occurs in the brain. (healthline.com)
The life expectancy of a person with an oligodendroglioma depends upon the grade of the tumor and how early it has been diagnosed. (healthline.com)
Chemotherapy uses strong medicines to kill tumor cells. (mayoclinic.org)
Anaplastic oligodendroglioma is a neuroepithelial tumor which is believed to originate from oligodendrocytes, a cell type of the glia. (wikipedia.org)
Since typically the cells of an anaplastic oligodendroglioma have already migrated into the surrounding healthy brain tissue at the time of diagnosis, a complete surgical removal of all tumor cells is not possible. (wikipedia.org)
Because this tumor is an "indolent condition" (a slowly progressive medical condition associated with little or no pain) and the potential morbidity associated with neurosurgery, chemotherapy and radiation therapy, most neuro-oncologists will initially pursue a course of watchful waiting and treat patients symptomatically. (wikipedia.org)
CHICAGO - Patients with a certain type of brain tumor could soon be treated with an oral targeted drug instead of undergoing more toxic chemotherapy and radiation, say researchers reporting new results that could potentially change the treatment landscape. (medscape.com)
Matt Larson, 36, was diagnosed with a stage 3 Anaplastic Oligodendroglioma brain tumor in May 2015. (denverite.com)
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (sncrf.org)
In November of 2022, I had a brain biopsy and was diagnosed with an oligodendroglioma grade 2 tumor. (dearjackfoundation.org)

When we were doing the study it became clear that we already knew that anaplastic oligodendroglial tumours at recurrence were sensitive to PCV chemotherapy. (ecancer.org)

This retrospective analysis investigated outcomes in patients with 1p19q co-deleted/partially deleted oligodendroglioma, oligoastrocytoma, anaplastic oligodendroglioma, or anaplastic oligoastrocytoma. (cambridge.org)
Median time to radiotherapy in 47 patients (44%) was 34.7 months and 41.2 months in 9 patients with co-deleted/incompletely co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma who received upfront temozolomide alone. (cambridge.org)

Evidence for giving radiotherapy and chemotherapy was of good quality, but sparse. (cochrane.org)
Whilst oligodendrogliomas are relatively rare, with only 40 new cases every year, and respond well to standard radiotherapy and chemotherapy treatments, astrocytomas are highly invasive and difficult to treat. (sciencedaily.com)

Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer. (astucespain.org)

A retrospective study on 1054 patients with anaplastic oligodendroglioma, presented during the 2009 ASCO Annual Meeting, suggests that PCV therapy may be effective. (wikipedia.org)
Patients with anaplastic oligodendroglioma with co-deletion for chromosomes 1p and 19q survive significantly longer after receiving chemotherapy immediately prior to radiotherapy, according to long-term follow-up of a randomized phase 3 study presented at the 2012 American Society of Clinical Oncology Annual Meeting. (cancertherapyadvisor.com)

In the course of the disease, it can degenerate into highly malignant oligodendroglioma, grade IV. (wikipedia.org)
The (malignant) anaplastic oligodendroglioma belongs to the group of diffuse glioma and arises in the central nervous system (brain and spinal cord) from precursor stem cells of the oligodendrocytes. (wikipedia.org)
The designation of grade III oligodendroglioma (high grade) generally subsumes the previous diagnoses of anaplastic or malignant oligodendroglioma. (wikipedia.org)

and temozolomide chemotherapy alone. (cochrane.org)

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. (thieme-connect.de)

It can be seen as favorable for the patient and makes a response to radiation or chemotherapy more likely. (wikipedia.org)

As a general rule, people with grade II oligodendrogliomas are likely to live for around 12 years following diagnosis . (healthline.com)
A precise diagnosis of oligodendrogliomas using molecular parameters is crucial to receive the best benefit from salvage treatment. (elsevierpure.com)

Three randomized controlled trials, which included 931 participants, assessed the role of chemotherapy alone or in addition to radiotherapy, or radiotherapy alone. (cochrane.org)
Until recently, the role of chemotherapy has been less clear. (johnshopkins.edu)

Genetic testing to look for certain mutations that chemotherapy responds very well to) Jordan is on a "wait and see" type of treatment now. (cancer.org)

We included randomized controlled trials (RCTs) of adults with AO, AOA or anaplastic astrocytoma (AA) comparing adjuvant treatment of chemotherapy, RT, or sequential chemotherapy and RT. (cochrane.org)
Based on the differences in participant selection with respect to the definition of AO (two versus three high-risk anaplastic features), the inclusion of AA and sequence of treatment (RT and chemotherapy), we could not consider the results from the three RCTs for meta-analysis. (cochrane.org)
There are many treatment options available and oligodendrogliomas appear to respond well to treatment. (healthline.com)
Low-risk" patients might defer treatment with radiation and chemotherapy and followed with surveillance only, while "high-risk" patients may benefit with upfront adjuvant treatment. (medscape.com)
For 48 years, new therapeutic options have been regularly tested as part of therapy studies to improve the treatment of anaplastic oligodendroglioma. (wikipedia.org)
He illustrated the importance of the treatment using the clinical case of a 21-year-old female who presented with new-onset seizure and was found to have an IDH-mutated grade 2 oligodendroglioma. (medscape.com)
Treatment for oligodendrogliomas and ependymomas includes surgical resection and radiation therapy. (online-family-doctor.com)
Treatment is a combination of surgical resection and chemotherapy. (msdmanuals.com)
Other types of chemotherapy given through a vein might be the treatment for glioblastoma that returns. (mayoclinic.org)

Some patients may live longer after surgical resection and adjuvant (supplemental) treatments such as radiation and chemotherapy. (aaroncohen-gadol.com)

however, oligodendrogliomas were classified histologically in this study, not by 1p/19q status. (medscape.com)

I was diagnosed with a grade three oligodendroglioma in July 2016 (it is butterfly-shaped, in both hemispheres of my brain). (braintumourresearch.org)

People with grade III oligodendrogliomas are expected to live an average of 3.5 years . (healthline.com)
About 50 to 70% of WHO grade III anaplastic oligodendrogliomas have combined allele losses on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q). (wikipedia.org)
As of 2022[update], a definitive cure is not possible with anaplastic oligodendrogliomas of WHO grade III. (wikipedia.org)
Kate Hickman has written an honest blog giving insight into her life with a grade three oligodendroglioma. (braintumourresearch.org)
Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas. (astucespain.org)
Histologic evidence of WHO grade 2 or 3 oligodendroglioma, defined as a glioma with 1p/19q codeletion in combination with any IDH1 or IDH2 mutation. (sncrf.org)
Like astrocytomas, oligodendrogliomas can evolve into more aggressive forms, such as anaplastic oligodendrogliomas (WHO grade III), which are managed accordingly. (msdmanuals.com)
Brain imaging confirms a grade 2 oligodendroglioma centred in the parietal lobe disturbing the praecuneus region. (youmakememore.net)

Oligodendrogliomas are typically characterized by deletion of the p arm of chromosome 1 and the q arm of chromosome 19 (1p/19q codeletion). (msdmanuals.com)
Prior chemotherapy with vincristine typically causes areflexia that is diffuse and symmetric. (medscape.com)

Radiation therapy and chemotherapy follow resection. (online-family-doctor.com)

However, the clinical impact of salvage treatments on outcomes of patients with recurrent oligodendrogliomas has not been precisely investigated. (elsevierpure.com)

Virtually all oligodendrogliomas also have a mutation in isocitrate dehydrogenase (IDH1 or IDH2). (medscape.com)

Oligodendrogliomas may be diagnosed at any age but occur most commonly in young and middle-aged adults between 25 and 45 years old. (medscape.com)
Oligodendroglioma is most common in adults, but it can happen at any age. (mayoclinic.org)

Induction chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck did not improve OS, according to a study presented at the 2012 American Society of Clinical Oncology Annual Meeting. (cancertherapyadvisor.com)

It had substantial changes com- diotherapy [12], and chemotherapy-combined radiotherapy pared to the previous edition of classification published in 2007. (bvsalud.org)
Oligodendrogliomas might be graded on a scale of A through D or I -IV depending on the classification system used. (cancer.org)

Anatomy3

Diseases12

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes5

Information Science2

Health Care5

Tumors19

Gliomas14

Procarbazine6

Astrocytoma and oligodendroglioma2

Adjuvant chemotherapy2

Newly diagnosed3

Progression-free sur4

Survival6

Oligoastrocytomas3

Regimens3

Surgery22

Tumor10

Recurrence1

Oligoastrocytoma2

Radiotherapy and chemotherapy2

High-dose chemotherapy1

Patients with anaplastic2

Malignant3

Temozolomide chemotherapy1

Compared with radiotherapy alone1

Response to radiation1

Diagnosis2

Role of chemotherapy2

Mutations1

Treatment9

Surgical resection1

Histologically1

20161

Grade8

Typically2

Resection1

Treatments1

Isocitrate1

Adults2

Oncology1

Classification2