• The EGFr is a member of the ErbB family of tyrosine kinase (TK) receptors found on the cell surface of normal and malignant tumor cells. (medscape.com)
  • In addition to being overexpressed in SCCHN tumor cells, there is evidence that EGFr is also abnormally activated in these malignant cells. (medscape.com)
  • Some data indicate that antioxidants may protect tumor cells as well as healthy cells from oxidative damage generated by radiation therapy and some chemotherapeutic agents. (nih.gov)
  • Chemotherapy affects both normal and tumor cells. (cancer.org)
  • and 3) translate understanding of these parameters into interventions that target invading tumor cells. (nih.gov)
  • In the advanced stage of cancer, autophagy provides sufficient nutrients for proliferation and metabolism of tumor cells and induces the survival of cancer cells, promote the metastasis of cancer cells to distant locations and increase their drug resistance ( 7 ). (spandidos-publications.com)
  • In this paper, we report that a conjugate of nitroxide with a hydrophobic cation, triphenyl-phosphonium (TPEY-Tempo), significantly protected brain endothelial cells from gamma-irradiation-induced apoptosis while radiosensitizing brain tumor cells. (cdc.gov)
  • Immunohistochemistry staining of tumor cells from patients. (niepokorny.org)
  • These cells find the manifestation of NK cell receptors (NKp46) and may recognize and destroy both MHC-I-positive and MHC-I-negative/low tumor cells without attacking regular cells [16]. (niepokorny.org)
  • 17. Expression of ARID1A in polycystic ovary syndrome and its effect on the proliferation and apoptosis of ovarian granulosa cells. (nih.gov)
  • Cancer develops when the balance between cell proliferation and cell death is disrupted, and the ensuing aberrant proliferation leads to tumor growth. (aacrjournals.org)
  • However, a number of recent studies have pointed out that in addition to being an inhibitor of cell proliferation, p21 acts as an inhibitor of apoptosis in a number of systems, and this may counteract its tumor-suppressive functions as a growth inhibitor. (aacrjournals.org)
  • Active cyclin/Cdk complexes phosphorylate and inactivate members of the retinoblastoma protein (Rb) family that are negative regulators of G 1 and S-phase progression, leading to induction of E2F-regulated gene expression and cell proliferation. (aacrjournals.org)
  • In glioma ( 28 ) and in vascular smooth muscle cells ( 29 ), p21 facilitates active cyclin-Cdk complex formation and induces cell proliferation. (aacrjournals.org)
  • Previous studies have demonstrated that tumorigenesis is caused by gene mutations in cells Such as TP53, which results in an unrestricted cellular proliferation and resistance to apoptosis ( 4-6 ). (spandidos-publications.com)
  • The knockdown of UBE2V2 inhibited cells proliferation, reduced the proportion of cells in S phase and promoted cell apoptosis. (researchsquare.com)
  • MTT assay and colony forming assay were used to assess the effect of matrine on growth and proliferation of HCC cells. (mdpi.com)
  • Numerous studies confirmed that deguelin activated the virus signaling pathway for inhibiting tumor cell proliferation with no or less toxicity ( 5 - 8 ), while demonstrating the highest activity in inhibiting DMBA-induced tumorigenesis compared with tephrosin, 13α-hydroxytephrosin and 13α-hydroxydeguelin. (spandidos-publications.com)
  • Apoptosis is a crucial step in cancer therapy and prevention, whereby cells undergo programmed death to eliminate the damaged and harmful cells and restrict cell proliferation. (spandidos-publications.com)
  • 13] The toxin binds directly to the major histocompatability complex (MHC) class II proteins on target cells, subsequently stimulating the proliferation of large numbers of T lymphocytes. (medscape.com)
  • Animal studies have shown that the severe pulmonary edema associated with aerosol exposure is likely secondary to T-cell proliferation within the respiratory mucosa and not the toxin itself. (medscape.com)
  • Cell growth and proliferation is associated with β-catenin translocation from the cytoplasm into the nucleus. (biomedcentral.com)
  • The nuclear β-catenin has an important function in many human malignancies [ 1 ] by stimulating cell growth and proliferation. (biomedcentral.com)
  • Interestingly, RSPO1 -mutated PPK skin expressed markers of increased proliferation, dedifferentiation and altered cell-cell adhesion. (biomedcentral.com)
  • It consists of persistent thickening of the epidermis over the palms and soles and is characterized by keratinocyte hyperproliferation and excessive production of horny layer (hyperkeratosis) that develop in response to an inherent fragility of the tissue or a dysregulation of cell proliferation. (biomedcentral.com)
  • Functionally, adipocyte niches elicit a fate switch in ALL cells towards slow-proliferation and cellular quiescence, highlighting the critical contribution of the adipocyte dynamic to disease establishment and chemotherapy resistance. (nature.com)
  • The A 3 adenosine receptor (A 3 AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. (nih.gov)
  • The hormones attach to these receptor sites and promote cell proliferation. (lifeextension.com)
  • KGF has been shown to regulate proliferation and differentiation in epithelial tissues and may regulate the stem cells of the hair follicle. (whollykaw.com)
  • Researchers are not sure how ViMs survive chemotherapy, but investigators ruled out mechanisms other cells use to resist radiation or certain chemotherapy drugs. (stjude.org)
  • Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? (nih.gov)
  • Despite nearly two decades of research investigating the use of dietary antioxidant supplementation during conventional chemotherapy and radiation therapy, controversy remains about the efficacy and safety of this complementary treatment. (nih.gov)
  • Several randomized clinical trials have demonstrated that the concurrent administration of antioxidants with chemotherapy or radiation therapy reduces treatment-related side effects. (nih.gov)
  • However, other data suggest that antioxidants can protect normal tissues from chemotherapy- or radiation-induced damage without decreasing tumor control. (nih.gov)
  • On the basis of our review of the published randomized clinical trials, we conclude that the use of supplemental antioxidants during chemotherapy and radiation therapy should be discouraged because of the possibility of tumor protection and reduced survival. (nih.gov)
  • Whole Brain Radiation induces neurological deterioration that is progressive and often irreversible. (cancer.org)
  • As if my wife's complications with Radiation Necrosis, brought on by Whole Brain Radiation and Taxol/Carboplatin chemotherapy weren't enough, she was subjected to improper medical protocol for brain and spinal MRI's for metastatic disease(unenhanced instead of enchanced-contrast), which left an undiagnosed tumor on her spine. (cancer.org)
  • Late delayed effects, occuring several months to many years later are classified into diffuse white-matter injury, radiation-induced arteriopathy & stroke and late delayed radiation necrosis. (cancer.org)
  • But new drugs and therapies help reduce the ill effects of chemotherapy and radiation. (webmd.com)
  • I still have plenty of energy," by the end of chemotherapy and radiation you may feel lucky if you can get out of bed. (webmd.com)
  • Lung cancer treatment depends on the subtype of the cancer and its stage, but can involve surgery, chemotherapy, and radiation. (lifeextension.com)
  • Based on this difference, we suggest a new strategy, utilizing protection of normal brain cells by mitochondria-targeted electron scavengers and antioxidants-nitroxides-thus allowing for the escalation of the radiation doses. (cdc.gov)
  • For chemotherapy treatment, the cannabinoids can also protect the brain cells from the neurotoxicity treatments, PEA, an endocannabinoid-like compound, can help protect the heart cells and CBD lessens the ulcers of radiation therapy. (projectcbd.org)
  • The majority of participants in this group had had either surgery, chemotherapy, or radiation therapy. (projectcbd.org)
  • Preclinical research indicates peppermint protects against radiation-induced DNA damage and cell death. (naturalblaze.com)
  • Now, a small, short-term experiment in mice indicates that prunes may protect our bones from the damaging effects of space radiation. (popsci.com)
  • That's not only good news for astronauts, but also for chemotherapy patients and radiation workers here on Earth. (popsci.com)
  • Normally, exposure to ionizing radiation increases the activity of cells whose job is to break down bone. (popsci.com)
  • Gamma radiation isn't exactly the same as space radiation, but both kinds are ionizing radiation, meaning they like to pull electrons off the atoms in your cells. (popsci.com)
  • Again, the prunes seemed to fully protect against the bone-damaging effects of ionizing radiation. (popsci.com)
  • If they could isolate the chemicals that may protect against radiation, that would make it easier to control the dosage. (popsci.com)
  • It also helps to reverse skin thinning, promote healing, protect from free radicals, UV radiation, and chemotherapy damage to the skin. (whollykaw.com)
  • Overexpression of TRIM21 protected NPC cells from radiation mediated cell apoptosis in vitro and in vivo. (biomedcentral.com)
  • According to Mount Sinai Hospital in New York, US researchers consider astragalus a possible treatment for patients with cancer whose immune systems have been weakened by chemotherapy or radiation. (todaysdietitian.com)
  • 1. Menstrual blood-derived endometrial stem cells ameliorate the viability of ovarian granulosa cells injured by cisplatin through activating autophagy. (nih.gov)
  • 6. Autophagy Promotes the Survival of Adipose Mesenchymal Stem/Stromal Cells and Enhances Their Therapeutic Effects in Cisplatin-Induced Liver Injury via Modulating TGF-β1/Smad and PI3K/AKT Signaling Pathways. (nih.gov)
  • 15. Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis. (nih.gov)
  • Impact Hearing loss, both adult and pediatric, due to life-saving cisplatin chemotherapies. (ca.gov)
  • These include some antibiotics and the chemotherapy drug cisplatin. (nih.gov)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • NGF at 5 ng/ml is able to protect neurons against the cisplatin damage. (neurofit.com)
  • There is currently no FDA-approved therapy for the prevention or treatment of cisplatin-induced hearing loss. (nih.gov)
  • Herein we examine the potential for statins to prevent cisplatin-induced ototoxicity. (nih.gov)
  • More robust antitumor activity is observed when the inhibitors are combined with standard chemotherapy agents and radiotherapy. (medscape.com)
  • This is because EGFr activation seems to protect malignant cells from chemotherapy- and radiotherapy-induced cell death. (medscape.com)
  • Blocking EGFr activation enhances tumor specific destruction by standard chemotherapy agents and radiotherapy. (medscape.com)
  • Responses to single agent ZD1839 in this population of SCCHN are very encouraging and may predict major interactions with standard chemotherapy and radiotherapy. (medscape.com)
  • Surgical resection combined with chemotherapy or radiotherapy remains the primary treatment for CC ( 2 ). (spandidos-publications.com)
  • Antioxidants and natural compounds can improve the effectiveness of radiotherapy and chemotherapy. (canceractive.com)
  • Recently, I was asked by a lady with Breast cancer about taking antioxidants at the same time as chemotherapy or radiotherapy. (canceractive.com)
  • One of the most stupid phrases you will hear uttered by doctors and nurses is that an antioxidant protects cells and that they don't want cancer cells 'protected' while they use chemotherapy or radiotherapy. (canceractive.com)
  • Many 'treatments' sensitise cancer cells, ensuring MORE are killed by chemotherapy or radiotherapy. (canceractive.com)
  • Moreover, the in vitro and in vivo results validated the finding that SERPINB5 promoted NPC cell radioresistance, and the radioresistant patients had higher SERPINB5 expression. (biomedcentral.com)
  • The possible approaches include using drugs or signaling molecules called cytokines to induce protection in the immune-compromised host. (stjude.org)
  • The cytokines cause a recruitment of additional inflammatory cells. (medscape.com)
  • Ingestion of SEB produces profound gastrointestinal (GI) symptoms, including anorexia, nausea, vomiting, and diarrhea, which are believed to be mediated through the release of cytokines from T cells in the lamina propria of the intestines. (medscape.com)
  • These cells also make cytokines, which can damage other cells and contribute to chronic inflammation during later life. (nih.gov)
  • However, the EGFr is expressed on the majority of squamous cell head and neck tumors in vivo and is highly overexpressed in many of these tumors. (medscape.com)
  • In vivo studies revealed that ADSCs transplantation reduced the apoptosis of ovarian granulosa cells and secretion of follicle-stimulating hormone. (biomedcentral.com)
  • These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)
  • This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
  • Dr. Leonard Hayflick first observed senescent cells in vivo in the early 1960s. (nih.gov)
  • The glycoprotein CD44 functions by binding to its major ligand hyaluronic acid (HA), which is expressed by BM stromal cells and endothelial cells. (haematologica.org)
  • EMT involves the following steps in tumour metastasis: firstly, epithelial tumour cells degrade the basement membrane and invade surrounding parenchymal tissues (invasion), and then epithelial tumour cells pass through endothelial cells into blood vessels and lymphatic channels (intravascular infiltration). (researchsquare.com)
  • comprising a highly diverse network of cellular (mesenchymal stroma, osteoblasts and endothelial cells), soluble and structural factors that work together to coordinate and maintain haematopoietic stem cell (HSC) function 11 . (nature.com)
  • 3. Endometrial stem cells repair injured endometrium and induce angiogenesis via AKT and ERK pathways. (nih.gov)
  • In the comprehensive signaling network of tumorigenesis, metastasis, apoptosis and angiogenesis, deguelin is pivotal in inducing apoptotic cell death and prohibiting their malignant transformation. (spandidos-publications.com)
  • Deguelin has been reported to kill cancer cells or inhibit tumor growth through targeting apoptosis, cell cycle arrest and anti-angiogenesis, including PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin pathways. (spandidos-publications.com)
  • Aspirin blocks the enzyme COX-2, which is responsible for the production of prostaglandin E2, a substance involved in inflammation that induces tumor-associated angiogenesis as well as aromatase expression. (lifeextension.com)
  • These findings highlighted the importance of finding a promising therapeutic strategy to inhibit oxidative damage and apoptotic cell death in DOX-related cardiotoxicity. (hindawi.com)
  • Drinking grape juice 30 minutes before meals for a week following each cycle of chemotherapy doesn't seem to reduce nausea or vomiting caused by chemotherapy. (medlineplus.gov)
  • One of the most common (and awful) side effects of many types of chemotherapy is nausea and vomiting . (webmd.com)
  • Some women are so affected by chemotherapy nausea that, even years later, they find themselves searching for a bathroom or a bucket at the mere sight of their oncologist. (webmd.com)
  • Now, a new drug is helping many more women get through chemotherapy nausea-free. (webmd.com)
  • Emend , approved by the FDA in 2003, works differently than many of the other standard anti-nausea medications used with chemotherapy. (webmd.com)
  • It's effective at staving off "delayed-onset" nausea, which hits 24 to 48 hours after a chemotherapy dose and can last as long as five days. (webmd.com)
  • In studies, Emend kept about 20% more patients nausea-free for up to five days following chemotherapy. (webmd.com)
  • A 2013 study found that peppermint oil was found to be effective in reducing chemotherapy-induced nausea, and at reduced cost versus standard drug-based treatment. (naturalblaze.com)
  • Yamoah overviewed the biological mechanisms of hearing and discussed his stem cell research, which seeks to regenerate hair cells of the inner ear in order to restore hearing. (ca.gov)
  • The Laboratory of Cardiac Physiology, led by Dr. Elizabeth Murphy, studies the molecular mechanisms involved in cardiac cell death, as well as the mechanisms that protect the heart against damage. (nih.gov)
  • Cancer cells are not foreign to the body but their biological function has been altered in that it doesn't respond to the body's normal mechanisms for controlling cell growth and reproduction. (cancer.org)
  • It has been recognized that genes identified from drug-induced resistant cell models may simply represent drug-induced transcriptional changes that may be irrelevant to resistance mechanisms [ 15 ]. (oncotarget.com)
  • The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. (aacrjournals.org)
  • Moreover, cancer cells can develop mechanisms to detoxify and eliminate doxorubicin from the cellular environment. (spandidos-publications.com)
  • 1 A better understanding of the adhesive mechanisms that facilitate the interactions between AML cells and the supportive microenvironment may pave the way for novel combination therapies antagonizing residual disease. (haematologica.org)
  • Our study was designed to investigate the role and related mechanisms of autophagy in matrine-induced apoptosis in hepatoma cells of HepG2 and Bel 7402 . (mdpi.com)
  • Whether cell types exposed to a high level of environmental insults possess cell type-specific prosurvival mechanisms or enhanced DNA damage repair capacity is not well understood. (ox.ac.uk)
  • DOX-induced oxidative damage and cardiomyocyte loss have been recognized as the potential causative mechanisms of this cardiac toxicity. (hindawi.com)
  • Nrf2 induction or overexpression is shown to heighten cellular defense mechanisms during metabolic stress and convey neuroprotection during toxin-induced stress to the point of reduced lesion development. (biologicpharmamedical.com)
  • Most patients had received prior chemotherapy but none had more then 1 prior regimen. (medscape.com)
  • We have identified a new form of housekeeping macrophage in mice that may in future be harnessed to protect against lung infections like bacterial pneumonia that remain one of the greatest threats to survival of cancer patients during chemotherapy," said senior and corresponding author Peter Murray, Ph.D., a member of the St. Jude Department of Infectious Diseases and Department of Immunology . (stjude.org)
  • The challenge has been how to create protective immunity in patients whose neutrophils have been severely depleted by chemotherapy. (stjude.org)
  • Working in a mouse model that mimics infection in chemotherapy-treated patients, the researchers were surprised to find that vaccination protected mice from lethal Pseudomonas aeruginosa pneumonia. (stjude.org)
  • Therapeutic Candidate or Device B cells will be isolated from patients suffering MPSI. (ca.gov)
  • We met a number of other patients that didn't make it through their chemotherapy treatments. (cancer.org)
  • Longer-lasting drugs to treat chemotherapy-induced anemia , which can leave patients drained and dragging, are now available, says Pegram. (webmd.com)
  • In primary AML BM samples from patients and the OCI-AML3 cell line, CD44 engagement by hyaluronan induced inside-out activation of VLA-4 resulting in enhanced leukemia cell adhesion on VCAM-1. (haematologica.org)
  • Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
  • Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
  • In recent years, despite having more diagnostic technologies and novel treatment methods, a large number of LUAD patients were still diagnosed as advanced stage and were resistant to traditional chemotherapy drugs so that their 5-year overall survival (OS) remains low[5]. (researchsquare.com)
  • A study of lung cancer patients found significantly higher 5-year survival rates and tumor regression rates in those who received melatonin each evening while undergoing chemotherapy compared with those who received chemotherapy alone. (lifeextension.com)
  • They presumed that the patients with intact versions would have fared better after surgery, because their p53 proteins would hit the self-destruct button in lingering cancer cells. (bioedonline.org)
  • These studies conflict with other reports that p53 is essential for patients' response to chemotherapy, so teasing apart p53's myriad roles will be no easy task. (bioedonline.org)
  • First Kansa Medical School in 2012, and then Ohio State Medical School in 2016 have shown that Intravenous vitamin C used with chemotherapy drugs actually produces a significant increase in survival times, the latter work being done in full clinical trials on patients with brain tumours and non-small cell lung cancer. (canceractive.com)
  • It's critical that we continue to raise awareness about the unmet need in CIN since it can be a life-threatening side effect of chemotherapy, and preventing it can make a significant impact on the lives of patients. (beyondspringpharma.com)
  • Many patients who undergo chemotherapy experience debilitating fatigue for months. (nih.gov)
  • Sharpless noted that "chemotherapy-induced fatigue is a limiting toxicity in many patients. (nih.gov)
  • He described a means to reduce the toxicity of chemotherapy for cancer patients, in a way to protect their hematopoietic stem cells. (nih.gov)
  • We have previously reported that palmoplantar keratoderma (PPK), predisposition to cutaneous squamous cell carcinoma (SCC) development and sex reversal segregate as autosomal recessive trait in patients carrying RSPO1 -mutations. (biomedcentral.com)
  • Patients holding BCL11B mutations show primary immunodeficiency due to T cell insufficiency [38C40]. (niepokorny.org)
  • Isoprenaline can also ameliorate the impairment of intestinal stem cells mediated by β2-adrenoreceptors after chemotherapy. (wikipedia.org)
  • Research Objective Development of a screen using inner ear sensory hair cell-like cells made by direct lineage reprogramming, for discovering drugs to ameliorate hearing loss during cancer chemotherapy. (ca.gov)
  • Additionally, RBAC has been shown to ameliorate irritable bowel syndrome and protect against liver injury caused by hepatitis or nonalcoholic fatty liver disease. (researchgate.net)
  • Overexpression of antioxidant enzymes can ameliorate DOX-induced cardiotoxicity in mice [ 7 , 8 ]. (hindawi.com)
  • As the old inhibitor of mitochondrial complex I (NADH), rotenone contributes to electron transport chain-blocking and ATP depletion, as well as cell toxicity. (spandidos-publications.com)
  • Both the U.S. EPA and U.S. FDA have received unpublished animal toxicity reports, which are protected, in part, as confidential business information. (nih.gov)
  • Activated protein kinase B (AKT) activation was essential for the protective effects of Mul against DOX-induced cardiac toxicity, and AKT inactivation abolished Mul-mediated protective effects against DOX cardiotoxicity. (hindawi.com)
  • In conclusion, Mul treatment attenuated DOX-induced cardiac toxicity via activation of the AKT signaling pathway. (hindawi.com)
  • Mul might be a promising therapeutic agent against DOX-induced cardiac toxicity. (hindawi.com)
  • 5. Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy. (nih.gov)
  • DOX-induced oxidative damage, inflammation accumulation, and myocardial apoptosis were largely attenuated by the treatment of Mul. (hindawi.com)
  • DOX-dependent oxidative damage induced the release of cytochrome C and subsequent activation of caspase 3, causing myocardial apoptosis [ 9 ]. (hindawi.com)
  • High levels of vitamin C (millimolar concentrations) are maintained in cells and tissues and are highest in leukocytes (white blood cells), eyes, adrenal glands, pituitary gland, and brain. (nih.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Amongst others, the succinate receptor is involved in recruitment of immune cells to transplanted tissues. (frontiersin.org)
  • Chemotherapy does cause collateral damage to normal tissues, and the broad tissue damage is one source of this fatigue," says Mark Pegram, MD, director of the Women's Cancer Program at the Jonsson Comprehensive Cancer Center at UCLA. (webmd.com)
  • Until we have more targeted therapies that don't damage normal tissues as much as chemotherapy does, we will have to try to manage fatigue as best we can. (webmd.com)
  • Ischemia is a common cause of cell dysfunction and death due to interruption of blood flow or oxygen availability to tissues. (biologicpharmamedical.com)
  • Over half a million Americans experience hearing loss every year from ototoxic drugs-drugs that can damage hair cells in the inner ear. (nih.gov)
  • In addition, about 15 percent of Americans between the ages of 20 and 69 have noise-induced hearing loss, which also results from damage to the sensory hair cells. (nih.gov)
  • In the heart, interruption of the blood supply can result in cardiac cell death and irreversible muscle damage. (nih.gov)
  • Asthma involves free-radical damage that selenium might protect against. (peacehealth.org)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • McDonald points out that p53 doesn't just spur cell suicide - it also helps cells to repair genetic damage. (bioedonline.org)
  • Those lipid changes sound and are very destructive, but prostate cancer can be particularly insensitive to them and to drugs designed to induce this sort of excess iron damage, because the cancer cells already require some similar changes to lipids in the cell membrane to ensure they have the large amount of energy they need to survive, grow and spread. (reachmd.com)
  • One way JKE-1674 works is by inhibiting GPX4, which has the added advantage of repairing some of the damage to the lipids that makes prostate cancer cells insensitive to death by ferroptosis. (reachmd.com)
  • A tumor-suppressor gene called p16INK4a (p16) activates the senescence process once it senses damage to a cell. (nih.gov)
  • By promoting error-prone DNA damage repair via NHEJ and suppressing apoptosis of damaged cells, our results suggest that BRN2 contributes to the generation of melanomas with a high mutation burden. (ox.ac.uk)
  • One of the b-glucuronidase inhibitors identified by the Redinbo research group protects BALB/cJ mice against CPT-11-induced diarrhea and intestinal damage. (jax.org)
  • They found that it protects BALB/cJ ( 000651 ) mice against CPT-11-induced diarrhea and intestinal damage. (jax.org)
  • It's known to be central to the pathology of stroke and one of the more common causes of permanent cell and tissue damage in heart disease. (biologicpharmamedical.com)
  • EGFr function is diverse, complex, and redundant in normal and malignant cells, and there are many ways to inhibit or manage its activation. (medscape.com)
  • 14. Activation of the Hippo/TAZ pathway is required for menstrual stem cells to suppress myofibroblast and inhibit transforming growth factor β signaling in human endometrial stromal cells. (nih.gov)
  • CKIs bind and inhibit the activity of cyclin/Cdk complexes and negatively regulate cell cycle progression (reviewed in Refs. (aacrjournals.org)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • Do chemotherapy drugs prevent antioxidants working? (canceractive.com)
  • Adipose-derived stem cells (ADSCs) were isolated and identified from human adipose tissue. (biomedcentral.com)
  • Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. (nih.gov)
  • Mul reduced spinal cord injury-induced apoptosis and inflammation and attenuated hepatic fibrosis by targeting nuclear factor E2-related factor 2 (Nrf2) in mice [ 11 , 12 ]. (hindawi.com)
  • ATF3 in turn induces expression of HMOX1, an enzyme and known antioxidant which basically cuts iron loose from places like hemoglobin so more can accumulate inside cells, which is lethal. (reachmd.com)
  • Adding to the outstanding outside-in antioxidant activity, curcumin III (BDMC) is shown to activate endogenous or internal antioxidant defence systems that protect organelles of the cell by inducing Nrf2 activity. (biologicpharmamedical.com)
  • Nrf2 is a regulator (transcription factor) of the endogenous antioxidant defense systems built into our cells - Catalase (CAT), Super Oxide Dismutase (SOD) , Glutathione peroxidase enzymes (GPx) and others like Hemoxygenase-1. (biologicpharmamedical.com)
  • Often, people who undergo chemotherapy develop aversions to certain foods, sometimes making it permanently difficult to eat those foods. (peacehealth.org)
  • 7. Autophagy induces G0/G1 arrest and apoptosis in menstrual blood-derived endometrial stem cells via GSK3-β/β-catenin pathway. (nih.gov)
  • 9. Nonfreezing Low Temperature Maintains the Viability of Menstrual Blood-Derived Endometrial Stem Cells Under Oxygen-Glucose Deprivation Through the Sustained Release of Autophagy-Produced Energy. (nih.gov)
  • 19. Guizhi Fuling Wan reduces autophagy of granulosa cell in rats with polycystic ovary syndrome via restoring the PI3K/AKT/mTOR signaling pathway. (nih.gov)
  • In the initial stage of cancer, autophagy promotes the survival of normal cells and inhibits carcinogenesis by removing damaged organelles and DNA. (spandidos-publications.com)
  • In addition, autophagy is a research target for cancer therapy by affecting cancer cells, stromal cells, and immune cells in the complex cancer microenvironment ( 8 ). (spandidos-publications.com)
  • Autophagy, also known as type II programmed cell death, is a highly-conserved process of cellular destruction that transfers intracellular substances (including proteins, lipids and organelles) to lysosomes for degradation. (spandidos-publications.com)
  • 2. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. (nih.gov)
  • St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy. (stjude.org)
  • This newly recognized cell type also showed enhanced anti-bacterial activity in mice that lacked neutrophils due to chemotherapy. (stjude.org)
  • When ViMs were transferred to unvaccinated mice with chemotherapy-depleted neutrophils, they were protected from lethal Pseudomonas infections. (stjude.org)
  • Researchers have found in mice that supporting cells in the inner ear, once thought to serve only a structural role, can actively help repair damaged sensory hair cells, the functional cells that turn vibrations into the electrical signals that the brain recognizes as sound. (nih.gov)
  • This notion is supported by data indicating that p21-null mice are more prone to spontaneous and induced tumorigenesis, and p21 synergizes with other tumor suppressors to protect against tumor progression in mice. (aacrjournals.org)
  • Based on these reports, we speculated that Mul might protect against DOX-related cardiac injury in mice. (hindawi.com)
  • downregulated T cell-associated genes such as for example and knockout mice neglect to MK-0812 go through -selection [27]. (niepokorny.org)
  • Chemotherapeutic drugs, particularly alkylating cytotoxics such as cyclophosphamide (CTX), play an important role to induce premature ovarian failure (POF). (biomedcentral.com)
  • Our experiment demonstrated that a single injection of high-dose CTX was a less damaging chemotherapeutic strategy than continuous injection of low-dose CTX, and tail-vein injection of ADSCs was a potential approach to promote the restoration of CTX-induced POF. (biomedcentral.com)
  • 1 These microenvironmental interactions contribute to protect leukemic stem cells from chemotherapeutic drugs, thus allowing residual disease after therapy, ultimately causing relapses. (haematologica.org)
  • We now know that increasing the number of ViMs in the tissue can compensate for the immune deficit caused by chemotherapy," Kamei said. (stjude.org)
  • Going forward we will explore other, more practical methods for use at the bedside to effectively induce tissue resident macrophages like ViMs. (stjude.org)
  • Here, we defined differentially expressed genes (DEGs) between pre-chemotherapy colorectal cancer (CRC) tissue samples of non-responders and responders for 5-fluorouracil and oxaliplatin-based therapy as clinically relevant drug resistance genes (CRG 5-FU/L-OHP ). (oncotarget.com)
  • This study suggests a novel strategy to extract clinically relevant drug resistance genes from both drug-induced resistant cell models and post-chemotherapy cancer tissue specimens. (oncotarget.com)
  • Because senescent cells don't divide, they can't regenerate tissue, Sharpless said. (nih.gov)
  • Their work has also shown that p53 can protect the mitochondrial genome and prevent chemotherapy-induced heart failure, an observation that they are further dissecting molecularly and translating to the clinics. (nih.gov)
  • Phosphorylation of PINK1 is not only required for the PINK1-mediated mitochondrial recruitment of Parkin but also induces its kinase activity toward Parkin. (sdbonline.org)
  • Glioma cells are reported to have less mitochondrial content compared to adjacent normal brain cells. (cdc.gov)
  • An extract of Stevia rebaudiana leaves and stevioside ameliorates lipopolysaccharide induced acute liver injury. (greenmedinfo.com)
  • Ischemic heart disease is a leading cause of death in the U.S. Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPSCs) have been studied as a therapy to improve cardiac function following acute or chronic ischemia. (nih.gov)
  • The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. (nature.com)
  • The onset of DOX-induced cardiotoxicity can be acute, occurring within 2-3 days or be chronic until several months after the end of chemotherapy [ 3 ]. (hindawi.com)
  • Current studies pay more attention to DOX-related chronic cardiomyopathy but lose sight of the clinical importance of DOX-induced acute cardiotoxicity. (hindawi.com)
  • Currently, there are no molecules with an actual cardioprotective effect on DOX-induced acute cardiotoxicity. (hindawi.com)
  • Acute inactivation of in adult T cells induces their reprogramming into induced T-to-NK cells (ITNKs) [16]. (niepokorny.org)
  • Furthermore, tumour cells metastasize to various parts of the body under the entire body fluid circulation system (systemic transport). (researchsquare.com)
  • Eventually, tumour cells surviving in the blood pass through capillaries into the distant parenchymal organs (extravasation) and continue to grow malignant tumours in the new matrix environment (colonization)[7-9]. (researchsquare.com)
  • In the process of morphological changes of neuroectoderm and mesoderm cells, Snail promotes the conversion of DE-cadherin expression to DN- cadherin type so that EMT occurs[11].In addition, EMT transformation promoted the expression of MMPs family proteins (MMP 1, 2, 7) through the up-regulated expression of Snail and SIP1, and degraded extracellular matrix proteins to increase tumour cell infiltration ability[12]. (researchsquare.com)
  • The results are surprising, because the p53 protein is a so-called 'tumour suppressor' that induces suicide in damaged cells, thereby preventing them from seeding new cancers. (bioedonline.org)
  • Sloan Kettering showed that using melatonin with chemotherapy produced a 40 per cent increased one year survival, and a 93 per cent better chance of the tumour disappearing. (canceractive.com)
  • The fact is that no chemotherapy drug kills off the cancer stem cells - the 3% of cancer cells in the heart of the tumour that control everything. (canceractive.com)
  • Dr. Young S. Kim of the National Cancer Institute in the USA has stated from her research that a poor diet will help the cancer stem cells and the tumour re-grow. (canceractive.com)
  • Abstract History Adoptive cell therapy (Work) can be a guaranteeing part of tumor immunotherapy especially, built T and NK cells that communicate chimeric antigen receptors (CAR) are becoming explored for dealing with hematopoietic malignancies but show limited medical benefits for solid tumour individuals, successful mobile immunotherapy of solid tumors needs new strategies. (niepokorny.org)
  • Mechanistically, adipocyte niche interaction targets posttranscriptional networks and suppresses protein biosynthesis in ALL cells. (nature.com)
  • Mechanistically, Bcl11b represses the transcription of Identification2 straight, which governs NK cell destiny, and Zbtb16, which is vital in innate-type T cells and innate lymphoid cells [20, 32C34]. (niepokorny.org)
  • 4. FTO protects human granulosa cells from chemotherapy-induced cytotoxicity. (nih.gov)
  • The body's immune system attacks and eliminates not only bacteria and other foreign substances but also cancer cells. (cancer.org)
  • One more piece is the body's natural mechanism to cope with this unhealthy pairing of iron and ROS so that a lot of good cells don't die as a result. (reachmd.com)
  • For example, chemotherapy can interfere with the body's ability to produce blood cells, Sharpless explained. (nih.gov)
  • Once destroyed or damaged by noise or drugs, sensory hair cells in the inner ears of humans don't grow back or self-repair, unlike the sensory hair cells of other animals such as birds and amphibians. (nih.gov)
  • Relatively low levels of vitamin C (micromolar concentrations) are found in extracellular fluids, such as plasma, red blood cells, and saliva [ 4 ]. (nih.gov)
  • Cultured PPK patient's keratinocytes exhibited increased expression of cell‒matrix adhesion proteins and extracellular matrix remodeling enzymes. (biomedcentral.com)
  • p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer. (nih.gov)
  • Cancer Cell 30(4):595-609. (nih.gov)
  • That can lead to a dramatic reduction in white blood cells, including the neutrophils that play a central role in combating bacterial and other infections that are a common complication of cancer chemotherapy. (stjude.org)
  • Until recently, few molecular signatures of drug resistance identified in drug-induced resistant cancer cell models can be translated into clinical practice. (oncotarget.com)
  • In the current review, we discuss the role of p21 in regulating cell death and the potential relevance of its expression in cancer. (aacrjournals.org)
  • In late 2004, Memorial Sloan-Kettering Cancer Center in New York made Emend part of its standard regimen of drugs for women undergoing breast cancer chemotherapy. (webmd.com)
  • On the basis of histopathology, lung cancer is composed of two types: Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC). (researchsquare.com)
  • Therefore, key regulatory components involved in apoptotic or anti-apoptotic pathways are necessary with a view to developing new targeting agents, with fewer side effects, eliminating cancer cells ( 9 ). (spandidos-publications.com)
  • Deguelin is known to induce apoptosis by disrupting anti-apoptosis signaling, such as the PI3K/Akt pathway in lung and breast cancer. (spandidos-publications.com)
  • Selenium appears to protect against a variety of cancers, including colon cancer. (peacehealth.org)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • Lung cancer occurs when cells in the lungs grow out of control. (lifeextension.com)
  • Staging: The extent of the cancer is determined by tumor size, whether cancer cells have spread to nearby lymph nodes, and whether additional metastatic events have occurred. (lifeextension.com)
  • On the flipside, the mutated version of the gene, which usually cannot protect against cancer, might work to a patient's advantage during therapy. (bioedonline.org)
  • This is thought to help the body deliver a knockout blow to cancer cells that are weakened by chemotherapy. (bioedonline.org)
  • THC and CBD often work together well, some of their functions being mediated by effects on a cancer cell's mitochondria (powerhouse of the cell). (projectcbd.org)
  • In six human cancer cell lines, the inhibition of total and nuclear expression of β-catenin by MSeA was dose and time dependent. (biomedcentral.com)
  • The biochemistry of a cancer cell is completely different to that of a healthy cell. (canceractive.com)
  • What protects a healthy cell is unlikely to afford any protection to a cancer cell. (canceractive.com)
  • And curcumin has a harmful effect on several unique processes (like the M-TOR pathway) only found in a cancer cell. (canceractive.com)
  • But it damages cancer cells and it sensitises them, which makes chemotherapy work better. (canceractive.com)
  • For example, increasing your blood oxygen levels by exercising or using Hyperbaric Oxygen renders cancer cells more sensitive to attack. (canceractive.com)
  • But if you don't kill off the cancer stem cells they can regrow. (canceractive.com)
  • Prostate cancer can come back from common hormone deprivation therapy with a vengeance and no clear treatment option, but scientists have early evidence that one way to kill these recurring cancer cells may be with a lot of iron. (reachmd.com)
  • The metal that is key to our red blood cells carrying oxygen and other body fundamentals also is known to be lethal to cells in big doses, but prostate cancer cells are essentially impervious to it, says Dr. Chunhong Yan, molecular biologist at the Georgia Cancer Center and Department of Biochemistry and Molecular Biology at the Medical College of Georgia. (reachmd.com)
  • But the MCG research team has found that the gene, ATF3, a regulator of cell stress which they have shown also can suppress prostate cancer, can make prostate cancer cells more vulnerable to a newer compound, JKE-1674, that can help induce ferroptosis. (reachmd.com)
  • Basically, if you reduce prostate cancer cells' ability to ignore stress, they will die, Yan says. (reachmd.com)
  • Another piece of the puzzle they have found is that the drug bortezomib, a chemotherapy agent used to treat multiple myeloma, a cancer of the plasma cells that normally produce antibodies to help protect us from infections, is a good partner because it can increase expression of ATF3, or activating transcription factor 3. (reachmd.com)
  • In a cell culture, Yan's team has watched increased ATF3 expression sensitize human prostate cancer cells to death by iron, and the new DOD funded studies are enabling the next steps: studying the induction in a mouse with human prostate cancer, called a humanized mouse model, to see whether ATF3-induced bortezomib paired with JKE-1674 again induces ferroptosis in advanced, typically lethal prostate cancer. (reachmd.com)
  • Yan and his colleagues also want to learn more about how ATF3 makes prostate cancer cells more vulnerable to death by iron with the help of agents like bortezomib. (reachmd.com)
  • NEW YORK, Sept. 09, 2021 (GLOBE NEWSWIRE) - BeyondSpring (the "Company" or "BeyondSpring") (NASDAQ: BYSI), a global pharmaceutical company focused on the development of cancer therapeutics, today announced three poster presentations of new data supporting the combination of plinabulin and G-CSF for the prevention of chemotherapy-induced neutropenia (CIN) at the European Society for Medical Oncology 2021 Congress taking place virtually September 16-21, 2021. (beyondspringpharma.com)
  • It is a novel, intravenous infused, patent-protected, NDA stage asset for CIN prevention and a Phase 3 anti-cancer candidate for non-small cell lung cancer (NSCLC). (beyondspringpharma.com)
  • Plinabulin triggers the release of the immune defense protein, GEF-H1, which leads to two distinct effects: first is a durable anticancer benefit due to the maturation of dendritic cells resulting in the activation of tumor antigen-specific T-cells to target cancer cells, and the second is early-onset of action in CIN prevention after chemotherapy by boosting the number of hematopoietic stem/progenitor cells (HSPCs). (beyondspringpharma.com)
  • A process that prevents damaged cells from dividing also prevents the development of cancer, said NCI director Dr. Ned Sharpless. (nih.gov)
  • Sharpless, who in addition to directing NCI is chief of the aging biology and cancer section in NIA'S Laboratory of Genetics and Genomics, said chemotherapy can trigger cellular senescence. (nih.gov)
  • These cells appear to drive some of the long-term toxicities of cancer chemotherapy," he said. (nih.gov)
  • Secreted R-spondin (RSPO) proteins play a key role in reproductive organ development, epithelial stem cell renewal and cancer induction by reinforcing canonical Wnt signaling. (biomedcentral.com)
  • Hormone receptor-positive tumors consist of cancer cells with receptor sites for estrogen, progesterone, or both. (lifeextension.com)
  • In some research studies, astragalus appears to promote apoptosis, or programmed cell death, and as an ingredient in herbal formulations, it may be helpful in certain types of cancer as well as possibly increase lymphocyte activity. (todaysdietitian.com)
  • As you recover from your transplant, your white blood cell count can become very low, also known as neutropenia pdf icon [PDF - 4 pages] . (cdc.gov)
  • It is filed for approval and has received Priority Review in the U.S. and China for the prevention of chemotherapy-induced neutropenia (CIN) with a PDUFA date of November 30, 2021 in the U.S. Plinabulin and docetaxel combination has met the primary endpoint of extending overall survival in a global, randomized, active controlled Phase 3 study (DUBLIN-3) in 2nd/3rd line NSCLC (EGFR wild type). (beyondspringpharma.com)
  • 8. Human menstrual blood-derived stem cells promote the repair of impaired endometrial stromal cells by activating the p38 MAPK and AKT signaling pathways. (nih.gov)
  • 11. Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury. (nih.gov)
  • 2 In AML, targeting CD44 reduced leukemic repopulation in serial transplantations by eradication of leukemic stem cells. (haematologica.org)
  • Stem cells from your own body (also called an autologous transplant). (cdc.gov)
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • If your stem cells come from another person, you will need to take anti-rejection medication. (cdc.gov)
  • If you receive stem cells from a donor, the transplanted stem cells may attack your body. (cdc.gov)
  • Besides, we further studied the EMT signaling pathway that promotes LUAD metastasis and other phenotypic experiments by using lentivirus to transfect LUAD cells. (researchsquare.com)
  • 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. (nih.gov)
  • In vitro assay also demonstrated that ADSC markedly attenuated CTX-induced senescence and apoptosis of granulosa cell. (biomedcentral.com)
  • This has made exploring potential pathways to protect or regrow hair cells in humans a major focus of hearing research. (nih.gov)
  • So it's possible, he says, that the intact p53 genes repair cancerous cells that are injured by chemotherapy, allowing them to regrow into tumours after surgery. (bioedonline.org)
  • My wife had previous chemotherapy treatments of Taxol and Carboplatin. (cancer.org)
  • Taxol induces cell death and destruction of neurite network in sensory neurons and Schwann cells co-culture from rat embryos. (neurofit.com)
  • Taxol induced sensory neurons death. (neurofit.com)
  • The effect on normal cells is the cause of side effects from chemotherapy. (cancer.org)
  • Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects. (neurofit.com)
  • One of the disadvantages of chemotherapy is its harmful side effects. (jax.org)
  • Among on the lung cancers, NSCLC is about 80% and mainly constitutes lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC)[2]. (researchsquare.com)
  • Although chemotherapy can treat cancers, it also spurs an increase in senescent cells, he said. (nih.gov)
  • 1 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital. (aacrjournals.org)
  • But having a mutated gene may help ward off tumours after chemotherapy. (bioedonline.org)
  • BRN2 also suppresses an apoptosis-associated gene expression program to protect against UVB-, chemotherapy- and vemurafenib-induced apoptosis. (ox.ac.uk)
  • EGFr is a central molecule in the regulation of normal and malignant cell function. (medscape.com)
  • Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. (spandidos-publications.com)
  • Growing attention has been focused on the application of natural flavonoids in the chemoprevention and chemotherapy of malignant diseases. (spandidos-publications.com)
  • To shrink these malignant tumours, doctors had hit them with a dose of chemotherapy before the surgery. (bioedonline.org)
  • 10. Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion. (nih.gov)
  • 12. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency. (nih.gov)
  • 16. Effects of platelet-rich plasma on the activity of human menstrual blood-derived stromal cells in vitro. (nih.gov)
  • In further consequence, the increased adhesion on VCAM-1 allowed AML cells to strongly bind stromal cells. (haematologica.org)
  • Within the bone marrow (BM), AML cells interact and communicate with stromal and immune cells and reprogram mesenchymal stromal cells to selectively support leukemic cells, while simultaneously suppressing normal hematopoiesis. (haematologica.org)
  • reveals the rescuing act that supporting cells and a chemical they produce called heat shock protein 70 (HSP70) appear to play in protecting damaged hair cells from death. (nih.gov)
  • When utricles that had not undergone heat shock were placed in the same culture as heat-shocked utricles, the hair cells in the untreated utricle were protected from cell death after exposure to an ototoxic antibiotic. (nih.gov)
  • Cell Death Dis 7: e2501. (sdbonline.org)
  • A/Swine/Iowa/30 were protected against death and major a new drug that kills bacteria without disturbing the human weight loss and had undetectable virus in respiratory tis- host. (cdc.gov)
  • The fact that TAp63α is usually in an inactive state prevents unintended cell death and thus preserves the limited reservoir of oocytes, which cannot be replaced after an animal is born. (elifesciences.org)
  • Chemotherapy drugs kill dividing cells, including cells in the bone marrow that give rise to different immune cells. (stjude.org)
  • CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone marrow (BM). (haematologica.org)
  • CD44-induced VLA-4 activation could be inhibited by the Src family kinase inhibitor PP2 and the multikinase inhibitor midostaurin. (haematologica.org)
  • Currently, there is still a lack of effective treatments to protect and restore ovarian secretory function. (biomedcentral.com)
  • My wife almost didn't make it through her chemotherapy treatments. (cancer.org)
  • You'll also learn about promising research on new and emerging treatments, and what dietary and lifestyle changes you can make that may help keep lung cells healthy. (lifeextension.com)
  • To evaluate the effects of ADSC on granulosa cells in vitro, CTX-induced senescent KGN cells were co-cultured with ADSCs, and senescent-related marker expression was investigated by immunofluorescent staining. (biomedcentral.com)
  • Cells that can no longer divide but continue to function are called senescent cells. (nih.gov)
  • We think senescent cells hang around a long time and do stuff that's undesirable and contribute to the pathology associated with advanced age," he said. (nih.gov)
  • For example, senescent cells might get in the way and contribute to the size of atherosclerotic plaques. (nih.gov)
  • Although the immune system can clear senescent cells, its ability to do so is limited and may decrease with age. (nih.gov)
  • In mouse studies, scientists are studying several approaches to clearing senescent cells. (nih.gov)
  • The amount of senescent cells varies from patient to patient. (nih.gov)
  • His research has helped show that while senescent cell production is helpful with wound-healing and tumor suppression, this process also contributes to multiple aging-related diseases. (nih.gov)
  • Importantly, unlike other immune cells types, the size of the ViMs population remained stable during chemotherapy. (stjude.org)
  • Macrophages are a type of white blood cell that engulf and digest bacteria and other foreign invaders as well as remove dead cells. (stjude.org)
  • Researchers called the newly recognized cell type vaccine-induced macrophages (ViMs). (stjude.org)
  • St. Jude Children's Research Hospital researchers have identified a new population of resident lung macrophages (pictured here), which they called vaccine-induced macrophages or ViMs. (stjude.org)
  • Interestingly, UBE2V2 expression is negatively correlated with B cells, CD4 + T cells, macrophages and dendritic cells. (researchsquare.com)
  • Earlier work in Dr. Hwang's lab revealed that p53, one of the most commonly mutated tumor suppressor genes that controls multiple pathways involved in cell growth, also regulates the mitochondria as part of its adaptive activities against oxidative and other cellular stresses. (nih.gov)
  • This cellular protection is also seen in the context of chemotherapy where concurrent Nrf2 induction protects healthy cells. (biologicpharmamedical.com)
  • Immunophenotypic and transcriptional MK-0812 information MK-0812 of MK-0812 sgT cells had been seen as a transcriptomics and cytometer, respectively. (niepokorny.org)
  • Finding a way to jumpstart this process in supporting cells offers a potential pathway to prevent hearing loss caused by certain drugs, and possibly by exposure to excess noise. (nih.gov)
  • Some chemotherapy drugs do permeate(pass through) the blood brain barier(the system that protects the brain from foreign substances by blocking their passage from the blood). (cancer.org)
  • Within 20 minutes of searching on the Web, I had found 7 clinical studies showing that, far from being a problem, curcumin made chemotherapy drugs work better. (canceractive.com)
  • In 1991, researchers at the Institute for Hormone Research announced that they had been able to induce the body to convert the stronger form of estrogen (estradiol) into the weaker form (estriol) without using drugs. (lifeextension.com)
  • Epithelial-mesenchymal transition (EMT) refers to the biological process of epithelial cells transforming into cells with mesenchymal phenotype through different signal pathways under adverse factors, which allows these cells to gain capability of infiltration and invasion and migration[6]. (researchsquare.com)