Chemotherapy for metastatic disease. Medical search. Frequent questions

Interferon or targeted radiotherapy may also be considered in patients who are not candidates for chemotherapy. (medscape.com)
The initial treatment of choice of uterine leiomyosarcoma is the surgical resection and, in addition to this, adjuvant therapy (including chemotherapy and radiotherapy) can be used to reduce the risk of recurrence, despite the fact that the clinical efficacy is still uncertain [ 2 ]. (hindawi.com)
The integration of combination chemotherapy and radiotherapy (RT) has now become a standard of care for patients with locally advanced NSCLC. (cancernetwork.com)
In such cases direct treatment such as surgery or radiotherapy, if possible, would be appropriate after first evaluating if more widespread metastatic disease is present. (cancer.org.au)
The patient received adjuvant third-generation chemotherapy with a taxane and an anthracycline, followed by radiotherapy to the breast, supraclavicular fossa and axilla. (cmaj.ca)
Chemotherapy and radiotherapy are associated with side effects which reduce tolerance to treatment and likelihood of tumour response. (cambridge.org)
Combinations of chemotherapy and radiotherapy are also improving outcomes of loco-regional non-small-cell lung cancer. (scienceblog.com)
A study comparing radiotherapy alone to sequential chemotherapy and radiation in locally advanced non-small-cell lung cancer, plus a correlation of gene expression level with survival (UK). (scienceblog.com)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)

In a proportion of prostate cancer patients, there is evidence of metastatic disease at diagnosis or the disease recurs as distant metastasis despite standard curative treatment. (thieme-connect.com)
Clinical and radiological followup showed no evidence of metastatic disease prior to the current presentation. (hindawi.com)

Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. (drugs.com)
2] Many chemotherapy regimens have been investigated for NSCLC, but the ability of these treatments to improve overall survival is debatable. (cancernetwork.com)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

The purpose of this study is to assess the antitumor effectiveness and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. (mayo.edu)
OTCQX: RHHBY), today announced the U.S. Food and Drug Administration (FDA) has approved Herceptin ® (trastuzumab) in combination with chemotherapy (cisplatin plus either capecitabine or 5-fluorouracil [5-FU]) for HER2-positive metastatic (cancer that has spread) cancer of the stomach or gastroesophageal junction, in men and women who have not received prior medicines for their metastatic disease. (news-medical.net)
A meta-analysis (n = 52 randomized trials encompassing 9,387 patients) of the Non-Small-Cell Lung Cancer Collaborative Group indicated that cisplatin- based chemotherapy provides a significant survival benefit for patients with locally advanced or metastatic disease. (cancernetwork.com)
[ 24 ] The MAGIC (Medical Research Council Adjuvant Gastric Infusional Chemotherapy) trial showed that patients treated with perioperative epirubicin, cisplatin, and 5-fluorouracil had a significantly higher overall survival rate compared with patients treated with surgery alone. (medscape.com)
Four cycles of postoperative intravenous-chemotherapy with paclitaxel and cisplatin was carried out. (researchsquare.com)

Treatment protocols for colon cancer are provided below, including adjuvant and neoadjuvant therapy for resectable disease and therapy for advanced or metastatic colon cancer. (medscape.com)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
3. Planned to start 1st line dihydropyrimidine (i e 5-FU or capecitabine) based chemotherapy in the adjuvant, neoadjuvant or palliative setting. (who.int)
Nationwide trends and outcomes of neoadjuvant chemotherapy in pancreatic cancer - an analysis of the Swedish national pancreatic cancer registry. (cancercentrum.se)

Chemotherapy and radiation therapy have been used in metastatic disease. (wikipedia.org)
It is also rich with plenty of up-to-date information, in a well-organized and easy to use format, focusing on the treatment of bladder cancer including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy. (intechopen.com)
Unresectable or widely disseminated tumors may be palliated by adrenolytic therapy with mitotane, antihormonal drugs (i.e., ketoconazole and metyrapone), systemic chemotherapy, and/or radiation therapy. (cancer.gov)
The approval was based on results from FOCUS , a single-arm, multicenter, open-label phase III clinical trial in 91 patients with uveal melanoma who had unresectable liver metastases and no extrahepatic disease or extrahepatic metastases limited to the bone, lymph nodes, subcutaneous tissues, or lung that could be resected or treated with radiation therapy. (aacr.org)
Induction chemotherapy is typically given to patients with stage III-IVB disease in order to shrink a primary tumor to reduce its bulkiness in preparation for future surgery or radiation therapy. (medscape.com)
In such circumstances, it is not urgent to proceed with completion surgery but prompt evaluation for distant spread of the anaplastic thyroid cancer and additional chemotherapy and radiation therapy to prevent recurrence of the cancer within the neck. (thyroidcancer.com)
Depending on histologic type, local extension into adjacent anatomical structures, presence of metastases, and the general health of the patient, treatment options may include surgical excision, radiation therapy, chemotherapy, and possibly immunotherapy. (cdc.gov)

Hyperprogressive disease during nivolumab chemotherapy in metastatic gastric cancer: Multicenter retrospective study in Japan. (ascopubs.org)
Trastuzumab is indicated for the treatment of certain HER2-positive early stage and metastatic breast cancer as well as HER2-positive metastatic gastric cancer. (prnewswire.com)
In January 2010, the European Commission approved Herceptin in combination with chemotherapy for people with metastatic stomach (gastric) cancer with tumors exhibiting high levels of HER2. (news-medical.net)
Early disease is defined as adenocarcinoma limited to the gastric mucosa and submucosa regardless of whether regional lymph nodes are involved (T1NxMx). (medscape.com)
The prognosis for early disease is excellent, with a 5-year survival rate between 85% and 90% as compared with 28%-40% in advanced gastric cancer. (medscape.com)
Unfortunately, most patients in clinical practice present with advanced or metastatic gastric cancer. (medscape.com)
therefore, trastuzumab in combination with chemotherapy is a treatment option for patients with HER2-positive advanced gastric cancer. (medscape.com)
Peptic Ulcer Disease A peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates. (msdmanuals.com)
EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)
report a case of a patient with metastatic gastric cancer with a meaningful response to the anti-programmed death-ligand 1 (PD-L1) antibody avelumab. (medscape.com)

Unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. (drugs.com)
Locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. (nih.gov)
KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. (merck.com)
KEYTRUDA is approved for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (businesswire.com)
Most patients present with advanced/unresectable or metastatic disease at diagnosis, and no second-line regimen has demonstrated clinical benefit. (cdc.gov)
This was a phase 2 study evaluating the efficacy and safety of regorafenib in patients who had advanced/unresectable or metastatic disease after receiving standard therapy. (cdc.gov)

Dr Marshall describes the impacts of microsatellite stability and instability on metastatic colorectal cancer. (ajmc.com)
Metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type, an anti-EGFR therapy. (nih.gov)
Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) have become accepted treatments for limited-volume peritoneal disease in appendiceal, ovarian, and colorectal malignancies, but there are limitations. (stanford.edu)
Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
Jake was diagnosed with colorectal cancer in 2011 and developed metastatic disease in 2013 to the liver and more recently the lungs. (caringbridge.org)
Fluorouracil-based chemotherapy for colorectal cancer usually is not limited by cumulative toxic effects and can be continued for long periods. (aafp.org)
Maughan and colleagues compared intermittent chemotherapy with continuous treatment in patients whose advanced colorectal cancer responded or stabilized after an initial 12-week course of chemotherapy. (aafp.org)
They recruited 354 patients with inoperable or metastatic colorectal cancer from 42 British cancer centers. (aafp.org)

Trastuzumab emtansine (ado-trastuzumab emtansine or T-DM1, trade name: Kadcyla, marketed by Genentech and Roche) was approved in February 2013 for the treatment of people with HER2-positive metastatic breast cancer (mBC) who had received prior treatment with trastuzumab and a taxane chemotherapy. (wikipedia.org)
Eligible patients had centrally confirmed, measurable HER2-positive metastatic breast cancer without prior chemotherapy or trastuzumab for metastatic disease. (prnewswire.com)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

This administration method allows for delivery of a higher dose of chemotherapy to the liver while avoiding systemic toxicity. (aacr.org)
KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)
The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)

Androgen deprivation therapy (ADT) combined with docetaxel or antiandrogens (abiraterone, enzalutamide, or apalutamide) improved the outcomes in men with metastatic hormone-sensitive prostate cancer (mHSPC). (thieme-connect.com)
Prior treatment with docetaxel chemotherapy for up to 6 cycles is permitted. (dana-farber.org)
Conclusion: Docetaxel improved PFS in patients starting bicalutamide due to PSA relapse after local therapy or localized disease without local therapy. (lu.se)
Confirmatory studies of the efficacy of docetaxel in the setting of PSA-only relapse in addition to endocrine therapies may be justified if longer follow-up will show increased metastatic-free survival. (lu.se)

Prior local therapy for prostate cancer (either before or after diagnosis of metastatic disease) is permitted. (dana-farber.org)
The disease is often metastatic at the time of diagnosis, though metastases may be microscopic. (vin.com)
Cats were required to have a complete medical record including a histologic diagnosis of mammary adenocarcinoma, with metastatic disease confirmed based on physical exam (PE), ultrasound, radiographs or CT. (vin.com)
19 cats had received chemotherapy prior to diagnosis of metastasis. (vin.com)
Cats who were asymptomatic at diagnosis had a significantly higher survival time (128 days) compared to those with symptoms of disease (14 days). (vin.com)
There was a very diffuse set of histories, with some cats receiving chemotherapy prior to diagnosis of metastasis, which may have contributed to drug resistance. (vin.com)
Besides radiopharmaceuticals that address metabolic processes, approaches focusing on disease-specific targets ( 1 , 2 ) are increasingly important for cancer diagnosis and treatment with radiopharmaceuticals. (snmjournals.org)

Palliation of metastatic functioning tumors may be achieved by resection of both the primary tumor and metastatic lesions. (cancer.gov)
Surgical resection of localized disease leads to a complete cure without any recurrence in 20-25% of patients with gastrinomas. (medscape.com)
5 Those who underwent an R0 resection had a median survival time of 24 months, whereas those who underwent an R1 resection had a median survival time of 10 months, which emphasizes both the aggressiveness of this disease and the importance of complete resection in these patients. (acc.org)
Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease: A national cohort study. (cancercentrum.se)

Basal cell carcinoma may sometimes show metastatic spread to regional lymph nodes and, occasionally, in-transit metastases. (cancer.org.au)
The study included 51 patients receiving ICI therapy between 2016 and 2020 for metastatic renal or urothelial carcinoma. (medpagetoday.com)
These investigators analyzed clinicopathological and outcomes data to better categorize the effects of 9 different types of variant histologies on disease-specific survival in patients with urothelial carcinoma of the bladder. (medpagetoday.com)
The prognostic significance of chronic kidney disease (CKD) in the management of upper tract urothelial carcinoma following radical nephroureterectomy remains unknown. (medpagetoday.com)
A new study compared survival outcomes among patients with metastatic bladder urothelial carcinoma across racial/ethnic groups with predicted life expectancy, as derived from Social Security Administration life tables. (medpagetoday.com)
The purpose of this study was to investigate the outcome, treatment related toxicity, and prognostic factors in cats with stage IV (metastatic) mammary carcinoma. (vin.com)
CHICAGO, June 5, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an interim analysis of Cohort 1 of the Phase 3 THOR study, evaluating treatment with BALVERSA ® (erdafitinib) versus chemotherapy in patients with metastatic or unresectable urothelial carcinoma (UC) and selected fibroblast growth factor receptor (FGFR) gene alterations who had received prior treatment with an anti-programmed death ligand 1 (PD-[L]1) agent. (janssen.com)
These results represent the first data from a randomized, controlled trial evaluating BALVERSA ® for the treatment of patients with FGFR-altered urothelial carcinoma, who often experience poor disease outcomes," said Yohann Loriot*, M.D., Ph.D., Institut Gustave Roussy and University of Paris-Saclay, France, and principal study investigator. (janssen.com)
Hepatocellular carcinoma is not the same as metastatic liver cancer . (medlineplus.gov)

In a patient who had been diagnosed in 2006 with appendiceal adenocarcinoma with peritoneal metastases after an incomplete surgery, palliative chemotherapy was administered. (karger.com)
For metastatic disease, chemotherapy is mainly palliative. (medscape.com)

People diagnosed with metastatic stomach cancer should have the HER2 status of their tumors determined with FDA-approved diagnostic tests, as only people with HER2-positive disease are eligible for treatment with Herceptin plus chemotherapy. (news-medical.net)
Investigators suggest basing personalized therapeutic choices for urothelial cancers on global assessments, rather than focusing on primary tumors, because of the high degree of genomic variability and discordance in metastatic disease. (medpagetoday.com)
Overview of Multiple Endocrine Neoplasias (MEN) The multiple endocrine neoplasia (MEN) syndromes comprise 4 genetically distinct familial diseases involving adenomatous hyperplasia and malignant tumors in several endocrine glands. (msdmanuals.com)
Using molecular characterization of treatment resistance and metastatic relapse we aim to identify new approaches for targeting resistant tumors with novel drugs and drug combinations. (lu.se)

Determine the maximum tolerated dose of vinorelbine and celecoxib in women with relapsed or metastatic breast cancer. (knowcancer.com)
Compare that to the cost of, for instance, the OncoType DX 21-gene assay for estrogen receptor-positive breast cancer, which costs nearly $4,000 and is paid for by insurance because its results can spare many women from even more expensive chemotherapy. (sciencebasedmedicine.org)
THP is also used to treat metastatic HER2-positive breast cancer. (lbbc.org)

Results of the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial (n=12,834), based on 3-year disease-free survival (DFS), showed that FOLFOX narrowly failed to meet the prespecified noninferiority threshold. (medscape.com)
Radical open surgical excision is the treatment of choice for patients with localized malignancies and remains the only method by which long-term disease-free survival may be achieved. (cancer.gov)
The presence of metastatic disease is associated with a very poor prognosis, with reported survival times in the range of 1 month. (vin.com)
Examination of Kaplan-Meier curves suggested a lower survival for cats treated with MTD chemotherapy, however this was not significant. (vin.com)
PIPAC is an emerging treatment that may convert the patient to resectable disease, and may increase survival without major morbidity, as indicated by many small studies. (stanford.edu)
For patients with metastatic disease, targeted therapies have already entered clinical practice or have shown survival benefit in clinical trials. (scienceblog.com)
Changes in 15 circulating plasma angiogenesis or inflammatory-related proteins and cytokeratin-18 (CK18), measured at baseline and during therapy until disease progression, were correlated with overall survival (OS) using time-varying covariate Cox models (TVC). (nature.com)
4 Unfortunately, most patients are present with advanced (non-resectable or metastatic) disease and their survival is ≤3 months, with best supportive care alone. (nature.com)
The five-year survival rate of advanced metastatic disease is low. (medscape.com)
Combination chemotherapy results in improvement in overall survival in comparison with single-agent treatment or supportive care. (medscape.com)
In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). (lu.se)

Photoimmunotherapy (PIT) is an experimental technique now in clinical trials if your head and neck cancer is not responding to radiation or chemotherapy, or when surgery is not feasible because the tumor is too hard to reach. (rush.edu)
The U.S. Food and Drug Administration (FDA) has approved a kit for hepatic delivery of the chemotherapy agent melphalan (HEPZATO KIT) as a treatment for adult patients with unresectable liver metastases from uveal melanoma, a type of cancer found in the eye. (aacr.org)
Since chemotherapy drugs like melphalan do not discriminate between normal cells and cancer cells, normal cells that divide frequently can also be damaged, resulting in side effects. (aacr.org)
Thanks to Lifesaving Cancer Research 18,000,000 cancer survivors in the United States are living with, through, and beyond their disease. (aacr.org)
How I Treat Metastatic Hormone-Sensitive Prostate Cancer? (thieme-connect.com)
1 ] The upfront management of men with metastatic hormone-sensitive prostate cancer (mHSPC) had been with only androgen deprivation therapy (ADT), for a long time, either with medical or surgical castration. (thieme-connect.com)
This phase II trial examines antiandrogen therapy interruptions in patients with hormone-sensitive prostate cancer that has spread to other places in the body (metastatic) responding exceptionally well to androgen receptor-pathway inhibitor therapy. (dana-farber.org)
The usual treatment for patients with metastatic prostate cancer is to receive hormonal medications including a medication to decrease testosterone levels in the body and a potent oral hormonal medication to block growth signals from male hormones (like testosterone) in the cancer cells. (dana-farber.org)
It's] required testing for every patient with metastatic colon [cancer], regardless of stage. (ajmc.com)
This typically involves radiation (high-energy beams to destroy cancer cells) and surgery (to remove the cancer), and it sometimes involves chemotherapy (cancer-killing drugs). (mayoclinic.org)
Have clinically non-metastatic bladder cancer (N≤1 M0) determined by imaging (computed tomography (CT) or magnetic resonance imaging (MRI) of the chest/abdomen/pelvis. (mayo.edu)
That was when Walter Isaacson's biography of Steve Jobs revealed that after his cancer had recurred as metastatic disease in 2010. (sciencebasedmedicine.org)
Speaking to the overall patient perspective on ICI therapy and associated toxicities, Guru Sonpavde, MD, a medical oncologist at the Dana-Farber Cancer Institute in Boston, who wasn't involved in the study, noted that most patients express optimism and enthusiasm for immunotherapy and are eager to avoid chemotherapy. (medpagetoday.com)
The correct operation depends upon the anaplastic thyroid cancer extent of invasion and is often only even considered appropriate when there is no evidence that there is any distant spread of the disease. (thyroidcancer.com)
Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities - a retrospective multicentre study. (vin.com)
He has expertise in delivering regional cancer therapies such as heated intraperitoneal chemotherapy (HIPEC). (stanford.edu)
The purpose of this study is to find out if giving a dose of heated chemotherapy in the abdomen immediately after surgery that is done to remove uterine leiomyosarcoma type of cancer will help lower the risk of the cancer coming back in the future. (stanford.edu)
On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA inhibitor for imaging and therapy (PSMA I&T) for 68 Ga-based PET and 177 Lu-based endoradiotherapeutic treatment in patients with metastatic and castration-resistant disease. (snmjournals.org)
As a consequence, PSMA has attracted attention as a target for molecular imaging and for targeted radioligand therapy, especially in metastatic castrate-resistant prostate cancer (mCRPC). (snmjournals.org)
Newly diagnosed cancer patients are frequently found suffering from a metastatic disease, which poses additional challenges to the delivery of effective therapies. (cambridge.org)
Metastatic cancer patients should receive a quantitatively and qualitatively adequate diet, and in case of reduced tolerance of food, artificial nutrition is indicated. (cambridge.org)
Lung cancer is a complex disease. (scienceblog.com)
It is one of the most complex cancers, and the more we learn about the biology of the disease, the more we realize that improved cancer care will result from multidisciplinary treatment," said Prof Robert Pirker, from the Medical University of Vienna, Austria. (scienceblog.com)
Over the past 5 years, researchers have established that for patients with operable cancer, surgery followed by chemotherapy can result in good outcomes. (scienceblog.com)
The use of BALVERSA ® in this setting supports recommendations for FGFR testing in all patients with metastatic urothelial cancer. (janssen.com)
One survey reported that about one half of British cancer specialists stopped chemotherapy after six months if patients with metastatic disease responded well, whereas 30 percent would stop therapy after three months, and 20 percent would continue therapy indefinitely. (aafp.org)
In the U.S., it is estimated there will be more than 66,000 new cases of uterine body cancer and nearly 13,000 deaths from the disease in 2021. (businesswire.com)
A 44-year-old nulliparous Chinese female without personal or family history of disease was admitted to the Hubei cancer hospital in October 2021, who presented with weight loss, anorexia and hiccups for 3 months. (researchsquare.com)
Dental care is also not covered when an eligible member has already received their once-per-lifetime dental exam and the cancer returns following initial treatment or becomes metastatic. (cdc.gov)
Metastatic disease is when a cancer has spread to other parts of the body. (cdc.gov)
Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. (lu.se)
Metastatic liver cancer starts in another organ (such as the breast or colon) and spreads to the liver. (medlineplus.gov)
If the cancer can't be completely treated, the disease is usually fatal. (medlineplus.gov)
If a primary lung cancer is detected, a metastatic workup (scans of the brain, liver, adrenals, and bones) might be indicated. (cdc.gov)

however, it is not indicated for metastatic disease confined to the lymph nodes. (medscape.com)

The management of metastatic BCC is largely based on clinical evidence and experience in the management of locally advanced BCCs. (cancer.org.au)
He has dedicated his clinical practice to the surgical management of metastatic disease, particularly to the liver and peritoneum. (stanford.edu)

In spite of that, the majority of patients are diagnosed with advanced disease (74%), equally locally or with distant metastases. (karger.com)
To overcome the lack of an agreed definition of locally advanced BCC (and, in particular, to avoid over-reliance on lesion size as an independent criterion) the term 'difficult-to-treat' has been proposed to identify BCCs that require a treatment approach similar to that of advanced disease. (cancer.org.au)
Tumour size alone does not necessarily determine whether the patient has locally advanced disease, as complexity may be more relevant. (cancer.org.au)
Patients with complex, locally advanced disease are best treated by a multidisciplinary team including surgeons, dermatologists, radiation oncologists and medical oncologists. (cancer.org.au)
Tumour response rate according to RECIST v1.1 (locally advanced and metastatic settings only). (who.int)

Jake has undergone multiple surgeries, greater than 100 chemotherapy treatments, countless radiation treatments, along with many other treatments, therapies, and miscellaneous healing processes. (caringbridge.org)

Third-line chemotherapy combining capecitabine plus bevacizumab was started, achieving good control of the tumour growth and a minor response in the second computed tomography scan. (karger.com)
Returning to this case, the patient was scheduled to begin chemotherapy with a combination of capecitabine and oxaliplatin. (medscape.com)

Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting. (drugs.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)

The treatment is indicated for patients whose metastases affect less than 50% of the liver and who have no or limited extrahepatic disease. (aacr.org)
[ 2 ] Base the treatment on factors related to ulcer disease, diarrhea, and malignant properties of the tumor. (medscape.com)
Must have remained on testosterone suppression for metastatic disease continuously (without treatment breaks) for 540-750 days (approximately 18 to 24 months) from time of first dose of LHRH agonist or antagonist by time of registration. (dana-farber.org)
First-line treatment with 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) and second-line treatment including 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) plus panitumumab showed inefficiency in controlling disease progression. (karger.com)
We decided to maintain the treatment, although forced bevacizumab "breaks" were necessary due to unexpected adverse events, with the patient suffering disease progression every time bevacizumab was stopped and reaching minor response again once the antiangiogenic treatment was reintroduced. (karger.com)
During more than 10 years after starting third-line treatment, the patient maintained good performance status and disease stability with this "up and down" management until January 2019, when a neurological adverse event during bevacizumab infusion drove us to abandon it definitely. (karger.com)
Patients with generalized myasthenia gravis treated with efgartigimod consistently exceeded treatment compared with placebo regardless of gender in age, disease duration, body mass index, and thymectomy. (ajmc.com)
Prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). (mayo.edu)
Today's approval of Herceptin in combination with chemotherapy provides an important new, personalized medicine for people with this life-threatening disease who have few treatment options. (news-medical.net)
The program implements and develops novel treatment strategies for patients affected with peritoneal malignancies and oligometastatic disease to the liver. (stanford.edu)
Initial human PET imaging studies using 68 Ga-PSMA I&T, as well as endoradiotherapeutic treatment of 2 patients with metastatic PC using 177 Lu-PSMA I&T, were performed. (snmjournals.org)
68 Ga-PSMA I&T shows potential for high-contrast PET imaging of metastatic PC, whereas its 177 Lu-labeled counterpart exhibits suitable targeting and retention characteristics for successful endoradiotherapeutic treatment. (snmjournals.org)
Surgery is the mainstay of treatment for nonmetastatic disease. (medscape.com)
Studies that have evaluated the role of multimodality treatment options for these patients include postoperative chemoradiation and perioperative chemotherapy. (medscape.com)
You and your doctor will discuss the best chemotherapy treatment for your situation. (lbbc.org)
Tell your doctor about any medicines you are taking, including vitamins, herbal supplements, and over-the counter-medicines, to make sure they will not interfere with your chemotherapy treatment. (lbbc.org)
Patients in the continuous therapy group also were reassessed every six weeks, but treatment was stopped only if clinically indicated by disease progression, unacceptable side effects, or patient choice. (aafp.org)
Overall, patients averaged 28 weeks of treatment, and 30 percent of them progressed to second-line chemotherapy. (aafp.org)
They found no advantage to continuing therapy until disease progression, and they recommend that serious consideration be given to pausing chemotherapy after the initial treatment course. (aafp.org)
A policy of stopping and rechallenging with the same chemotherapy extends the patient's treatment options and delays the introduction of second-line treatments. (aafp.org)
BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
Current treatment of high-risk neuroblastoma includes a combination of chemotherapies, surgery, targeted therapy, anti-GD2 therapy, and more. (lu.se)
One such example is triple PIM/PI3K/mTOR inhibition which, in combination with chemotherapy, is a promising anti-neuroblastoma treatment strategy ( Mohlin*, Hansson* et al, EMBO Mol Med, 2019 ). (lu.se)

Liver metastases occur in up to 95% of patients with metastatic disease, and these lesions are often unresectable . (aacr.org)

Only one month of disease-free after four cycles of postoperative chemotherapy was remained when metastatic tumor developed in liver. (researchsquare.com)

In metastatic disease, frontline immunotherapy is a standard instead of chemotherapy. (ajmc.com)

After surgical intervention, an adjuvant chemotherapy with doxorubicin was administered to the patient. (hindawi.com)

2006). Andrews' Diseases of the Skin: Clinical Dermatology. (wikipedia.org)
1 The improvement in clinical outcomes with ICI therapy has led to their integration among standard-of-care treatments in both localized and metastatic disease settings. (medpagetoday.com)
Clinical trials and real-world data indicate that although ICI monotherapy is generally well-tolerated and has a lower AE incidence than chemotherapies, moderate-to-severe irAEs can be associated with a decline in organ function, reductions in QoL, and death. (medpagetoday.com)
Most patients who stopped continuous therapy (44 percent) did so because of disease progression, but other reasons included toxicity (16 percent), clinical decision (16 percent), and patient choice (14 percent). (aafp.org)
The Clinical Center of Excellence or Nationwide Provider Network Clinical Director can authorize the one-time dental exam prior to an organ transplant or start of chemotherapy/radiation. (cdc.gov)
Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe. (cancercentrum.se)
Referral to a specialist with expertise and experience treating lung disease is reasonable, given positive findings from the initial clinical assessment. (cdc.gov)

The detection of metastatic lesions may allow effective palliation of both functioning and nonfunctioning lesions. (cancer.gov)
Overall, the bone lesions were not thought to be metastatic, but repeat imaging in 3-6 months was recommended. (cmaj.ca)

However, outcomes did not differ by molecular groups among infants with nonmetastatic (M0) disease. (bvsalud.org)
The prevalence of hypertensive disorders of pregnancy is on the rise, putting more women at risk for adverse pregnancy-related outcomes and atherosclerotic cardiovascular disease later in life. (cdc.gov)

based on the exam results, follow-up medically necessary dental care (such as deep cleaning, fillings, and extractions) before an organ transplant and/or the start of chemotherapy or radiation. (cdc.gov)

To our knowledge, this disease-free interval is the longest among previous reports of pulmonary metastasis of uterine leiomyosarcoma. (hindawi.com)

Potential candidates for HPI therapy include patients with inoperable BCC, those in whom surgery is not appropriate, and those with metastatic BCC who have an adequate performance status. (cancer.org.au)
Before surgery, the tumor may be treated with chemotherapy to reduce its size. (medlineplus.gov)

Although the PCb combination achieved lower toxicity, patients treated with GC showed a trend toward a slightly higher median time to progressive disease (ie, a 1-month improvement). (cancernetwork.com)

The dose usually is 4-8 times higher than the dose administered to patients with peptic ulcer disease. (medscape.com)

however, adjuvant therapy may be considered in patients with high-risk disease. (medscape.com)
Therapy is based on radical mastectomy and potentially chemotherapy. (vin.com)
Nine cats (12.3%) received MTD chemotherapy, 15 cats (20.5%) received MC therapy, and 10 cats (13.7%) received TP. (vin.com)
In 80 percent of cases, therapy was reinstituted because of disease progression. (aafp.org)

Osseous sarcoidosis is an uncommon manifestation of sarcoidosis that can mimic metastatic bone disease on imaging. (cmaj.ca)
Patients were required to have adequate bone marrow and renal function and could not have had previous chemotherapy for metastatic disease. (aafp.org)
The models recapitulate many of the features of bone marrow metastatic disease in neuroblastoma patients. (lu.se)

However, metastatic disease carries a poor prognosis. (wikipedia.org)
The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. (hindawi.com)

Incidence and severity of other chemotherapy induced adverse effects according to CTCAEv5.0. (who.int)
Incidence of in-patient care for chemotherapy induced gastrointestinal mucositis including number of days in hospital and with parenteral fluids. (who.int)

The retrospective nature and lack of blinding means that some bias may have been present, with sicker cats receiving more aggressive chemotherapy. (vin.com)

Chemotherapy reduces tumor size and improves the symptoms secondary to metastatic effects of the tumor. (medscape.com)

There was no evidence of malignant disease. (cmaj.ca)

Anatomy6

Organisms2

Diseases90

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment83

Phenomena and Processes8

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science2

Health Care29

Radiotherapy11

Evidence of metastatic disease2

Regimens4

Cisplatin5

Neoadjuvant4

Radiation therapy7

Gastric10

Unresectable or metastatic6

Colorectal11

Trastuzumab3

Systemic3

Docetaxel4

Diagnosis7

Resection4

Carcinoma9

Palliative2

Tumors4

Breast cancer3

Survival11

Cancer34

Lymph nodes1

Management of metastatic2

Locally5

Therapies1

Capecitabine2

Taxane2

Treatment23

Metastases1

Postoperative1

Immunotherapy1

Doxorubicin1

Clinical7

Lesions2

Outcomes2

Start of chemotherapy1

Metastasis1

Surgery2

Combination1

Dose1

Therapy4

Bone3

Prognosis2

Incidence2

Retrospective1

Tumor size1

Malignant1