• The aim of this study was to evaluate the clinical efficacy and safety of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy. (elsevierpure.com)
  • Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
  • Taxotere (docetaxel) and Taxol (paclitaxel), both for chemotherapy. (epill.com)
  • The treatment of breast cancer with doxorubicin and cyclophosphamide is enhanced by adjuvant treatment with docetaxel. (wikipedia.org)
  • Adjuvant chemotherapy with S-1 plus docetaxel for highly advanced gastric cancer patients]. (elsevierpure.com)
  • Adjuvant chemotherapy with S-1 monotherapy might be insufficient for Stage IIIB highly advanced gastric cancer patients. (elsevierpure.com)
  • Our retrospective study was to evaluate the feasibility and safety of adjuvant chemotherapy with S-1 plus docetaxel. (elsevierpure.com)
  • Five patients tolerated adjuvant chemotherapy with S-1 plus docetaxel for 1 year (17 courses of treatment). (elsevierpure.com)
  • We concluded that S-1 plus docetaxel as adjuvant chemotherapy is a promising strategy for patients with highly advanced gastric cancer. (elsevierpure.com)
  • Dive into the research topics of '[Adjuvant chemotherapy with S-1 plus docetaxel for highly advanced gastric cancer patients]. (elsevierpure.com)
  • Overall, research in this area suggests that adjuvant chemotherapy is only likely to help people with the highest risk of their sarcoma coming back. (cancerresearchuk.org)
  • Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
  • In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)
  • In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
  • Women with stage I-III, hormone receptor-positive/negative, HER2-negative breast cancer treated with adjuvant FEC-D chemotherapy from 2007 through 2014 in Alberta, Canada, were included. (jnccn.org)
  • Treatment of early-stage breast cancer with adjuvant chemotherapy has improved survival. (jnccn.org)
  • In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
  • Chemotherapy regimens for esophageal cancer have been found to work better when drugs are combined. (epnet.com)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. (hindawi.com)
  • Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)
  • G-CSFs have been shown to reduce overall mortality risk [ 8 , 11 ], reduce the incidence of other adverse events (grade 2 or greater anaemia, asthenia, anorexia, myalgia, nail disorders, and oral mucositis) associated with docetaxel-based chemotherapy regimens, and increase health related quality of life and consequently treatment compliance [ 8 , 12 ]. (hindawi.com)
  • R esearchers at the University of Texas MD Anderson Cancer Center compared six breast cancer chemotherapy regimens to determine which caused more toxic side effects by requiring the patients to be hospitalized for infections, fever, dehydration or low blood counts. (time.com)
  • 2.Patient has stage IIIB or IV diagnosis and must have received one or two prior regimens (including platinum- doublet) of cytotoxic chemotherapy for the treatment of locally advanced or metastatic NSCLC. (who.int)
  • We randomly assigned participants (1:1) to receive either trastuzumab emtansine plus pertuzumab or docetaxel, carboplatin, and trastuzumab plus pertuzumab. (nih.gov)
  • Between June 25, 2014, and June 15, 2015, we randomly assigned 444 patients to neoadjuvant treatment with trastuzumab emtansine plus pertuzumab (n=223) or docetaxel, carboplatin, and trastuzumab plus pertuzumab (n=221). (nih.gov)
  • Another alternative is to combine carboplatin with docetaxel. (medscape.com)
  • Cisplatin, carboplatin, and paclitaxel are chemotherapy agents approved for the initial treatment of ovarian cancer. (medscape.com)
  • In hormone-refractory prostate cancer docetaxel improves life expectancy and overall life quality. (wikipedia.org)
  • Recent randomized controlled trials (RCTs) examined the role of adding androgen receptor signaling inhibitors (ARSIs), including abiraterone acetate (ABI), apalutamide, darolutamide (DAR), and enzalutamide (ENZ), to docetaxel (DOC) and androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). (nih.gov)
  • The study aimed to compare the efficacy and safety of androgen deprivation therapy (ADT) with abiraterone or docetaxel versus ADT alone as neoadjuvant therapy in patients with very-high-risk localized prostate cancer. (frontiersin.org)
  • Compared with ADT alone, neoadjuvant therapy with ADT plus docetaxel or abiraterone could achieve better pathological outcomes (pCR or MRD) for very-high-risk localized prostate cancer. (frontiersin.org)
  • androgen deprivation, chemotherapy , hormone therapy , immunotherapy and palliatives for advanced prostate cancer. (zerocancer.org)
  • Hormone therapy is a treatment option for advanced prostate cancer, as are chemotherapy and immunotherapy . (medicalnewstoday.com)
  • The intention of this study is to describe the impact and underlying potential basis of the prostate-specific antigen (PSA) flare-up phenomenon in patients with hormone-refractory prostate cancer (HRPC) treated with docetaxel-based chemotherapy. (springer.com)
  • Yagoda A, Petrylak D (1993) Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer. (springer.com)
  • Petrylak DP, Tangen CM, Hussain MH et al (2004) Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. (springer.com)
  • Tannock IF, de Wit R, Berry WR et al (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. (springer.com)
  • Oudard S, Banu E, Beuzeboc P et al (2005) Multicenter randomized phase II study of two schedules of docetaxel, estramustine, and prednisone versus mitoxantrone plus prednisone in patients with metastatic hormone-refractory prostate cancer. (springer.com)
  • Olbert PJ, Hegele A, Kraeuter P et al (2006) Clinical significance of a prostate-specific antigen flare phenomenon in patients with hormone-refractory prostate cancer receiving docetaxel. (springer.com)
  • In some cases, people are treated with a single type of chemotherapy. (medlineplus.gov)
  • But often, people get more than one type of chemotherapy at a time. (medlineplus.gov)
  • Below we look at each type of chemotherapy in more detail, along with their potential side effects. (healthline.com)
  • Docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy can cause severe adverse events, including neutropenia and febrile neutropenia. (biomedcentral.com)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • Trastuzumab, when used with chemotherapy, may help stop tumor growth in cancers with an excess amount of HER2. (epnet.com)
  • If your doctor recommends you stop docetaxel due to side effects, you may still be able to continue treatment with pertuzumab and trastuzumab. (lbbc.org)
  • Eligible patients had centrally confirmed, measurable HER2-positive metastatic breast cancer without prior chemotherapy or trastuzumab for metastatic disease. (prnewswire.com)
  • Some types of chemotherapy damage the genetic material inside the cell that tells it how to copy or repair itself. (medlineplus.gov)
  • Below are the seven main types of chemotherapy, the types of cancer they treat, and examples. (medlineplus.gov)
  • More likely than other types of chemotherapy to cause painful nerve damage. (medlineplus.gov)
  • What are the different types of chemotherapy? (healthline.com)
  • This table shows which cancers these types of chemotherapy are typically used for. (healthline.com)
  • Some types of chemotherapy drugs can cause neuropathy. (cancer.net)
  • Docetaxel has also been found to have greater cellular uptake and is retained longer intracellularly than paclitaxel allowing docetaxel treatment to be effective with a smaller dose, leading to fewer and less severe adverse effects. (wikipedia.org)
  • We did a phase 3 trial to assess a neoadjuvant regimen for HER2-positive breast cancer that replaces traditional systemic chemotherapy with targeted treatment. (nih.gov)
  • A considerable portion of HRPC patients experience an initial PSA flare-up under systemic chemotherapy. (springer.com)
  • Standard chemotherapy works by killing cancer cells and some normal cells. (medlineplus.gov)
  • They may work when standard chemotherapy drugs have not worked. (epnet.com)
  • 2008). Patients receiving chemotherapy with a goal of cure must receive full doses of standard chemotherapy on schedule to achieve optimal outcomes (Bonadonna et al. (medscape.com)
  • The study included 42 participants in the ADT group, 47 in the ADT plus docetaxel group, and 48 in the ADT plus abiraterone group. (frontiersin.org)
  • This phase I study aimed to determine the maximal tolerated dose (MTD) of the combination of pazopanib with two different schedules of docetaxel. (eur.nl)
  • Both schedules of docetaxel could be combined with 400 mg/day pazopanib. (eur.nl)
  • Conclusions: Both treatment schedules of docetaxel combined with pazopanib are feasible but at doses for both drugs that are considerably lower than the recommended single-agent doses. (eur.nl)
  • Treatment with docetaxel increases survival time in people with certain types of cancer. (wikipedia.org)
  • Improved median survival time and response indicates that docetaxel slows metastatic cancer progression and can lead to disease-free survival. (wikipedia.org)
  • As well as inhibiting mitosis, the presence of docetaxel has been found to lead to the phosphorylation of the oncoprotein bcl-2, which leads to apoptosis of cancer cells that had previously blocked the apoptotic inducing mechanism, leading to tumour regression. (wikipedia.org)
  • Docetaxel and paclitaxel have comparable efficacy metastatic breast cancer but paclitaxel has less severe side effects. (wikipedia.org)
  • Chemotherapy is the use of medicine to treat cancer. (medlineplus.gov)
  • Chemotherapy kills cancer cells. (medlineplus.gov)
  • Purpose: To compare the efficacy of neoadjuvant (NA) docetaxel (DOC) with anthracycline-based therapy and determine the efficacy of NA DOC in patients with breast cancer initially failing to respond to anthracycline-based NA chemotherapy (CT). (elsevierpure.com)
  • Chemotherapy is one treatment option that involves receiving medication that keeps cancer cells from spreading. (healthline.com)
  • Keep reading as we break down the different types of chemotherapies used to treat cancer, and what to expect in terms of side effects. (healthline.com)
  • Chemotherapy is a chemical drug therapy that's often used to destroy cancer cells in your body. (healthline.com)
  • Chemotherapy may be used as the primary treatment for your cancer, or it may be used to prepare you for other treatments such as radiation therapy or surgery. (healthline.com)
  • One 2017 study showed that the FDA approved at least 150 chemotherapy drugs to treat cancer. (healthline.com)
  • According to the National Cancer Institute , alkylating agents are the most common category of drugs used in chemotherapy today. (healthline.com)
  • Chemotherapy uses anticancer (cytotoxic) drugs to destroy cancer cells. (cancerresearchuk.org)
  • This means the cancer cells are more likely to be killed by chemotherapy. (cancerresearchuk.org)
  • Unfortunately, even if the chemotherapy shrinks it completely, there is a risk of the cancer coming back at some time in the future. (cancerresearchuk.org)
  • A phase I trial of docetaxel based induction and concomitant chemotherapy in patients with locally advanced head and neck cancer. (uchicago.edu)
  • Chemotherapy travels through the bloodstream to reach cancer throughout the body. (healthline.com)
  • Chemotherapy and targeted therapy are used to treat esophageal cancer. (epnet.com)
  • Chemotherapy uses drugs to kill cancer cells. (epnet.com)
  • Chemotherapy for esophageal cancer is most often used in combination with radiation therapy (called chemoradiation). (epnet.com)
  • When used alone, chemotherapy is not an effective treatment for esophageal cancer or long-term survival. (epnet.com)
  • Chemotherapy for esophageal cancer may given before or after surgery . (epnet.com)
  • Unlike chemotherapy, targeted therapy drugs attack cancer cells without harming healthy cells. (epnet.com)
  • Chemotherapy is a general term for medications used to destroy or stop the growth of cancer cells. (curesearch.org)
  • This Children's Cancer and Chemotherapy video explains how cancer treatments are developed and administered. (curesearch.org)
  • Chemotherapy works by interfering with the ability of cancer cells to divide and duplicate themselves. (curesearch.org)
  • Chemotherapy can be given through the bloodstream to reach cancer cells all over the body, or it can be delivered directly to specific cancer sites. (curesearch.org)
  • Chemotherapy is given in different ways depending on the cancer type and the medicines used. (curesearch.org)
  • The length of treatment depends upon the cancer type and how responsive it is to the chemotherapy. (curesearch.org)
  • According to researchers at the H. Lee Moffitt Cancer Center & Research Institute, men with a mutation in their VAC14 gene are more susceptible to Docetaxil chemotherapy induced neuropathy and nerve pain. (malecare.org)
  • Docetaxel works by damaging the structure or the "skeleton" that supports cancer cells. (lbbc.org)
  • In breast cancer patients, it is unclear whether measuring p53, mdm-2, or p21 expression provides information on how patients will respond to chemotherapy. (lu.se)
  • Researchers have found that patients who have breast cancer who undergo treatment with taxanes show a pattern of clinically meaningful, persistent sensory and motor symptoms associated with chemotherapy-induced peripheral neuropathy, according to new findings presented by Trivedi et al at the 2023. (ascopost.com)
  • This information describes nail changes that you may have while taking chemotherapy or other anti-cancer treatments and how to help manage them. (mskcc.org)
  • Chemotherapy and other cancer treatments may cause nail changes. (mskcc.org)
  • I offer systemic anti-cancer therapy (chemotherapy, immunotherapy, targeted oral therapies, novel anti-hormonal agents) and radiation therapy for cancers of prostate, bladder, kidney and penis. (spirehealthcare.com)
  • Chemotherapy is sometimes combined with radiation therapy to treat stomach cancer. (cancer.ca)
  • The chemotherapy drugs help make the cancer cells more sensitive to radiation therapy. (cancer.ca)
  • Chemotherapy for stomach cancer is usually given by a needle into a vein (intravenously). (cancer.ca)
  • Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. (cancer.ca)
  • Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial in maximizing patients' quality of life and optimizing outcomes of cancer therapy, and can be done more effectively than ever before. (medscape.com)
  • Patients with cancer often approach chemotherapy treatment with preconceived ideas about what their experience will entail. (medscape.com)
  • Our aim was to develop an analytical method for simultaneous detection and quantification of widely used cancer drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)
  • Conclusions: Development of a sensitive high-throughput multi-analyte cancer chemotherapy assay is feasible using an MRM-IDA-EPI method. (cdc.gov)
  • Cognitive changes may occur during chemotherapy to treat cancer and, therefore, it is necessary to identify them since they represent neurological complications with a high rate of improvement when treated. (bvsalud.org)
  • This research evaluated executive functions in women with breast cancer undergoing chemotherapy. (bvsalud.org)
  • It is concluded that there were impairments in executive functions related to working memory, focused attention, inhibitory control and general impulsivity in the group of women with breast cancer who received chemotherapy. (bvsalud.org)
  • Chemo brain describes problems with thinking (cognition, memory, attention) that may occur as a result of receiving chemotherapy to treat cancer. (cdc.gov)
  • the TC regimen, for example, is linked to the most hospitalizations but that's because it involves more intensive doses of chemotherapy in half the time - 12 weeks - of all of the other options, which are spread out over 24 weeks. (time.com)
  • Methods: In a 3 + 3 + 3 design, patients with advanced solid tumors received escalating doses of oral pazopanib combined with docetaxel given either every 3 weeks (D3w) or weekly at days 1, 8, and 15 every 28 days (D1w). (eur.nl)
  • Your healthcare team will consider your personal needs to plan the drugs, doses and schedules of chemotherapy. (cancer.ca)
  • Docetaxel is in the taxane family of medications. (wikipedia.org)
  • This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
  • Many people survive beyond five years with treatment from docetaxel, however it is difficult to attribute these findings directly to treatment with docetaxel. (wikipedia.org)
  • Conjunctive treatment of prednisone with docetaxel has been shown to lead to improved survival rate as well as improved quality of life and reduction of pain compared with treatments with mitoxantrone. (wikipedia.org)
  • Research is continuing to try to improve the results of chemotherapy treatment for sarcoma. (cancerresearchuk.org)
  • Generally, any positive effects from chemotherapy treatment alone are short-lived. (epnet.com)
  • The decision of treatment with chemotherapy based on Oncotype was compared with the standard of treatment based on clinical-pathological criteria. (isciii.es)
  • You and your doctor will discuss the best chemotherapy treatment for your situation. (lbbc.org)
  • Tell your doctor about any medicines you are taking, including vitamins, herbal supplements, and over-the counter-medicines, to make sure they will not interfere with your chemotherapy treatment. (lbbc.org)
  • Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)
  • Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)
  • There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)
  • Prior treatment with docetaxel chemotherapy for up to 6 cycles is permitted. (dana-farber.org)
  • This column reviews the history and pathophysiology of treatments for CINV, as well as patient- and chemotherapy-specific risk factors that should be considered to optimize treatment outcomes in patients with CINV. (medscape.com)
  • According to treatment guidelines in the regional care pro- recur in spite of chemotherapy. (lu.se)
  • The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)
  • Side effects of chemotherapy will depend mainly on the type of drug or combination, the dose, how it's given, if radiation therapy is given at the same time and your overall health. (cancer.ca)
  • Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)
  • patients who have received prior chemotherapy should be given a lower dose initially. (medscape.com)
  • Docetaxel is also used in combination with capecitabine, a DNA synthesis inhibitor. (wikipedia.org)
  • Among these patients with secondary resistance to immunotherapy, median OS was 11.1 months with Tedopi, vs 7.5 months with docetaxel . (medscape.com)
  • Peripheral neuropathy caused by chemotherapy is a very common problem for many of us as we go through a chemotherapy regime. (malecare.org)
  • When chemotherapy causes neuropathy, it is called "chemotherapy-induced peripheral neuropathy" or CIPN. (cancer.net)
  • The American Society of Clinical Oncology (ASCO) does not recommend the use of the dietary supplement acetyl-L-carnitine or any medication or supplement to prevent peripheral neuropathy caused by chemotherapy. (cancer.net)
  • Chemotherapy can be effective either on its own or with other treatments. (healthline.com)
  • The results, published in the Journal of Clinical Oncology , should help patients to be more informed about their chemotherapy options, says Barcenas, and prompt more research into ways that the right treatments can be matched to the right patients. (time.com)
  • Pemetrexed was one of the chemotherapy treatments. (who.int)
  • There are more than 100 different chemotherapy drugs. (medlineplus.gov)
  • How chemotherapy drugs work. (medlineplus.gov)
  • Chemotherapy drugs are broadly classified based on their mode of action. (healthline.com)
  • Your doctor or nurse may ask you to take part in a clinical trial to test new chemotherapy drugs. (cancerresearchuk.org)
  • There are a number of chemotherapy drugs used to treat soft tissues sarcoma. (cancerresearchuk.org)
  • Targeted therapy drugs are like chemotherapy drugs because they also travel through the bloodstream. (healthline.com)
  • There are a variety of chemotherapy drugs. (epnet.com)
  • A medical oncologist will determine how many cycles of chemotherapy are needed and what combination of drugs will work best. (epnet.com)
  • 2.Patient with a history of severe hypersensitivity reaction to pemetrexed or docetaxel or any known excipients of these drugs. (who.int)
  • Application of an innovative high-throughput liquid chromatography-tandem mass spectrometry method for simultaneous analysis of 18 hazardous drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)
  • p53, mdm-2, p21, and mib-1 expression were not significantly associated with response to chemotherapy, time to progression, or overall survival in the whole patient population or in the docetaxel group. (lu.se)
  • Enhanced effects of radiation therapy when combined with docetaxel has been observed in mice. (wikipedia.org)
  • How often and how long chemotherapy is given depends on the type of drug or drug combination used and if radiation therapy is used at the same time. (cancer.ca)
  • More than half of the people who receive chemotherapy experience at least one side effect. (healthline.com)
  • Despite advances in oncology care, many people still believe that all patients who receive chemotherapy will experience intractable vomiting. (medscape.com)
  • Methods: We examined the feasibility of alternate high-performance liquid chromatographic-tandem mass spectrometry methods to simultaneously detect eighteen chemotherapy analytes in plasma and urine. (cdc.gov)
  • As with all chemotherapy, adverse effects are common, and many side effects have been documented. (wikipedia.org)
  • Fewer serious adverse effects were reported with the vaccine than with chemotherapy (11.4% with Tedopi and 35.1% with docetaxel). (medscape.com)
  • High tumor proliferation has previously been associated with response to chemotherapy. (lu.se)
  • The results of our phenotype analysis also indicate that it is more likely that a panel of tumor biological factors instead of only one single factor may be needed for better prediction of chemotherapy response. (lu.se)
  • The Journal of antimicrobial chemotherapy 2018 6 73 (8): 2129-2136. (cdc.gov)
  • Kreis W, Budman DR, Fetten J et al (1999) Phase I trial of the combination of daily estramustine phosphate and intermittent docetaxel in patients with metastatic hormone refractory prostate carcinoma. (springer.com)
  • Docetaxel 100 mg m -2 was administered as a 1 hour intravenous (IV) infusion every 3 weeks to 41 patients. (elsevierpure.com)