Chemotherapy agents cisplatin. Medical search. Frequent questions

The purpose of this study is to assess the antitumor effectiveness and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. (mayo.edu)
The dual primary hypotheses are preoperative EV + pembrolizumab and RC + PLND (Arm A) will achieve superior pathologic complete response (pCR) rate and perioperative EV and pembrolizumab and RC + PLND (Arm A) will achieve superior event free survival (EFS) compared with neoadjuvant gemcitabine + cisplatin and RC + PLND (Arm B). (mayo.edu)
2) Determine the effect of AG1 antibody in combination therapy with chemotherapeutic agents (docetaxel, cisplatin and gemcitabine) that are used in the standard of care for NSCLC. (inknowvation.com)
Initially, optimal therapeutic dose for docetaxel, cisplatin and gemcitabine will be determined using A549 and NCI-H1299 xenografts in a monotherapy regimen. (inknowvation.com)
Currently, first-line treatment for locally advanced or metastatic cholangiocarcinoma consists of chemotherapy with gemcitabine and cisplatin. (ascopost.com)
The US Food and Drug Administration (FDA) has approved toripalimab-tpzi (Loqtorz, Coherus BioSciences) in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic or recurrent locally advanced nasopharyngeal carcinoma. (medscape.com)
Patients were randomly assigned evenly to either toripalimab or placebo on a background of cisplatin and gemcitabine, followed by toripalimab or placebo continuation. (medscape.com)
The recommended toripalimab dose with cisplatin and gemcitabine is 240 mg every 3 weeks until disease progression or unacceptable toxicity for up to 24 months. (medscape.com)
ARID1A Mutation from Targeted NGS Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer. (cdc.gov)

Carboplatin is a chemotherapy drug that has been on the market since the 1980s, and has been popular for treating a variety of cancers, including lung and ovarian cancer. (maacenter.org)
Unlike its parent compound, Cisplatin, Carboplatin has generally caused less severe side effects in patients, causing some disagreement around cisplatin versus carboplatin. (maacenter.org)
The combination of entinostat with either cisplatin, carboplatin, irinotecan, epirubicin, or etoposide led to strong synergy in a subset of resistant SCLC cells. (sciencenet.cn)
Pemetrexed and cisplatin (carboplatin substitution was permitted) alone. (merck.com)
Standard treatment for ovarian cancer includes comprehensive, debulking surgery to remove as much of the tumor as possible, as well as chemotherapy with drugs including a platinum agent (carboplatin/cisplatin) and paclitaxel. (cdc.gov)

Regimens of radiotherapy and chemotherapy that contain cisplatin improve the rates of survival and progression-free survival among women with locally advanced cervical cancer. (nih.gov)
Used both as single agent and in multiagent regimens for the treatment of malignant GTN. (medscape.com)
Part of multiagent chemotherapy regimens used to treat high-risk metastatic GTN. (medscape.com)
One of the drugs in multiagent chemotherapy regimens used to treat patients with high-risk metastatic GTN. (medscape.com)
The group also uncovered another, previously unknown, risk factor for hearing loss: concurrent use of vincristine, a second chemotherapy agent often added to treatment regimens. (chla.org)
Most chemotherapy regimens consist of 5-fluorouracil (5-FU), alone or in combination with a variety of other agents like doxorubicin, cisplatin, mitomycin C, cyclophosphamide and oxaliplatin. (cochrane.org)
Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. (hindawi.com)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)
G-CSFs have been shown to reduce overall mortality risk [ 8 , 11 ], reduce the incidence of other adverse events (grade 2 or greater anaemia, asthenia, anorexia, myalgia, nail disorders, and oral mucositis) associated with docetaxel-based chemotherapy regimens, and increase health related quality of life and consequently treatment compliance [ 8 , 12 ]. (hindawi.com)
Cisplatin-based highly emetogenic chemotherapy (HEC) regimens, which are key treatments for some of malignant tumors, were conventionally administered after an antiemetic premedication with dexamethasone plus a 5-hydroxytryptamine 3 receptor antagonist (5-HT 3 RA) such as ondansetron or granisetron. (medscape.com)

He was started on a combination of cisplatin and etoposide in a neoadjuvant fashion. (ispub.com)
He was started on cisplatin and etoposide and had a partial response to chemotherapy. (ispub.com)
We have now determined that PID1 increases the killing effect of etoposide and cisplatin, two common types of chemotherapy. (sciencedaily.com)
When these cells were treated with etoposide and cisplatin, killing of cancer cells increased. (sciencedaily.com)
Further experiments allowed the investigators to determine that etoposide caused more PID1 mRNA and PID1 protein to be generated, while cisplatin caused a decrease in PID1 protein, although it did increase the PID1 mRNA. (sciencedaily.com)

The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
Chemotherapy agents such as doxorubicin, cisplatin, and 5-fluorouracil are the primary choices for treating liver cancer cases but the response rate and overall survival remained poor [ 3 , 4 ]. (hindawi.com)
Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
We also collected surface wipe samples for cyclophosphamide, ifosfamide, and doxorubicin at the beginning of the work day before the chemotherapy drugs were unpacked and at the end of the work day after the last chemotherapy treatment was completed. (cdc.gov)
Various chemotherapeutic protocols have been reported, including single agent cisplatin and multi agent doxorubicin, cisplatin and piroxicam. (vin.com)

Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel. (cdc.gov)

Antimetabolite antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
Antimicrotubular antineoplastic agents prevent cell growth and proliferation. (medscape.com)
Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)

The combination of topotecan and cisplatin improves overall survival. (medscape.com)
We carried out a multicenter, open randomized trial to determine whether adjuvant chemotherapy would improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer. (nih.gov)
These results suggest that platinum-based adjuvant chemotherapy improves survival and delays recurrence in patients with early-stage ovarian cancer. (nih.gov)
Chemotherapy may be used curatively in the hopes of achieving a partial response or complete response to extend survival, or these drugs may be applied palliatively to alleviate symptoms. (maacenter.org)
Most often, Alimta is used in combination with cisplatin as a first-line therapy after a clinical trial showed pemetrexed plus Cisplatin extended the patients' survival to about 12 months, compared to 9 months when treated with cisplatin on its own. (maacenter.org)
Another clinical trial conducted between 2008 and 2014, found a median survival of 16 months for 225 patients treated with a combination of pemetrexed + Cisplatin. (maacenter.org)
In clinical trials, however, Avastin in combination with other chemotherapy drugs has shown improvement in overall survival and quality of life among mesothelioma patients. (maacenter.org)
This "triplet" therapy showed promising results, with patients' experiencing a median survival of 19 months versus 16 months with the combination of just Alimta and Cisplatin. (maacenter.org)
In patients with medially inoperable or unresectable tumors, primary radiotherapy, with or without chemotherapy, has provided a survival advantage and significant palliation over stent placement or bypass surgery alone. (medscape.com)
In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)
In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
In this study, we demonstrated that NSCLC-derived CAFs were innately resistant to cisplatin treatment and CAFs-conditioned medium significantly promoted the survival rate of NSCLC cells after cisplatin treatment. (dovepress.com)
5 To date, platinum-based chemotherapy is the most effective therapy to treat advanced NSCLC patients, 6 with a significantly higher survival and response rate. (dovepress.com)
Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
Immune checkpoint Inhibitors Nivolumab, and ipililumab targeting programmed cell death 1 and cytotoxic T-lymphocyte antigen 4 have shown superiority as frontline treatment as compared to standard of care chemotherapy: survival 18.1 months versus 14.1 months. (standardofcare.com)
The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment. (cochrane.org)
Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)

For patients with metastatic disease, cisplatin remains the most active agent. (medscape.com)
The first-line approval was based on the JUPITER-02 trial in 289 patients who had not received previous systemic chemotherapy for recurrent or metastatic disease. (medscape.com)

The question of whether platinum-based adjuvant chemotherapy can improve outcomes in patients with early-stage epithelial ovarian cancer is an important one. (nih.gov)
Between August 1991 and January 2000, 477 patients in 84 centers in five countries were randomly assigned to receive either adjuvant chemotherapy immediately following surgery (n = 241) or no adjuvant chemotherapy until clinically indicated (n = 236). (nih.gov)
No suitable evidence was found to determine the role of adjuvant chemotherapy, when compared with placebo or any other or no adjuvant treatment, in the management of adenocarcinoma of the small intestine. (cochrane.org)
There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. (cochrane.org)
Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment. (cochrane.org)
Singhal N, Singhal D. Adjuvant chemotherapy for small intestine adenocarcinoma. (cochrane.org)

Has received prior systemic anticancer therapy including investigational agents within 3 years of randomization or any radiotherapy to the bladder. (mayo.edu)
The current treatments for melanoma are surgery, which is performed in the early stages of the disease, and neoadjuvant treatments for advanced patients, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and combination therapy [ 2 , 3 ]. (medsci.org)
Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)

Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
The laboratory has developed agents that can block the action of this growth factor on tumor formation. (inknowvation.com)
For palliative treatment, celiac-plexus block via regional injection of alcohol or other sclerosing agent can relieve pain in the mid back from retroperitoneal tumor growth. (medscape.com)
Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
To determine how PID1 interacts with chemotherapy, the researchers engineered tumor cells to overexpress, or increase production, of PID1. (sciencedaily.com)
To test this, the researchers pretreated the tumor cells with an agent that selectively inhibits protein degradation, then exposed the cells to cisplatin. (sciencedaily.com)
Bioreductive agents, such as Tirapazamine (TPZ), are preferentially cytotoxic in hypoxia and show activity against a variety of tumor cell lines ( 1 - 4 ). (aacrjournals.org)
Understanding the mechanism underlying the role of tumor stroma, especially cancer-associated fibroblasts (CAFs), during chemoresistance would significantly contribute to the clinical application of chemotherapy agents. (dovepress.com)
Combination treatment with entinostat and cisplatin significantly decreased tumor growth in vivo . (sciencenet.cn)
When cytotoxic agents alone are administered, the majority of the drug leaks out of the tumor. (ahdbonline.com)
In a press release , Coherus CEO Denny Lanfear said that the company is "particularly excited to now turn our attention to developing Loqtorzi across multiple tumor types in combination with [immuno-oncology] agents that target the tumor microenvironment," including other agents the company is developing. (medscape.com)
Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
Patients with a malignant solid tumor who would receive HEC containing 50 mg/m 2 or more cisplatin were randomly assigned to either palonosetron (0.75 mg) arm (Arm P) or granisetron (1 mg) arm (Arm G), on day 1, both arms with dexamethasone (12 mg on day 1 and 8 mg on days 2-4) and aprepitant (125 mg on day 1 and 80 mg on days 2-3). (medscape.com)
Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030. (cdc.gov)

It is indicated as part of a combination chemotherapy regimen for persistent, recurrent, or metastatic carcinoma of the cervix. (medscape.com)
The present application proposes feasibility studies to investigate if this agent can be inhibit lung cancer, particularly on small cell lung carcinoma. (inknowvation.com)
In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
The FDA also approved toripalimab , a programmed death receptor 1-blocking antibody, as a single agent for recurrent unresectable or metastatic nasopharyngeal carcinoma with disease progression on or after a platinum-containing chemotherapy. (medscape.com)
Efficacy of toripalimab as a single agent was evaluated in the POLARIS-02 study in 172 patients with unresectable or metastatic nasopharyngeal carcinoma who had received prior platinum-based chemotherapy or had progressed within 6 months of its completion in the neoadjuvant, adjuvant, or definitive chemoradiation setting. (medscape.com)
The recommended dose as a single agent for previously treated nasopharyngeal carcinoma is 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity. (medscape.com)

Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. (sciencenet.cn)
Like other chemotherapeutic agents, it also destroys some healthy cells in this process. (news-medical.net)

An example of this could be gentamicin, given to treat a serious infection, or some types of chemotherapy drugs used to treat cancers. (batod.org.uk)

Although the US Food and Drug Administration (FDA) has approved this agent only for the treatment of testicular cancer, it has several off-label indications, including treatment of cervical cancer. (medscape.com)
Indicated for treatment of recurrent or metastatic cervical cancer with disease progression on or after chemotherapy whose tumors express PD-L1 (CPS 1 or greater) as determined by an FDA-approved test. (medscape.com)
Use as single agent or as part of multiagent regimen for treatment of malignant GTN. (medscape.com)
Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
Treatment options include chemotherapy, surgery, and other targeted therapies. (medicalnewstoday.com)
DBL Cisplatin Injection has been chosen as your therapy, as the benefits of treatment are expected to be greater than the unwanted or side effects. (news-medical.net)
It is recommended that you and your doctor discuss your need for cisplatin treatment during pregnancy and the possible risks and benefits of using cisplatin during pregnancy. (news-medical.net)
Avoid becoming pregnant by using effective birth control during your treatment with cisplatin and for at least 26 weeks after you stop treatment (at least 31 weeks if have kidney disease). (news-medical.net)
Males: Tell your doctor or pharmacist if your partner intends to become pregnant while you are being given cisplatin, or shortly after you have stopped treatment. (news-medical.net)
It is recommended that you use effective contraception while you are using cisplatin and for at least 14 weeks after you stop treatment (at least 19 weeks if you have kidney disease). (news-medical.net)
Prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). (mayo.edu)
In addition, chemotherapy, surgery, or radiation are often combined to increase the effectivity of the treatment. (aiche.org)
Moreover, triple negative breast cancer (TNBC) tends to metastasize faster than other kinds of breast cancer, resulting in a worse prognosis and often chemotherapy as the only treatment for metastasis. (aiche.org)
The oncologist recommends treatment with cisplatin, an effective chemotherapy agent. (chla.org)
The course of treatment will also be influenced if these drugs are being implemented individually, as part of a multimodal treatment with either surgery or radiation therapy, or if they are being used in tandem with another chemotherapy drug. (maacenter.org)
The treatment for leukoplakia is to remove any obvious etiologic agent. (experts.com)
Twenty-four patients had not received treatment prior to the study while five had surgery and five had chemotherapy. (survivingmesothelioma.com)
The treatment consisted of one chemotherapeutic agent liposome-entrapped cisplatin analog: L-NDDP. (survivingmesothelioma.com)
Pre-treatment with curcumin significantly ameliorated inflammation and apoptosis induced by cisplatin. (thieme-connect.com)
Even though various treatment strategies namely saline hydration and diuresis have been suggested for prevention of cisplatin-induced kidney damage, but its prevalence is still high. (thieme-connect.com)
Cisplatin-based chemotherapy agents used in childhood cancer treatment can result in sensori-neural deafness. (batod.org.uk)
Historically, chemotherapy played a small role in the treatment of brain tumors. (sciencedaily.com)
Two studies reported at the European Society for Medical Oncology (ESMO) Congress 2019-ClarIDHy and FIGHT-202-demonstrated clinical benefits with novel molecularly targeted agents in the treatment of advanced cholangiocarcinoma. (ascopost.com)
These finding are particularly beneficial in the treatment of recurrent cancer when maintaining a good quality of life during chemotherapy is a priority and allows patients to have a natural, nutritional approach to preventing and managing chemotherapy adverse effects. (researchgate.net)
The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)
Chemotherapy have shown inferior to radiation therapy, but may be considered when RT is not available or as rescue treatment after RT. (vin.com)
Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)
There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)
Other treatment options includes conventional chemotherapy, locoregional therapy, systemic targeted therapy, and palliative best supportive care. (bvsalud.org)
The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
Combinatory treatment of the inhibitors with chemotherapeutic agent cisplatin showed synergistic effects. (lu.se)
1. Patient has received neoadjuvant/adjuvant systemic chemotherapy for primary Stage IIIc2 or IV disease and has had a recurrence or PD within 6 months of completing chemotherapy treatment prior to entering the study. (who.int)
Chemotherapy-induced nausea and vomiting (CINV) is a non-hematologic toxicity of chemotherapy that severely impairs the quality of life of patients and reduces their treatment compliance. (medscape.com)

Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. (chla.org)
To overcome this issue, the team reviewed all of the study data using the same international consensus system for cisplatin-induced hearing loss (developed by the International Society of Pediatric Oncology), enabling investigators to compare hearing loss using more than 2,000 tests from patients treated at 19 different institutions. (chla.org)
In fact, the prevalence of cisplatin-induced kidney damage was 34% after fourth cycles and 52% after six cycles of cisplatin chemotherapy in adult cancer patients treated with cisplatin at a dose of ≥60 mg/m 2 at Dharmais National Cancer Hospital, Jakarta, Indonesia [ 6 ]. (thieme-connect.com)
A polymorphisms toward lung cancer susceptibility and its association with clinical outcome in North Indian patients treated with platinum-based chemotherapy. (cdc.gov)

Providing the most effective chemotherapy to women has the potential to reduce deaths from ovarian cancer substantially. (cdc.gov)

As alkylating agent, mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)

The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)

According to the JIB extract's anti-melanoma capacity, to assess the synergistic effects of cisplatin and JIB extract. (medsci.org)

Most advanced and recurrent cases therefore will receive systemic chemotherapies as the alternative approach. (hindawi.com)

What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
Research done in the last decade has shown that certain tumors of the brain and spinal cord, are sensitive to chemotherapy. (sciencedaily.com)
A novel intratumoral chemotherapy agent delivered by direct injection permits the dispersion of cytotoxic drugs into cancer cells to eradicate tumors. (ahdbonline.com)

[ 8 ] In patients receiving moderately emetogenic chemotherapy (MEC), better CINV control was obtained with palonosetron than with a first-generation 5-HT 3 RA, [ 9 ] which supports current guideline recommendations for palonosetron use as a part of antiemetic premedication for MEC. (medscape.com)

During our first site visit in September 2009, we measured the face velocity of the Class 2 BSC where chemotherapy drugs were mixed and collected surface and hand wipe samples for platinum-containing chemotherapy drugs. (cdc.gov)
In November 2010, during our second evaluation, we collected surface wipe samples (but no hand wipe samples) for platinum-containing chemotherapy drugs in similar locations as in the 2009 evaluation. (cdc.gov)
Platinum-containing chemotherapy drugs were detected in most surface wipe samples during both evaluations but not on the two hand wipes collected in 2009 from nurses who had recently handled platinum-containing chemotherapy drugs. (cdc.gov)

This therapy has been performed with and without concurrent chemotherapy as a radiation sensitizer. (medscape.com)

This agent is used in combination with radiation therapy. (medscape.com)
A combination of alimta and cisplatin has remained the standard of care for years. (maacenter.org)
Side effects can vary greatly dependent on the combination of chemotherapy drugs. (maacenter.org)
In a clinical trial held from 2008 to 2014, 223 patients received a combination of Avastin, Alimta and Cisplatin. (maacenter.org)
Cisplatin has been used as a standard agent of combination chemotherapy in several cancers, such as nasopharyngeal, lung, and ovarian cancer. (thieme-connect.com)
The safety profile of KEYTRUDA in combination with chemotherapy in this study was consistent with previously reported studies. (merck.com)

Cisplatin has been used to treat cancers in children and adults for more than fifty years, but for the first time, we have insights into how something as simple as adjusting our dosing approach may prevent hearing loss and still maintain effective treatments. (chla.org)
We have gathered data from the largest group ever of cisplatin-treated children and adolescents with a wide variety of cancers," she says. (chla.org)
Mitotane is a common chemotherapeutic agent used for adrenal gland because it can block adrenal gland hormone production and destroys cancers cells. (news-medical.net)

However, it has many severe side effects that limit the therapeutic use of cisplatin, one of them is kidney damage [ 1 ] [ 2 ]. (thieme-connect.com)
This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
7 , 8 Alternatively, cisplatin (cis-Diamminedichloro-platinum(II))-based therapeutic strategy has a relatively low response rate, significant side effects, and acquired or intrinsic chemoresistance. (dovepress.com)

Chemotherapy should be administered in conjunction with radiation therapy to most patients with stage IB (high-risk) to stage IVA cervical cancer. (medscape.com)
Your doctor should discuss this issue with you before you begin therapy with cisplatin. (news-medical.net)
Although recent targeted cancer therapy agents such as sorafenib demonstrate an improved clinical outcome in advanced liver cancer cases [ 5 ], the overall mortality rate of liver cancer still exceeds 90% worldwide [ 1 ]. (hindawi.com)
Targeted therapy drugs are like chemotherapy drugs because they also travel through the bloodstream. (healthline.com)
Children who received higher doses of the chemotherapy were more likely to experience hearing loss, even when the total amount of cisplatin over the course of the therapy was the same. (chla.org)
In this paper, we will report the results of randomized phase III study to evaluate the efficacy of palonosetron versus granisetron in the standard triplet antiemetic therapy for cisplatin-based HEC. (medscape.com)

Worsening of neuropathic symptoms after completing the last chemotherapy course may occur. (iasp-pain.org)

9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair. (sciencenet.cn)
The efficacy of HDACi and chemotherapy in SCLC was investigated both in vitro and in vivo . (sciencenet.cn)
There has been no phase III study of comparing the efficacy of first- and second-generation 5-HT 3 receptor antagonists in the triplet regimen with dexamethasone and aprepitant for preventing chemotherapy-induced nausea and vomiting after highly emetogenic chemotherapy (HEC). (medscape.com)

DBL Cisplatin Injection is a platinum-containing medicine and is used as an anticancer drug to interfere with the growth of cancer cells and eventually destroy them. (news-medical.net)
Many cancer patients need to abort chemotherapy due to complications arising from its side effects, and this is a primary contributor to mortality. (aiche.org)
These results together suggested that TCEE is a potential ingredient for developing an integrated chemotherapy for human liver cancer. (hindawi.com)
Chemotherapy travels through the bloodstream to reach cancer throughout the body. (healthline.com)
Chemotherapy for patients with adrenal cancer may be administered via intravenous injection or oral medications. (news-medical.net)
The review included exposure to environmental agents carcinogenic to humans (International Agency for Research on Cancer classification), as well as lifestyle factors known to affect cancer risk. (who.int)
RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
L'analyse incluait l'exposition aux agents environnementaux cancérogènes pour l'homme (classification du Centre international de recherche sur le cancer) ainsi que les facteurs liés au mode de vie connus pour augmenter le risque de cancer. (who.int)
Les risques de cancer les plus élevés pour les Qatariens proviendraient de facteurs associés aux modes de vie, en particulier l'obésité, la sédentarité et le tabagisme. (who.int)
It was later decided to include nitions of carcinogens were based on pollution, occupational exposure to a review of lifestyle factors that are the January 2013 list of agents classified carcinogenic compounds, and lifestyle known to influence cancer risk. (who.int)

Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
According to Erdreich-Epstein, accounts in the literature suggest that cisplatin diminishes the amount of proteins that contribute to death of the cells, thereby leading to resistance to cisplatin and protection of the cells from death by cisplatin. (sciencedaily.com)
If we can figure out how to block breakdown of PID1, we may be able to prevent drug resistance and make chemotherapy more effective. (sciencedaily.com)
Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)

Pt NPs anticancer activity was tested performing cell viability experiments with TNBC and comparing with a common chemotherapeutic drug (cisplatin). (aiche.org)

Note: Low-dose cisplatin given as a radiation sensitizer or hormonal therapies do not exclude patients from study participation. (who.int)

A CHLA oncologist led a pivotal clinical trial leading to the approval of the first drug to prevent cisplatin hearing loss in children. (chla.org)
Researchers have conducted a variety of clinical trials testing different combinations and single-agent applications of chemotherapy drugs for mesothelioma. (maacenter.org)
These data further define the mechanism of action of TPZ and suggest that as a single agent, TPZ would only have clinical activity against p53-functional neuroblastomas. (aacrjournals.org)
Using a traditional approach this study provides pre-clinical data to support the benefits previously observed and reported in the clinical setting and supports future endeavors to integrate AHCC into standard of care to be given with chemotherapy. (researchgate.net)

As the major drawback of chemotherapy is the toxicity, cell viability experiments were also performed on fibroblasts. (aiche.org)
The results showed no apparent toxicity of Pt NPs for healthy cells in contrast to cisplatin. (aiche.org)
Pheromone preparations are characterized with high selectiveness of action, low toxicity, and low concentrations of active agent which makes them environmentally friendly protectors of plants. (export.by)

Intrastrand cross-linking of DNA and inhibition of DNA precursors are among the proposed mechanisms of action for cisplatin. (medscape.com)
Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC. (sciencenet.cn)
In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. (sciencenet.cn)

Single entinostat- or chemotherapy significantly reduced cell viability in human neuroendocrine SCLC cells. (sciencenet.cn)

DBL Cisplatin Injection may be used alone or with other anticancer therapies. (news-medical.net)

Of these medications, dexamethasone has been reported most frequent as a causative agent in persistent/intractable hiccups. (lww.com)
There are several case reports of patients developing prolonged hiccups after chemotherapy administration, including dexamethasone. (lww.com)

This leaflet answers some common questions about DBL Cisplatin Injection. (news-medical.net)
DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)
The active ingredient in DBL Cisplatin Injection passes into breast milk and there is a possibility that your baby may be affected. (news-medical.net)

Patients who have received prior chemotherapy should be given a lower dose initially. (medscape.com)
Platinum-induced peripheral neurotoxicity (PIPN) is a common side effect of platinum-based chemotherapy that may cause dose reduction and discontinuation, with oxaliplatin being more neurotoxic. (iasp-pain.org)
Curcumin was given at a dose of 100 mg/kg orally for nine days, starts one week before giving a single dose of cisplatin. (thieme-connect.com)

Effective antineoplastic used in patients with chemotherapy-resistant malignant GTN. (medscape.com)
Alimta is the first and only chemotherapy drug to be approved by the U.S. Food and Drug Administration (FDA) to treat malignant pleural mesothelioma. (maacenter.org)

This drug is a platinum-based agent. (survivingmesothelioma.com)
In addition, curcumin downregulated Ctr1 and OCT2 drug transporters as compared to cisplatin group. (thieme-connect.com)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
Health hazard evaluation report: HETA-2009-0148-3158, chemotherapy drug exposures at an oncology clinic - Florida. (cdc.gov)
One of these four reported a recurring "burning" rash on his nose after handling chemotherapy drug waste. (cdc.gov)
However, three employees reported inadequate training on the potential short- and long-term health effects of chemotherapy drug exposure. (cdc.gov)
Considering the inconsistent use of PPE and presence of chemotherapy drug residue in the clinic work area, employees are at risk of both acute and chronic health effects from exposure to chemotherapy drugs. (cdc.gov)

Objective In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. (thieme-connect.com)
This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. (thieme-connect.com)
Conclusions These data indicate that curcumin has nephroprotective properties against cisplatin-induced kidney damage in rats and this effect is associated with its anti-inflammatory and anti-apoptosis profiles, in addition to its antioxidant. (thieme-connect.com)
9 ] reported curcumin administration provided protection against cisplatin-induced renal tubular cell apoptosis. (thieme-connect.com)

Platinum-based compounds result in more prolonged neuropathic symptoms in comparison to other chemotherapy agents. (iasp-pain.org)

Anatomy2

Organisms2

Diseases35

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes10

Information Science1

Health Care10

Gemcitabine9

Carboplatin5

Regimens11

Etoposide5

Doxorubicin7

Paclitaxel1

Antineoplastic agents3

Survival18

Metastatic disease2

Adjuvant chemotherapy6

Radiotherapy3

Tumor15

Carcinoma6

Chemotherapeutic agents2

Types of chemotherapy1

Treatment35

Patients Treated4

Effective chemotherapy1

Alkylating Agent1

Docetaxel1

Synergistic effects1

Recurrent1

Tumors3

Moderately emetogenic1

Platinum-containing c3

Concurrent1

Combination6

Cancers3

Therapeutic3

Therapy6

Last chemotherapy1

Efficacy4

Cancer10

Resistance4

Common chemotherapeutic1

Radiation1

Clinical4

Toxicity3

Inhibition3

Cell viability1

Therapies1

Dexamethasone2

Injection3

Dose3

Malignant2

Drug7

Apoptosis4

Compounds1