Chemotherapy agents antineoplastic agents. Medical search. Frequent questions

Used both as single agent and in multiagent regimens for the treatment of malignant GTN. (medscape.com)
Part of multiagent chemotherapy regimens used to treat high-risk metastatic GTN. (medscape.com)
One of the drugs in multiagent chemotherapy regimens used to treat patients with high-risk metastatic GTN. (medscape.com)
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) plus one of four platinum-based chemotherapy regimens compared to the efficacy and safety of placebo plus one of four platinum-based chemotherapy regimens in the treatment of adult women with persistent, recurrent, or metastatic cervical cancer. (clinicaltrials.gov)
Possible chemotherapy regimens include: paclitaxel plus cisplatin with or without bevacizumab and paclitaxel plus carboplatin with or without bevacizumab. (clinicaltrials.gov)
These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
The results alert to a potential risk in current empirically based continuous low-dose chemotherapy regimens such as metronomic chemotherapy. (researchsquare.com)

Chemotherapy should be administered in conjunction with radiation therapy to most patients with stage IB (high-risk) to stage IVA cervical cancer. (medscape.com)
Although the US Food and Drug Administration (FDA) has approved this agent only for the treatment of testicular cancer, it has several off-label indications, including treatment of cervical cancer. (medscape.com)
Indicated for treatment of recurrent or metastatic cervical cancer with disease progression on or after chemotherapy whose tumors express PD-L1 (CPS 1 or greater) as determined by an FDA-approved test. (medscape.com)
Cisplatin, carboplatin, and paclitaxel are chemotherapy agents approved for the initial treatment of ovarian cancer. (medscape.com)
Our results suggested that VCO may benefit cancer patients on MTX chemotherapy against kidney injury. (nih.gov)
Conventional cancer treatments rely on radiotherapy and chemotherapy. (nih.gov)
Patients with breast cancer who carry a TLR4 loss-of-function allele relapse more quickly after radiotherapy and chemotherapy than those carrying the normal TLR4 allele. (nih.gov)
Our aim was to develop an analytical method for simultaneous detection and quantification of widely used cancer drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)
Conclusions: Development of a sensitive high-throughput multi-analyte cancer chemotherapy assay is feasible using an MRM-IDA-EPI method. (cdc.gov)
Currently, more than one million cancer patients receive outpatient chemotherapy or radiation therapy each year [6]. (cdc.gov)
BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC). (lu.se)
First, it acts as a drug adjuvant to the chemotherapy, making it work more effectively against cancer cells. (concordia.ca)
Pemetrexed injection is used in combination with other chemotherapy medications as a first treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. (medlineplus.gov)
Pemetrexed injection is also used alone to treat NSCLC as ongoing treatment in people who have already received certain chemotherapy medications and whose cancer has not worsened and in people who could not be treated successfully with other chemotherapy medications. (medlineplus.gov)
Pemetrexed injection is also in combination with another chemotherapy medication as a first treatment for malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity) in people who cannot be treated with surgery. (medlineplus.gov)
Adherence to ASCO and ONS standards for safe chemotherapy administration should be a goal of all providers of adult cancer care. (ons.org)
Clinical Oncological Society of Australia: Guidelines for the Safe Prescribing, Dispensing and Administration of Cancer Chemotherapy. (ons.org)
Bonnabry P, Cingria L, Ackermann M, et al: Use of a prospective risk analysis method to improve the safety of the cancer chemotherapy process. (ons.org)
Fischer DS, Alfano S, Knobf MT, et al: Improving the cancer chemotherapy use process. (ons.org)
Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
The question of a well-defined role for the use of neoadjuvant chemotherapy in the treatment of ovarian cancer is recognized to be one of the most hotly debated issues in the management of female pelvic malignancies. (cancernetwork.com)
1] A second group, including the team headed by Dr. Peter Schwartz at Yale, have proposed (and provided data to support the concept) that the delivery of cytotoxic chemotherapy to women with known or suspected ovarian cancer prior to considering an attempt at surgical resection is a rational therapeutic alternative. (cancernetwork.com)
a) Extensive retrospective data have clearly demonstrated the major favorable impact on survival associated with successful primary surgical cytoreduction that leaves an ovarian cancer patient with no, or only minimal, macroscopic disease prior to the initiation of cytotoxic chemotherapy. (cancernetwork.com)
b) There is concern that the delivery of chemotherapy in the presence of large-volume cancer will increase the risk for the development of chemotherapy-resistant cells, or reduce the ability of drugs to eliminate cells that are only modestly sensitive to the available antineoplastic agents. (cancernetwork.com)
b) The neoadjuvant chemotherapy approach may permit a larger percentage of patients to become free of gross macroscopic cancer after surgery (performed following two to six cycles of systemic drug treatment). (cancernetwork.com)
Considering the fact that some of the residual tumors masses may have contained poorly vascularized cancer cells that are not inherently chemoresistant, continuation of active chemotherapy following surgery may have legitimate potential to improve the overall effectiveness of the multimodality management program. (cancernetwork.com)
c) The neoadjuvant chemotherapy approach will define the 20% to 40% of the ovarian cancer patient population with inherently chemotherapy-resistant disease (no or minimal response to the initial drug therapy) for whom a subsequent aggressive surgical procedure would not appear to be justified. (cancernetwork.com)
It is relevant to acknowledge here that use of the term "neoadjuvant chemotherapy" in the management of a patient with ovarian cancer should only be employed in the setting where there is the legitimate intent to subsequently perform surgical cytoreduction, assuming a reasonable response to the initial drug program. (cancernetwork.com)
Mitomycin should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (nih.gov)
Drugs used in chemotherapy halts this division and kills cancer cells. (yashodahospitals.com)
Despite being the most effective broad-spectrum chemotherapeutic agent in cancer treatment, Bleomycin has limited uses due to poor drug delivery abilities and toxicity. (yashodahospitals.com)
According to the stage of cancer and the degree of the complication, current treatment methods rely on the success of chemotherapy either alone or combined with surgical resection or radiation therapy. (frontiersin.org)
IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. (guidelinecentral.com)
Cancer chemotherapy / Martin J. Cline, Charles M. Haskell. (who.int)
Cancer chemotherapy handbook / Robert T. Dorr, William L. Fritz. (who.int)
Aim: To assess feasibility, complications and efficacy of induction chemotherapy followed by standard chemoradiotherapy in patients with bulky anal canal cancer. (uniroma1.it)
Conclusion: Induction chemotherapy has the potential to become a standard approach in patients with bulky human papillomavirus-negative anal canal cancer. (uniroma1.it)
4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
9. When cancer is treated with surgery followed by chemotherapy it is referred to as adjuvant therapy. (studylib.net)
Cancer treatment to relive symptoms of advanced disease is referred to as palliative chemotherapy. (studylib.net)
Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)

Cisplatin is the agent used most commonly, although 5-fluorouracil also is used frequently. (medscape.com)
For patients with metastatic disease, cisplatin remains the most active agent. (medscape.com)
DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)
At present, the combination of metoclopramide and dexamethasone offers an optimal protection in approximately 50% of patients on cisplatin chemotherapy. (elsevierpure.com)

As a result, the clinical development of metronomic chemotherapy has been impeded by numerous limitations, including the lack of its basic pharmacological data, ambiguity of its definition and the resulting empiric design of treatment protocols. (researchsquare.com)
The current metronomic chemotherapy protocols applied clinically are exclusively empirical in terms of dosing (e.g., half, one third, one tenth of the maximum tolerated dose) and scheduling (e.g., weekly, twice a week, thrice a week, daily) due to the lack of theory-based dose setting method. (researchsquare.com)
At present moment the company produces 10 generic drugs, which are included into Standard treatment protocols of chemotherapy of various tumors: Cytarabin (a lyophilized powder for injections and a solution for injections), Leucladin, Fludarabel, Methotrexate, Zoledronic acid. (belmedpreparaty.com)

Application of an innovative high-throughput liquid chromatography-tandem mass spectrometry method for simultaneous analysis of 18 hazardous drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)
Patton J: Increased use of oral chemotherapy drugs spurs increased attention to patient compliance. (ons.org)
The syndrome may occur at any time during systemic therapy with mitomycin as a single agent or in combination with other cytotoxic drugs, however, most cases occur at doses ≥60 mg of mitomycin. (nih.gov)
Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)

Methotrexate (MTX) is an efficacious anticancer agent constrained in clinical use due to its toxicity on non-targeted tissue, a considerable source of worry to clinicians. (nih.gov)
Second, it appears to protect healthy cells from the toxicity of the chemotherapy. (concordia.ca)
The efficacy and toxicity data of the available anti-emetics and their role in chemotherapy-induced emesis are reviewed. (elsevierpure.com)

As alkylating agent, mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
Alkylating chemotherapy agents inhibit cell growth and proliferation. (medscape.com)
Alkylating antineoplastic agent and anthracyclins are two examples. (wikipedia.org)
Antineoplastic with alkylating activity. (cancer.gov)
This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. (scirp.org)

This method can be used to rapidly rule out systemic exposure to accidental acute chemotherapy spills in health care workers. (cdc.gov)
American Society of Clinical Oncology: Criteria for facilities and personnel for the administration of parenteral systemic antineoplastic therapy. (ons.org)
For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
Hemolytic Uremic Syndrome (HUS) a serious complication of chemotherapy, consisting primarily of microangiopathic hemolytic anemia, thrombocytopenia, and irreversible renal failure has been reported in patients receiving systemic mitomycin. (nih.gov)

Cytotoxic chemotherapy can induce acute, delayed and anticipatory nausea and vomiting. (elsevierpure.com)

Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle. (wikipedia.org)

There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)

In 2008, the American Society of Clinical Oncology (ASCO) and the Oncology Nursing Society (ONS) invited a broad range of stakeholders to create a set of standards for the administration of chemotherapy to adult patients in the outpatient setting. (ons.org)
Today, most oncologists would quite reasonably limit their own use of neoadjuvant chemotherapy, based on the extensive series of retrospective reports dealing with primary surgical cytoreduction, and long-standing teaching and clinical experience, rather than on the availability of data generated from evidence-based clinical trials. (cancernetwork.com)
Metronomic chemotherapy from rationale to clinical studies: A dream or reality? (unica.it)

Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
During chemotherapy or radiotherapy, DCs require signaling through TLR4 and its adaptor MyD88 for efficient processing and cross-presentation of antigen from dying tumor cells. (nih.gov)
This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
10. When chemotherapy is given to shrink a tumor it is referred to as neoadjuvant, 11. (studylib.net)

Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
The primary study hypotheses are that the combination of pembrolizumab plus chemotherapy is superior to placebo plus chemotherapy with respect to: 1) Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) as assessed by the Investigator, or, 2) Overall Survival (OS). (clinicaltrials.gov)

American Society of Health-System Pharmacists: ASHP guidelines on preventing medication errors with antineoplastic agents. (ons.org)
Gandhi TK, Bartel SB, Shulman LN, et al: Medication safety in the ambulatory chemotherapy setting. (ons.org)
Goldspiel BR, DeChristoforo R, Daniels CE: A continuous-improvement approach for reducing the number of chemotherapy-related medication errors. (ons.org)

This agent is used in combination with radiation therapy. (medscape.com)
As a class, NSCLCs are relatively insensitive to chemotherapy and radiation therapy compared with SCLC. (medpagetoday.com)
Recently it has become a focus of interest, in treatment of Glioblastoma along with different forms of radiation and chemotherapy. (scirp.org)

Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)

The management in metastatic cases remains mainly palliative and includes multimodality approach comprising 131 I-mIBG therapy, SSTR-targeted therapies, chemotherapy, surgical debulking (where feasible), and novel antineoplastic agents. (thieme-connect.com)
It has been shown to be useful in the therapy of disseminated adenocarcinoma of the stomach or pancreas in proven combinations with other approved chemotherapeutic agents and as palliative treatment when other modalities have failed. (nih.gov)

This rules out chemotherapy and tumour-killing antineoplastics used in oncology, for instance. (concordia.ca)
We know from oncology that melatonin has two effects when it is administered with chemotherapy," Gamberi explains. (concordia.ca)
Shulman LN, Miller RS, Ambinder EP, et al: Principles of safe practice using an oncology EHR system for chemotherapy ordering, preparation, and administration, part 1 of 2. (ons.org)

Metronomic chemotherapy (MC) refers to the close administration of a chemotherapeutic drug for a long time with no extended drug-free breaks. (unica.it)

Antimetabolite antineoplastic agents inhibit cell growth and proliferation. (medscape.com)

Treatment with intravenous chemotherapeutic agents may be associated with a wide gamut of cutaneous adverse effects. (cdlib.org)
The reported immediate adverse effects are nausea, vomiting, transient myelosuppression-prominently isolated thrombocytopenia (more common with chemotherapy), and rarely delayed effects-thyroid hypofunction and persistent myelosuppression. (thieme-connect.com)

Serpentine erythematous or hyperpigmented streaks along the superficial venous network proximal to the site of injection may occur as a distinctive eruption after infusion of several chemotherapeutic agents. (cdlib.org)
Erythematous or hyperpigmented linear streaks along the superficial venous network proximal to the site of injection have been reported after infusion of several chemotherapeutic agents [ 1 ]. (cdlib.org)
She noticed a red line spreading along the path of infusion of the chemotherapeutic agent. (cdlib.org)

a) The neoadjuvant chemotherapy approach is associated with reduced treatment-related morbidity. (cancernetwork.com)

There are clearly patients for whom it is believed that surgery is not warranted (eg, the very elderly, a patient with severe symptomatic coronary artery disease), and where chemotherapy may serve as the primary therapeutic modality. (cancernetwork.com)

Five completed the scheduled induction chemotherapy and all patients completed the programmed concomitant chemoradiotherapy. (uniroma1.it)

Use as single agent or as part of multiagent regimen for treatment of malignant GTN. (medscape.com)
It is indicated as part of a combination chemotherapy regimen for persistent, recurrent, or metastatic carcinoma of the cervix. (medscape.com)
Patients who have contraindication to the lymphodepletion chemotherapy regimen. (moffitt.org)

Effective antineoplastic used in patients with chemotherapy-resistant malignant GTN. (medscape.com)
Patients who have received prior chemotherapy should be given a lower dose initially. (medscape.com)
Several antineoplastic agents elicit a response in patients whose disease is resistant to platinum-based therapies. (medscape.com)
Hollywood E, Semple D: Nursing strategies for patients on oral chemotherapy. (ons.org)
One is delayed or impaired wound healing, which frequently occurs in the patients undergoing surgery due to long-term chemotherapy ( 1 ). (ijbs.com)
Previous studies reported that old patients had high risks in chemotherapy ( 9 ) and the wound healing was compromised with the increase of age ( 10 ). (ijbs.com)
Before standard chemoradiotherapy, patients received induction chemotherapy with 3 cycles of 75 mg/m2cisplatin and 750 mg/m25-fluorouracil. (uniroma1.it)

Data about sociodemographic characteristics, the type of neoplasm and the chemotherapy scheme proposed were collected. (bvsalud.org)

A 45-year-old woman, a patient with recurrent breast carcinoma, was scheduled for chemotherapy with docetaxel 100 mg/m² cycled every 21 days. (cdlib.org)
Metastatic non-small cell bronchogenic carcinoma: a randomized trial of sequential vs combination chemotherapy. (uchicago.edu)

Standard postoperative chemotherapy is combination therapy with platinum and paclitaxel. (medscape.com)

Hartigan K: Patient education: The cornerstone of successful oral chemotherapy treatment. (ons.org)
Moore S: Facilitating oral chemotherapy treatment and compliance through patient/family-focused education. (ons.org)
Patient is currently participating in another investigation treatment study or has participated in a study of an investigational agent within 4 weeks prior to leukapheresis. (moffitt.org)
However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)
Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
Because of this peculiar way of administration, MC can be viewed as a form of long-term 'maintenance' treatment, and can be integrated with standard and conventional chemotherapy in a 'chemo-switching' strategy. (unica.it)

This agent is also a potent radiosensitizer. (medscape.com)
Selpercatinib (Retevmo, Retsevmo) is a potent antineoplastic agent. (globaldata.com)

Initially used as a single agent, it has now been used in combination in chemotherapy. (yashodahospitals.com)

The use of two or more chemotherapy agents is referred to as combination therapy 6. (studylib.net)

Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
So far, high-dose metoclopramide (3-6 mg·kg -1 ·d -1 ) was the most effective single agent in the control of acute emesis. (elsevierpure.com)

Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)

The patient had premedication with oral dexamethasone (8 mg twice daily) and ondensetron (8 mg twice daily), started one day prior to chemotherapy and continued for three more days. (cdlib.org)
Lee CR, Nicholson PW, Souhami RL, et al: Patient compliance with oral chemotherapy as assessed by a novel electronic technique. (ons.org)

A combined effect is attributed to its antineoplastic activity inhibiting the cell's uncontrolled cell division. (yashodahospitals.com)

Anatomy6

Organisms6

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Phenomena and Processes21

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