This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
Although immunotherapy using tumor infiltrating cells (TIL) or vaccine treatment have been expected as a promising modality to treat cancer, recent reports have indicated several mechanisms in tumor tissues to protect cancer cells from immune attacks [ 10 ]. (biomedcentral.com)
Clinical3
This report shows the characterization of the humoral response elicited after vaccination with 400 µg of antigen combined with 200 µg of VSSP in cancer patients representative of the Cuban real clinical practice setting. (researchsquare.com)
CIGB-247 was immunogenic in a broader patient population, and induced Bevacizumab-like polyclonal antibodies, indicating that the VEGF-specific antibody response could have a potentially relevant clinical activity. (researchsquare.com)
Regarding the clinical outcome, one patient achieved complete response and 6 patients revealed stable disease for 4 to 7 months. (biomedcentral.com)
Combination3
These elicited antibodies impaired the high affinity interaction between VEGF and monoclonal antibody Bevacizumab, an antiangiogenic drug approved in combination with chemotherapy for the treatment of different tumors. (researchsquare.com)
So far, the most successful passive immunotherapy directed to VEGF is Bevacizumab, a monoclonal antibody that neutralizes the binding of VEGF to its receptors [5], which has been approved, in combination with chemotherapy, for the treatment of different tumors [6-12]. (researchsquare.com)
The FLT3 inhibitors sorafenib, midostaurin, quizartinib and gilteritinib have been tested in monotherapy in several settings including refractory or relapsed AML (R/R AML), post-transplant maintenance as well as in combination with intensive chemotherapy (ICT) or non-intensity regimens. (dovepress.com)
Complete response1
This regimen is associated with approximately 65% overall response rate (ORR) including ≈35% complete response (CR) and about 15 months overall survival (OS). (dovepress.com)
Cytotoxic3
in contrast to tumor necrosis factor-α (TNFα), cytotoxic drugs failed to induce MnSOD mRNA, protein, or activity in A549 cells. (charismaticplanet.com)
The classes of agents described in this review include novel cytotoxic chemotherapies (CPX-351 and vosaroxin), epigenetic modifiers (guadecitabine, IDH inhibitors, histone deacetylase (HDAC) inhibitors, bromodomain and extraterminal (BET) inhibitors), FMS-like tyrosine kinase receptor 3 (FLT3) inhibitors, and antibody-drug conjugates (vadastuximab), as well as cell cycle inhibitors (volasertib), B-cell lymphoma 2 (BCL-2) inhibitors, and aminopeptidase inhibitors. (biomedcentral.com)
Therefore, new formulations of cytotoxic chemotherapy that have similar mechanisms of action might continue to improve outcomes. (biomedcentral.com)
Acute1
Myelosuppression is the acute dose-limiting toxicity for most nonspecific chemotherapy. (basicmedicalkey.com)
Cancer treatment1
Therapeutic resistance to radiation and chemotherapy is one of the major obstacles in cancer treatment. (biomedcentral.com)
Treatments3
Meanwhile, contrary to the chemo drugs alone, combined treatments significantly induced apoptosis in the treated cells. (biomedcentral.com)
It involves simultaneous administration of more than one type of treatments such as two or more chemotherapies or merging chemotherapy with radiation/adjuvant therapy. (biomedcentral.com)
There is no standard treatment as mesothelioma is primarily resistant to all treatments including chemotherapy. (charismaticplanet.com)
Asbestos-induced oxidative stress is thought to play an essential role in the pathogenesis of mesothelioma in the process possibly increasing the expression of the major antioxidant defense mechanisms of the cells. (charismaticplanet.com)
Monoclonal antibodies that target cellular antigens induce cell death by a variety of mechanisms that involve the host immune system. (basicmedicalkey.com)
Induction2
MnSOD can be induced by TNFα, but the induction, however, does not provide any protection against repeated oxidant exposures. (charismaticplanet.com)
Concurrently, various promising agents have been evaluated in clinical trials, but the classical upfront treatment of AML (intensive induction with 7 days of cytarabine plus 3 days of an anthracycline (7 + 3), followed by consolidation chemotherapy or hematopoietic cell transplant (HCT)) has remained steadfast over the last 40 years. (biomedcentral.com)
Cells4
In this review, we focused on combination therapy, particularly with apigenin augmenting the anti-cancer effects of chemo drugs on tumor cells, reduce their side effects, subdue drug resistance, and protect healthy cells. (biomedcentral.com)
Traditional chemotherapy affects rapidly proliferating cells. (basicmedicalkey.com)
Chemotherapy can be either "cell-cycle phase specific," targeting one specific phase of the cell cycle, or "cell-cycle phase nonspecific," targeting all proliferating cells regardless of their place in the cell cycle. (basicmedicalkey.com)
Ovarian tumor was induced in the mice by intraperitoneal (IP) administration of 5 106 Identification8-fLuc cells dissolved in 100 L cool Phosphate-Buffered Saline (PBS). (baxkyardgardener.com)
Essential1
Prospective dose modification of some chemotherapy and targeted therapies are essential in patients with impaired organ function to reduce the risk of severe adverse events. (basicmedicalkey.com)
Role1
We therefore explored the role of the innate immune system in the inhibition of the adaptive immune response. (baxkyardgardener.com)