• Therefore, we recommended adjuvant radiotherapy and chemotherapy as the alternative management. (psychiatryinvestigation.org)
  • As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
  • With the support of various diagnosis technologies including positron emission tomography (PET), magnetic resonance imaging (MRI), and computed tomography (CT), surgery, radiotherapy, chemotherapy, and hormone therapy are generally applied to treat patients with cancer, including those three deadliest carcinomas. (frontiersin.org)
  • Bone sarcomas such as osteosarcoma and chondrosarcoma are frequently refractory to conventional chemotherapy and radiotherapy that exhibit poor prognosis. (oncotarget.com)
  • Accumulated evidence suggests that bone sarcomas are highly resistant to chemotherapy and radiotherapy, and thus surgical resection is considered as the crucial treatment strategy [ 3 ]. (oncotarget.com)
  • 2021 ). The current standard of care is known as the 'Stupp regimen' and consists of surgical resection followed by treatment with radiotherapy and the alkylating chemotherapeutic agent, temozolomide, increasing overall survival (OS) to a median of 14.6 months (Stupp et al. (biomedcentral.com)
  • Furthermore, chemotherapy and radiotherapy have not substantially improved the survival of patients over the last several years [ 4 ]. (biomedcentral.com)
  • RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
  • Downregulation of UCA1 enhanced the radiosensitivity of CCL244 cells via inhibition of the colony formation, proliferation and promotion of radiation-induced apoptosis and G2/M arrest. (bvsalud.org)
  • Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • Paclitaxel triggers anti-mitotic actions by impeding the cell cycle in the late Everolimus mTOR inhibitor stages of mitosis, backing microtubule formation, and eventually inducing apoptosis. (gp120-inhibitors.com)
  • During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
  • however, DHCer induces autophagy and may be important in the regulation of this important cellular process. (sphingolipidclub.com)
  • We previously demonstrated that GH protects breast cancer cells towards the cytotoxic effects of doxorubicin, inducing chemoresistance. (endocrine-abstracts.org)
  • However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • NF-κB is really a ubiquitous transcription aspect governed by many stimuli including hypoxia cytokines ME0328 and chemotherapeutic medications and has emerged being a focus on for cancers. (healthcarecoremeasures.com)
  • "Toxic effects and chemoresistance are major hurdles in chemotherapy and to avoid these problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called "metronomic chemotherapy" has emerged. (peoplebeatingcancer.org)
  • It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, Immuno-therapy or some mixture of the four. (medicalmarijuana.com)
  • Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
  • The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. (endocrine-abstracts.org)
  • For this look at neuropathy, we'll be discussing two specific types: diabetic peripheral neuropathy (DPN) and chemotherapy-induced peripheral neuropathy (CIPN). (abmp.com)
  • Peripheral neuropathy may reduce length and dosing of chemotherapeutic Eumycetoma treatment. (gp120-inhibitors.com)
  • Conclusions/Significance These outcomes claim that hypoxia or overexpression of HIF-1α induces the EMT that's largely reliant on NF-κB in pancreatic cancers cells. (healthcarecoremeasures.com)
  • Launch Pancreatic cancers which is one of the most intense and lethal malignancies worldwide is normally extremely resistant to chemotherapy FTSJ2 [1]. (healthcarecoremeasures.com)
  • Some latest studies demonstrated that hypoxia can activate NF-κB and induce level of resistance of pancreatic cancers cells to gemcitabine [21]-[23]. (healthcarecoremeasures.com)
  • The importance of these pathways in cancer prevention is illustrated by the fact that individuals who inherit mutations in any one of the many genes that participate in these stress-induced signal transduction pathways have a very high incidence of cancer. (the-scientist.com)
  • The higher (600 mg) dose ameliorated the stress induced by the test, and produced significantly improved self-ratings of calmness and alertness. (lifeextension.com)
  • Chemotherapeutic agents, corticosteroids, and monoclonal antibodies are used to reduce the disease burden, and bisphosphonates are used to promote bone healing and to provide secondary prophylaxis against skeletal-related events (eg, hypercalcemia, bone fracture, spinal cord compression, need for radiation, and need for surgery). (medscape.com)
  • From the perspective of cancer, DNA damage causes the disease, but it is also used to treat the disease via radiation and many chemotherapeutic agents. (the-scientist.com)
  • Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
  • Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)
  • Such regimen involves the frequent administration of conventional chemotherapeutic agents at very low doses to target activated endothelial cells in tumors, the advantages of which include minimal adverse effects and a rare chance of developing acquired drug resistance. (peoplebeatingcancer.org)
  • Nevertheless, chemotherapy agents can cause neurological and psychiatric complications. (psychiatryinvestigation.org)
  • Introduced in 1958, 5-Fluorouracil (5-FU) is one of the most common chemotherapeutic agents. (psychiatryinvestigation.org)
  • MDR1 codes for P-glycoprotein (P-gp), a member of the ABC transporter superfamily of proteins that promote cellular efflux of chemotherapeutic agents. (sphingolipidclub.com)
  • Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
  • The development of specific chemotherapeutic agents has revolutionized the prognosis of tuberculosis and tuberculous infection, making tuberculosis truly curable and preventable. (cdc.gov)
  • The use of radiation therapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers. (medicalmarijuana.com)
  • In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
  • History Epithelial to mesenchymal changeover (EMT) induced by hypoxia is among the critical factors behind treatment failure in various types of individual cancers. (healthcarecoremeasures.com)
  • Hypoxia can be an environmental stimulus that has an integral function in cancers and advancement development. (healthcarecoremeasures.com)
  • Tumoral hypoxia or appearance HIF-1 (hypoxia-inducible aspect-1) continues to be associated with an intense phenotype which correlates with an unhealthy reaction to chemotherapy along with a worse general survival of cancers sufferers [5] [6]. (healthcarecoremeasures.com)
  • The theory suggests that conventional chemotherapies kill differentiated or differentiating cells, which form the bulk of the tumor but do not generate new cells. (wikipedia.org)
  • One key malignant phenotype of cancer cells is their ability to resist chemotherapeutics, and elements of the ECM can promote chemoresistance in cancer cells through a variety of signaling pathways, inducing changes in gene expression and protein activity that allow resistance. (peoplebeatingcancer.org)
  • In this review, we discuss how the properties of the tumor microenvironment promote chemoresistance in cancer cells, and the interplay between these external stimuli. (peoplebeatingcancer.org)
  • Most dramatically, lemon balm extracts induced sleep in mice that had been given tiny (non-sleep-inducing) doses of traditional sedative medications. (lifeextension.com)
  • Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • The condition is more prevalent in chemotherapy patients who drink alcohol heavily or are severely malnourished. (abmp.com)
  • Cisplatin-based chemotherapy has been the best option for decades, but only 50% of patients benefit in the form of objective responses, and just 13-25% experience a complete response [ 1 ]. (iospress.com)
  • Patients generally have chemotherapy after surgery for cancer, regardless of its stage. (psychiatryinvestigation.org)
  • Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
  • Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. (usherbrooke.ca)
  • Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)
  • 3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
  • As the underlying cellular mechanisms remain incompletely understood pharmacotherapies for chemotherapy-induced neuropathy are limited. (gp120-inhibitors.com)
  • RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
  • Drug-induced damage to these structures of the auditory and balance system can result in hearing loss, tinnitus , and dysequilibrium or dizziness . (medscape.com)
  • Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)
  • Set the longer session reason of this chemotherapeutic power in this square footage, cases of resistance to miltefosine procure been reported predominantly in India. (wgc2010.sk)
  • Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). (mdpi.com)
  • KEGG pathway term mTOR signaling pathway is observed to be meliorated in this tricluster and has been reported to be associated Inhibitors,Modulators,Libraries with estrogen induced breast cancer cell. (ampk-signal.com)
  • The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
  • We report the case of a woman who developed an acute manic episode after receiving 5-FU chemotherapy during treatment for rectal cancer. (psychiatryinvestigation.org)
  • Previously it was thought that they act by targeting angiogenesis, but recently additional mechanisms have been discovered which has established metronomic chemotherapy as a type of multi-targeted therapy. (peoplebeatingcancer.org)
  • Although the mechanisms of gene activation are still unclear, ceramide's role as a messenger of cytotoxic response to chemotherapy might be linked to the MDR pathway. (sphingolipidclub.com)
  • The central nervous system is relatively safe from such toxicity because the blood-brain barrier protects it, and it has a slower cell proliferation rate. (psychiatryinvestigation.org)
  • Activation of Wnt/β-catenin signaling with Wnt3a or GSK-3β inhibitor drives the proliferation of bone sarcoma cells, whereas downregulation of activated Wnt signaling with dnTCF4 or siLEF1 suppresses bone sarcoma proliferation and induces cell cycle arrest. (oncotarget.com)
  • Even cells that exhibit rapid cell division such as those found in bone marrow or intestine are not affected as they are protected by high impedance of the bone, and slower replication times compared to cancerous cells respectively (Blatt et al. (biomedcentral.com)
  • these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative damage. (biomedcentral.com)
  • Because the bacterial biofilm is responsible for an aggressive surgical approach and prolonged antibiotic treatment, the nanoparticles have been functionalized with a functional coating able to both disaggregate the biofilm, hamper premature antibiotic release and protect the intact bone. (ucm.es)
  • After a mild onset, discomfort increases with each additional chemotherapy dose, usually moving proximal as the pain worsens. (abmp.com)
  • The patient presented manic symptoms after 4th cycle of 5-FU chemotherapy after surgery of rectal cancer. (psychiatryinvestigation.org)
  • After cessation of chemotherapy and administration of olanzapine and divalproex sodium, symptoms were subsided within 10 days. (psychiatryinvestigation.org)
  • In addition, erythropoietin is used to treat anemia, either alone or in conjunction with chemotherapy. (medscape.com)
  • The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
  • The chemotherapeutic agent used, dosing schedule, type of cancer, and presence of additional medical complications make a difference to the occurrence and severity of chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • The knowledge gained from the preclinical studies of metronomic chemotherapy, along with clinical experience, will help to design better therapeutic protocols against cancer. (peoplebeatingcancer.org)
  • Although TTFields have a favourable side effect profile, particularly compared to cytotoxic chemotherapy, survival benefits remain limited (~ 4.9 months) after an extensive treatment regime (20 hours/day for 18 months). (biomedcentral.com)
  • Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
  • Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. (medscape.com)
  • This response protects your frame from germs and infections. (usa-good.com)
  • In this regard, photoresponsive DDSs that employ light as an external stimulus can offer a precise spatiotemporal control of drug release at desired sites of interest. (biomedcentral.com)
  • Herein, we summarize the recent development of NIR photoresponsive DDSs with on-demand drug release profiles for cancer photo-chemotherapy. (biomedcentral.com)
  • CIPN is caused by the administration of neurotoxic (nerve-damaging) chemotherapeutic drugs. (abmp.com)
  • Mast cells can also be induced to release mediators by other non-particular stimuli including changes in temperature, pressure, alcohol and workout amongst others. (usa-good.com)
  • Although general therapeutic strategies and existent nanomedicine have been applied in relating cancer treatments, the side effects and potential damage induced by the off-target effect greatly lower the therapeutic efficiency. (frontiersin.org)
  • Cannabinoids curb neuropathic pain induced by traumatic nerve damage, harmful insults and metabolic changes. (gp120-inhibitors.com)
  • Gabapentin, amytriptyline and opioids are used to treat chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • In DPN, the cause is uncontrolled blood glucose, while CIPN is a side effect of chemotherapy. (abmp.com)
  • In another 2004 study, lemon balm was examined for its effect on laboratory-induced stress in humans. (lifeextension.com)