Chemotactic protein ccl17 attracts immune. Medical search. Frequent questions

In this study, we have characterized the T H 2-like chemokine profile (CCL17, CCL18, CCL20, CCL22) in patients with RRP and asked whether it was modulated in patients who had achieved significant clinical improvement. (biomedcentral.com)
CCL17, CCL18 and CCL22 messenger RNAs (mRNAs) were increased in papillomas compared with clinically normal laryngeal epithelium of the RRP patients. (biomedcentral.com)
Patients with RRP expressed more CCL17 ( p = 0.003), CCL18 ( p = 0.0003), and CCL22 ( p = 0.007) in their plasma than controls. (biomedcentral.com)
There was a significant correlation between sustained clinical remission in additional patients with RRP and reduced levels of CCL17 ( p = 0.01), CCL22 ( p = 0.002) and CCL18 ( p = 0.05). (biomedcentral.com)
Myeloid DC process allergens and release CCL17 and CCL22 to attract TH2 to injured region. (knowyourasthma.com)
DESIGN: The roles of GM-CSF, CCL17, CCR4, and CCL22 in various experimental OA models, including those incorporating obesity (eight-week high-fat diet), were investigated using gene-deficient male mice. (bvsalud.org)
The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity. (bvsalud.org)

Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and C. All of these proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called chemokine receptors, that are selectively found on the surfaces of their target cells. (wikipedia.org)
Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. (wikipedia.org)
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. (lookformedical.com)
Interferon pathway-related cytokines/chemokines, including interleukin (IL) 18, macrophage inflammatory protein 3α, and IL-33, were elevated, but tumor necrosis factor-α, IL-6, CXCL8 (formerly IL-8), and cytokines acting through C-C chemokine receptor 2 and CCR5 were lower among case-patients than controls. (cdc.gov)
Another reported that IL-10, C-X-C motif chemokine ligand 10 (CXCL-10, formerly IFN-γ inducible protein 10) and CC chemokine ligand 2 (CCL2, formerly monocyte chemoattractant protein 1) levels were higher in patients with high viral loads ( 12 ), but patients with severe disease had higher levels of CXCL10 and CCL2 than did patients with less-severe cases. (cdc.gov)
Among the results was evidence that there was differential chemokine mRNA expression by the papilloma tissues, which suggested that the virus might be able to polarize the patients' innate immune responses. (biomedcentral.com)
TARC (or CCL17) is a Th2 chemokine used as an activity marker for atopic dermatitis (AD). (bvsalud.org)

Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy', and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. (wikipedia.org)
In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as well as in the pathogenesis of diseases like cancers. (wikipedia.org)
Cytokine proteins are classified as chemokines according to behavior and structural characteristics. (wikipedia.org)
Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. (wikipedia.org)
Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing. (wikipedia.org)
PGE 2 can bias the adaptive immune response away from an effective T H 1-like pattern ( 16 ), and can enhance expression of T H 2-like chemokines by innate immunocytes ( 16 , 17 ). (biomedcentral.com)
Comprehensive proteomic screening of chemokines in the blister fluids of DEB-affected mice was conducted to define the inflammatory and immune activities, thus providing potential to examine local biological mechanisms and define the protein signature within lesional skin as a potential marker of disease activity. (biomedcentral.com)
Assessment of blister fluid-derived chemokines showed a persistent presence of several chemotactic molecules, including CXCL1 + 2 and CXCL5. (biomedcentral.com)

OBJECTIVES: We have previously identified a granulocyte macrophage-colony stimulating factor (GM-CSF)/C-C motif ligand 17 (CCL17) pathway in monocytes/macrophages, in which GM-CSF regulates the formation of CCL17, and it is important for an experimental osteoarthritis (OA) model. (bvsalud.org)
In the skin, H1Rs are expressed on vascular smooth muscle cells, endothelial cells, neurons, and different immune cells such as monocytes, neutrophils, DCs, and T and B cells where their activation drives the typical symptoms of immediate hypersensitivity responses, comprising edema and pruritus [ 10 ]. (springeropen.com)

These proteins have historically been known under several other names including the SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. (wikipedia.org)
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. (lookformedical.com)
Multiscale models should also be used to investigate how chronic inflammation could be caused by prolonged exposure to different kinds/levels of trauma, increased activation and diffusion of chemotactic attractants or high levels of inflammatory cytokines at a site of injury. (knowyourasthma.com)

Inflammatory: these are formed under pathological conditions (on pro-inflammatory stimuli, such as IL-1, TNF-alpha, LPS, or viruses) and actively participate in the inflammatory response attracting immune cells to the site of inflammation. (wikipedia.org)
Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)
When the barrier function of the skin is breached, inflammatory wound healing is initiated, whereby the immune system takes over a major role in orchestrating the subsequent phases of skin repair [ 14 ]. (biomedcentral.com)
In addition to its pro-pruritic effect, several studies acknowledge a role for the H1R on immune cells in mediating inflammatory effects of allergic skin diseases with antagonism of the H1R by several drugs demonstrating anti-inflammatory properties in different experimental models of AD [ 15 - 19 ]. (springeropen.com)

Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
Damaged epithelial cells release CCL11 to recruit eosinophils which attract more proinflammatory mediators to the damaged region. (knowyourasthma.com)
Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
Immunologically, AD is driven by TSLP-secretion by keratinocytes and epithelial cells which modulate dendritic cell (DC) and basophil function to preferentially induce a Th2 immune response. (springeropen.com)

A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)

Using these ligands is possible routing antigen-presenting cells (APC) to lymph nodes during the adaptive immune response. (wikipedia.org)

Such temporally- and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation. (biomedcentral.com)
Cutaneous wound healing is a temporally- and spatially-synchronized cascade of cellular and immune responses dedicated to re-establishing skin integrity and function [ 3 ]. (biomedcentral.com)
Wang M, Yu F, Wu W, Wang Y, Ding H, Qian L. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. (ijbs.com)
This review will update the current knowledge about EBV miRNAs implicated in host immune responses. (ijbs.com)

They are released by many different cell types and serve to guide cells of both innate immune system and adaptive immune system. (wikipedia.org)

EBV can not be completely cleared once entry into the host cells and ultimately establishes life-long latent infection in host, indicating that EBV has developed elaborate strategies to evade host immune surveillance [ 4 ]. (ijbs.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)

However, despite encouraging results, these trials revealed that the majority of curative effects resulted from the secretion of various paracrine factors elicited by transplanted cells rather than from donation of the therapeutic protein to the affected cutaneous tissue [ 11 ]. (biomedcentral.com)
In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. (biomedcentral.com)
This function of the cutaneous system is mediated by a myriad of highly specialized immune cells. (biomedcentral.com)

Intriguingly, EBV miRNAs directly suppress host antiviral immunity by interfering with antigen presentation and immune cell activation. (ijbs.com)

Human OA sera were collected for circulating CCL17 levels (ELISA) and OA knee synovial tissue for gene expression (qPCR). (bvsalud.org)

Toward understanding the immune mechanism(s) that prevents patients with RRP from clearing or controlling their HPV infection, we previously performed a paired messenger RNA (mRNA) microarray study that characterized the repertoires of genes expressed in papillomas versus those expressed by autologous clinically normal laryngeal tissues ( 6 ). (biomedcentral.com)
Collectively, these studies demonstrate that recruitment of mADSC into DEB skin is tightly controlled by disease-site chemotactic activities and suggest a potential mechanism for effective application of therapeutic stem cells for DEB. (biomedcentral.com)

The majority of blister-originated chemotactic signals were associated with preferential recruitment of CD45 + CXCR2 + and CD11b + CXCR2 + leukocytes. (biomedcentral.com)

and a variety of other immune cells. (lookformedical.com)
Both IL-10 and IL-4 are upregulated in papillomas and in peripheral blood mononuclear cells exposed to HPV-11 E6 protein, and the tissues and cells express a concomitant decrease in IFN-Y, IL-12 and IL-18 ( 7 ). (biomedcentral.com)
To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. (biomedcentral.com)
In interaction with other non-immune cells, such immune cell subsets ensure the functionality and integrity of the skin layers [ 1 ]. (biomedcentral.com)
To this end and within their broad functionality and operationality, Tregs are able to adopt unique features of skin cells and contribute to the skin's role as an immune barrier. (biomedcentral.com)
EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)

EBV can establish life-long latent infection in host due to the balance between EBV and host immune system. (ijbs.com)

These studies provided proof-of-concept data suggesting that adult stem cell-derived connective tissue proteins can participate directly in restoration of defective extracellular matrix and demonstrating the feasibility of systemic cellular therapy for DEB. (biomedcentral.com)

Overall, CCL20 mRNA expression was not increased, but there was intense, selective CCL20 protein expression in the basal layer of the papillomas. (biomedcentral.com)

The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)

Topical application of MC903 to ear skin increased the expression of not only TSLP but also CCL17, CCL22, the Th2 cytokine IL-4, and the Th17 cytokine IL-17A. (kindai.ac.jp)
Methods: We performed RNA-Seq with CAN-2409 treated patient-derived glioma stem-like cells and tumors of C57/BL6 mice and compared KEGG pathway usage and differential gene expression focusing on immune cell and cytokine profiles. (bvsalud.org)

Using these ligands is possible routing antigen-presenting cells (APC) to lymph nodes during the adaptive immune response. (wikipedia.org)
Both immune and non-immune cells express these receptors and ligands, and the impact of this expression differs according to cell types. (frontiersin.org)
The CCR4 ligands CCL17 and CCL22 have been reported to be upregulated in the skin lesions of AD patients. (kindai.ac.jp)

Another reported that IL-10, C-X-C motif chemokine ligand 10 (CXCL-10, formerly IFN-γ inducible protein 10) and CC chemokine ligand 2 (CCL2, formerly monocyte chemoattractant protein 1) levels were higher in patients with high viral loads ( 12 ), but patients with severe disease had higher levels of CXCL10 and CCL2 than did patients with less-severe cases. (cdc.gov)
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. (bvsalud.org)

They bind to 19 G protein-coupled seven transmembrane receptors that form either homodimers or heterodimers ( 7 - 11 ). (frontiersin.org)

This superfamily consists of 48 proteins classified into 4 groups (XCL, CCL, CXCL, and CX3CL) based on the position of two cysteine residues in their sequence. (frontiersin.org)
In mammals, arginine residues within proteins can be converted into citrulline by peptidylarginine deiminase (PAD) enzymes. (bvsalud.org)

11/05/2007) TOTAL 2008 NEW DESCRIPTORS = 456 MH - A Kinase Anchor Proteins UI - D054758 MN - D12.644.360.24.65 MN - D12.776.157.57.01 MN - D12.776.476.24.69 MS - A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. (nih.gov)

A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. (frontiersin.org)
Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. (frontiersin.org)
Chemokine receptors (red) influence melanoma tumor cell migration/invasion or immune cell trafficking to the tumor lesions. (frontiersin.org)

Patient outcome is dictated by the capacity of immune cells to mount an effective anti-tumor response. (frontiersin.org)
Elevated tumor immune infiltration is often associated with a favorable prognosis in many malignancies ( 1 - 3 ) including melanoma ( 4 - 6 ). (frontiersin.org)
Although fundamental in the anti-tumor immune response, tumor infiltration by immune cells is a challenging process. (frontiersin.org)
Immune cells are guided from the circulation to the tumor microenvironment by an evolutionarily conserved and sophisticated system in the form of the chemokine network. (frontiersin.org)
The progress in understanding T cell function in cancer has and will continue to improve harnessing of the immune system across broader tumor types to benefit more patients. (salk.edu)

Migration to, and infiltration of, tumors by immune cells is critical for achieving this goal. (frontiersin.org)
On one hand, selective expression drives the recruitment of specific immune cells into tumors, subsequently influencing patient prognosis. (frontiersin.org)

Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. (kindai.ac.jp)

Ablation of β-adrenergic signalling limits the progression of T cells towards the exhausted state in chronic infection and improves effector functions when combined with immune checkpoint blockade (ICB) in melanoma. (salk.edu)

Cancer immunoprevention, the engagement of the immune system to prevent cancer, is largely overshadowed by therapeutic approaches to treating cancer after detection. (salk.edu)

CD8 T cells are essential components of the immune response against viral infections and tumours, and are capable of eliminating infected and cancerous cells. (salk.edu)

Inflammatory: these are formed under pathological conditions (on pro-inflammatory stimuli, such as IL-1, TNF-alpha, LPS, or viruses) and actively participate in the inflammatory response attracting immune cells to the site of inflammation. (wikipedia.org)
Of note, Thymic stromal lymphopoietin (TSLP), a master regulator of the Th2 immune response, promotes the expression of CCL17 and CCL22 in AD skin lesions. (kindai.ac.jp)

Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC-AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA. (nih.gov)

They are released by many different cell types and serve to guide cells of both innate immune system and adaptive immune system. (wikipedia.org)
Loss of the epithelial cell barrier can contribute to the influx of proteins and other macromolecules into the alveolar compartment. (medscape.com)
We searched for novel combination therapies based on the expression patterns of membrane proteins in CRC cell lines. (kindai.ac.jp)
immune cell gene profiling showed reduction of myeloid associated genes. (bvsalud.org)

It is a known fact that the post-translational modifications (PTMs) of proteins have a significant impact on their properties. (bvsalud.org)

Several studies suggested an important role for MCP-1 in the massive inflammation at the damaged joint, in part due to its chemotactic and angiogenic effects. (bvsalud.org)

They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. (nih.gov)

Anatomy41

Organisms16

Diseases20

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes47

Disciplines and Occupations1

Information Science3

Health Care2

CCL227

Chemokine7

Chemokines9

MONOCYTES2

Cytokines3

Inflammatory4

Epithelial cells4

Monocyte1

Adaptive immune r1

Responses4

Innate1

Surveillance2

Cutaneous3

Immunity1

Levels1

Mechanism2

Recruitment1

Cells7

System1

Tissue1

Expression1

Family1

Cytokine2

Ligands3

CCL22

Transmembrane receptors1

Residues2

Selectively1

Chemokine receptors3

Tumor5

Tumors2

Pathogenesis1

Melanoma1

Therapeutic1

Viral1

Response2

Bind1

Cell4

Properties1

Effects1

Role1