• The chemoradiotherapy regimen consisted of cisplatin (50 mg/m 2 ) on days 1 and 29 concurrent with volume-directed external-beam radiation therapy, followed by carboplatin given at a dose to achieve an area under the concentration-time curve (AUC) of 5-6 plus paclitaxel (175 mg/m 2 every 21 days for four cycles). (medscape.com)
  • The current standard of care for locally advanced nasopharyngeal carcinoma of gemcitabine/cisplatin induction followed by concurrent chemoradiotherapy was established by Zhang et al in 2019. (ascopost.com)
  • The CONTINUUM trial randomly assigned 425 patients in China with stage III/IV nasophargyneal carcinoma to receive gemcitabine/cisplatin induction followed by concurrent chemoradiotherapy with or without sintilimab, a novel PD-1 antibody with a higher affinity for PD-1 than other immune checkpoint inhibitors. (ascopost.com)
  • Low-dose cisplatin and 5-fluorouracil (LDPF) chemotherapy with daily radiotherapy (RT) is used as an alternative chemoradiotherapy regimen for locally advanced esophageal carcinoma. (nih.gov)
  • We evaluated whether RT plus LDPF chemotherapy had an advantage in terms of survival and/or toxicity over RT plus standard-dose cisplatin and 5-fluorouracil (SDPF) chemotherapy in this study. (nih.gov)
  • Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. (uchicago.edu)
  • Received weekly cisplatin 40 mg m2 for 5 to 6 cycles as concurrent chemotherapy with radiation therapy. (who.int)
  • The last dose of cisplatin must be administered prior to, or concurrently with, the final dose of radiation. (who.int)
  • Interestingly, apoptosis occurred in mt-p53 tumors although only at high doses of cisplatin and not at the magnitude detected in wt-p53 tumors. (elsevierpure.com)
  • The trial met its primary endpoint, showing superior overall survival (OS) with Opdivo plus Yervoy versus chemotherapy (pemetrexed and cisplatin or carboplatin) in all randomized patients. (pharmiweb.com)
  • In both arms, chemoradiation consisted of 40 mg/m2 of cisplatin once every week for five weeks plus external beam radiation (EBRT) ranging from 40 Gy to 50.4 Gy given in 20 to 28 fractions. (curetoday.com)
  • A 57-year-old woman diagnosed with intestinal spinocellular carcinoma, showed OM score 3 (WHO) after 5-fluorouracil and cisplatin chemotherapy. (bvsalud.org)
  • Alternatively, seemingly active chemotherapy regimens may have been suboptimal. (jnccn.org)
  • To de-intensify the present typical of care would require decreasing the current radiation dose and/or the chemotherapy regimens. (trpv1inhibitor.com)
  • The association between chemotherapy regimens and survival endpoints, including distant metastasis-free survival (DMFS), overall survival (OS) and disease-free survival (DFS), were evaluated and adjusted with PS. (biomedcentral.com)
  • Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
  • In a systematic review that compared the effectiveness of these regimens, Amarasena et al concluded that platinum-based chemotherapy regimens did not provide a statistically significant benefit over non-platinum-based agents in survival or overall tumor response. (medscape.com)
  • The investigators suggested that non-platinum-based chemotherapy regimens may have a better risk-benefit profile. (medscape.com)
  • Furthermore, several randomised trials have shown that the addition of alkylating chemotherapy, either temozolomide or nitrosourea-based regimens, to radiotherapy results in prolonged survival. (smw.ch)
  • For medically fit patients, perioperative neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is appropriate. (medscape.com)
  • Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. (uchicago.edu)
  • Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. (biomedcentral.com)
  • They were all treated with Intensity-modulated radiation therapy (IMRT) combined with systemic treatments, including radiotherapy alone (RT alone), neoadjuvant chemotherapy followed by radiotherapy (NACT+RT), CCRT, NACT+CCRT, NACT followed by radiotherapy and adjuvant chemotherapy (NACT+RT+AC), CCRT+AC and NACT+CCRT+AC. (oncotarget.com)
  • In recent years, as most evidence solidified the role of concurrent chemotherapy and radiation as either primary or postoperative therapy for locally advanced head and neck cancer, induction chemotherapy fell out of scope and practice. (jnccn.org)
  • However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
  • Over the previous 30 years, several randomized trials have now established that remedy intensification with all the addition of concurrent chemotherapy and altered radiotherapy fractionation schedules [115] can boost locoregional disease manage prices and survival. (trpv1inhibitor.com)
  • Purpose/Objective(s): Institutional experience over the 10-year period of the use of hyperfractionated radiation therapy (Hfx RT) with or without concurrent chemotherapy (CHT) in stage III non-small cell lung cancer (NSCLC) was reviewed. (coek.info)
  • Must have received at least 2 doses of platinum based chemotherapy concurrent with ≥ 60 Gy definitive radiation therapy to all known tumor sites, and not have known progression of disease. (stanfordhealthcare.org)
  • For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
  • Platinum-based chemotherapy, when administered before chemoradiotherapy, improved progression-free and overall survival for patients with locally advanced cervical cancer. (curetoday.com)
  • Platinum-based chemotherapy, given before chemoradiation, improved outcomes for patients with advanced cervical cancer. (curetoday.com)
  • Patients with locally advanced cervical cancer saw an improvement in survival when they added platinum-based chemotherapy before chemoradiation, compared to those who had chemoradiation alone, according to findings from the phase 3 INTERLACE clinical trial. (curetoday.com)
  • For this study, Matei and colleagues hypothesized that systemic chemotherapy and tumor volume-directed radiotherapy would improve recurrence-free survival and overall survival in comparison with systemic chemotherapy alone for patients with surgically staged III/IVA uterine cancer. (medscape.com)
  • Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
  • Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
  • With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
  • Brachytherapy is a cancer treatment using high radiation dose to the tumor, without irradiating the adjacent tissues. (brachycenter.com)
  • Strategies being investigated include reductions in radiation dose, response-tailored dose reduction after induction chemotherapy, and use of novel biomarkers such as HPV circulating tumor DNA to guide treatment. (ascopost.com)
  • Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy. (uchicago.edu)
  • Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. (uchicago.edu)
  • Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. (uchicago.edu)
  • However, three patients had primary tumor progression at 7, 9, and 15 months after irradiation with total doses of 56.8, 58.4, and 68.3 Gy in EQD2, respectively. (iiarjournals.org)
  • Even in such patients, radiation therapy has been positively used with palliative intent to relieve severe symptoms, including bleeding and pain, via primary tumor control. (iiarjournals.org)
  • In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. (biomedcentral.com)
  • The aim of this retrospective study was to investigate whether tumor budding is a prognostic factor for survival in patients with rectal cancer who received neoadjuvant chemoradiotherapy. (biomedcentral.com)
  • Clinical trial: bosting RT dose to metabolic active tumor subvolumes to improve local control. (utoronto.ca)
  • For example, image-guided radiation therapy (IGRT), has allowed the daily localization of the tumor immediately prior to treatment and thus eliminated the large and frequent localization errors, ensuring the tumor receives the prescribed radiation dose. (utoronto.ca)
  • Nanowerk News ) Making a tumor more sensitive to radiotherapy is a primary goal of combining chemo and radiation therapy to treat many types of cancer, but with the chemotherapy drugs come unwanted side effects. (nanowerk.com)
  • The nanoparticles target tumor cells, the investigators explain, thus sparing normal tissue and avoiding the systemic side effects often associated with chemotherapy drugs. (nanowerk.com)
  • The chemotherapy-only regimen consisted of carboplatin (to achieve an AUC of 6) plus paclitaxel (175 mg/m 2 ) every 21 days for six cycles. (medscape.com)
  • To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 2. (stanford.edu)
  • To determine the maximum-tolerated dose (MTD) when capecitabine - oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 3. (stanford.edu)
  • Aim: To determine the role of radiation therapy for patients with bone metastasis from uterine cervical cancer and identify an optimal radiation regimen. (iiarjournals.org)
  • Several chemotherapy combinations are active in SCLC, but usually a platinum-containing regimen is chosen. (medscape.com)
  • It has been 15 years since the 2008 approval by the Food and Drug Administration (FDA) of injectable Emend (fosaprepitant dimeglumine) as part of a three-day combination treatment regimen to prevent acute and delayed chemotherapy-induced nausea and vomiting (CINV) for patients who received highly emetogenic chemotherapy (HEC). (curetoday.com)
  • Concomitant with radiation, fluorouracil based chemotherapy remains the standard, and although toxicity is decreased with continuous infusion fluorouracil, oral capecitabine is non-inferior to the continuous infusion regimen. (biomedcentral.com)
  • In 2004, a randomized trial from Germany was published establishing a regimen of preoperative chemoradiotherapy and surgery followed by additional cycles of chemotherapy alone as the standard of care for clinical stages T3 or T4, or for node-positive rectal cancer [ 3 ]. (biomedcentral.com)
  • Is there an optimal chemotherapy regimen? (touchoncology.com)
  • Chemotherapy is the mainstay of treatment for high-risk endometrial carcinoma, and it looks to stay that way, as adding radiation on top does not improve survival over that seen with chemotherapy alone, according to new findings. (medscape.com)
  • A final analysis of data from the NRG258 trial, with a median follow-up of 112 months for overall survival, showed no significant difference between the two arms: the stratified ratio for death comparing chemoradiation therapy vs chemotherapy alone was 1.05 (log-rank two-sided P = .72). (medscape.com)
  • As previously reported, chemoradiation did not improve progression-free survival compared to chemotherapy alone," said lead author Daniela Matei, MD, chief of reproductive science in medicine in the Department of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, Illinois. (medscape.com)
  • That study showed improved progression-free and overall survival in the chemoradiotherapy arm. (medscape.com)
  • They show that chemotherapy plus radiation was not associated with longer relapse-free survival than chemotherapy alone ( N Engl J Med . (medscape.com)
  • The failure of older randomized trials to show a survival benefit from induction chemotherapy can be attributed to several factors. (jnccn.org)
  • Patient five-year survival rate has significantly increased from 1% with surgery to 26% after the application of combination chemotherapy. (wikipedia.org)
  • Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. (uchicago.edu)
  • HPV(+) cancers seem much more sensitive to chemo Abc Inhibitors MedChemExpress radiation as sufferers with low risk HPV(+) oropharyngeal cancers have almost double the overall survival as patients higher threat HPV() cancers. (trpv1inhibitor.com)
  • The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine (triweekly XELOX) or capecitabine. (biomedcentral.com)
  • The unaltered survival implies that low-dose weekly oxaliplatin was unable to further eliminate tumour micrometastasis, providing a rationale for intensified systemic treatment. (biomedcentral.com)
  • Therefore, we focused on the comparison of long-term survival outcomes and the adverse effects of capecitabine plus neoadjuvant radiation with or without triweekly oxaliplatin in LARC patients. (biomedcentral.com)
  • Nonrandomized trials of combination chemotherapy have shown superior response rates and survival compared with single-agent chemotherapy. (medscape.com)
  • At univariate analysis, the overall survival received benefit from Karnofsky performance status (KPS) $80, three-dimensional conformal radiotherapy, total dose more 60 Gy and ATM 81165C allele. (coek.info)
  • In the CheckMate -743 trial, this dual immunotherapy combination demonstrated a clinically meaningful improvement in survival over the standard of care, with 41% of patients who received Opdivo plus Yervoy still alive at two years, compared to only 27% with chemotherapy," said Abderrahim Oukessou, M.D., vice president, thoracic cancers development lead, Bristol Myers Squibb. (pharmiweb.com)
  • According to treatment modalities, NSE (neuron-specific enolase) (p=0.006) and response to overall treatment (p=0.003) were associated with overall survival in radiotherapy alone group, and response to overall treatment (p=0.007) in induction chemotherapy group. (e-roj.org)
  • An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
  • Radiation oncology and the new biology. (uchicago.edu)
  • Role of gene therapy in radiation oncology. (uchicago.edu)
  • Elderly patients with SCLC who have a good performance status (PS) (ie, Eastern Cooperative Oncology Group [ECOG] PS 0 or 1) and intact organ function should receive standard carboplatin-based chemotherapy. (medscape.com)
  • 1 Department of Radiation Oncology, School of Medicine, Korea. (e-roj.org)
  • By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
  • 5 Both trials reported benefits from the addition of PD-1 inhibitors regardless of PD-L1 expression, suggesting the addition of immunotherapy to chemotherapy may soon become standard of care for patients with nasopharyngeal carcinoma in both curative and recurrent/metastatic disease. (ascopost.com)
  • Should immunotherapy be employed concurrent with chemoradiotherapy? (touchoncology.com)
  • On the basis of this background, we retrospectively explored the possible treatment option and hypothesized that patients with bulky lymph nodes would benefit from additional chemotherapy other than the concurrent modality. (oncotarget.com)
  • However, the Hematological Toxicity (Hem T) increases with the addition of chemotherapy and the risk may be severe [ 5 ]. (oncologyradiotherapy.com)
  • Many advances in RT techniques and schedules are attempted to improve outcomes of the disease starting from intracavitary brachytherapy, intensity modulated RT to simultaneous modulated accelerated RT, all showing some promise with most significant benefit seen with addition of chemotherapy, especially in intermediate (Stage II) and advanced (Stage III, IVA, IVB) cases. (intechopen.com)
  • Methods: Between 2007 and 2017, patients with clinically staged II-III rectal cancer who were treated with preoperative chemoradiotherapy using either triweekly XELOX (oxaliplatin 130 mg/m 2 plus capecitabine 825 mg/m 2 ) or capecitabine were included. (biomedcentral.com)
  • A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surgery were included. (biomedcentral.com)
  • Other clinical studies from the United States, Europe, and Asia have also influenced the treatment strategies for operable rectal cancer, as various approaches using preoperative or postoperative radiotherapy, with or without chemotherapy, have been examined. (biomedcentral.com)
  • Treatment is a combination of surgical resection and chemotherapy. (msdmanuals.com)
  • The fact that cetuximab is an antibody targeting the cancer cell membrane and is thus connected with decrease toxicity, renders radiation with cetuximab or bioradiotherapy distinct from chemoradiotherapy. (trpv1inhibitor.com)
  • Triweekly XELOX was not associated with an increased risk of severe toxicity during chemoradiotherapy, but it increased the risk of postoperative complications compared to capecitabine. (biomedcentral.com)
  • However, even those who have poor prognostic factors (eg, poor PS, medically significant concomitant conditions) may still be considered for chemotherapy if appropriate precautions are taken to avoid excessive toxicity and further decline in PS. (medscape.com)
  • Toxicity associated with radiation therapy is decreased by placing the patient in the prone position on a belly board, however for patients who cannot tolerate prone positioning, IMRT decreases the volume of normal tissue irradiated. (biomedcentral.com)
  • [ 3 ] . For patients who received preoperative chemotherapy, the addition of postoperative radiotherapy has not demonstrated additional benefit. (medscape.com)
  • However, the reports were both based on small sample sizes, and no clear evidence exists for the superiority of triweekly XELOX compared to capecitabine alone with preoperative chemoradiotherapy in patients with LARC. (biomedcentral.com)
  • Locally advanced rectal cancers are treated with preoperative local radiation and simultaneous chemotherapy. (biomedcentral.com)
  • What about induction chemotherapy followed by CRT, would that give better systemic control without losing the advantage of better locoregional provided by concurrent CRT? (oncolink.org)
  • Nevertheless, it remains unclear irrespective of whether bioradiotherapy provides as good locoregional manage as chemoradiotherapy. (trpv1inhibitor.com)
  • In these patients who are poor candidates for resection, a combination of chemotherapy, locoregional therapies like ablation, transarterial chemo and radioembolization, and in very advanced and metastatic disease, external radiation are the available options. (mdpi.com)
  • In this multicenter phase 3 trial, the efficacy and safety of 60 Gy and 50 Gy doses delivered with modern radiotherapy technology for definitive concurrent chemoradiotherapy (CCRT) in patients with inoperable esophageal squamous cell carcinoma (ESCC) were evaluated. (figshare.com)
  • 1 Early clinical studies of the EGFR monoclonal antibody in combination with radiotherapy primarily included head and neck squamous cell carcinoma, and the study of its combination with radiation therapy for NSCLC was performed relatively late. (dovepress.com)
  • Radiation is a feasible option for patients with squamous cell carcinoma of the anterior nasal cavity mucosa who refuse rhinectomy, according to our recent research. (mskcc.org)
  • The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
  • More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
  • Systemic steroid administration required to manage toxicities arising from radiation therapy delivered as part of the chemoradiation therapy for locally advanced NSCLC is allowed. (stanfordhealthcare.org)
  • NSCLC patients (68 cases) were treated with concurrent radiotherapy and chemotherapy, every patient's normal tissue were controlled with a same radation dose. (esmo.org)
  • 68 local advanced NSCLC patients with concurrent chemoradiotherapy were detected the levels of Ape1/Ref-1, ICAM-1 and IL-17A in serum by ELISA before radiotherapy and in the 14th week after radiotherapy. (esmo.org)
  • IL-17A in serum could be the predictive factors of radiation pneumonitis for local advanced NSCLC patients with concurrent chemoradiotherapy. (esmo.org)
  • Until recently, the standard of care for patients with stage III (locally advanced), unresectable non-small cell lung cancer (NSCLC) was platinum-based, doublet chemotherapy together with radiotherapy (chemoradiotherapy). (touchoncology.com)
  • We performed this study to evaluate the prognostic factors and the effect of induction chemotherapy in locally advanced non-small cell lung cancer (NSCLC). (e-roj.org)
  • We aimed to evaluate the safety and efficacy of adding capecitabine (a known radiosensitizer by direct and abscopal effects) to concurrent radiation in the adjuvant setting after resection of pancreatic adenocarcinoma. (iiarjournals.org)
  • Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. (uchicago.edu)
  • Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. (uchicago.edu)
  • The median total dose of 60.2 Gy in the 2 Gy per fraction-equivalent dose (EQD2) was delivered to cervical tumors of all patients. (iiarjournals.org)
  • Results: In 18 of 20 patients, the primary tumors disappeared or were markedly reduced after radiation therapy. (iiarjournals.org)
  • For patients who are expected to survive for more than 1 year, almost curative-dose irradiation to primary tumors is recommended. (iiarjournals.org)
  • Mismatch repair-deficient tumors do not respond well to chemotherapy applied in the neoadjuvant, adjuvant, or metastatic settings. (cancer.gov)
  • Treatment protocols for cervical cancer are provided below, including treatment by stage, chemoradiation therapy, and chemotherapy. (medscape.com)
  • Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small. (oncolink.org)
  • After Dillman study (CALGB 8433), French CEBI 138 study (Le Chevalier et al 1991) and RTOG 8808 study (Sause et al ), chemotherapy has been routinely added to radiotherapy (RT) for unresectable Stage III patients. (oncolink.org)
  • In the updated analyses, median OS and 3-year OS were 13.1 months and 25.9%, respectively, for arm A and 14.4 months and 25.7%, respectively, for arm B. Daily RT plus LDPF chemotherapy did not qualify for further evaluation as a new treatment option for patients with locally advanced unresectable esophageal cancer. (nih.gov)
  • Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. (uchicago.edu)
  • Willing to potentially receive further consolidation chemotherapy with carboplatin and pemetrexed or carboplatin and paclitaxel as specified by the protocol, but not be currently intended to receive additional consolidation chemotherapy apart from this protocol 5. (stanfordhealthcare.org)
  • Induction chemotherapy with weekly paclitaxel and carboplatin delivered immediately before chemoradiation should be considered the new standard in locally advanced cervical cancer and is feasible across diverse health care settings," lead study author Mary McCormack, of University College London in the United Kingdom, said in a presentation of the data. (curetoday.com)
  • In addition, as seen in other disease sites (head and neck cancer, sarcoma), postoperative radiation for patients with incompletely resected malignancies continues to play an important role ( 6 ). (iiarjournals.org)
  • Current or prior use of immunosuppressive medication within 14 days before enrollment, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid. (stanfordhealthcare.org)
  • According to the systemic treatment modalities delivered, we classified all 547 patients into non-adjuvant chemotherapy (non-AC) group (341 patients) and adjuvant chemotherapy (AC) group (206 patients). (oncotarget.com)
  • Medically unfit patients can be treated with chemoradiotherapy or chemotherapy. (medscape.com)
  • At 60 months, the percentage of patients alive and relapse free was 59% in the chemoradiotherapy group and 58% in the chemotherapy-only group (hazard ratio [HR], 0.90). (medscape.com)
  • Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
  • Cumulative burden of symptomatology in patients with gynecologic malignancies undergoing chemotherapy. (moffitt.org)
  • Together with our colleagues, we analyzed the results for 11 patients who refused surgery and were treated with radiation, with or without chemotherapy, at Memorial Sloan Kettering Cancer Center between January 2000 and July 2018. (mskcc.org)
  • Patients were randomly assigned to receive RT (2 Gy/fraction, total dose of 60 Gy) with SDPF (arm A) or LDPF (arm B) chemotherapy. (nih.gov)
  • Patients and Methods: A total of 20 patients with bone metastases from uterine cervical cancer received radiation therapy to the pelvis. (iiarjournals.org)
  • Thirteen patients underwent chemotherapy during and/or following radiation therapy. (iiarjournals.org)
  • Conclusion: Radiation therapy is effective for relief of pelvic symptoms in patients with bone metastasis from uterine cervical cancer. (iiarjournals.org)
  • Extensive-stage SCLC (ie, SCLC that has spread beyond the supraclavicular areas, or with distant metastases) remains incurable with current management options, and patients are treated with combination chemotherapy. (medscape.com)
  • In recent years, the media has reported radiation therapy incidents with severe detrimental effects on several hundreds of patients, including death, in France, Canada, the United Kingdom, and the United States. (utoronto.ca)
  • Patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy reported higher quality of life and were less likely to experience vomiting when receiving fosaprepitant every week as opposed to every three weeks. (curetoday.com)
  • Weekly fosaprepitant decreased vomiting in patients undergoing chemoradiotherapy, accoriding to a recnet study. (curetoday.com)
  • Patients with nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy who received fosaprepitant every week were less likely to experience vomiting and had greater quality of life than those who received fosaprepitant every three weeks, according to the findings of a new study. (curetoday.com)
  • In 2016 single-dose injectable Emend, when combined with other drugs treating nausea and vomiting, was approved by the FDA to prevent delayed CINV in patients who'd received moderately emetogenic chemotherapy (MEC). (curetoday.com)
  • Of the patients who responded to Opdivo plus Yervoy , 32% had ongoing responses at two years (vs. 8% of chemotherapy responders). (pharmiweb.com)
  • Nasopharyngeal carcinoma (NPC) patients with N2-3 diseases are prone to develop distant metastasis even treated with standard concurrent chemoradiotherapy (CCRT). (oncotarget.com)
  • With a median follow-up time of 53.8 months, adjuvant chemotherapy significantly decreased the risk of distant metastasis (HR 0.413, 95% CI 0.194-0.881, p = 0.022) as well as significantly increased the OS (HR 0.398, 95% CI 0.187-0.848, p = 0.017) in patients with N3 disease. (oncotarget.com)
  • The addition of adjuvant chemotherapy seemed to provide benefits to patients with N3 stage NPC and the current study may indicate the need for further randomized investigation. (oncotarget.com)
  • Intensity-modulated radiation therapy (IMRT) has greatly improved the local control rate to above 90% [ 3 ] but failed to further reduce the distant metastases of patients with bulky lymph nodes (N2-3) [ 4 ]. (oncotarget.com)
  • Patients needed to be fit for chemotherapy and radical radiotherapy and have adequate renal, liver and bone marrow function. (curetoday.com)
  • Patients were not allowed to have nodes above aortic bifurcation on imaging and prior pelvic radiation was not permitted. (curetoday.com)
  • Patients also received brachytherapy at a minimum total of biologically equivalent doses of 78 Gy. (curetoday.com)
  • At a time when modern radiation treatment like intensity-modulated radiotherapy (IMRT) are accomplishing great good local control, distant metastases are getting to be the transcendent design of treatment failure, particularly in patients with locally progressed illness. (intechopen.com)
  • Eighty-five patients were treated with radiotherapy alone, forty-five with induction chemotherapy and radiotherapy. (e-roj.org)
  • Of the patients, 129 patients received total dose above 59.6 Gy (56~66 Gy, median 60 Gy). (e-roj.org)
  • But, in patients with CR to overall treatment, distant metastasis were found in 11/19 patients with radiotherapy alone, and 3/13 patients with induction chemotherapy and radiotherapy (p=0.07). (e-roj.org)
  • At least in CR patients, there was decreased tendency in distant metastasis with induction chemotherapy. (e-roj.org)
  • Of the 63 patients reviewed, 61 patients (97%) completed concurrent chemoradiotherapy. (iiarjournals.org)
  • Oral mucositis (OM) is a debilitating acute inflammation of patients undergoing cancer therapy including high doses of chemotherapy or head and neck radiotherapy. (bvsalud.org)
  • High dose-rate brachytherapy boost for intermediate risk prostate cancer: Long-term outcomes of two different treatment schedules and early biochemical predictors of success. (brachycenter.com)
  • The most common form of internal radiation therapy is brachytherapy, where temporary or permanent radiation sources are placed inside the body next to or inside the cancer. (cancercouncil.com.au)
  • i A total dose of 45 Gy for EBRT to the pelvis ii If brachytherapy is used, normal tissues should be limited with 2 cc rectal dose 75 Gy, sigmoid 2 cc dose 75 Gy, and 2 cc bladder dose 90 Gy. (who.int)
  • Chemotherapy based around a doublet or triplet platinum/fluoropyrimidine combination is given for metastatic disease. (medscape.com)
  • Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)
  • History of another primary malignancy and currently undergoing active treatment (ie, chemotherapy, hormonal therapy, biologics) 7. (stanfordhealthcare.org)
  • Radiation therapy is a localised treatment, which means it generally affects only the area being treated. (cancercouncil.com.au)
  • It's estimated that radiation therapy would be a suitable treatment for 50% of people with cancer. (cancercouncil.com.au)
  • To achieve remission or cure - Radiation therapy may be given as the main treatment to cause the cancer to reduce (remission) or disappear (curative or definitive radiation therapy). (cancercouncil.com.au)
  • Having radiation therapy and chemotherapy together increases the success of the treatment compared with having either treatment on its own. (cancercouncil.com.au)
  • They also depend on the radiation therapy treatment area. (cancercouncil.com.au)
  • Variables potentially influencing chemotherapy treatment selection were used to generate propensity scores (PS). (biomedcentral.com)
  • PACCE: A Randomized, Open-Label, Controlled, Clinical Trial of Chemotherapy and Bevacizumab With and Without Panitumumab in the First-line Treatment of Subjects With A Phase 3 Clinical Trial Comparing Infusional 5 Fluorouracil, Leucovorin, and Oxaliplatin. (med-abstracts.com)
  • Platinum-based concurrent chemoradiotherapy represents the gold standard in the treatment of locally advanced nasopharyngeal carcinoma (NPC) [ 1 , 2 ] in the era of 2D radiotherapy. (oncotarget.com)
  • Findings, which were presented at the 2023 ESMO Congress , showed that induction (given before the main treatment to shrink cancer) chemotherapy followed by chemoradiation reduced the risk of progression or death by 35% vs chemoradiation alone. (curetoday.com)
  • There are numerous results from clinical trials looking at combined radiation treatment (RT) and chemotherapy for NPC. (intechopen.com)
  • Now, investigators from the University of North Carolina report what they believe is the first pre-clinical demonstration of the potential of molecularly targeted nanoparticles as a promising new class of agents that can improve chemoradiotherapy treatment. (nanowerk.com)
  • Chemoradiation did reduce the incidence of vaginal, pelvic, and para-aortic recurrences compared to chemotherapy, as we also previously reported, but distant recurrences were more common with chemoradiation," she said. (medscape.com)
  • Results: There was statistically significant difference in favor of IMRT bone marrow sparing plans regarding a lower dose to organs at risk, total pelvic bone and bowel. (oncologyradiotherapy.com)
  • Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)
  • Over the last 17 years, stereotactic body radiation therapy (SBRT) has shown a high degree of safety and local control for stage I lung cancers and other localized malignancies. (frontiersin.org)
  • Early-stage head and neck cancers, localized to theprimary site without regional lymph node metastases have excellentcure rates with either surgery or radiation therapy. (cancernetwork.com)
  • Similarly, a recent trial recommended that bioradiotherapy has extra local failures than chemoradiotherapy in individuals with laryngeal cancers [119]. (trpv1inhibitor.com)
  • Chemotherapy can be helpful in controlling cancers that have spread (metastases) because the whole body is treated. (veritalife.com)
  • Nevertheless, the ECOG trial can be a major advance towards remedy de-intensification although there was no direct comparison among bioradiotherapy and chemoradiotherapy.OncotargetDNA interaction. (trpv1inhibitor.com)
  • Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. (uchicago.edu)
  • Fifty Gy should be considered as the recommended dose in CCRT for ESCC. (figshare.com)
  • Unlike substantial evidence in the prevention of chemotherapy-induced nausea and vomiting (CINV), research in the prevention of nausea and vomiting caused by concurrent chemoradiotherapy (CCRT) is currently lacking," Sun Yat-Sen University researchers wrote in the JAMA Network Open study, which they posited was to their knowledge, "the first study to assess the efficacy and safety of fosaprepitant during combined radiotherapy-HEC. (curetoday.com)
  • Image-guided robotic stereotactic body radiation therapy for liver metastases: is there a dose response relationship? (google.fr)
  • As Wang explained, "docetaxel is a proven drug used in chemoradiotherapy, but it leads to many unwanted side effects on normal organs. (nanowerk.com)
  • Further investigation found that the timing of radiation after dosing was critical, with the two formulations displaying equal efficacy if radiation was postponed for 24 hours after dosing with the nanoparticle, compared to the one-hour delay used with free docetaxel. (nanowerk.com)