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  • efficacy
  • Thus the efficacy and safety data from these studies potentially supports FDA marketing approval (NDA applications) for chemoprevention indications, and certainly facilitates decisions regarding the most appropriate recommendations for subsequent large, community-based efficacy studies. (nih.gov)
  • tumor
  • Identification of alternative NSAID targets and elucidation of the biochemical processes by which they inhibit tumor growth could lead to the development of safer and more efficacious drugs for cancer chemoprevention. (frontiersin.org)
  • prostate
  • This is one of the first efforts to unite experts of all major groups and centers worldwide in the highly fascinating and thought-provoking field of chemoprevention of cancer, especially of the breast, colon and prostate. (springer.com)
  • agents
  • Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. (ingentaconnect.com)
  • (3) report that promoting proteasomal degradation of cyclin D1 and cyclin E, which results in cell cycle arrest at the G 1 phase, is a mechanism of cancer chemoprevention by all- trans- retinoic acid (RA) and some other structurally unrelated agents. (aacrjournals.org)
  • high risk
  • Families with familial adenomatous polyposis (FAP), with hundreds of precancerous polyps in the colon and rectum, is a population at very high risk, meriting chemoprevention using drugs such as Celebrex in children with FAP, to help delay or control growth of adenomatous polyps. (cancersupportivecare.com)