The most widely used therapeutic combination is intradiscal injection of an O2-O3 mixture (chemonucleolysis), followed by peri-radicular injection of O2-O3, steroid and local anesthetic to enhance the anti-inflammatory and analgesic effect. (cjscons.com)
Intervertebral2
One hundred and twenty-two lumbar intervertebral discs from 43 mongrel dogs were used to study the effect of chemonucleolysis on the flexion, torsion, and lateral bending flexibilities of the disc. (cdc.gov)
Chemonucleolysis - A surgical procedure in which an enzyme is injected to dissolve a portion of the intervertebral disc. (medispera.com)
Lumbar disc1
The effects of chemonucleolysis on the mechanical properties of the canine lumbar disc. (cdc.gov)
Spine2
Because of its proteolytic activity, it is the main molecule in the process of chemonucleolysis, used in some procedures like the treatment of herniated lower lumbar discs in the spine by a nonsurgical method. (wikipedia.org)
24 Spine surgeries, penetrating wounds, chemonucleolysis or discogphaphy may directly inoculate the spine as well. (wheelessonline.com)
Nucleus2
There are a number of other, less invasive treatments such as cortisone injection, which has been a standard procedure for 30 years, and chemonucleolysis, in which the soft nucleus is dissolved away by a powerful enzyme such as chymopapain, derived from papaya. (healthy.net)
The evidence on other minimally invasive techniques remains unclear (with the exception of chemonucleolysis using chymopapain, which is no longer widely available). (cochrane.org)
Chemonucleolysis using chymopapain has also high success rate (80%) with low recurrences but not popular owing to the chances of anaphylaxis following intradiscal chymopapain injection. (daradia.com)
Discectomy4
Trials showed that discectomy produced better outcomes than chemonucleolysis, which in turn was better than placebo. (cochrane.org)
Many of the early trials were of some form of chemonucleolysis, whereas the majority of the later studies either compared different techniques of discectomy or the use of some form of membrane to reduce epidural scarring. (cochrane.org)
However, other trials show that discectomy produces better clinical outcomes than chemonucleolysis and that in turn is better than placebo. (cochrane.org)
Over 4 months (longest case: 18 months) follow up revealed as follows: 40 cases (78%) revealed excellent results: 4 cases (7.8%) received discectomy 3-6 months after chemonucleolysis because of recurred symptoms: no anaphylaxis and no major complications were noted. (e-jyms.org)
Injection2
The results of this preclinical study suggest that PRPr injection therapy may be indicated for patients with LDH who have poor recovery from disc degeneration after chemonucleolysis treatment with condoliase. (biomedcentral.com)
Injection of ozone for slipped disc or discogenic radiculopathy (low back pain with radiation to legs) has developed as a nonoperative treatment of slipped disc/ slip disc (or called ozone therapy for slip disc) which is an alternative to chemonucleolysis and disc surgery. (daradia.com)
Lumbar5
Because of its proteolytic activity, it is the main molecule in the process of chemonucleolysis, used in some procedures like the treatment of herniated lower lumbar discs in the spine by a nonsurgical method. (wikipedia.org)
The effects of chemonucleolysis on the mechanical properties of the canine lumbar disc. (cdc.gov)
Ocurre con mayor frecuencia en la región lumbar inferior. (bvsalud.org)
Clinical Analysis of Chemonucleolysis for Treatment of Lumbar Disc Herniation. (e-jyms.org)
During last 48 months, in our department 5 patients with single or multiple herniated lumbar discs have received chemonucleolysis. (e-jyms.org)
Surgery2
Many trials provided limited information on complications, but generally included recurrence of symptoms, need for additional surgery and allergic reactions (chemonucleolysis). (cochrane.org)
Ejeskar A, Nachemson A, Herbert P. Surgery versus chemonucleolysis forherniated lumber disc. (ijoro.org)
Disc1
For various reasons including concerns about safety, chemonucleolysis is not commonly used today to treat prolapsed disc. (cochrane.org)
Months1
In general, however, flexion and torsion flexibilities did not return to control values 6 months following chemonucleolysis. (cdc.gov)