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Chemokine CCL2Chemokine CCL3ChemokinesMonocyte Chemoattractant ProteinsChemokine CCL4Macrophage Inflammatory ProteinsReceptors, CCR2Chemokine CCL8Chemotactic FactorsChemokine CCL7Chemokines, CCChemokines, CXCCytokinesReceptors, ChemokineChemokine CCL5MonocytesMacrophagesInterleukin-8RNA, MessengerChemotaxis, LeukocyteInflammationCells, CulturedTumor Necrosis Factor-alphaChemotaxisMice, Inbred C57BLLipopolysaccharidesNF-kappa BInterleukin-6Inflammation MediatorsCell MovementReceptors, CytokineChemokine CXCL10Mice, KnockoutGene Expression RegulationMonokinesChemokine CXCL2Disease Models, AnimalGene ExpressionEnzyme-Linked Immunosorbent AssayUp-RegulationReverse Transcriptase Polymerase Chain ReactionSignal TransductionChemokine CCL11NeutrophilsLeukocytes, MononuclearLeukocytesNeutrophil InfiltrationCell LineVascular Cell Adhesion Molecule-1Interleukin-1Intercellular Adhesion Molecule-1Endothelium, VascularAtherosclerosisLungImmunohistochemistryInterferon-gammaBiological MarkersAnti-Inflammatory AgentsMice, Inbred BALB CReceptors, CCR5FibrosisMacrophage ActivationRecombinant ProteinsChemokine CXCL1Rats, Inbred LewVasculitisChemokines, CX3CBronchoalveolar Lavage FluidEndothelial CellsCoculture TechniquesCell Adhesion MoleculesChemokine CCL1Flow CytometryDose-Response Relationship, DrugFibroblastsTime FactorsMolecular Sequence DataT-LymphocytesInterleukin-10Transcription Factor RelAAntibodiesPorphyromonas gingivalisMacrophages, AlveolarKidneyInterleukin-1betaEpithelial CellsImmunity, InnateBlotting, WesternToll-Like Receptor 2Transcription Factor AP-1Synovial MembraneToll-Like Receptor 4Chemokine CXCL9MicrogliaTransfectionSkinp38 Mitogen-Activated Protein KinasesRats, Sprague-DawleyMuscle, Smooth, VascularMacrophages, Peritoneal
CCL2LigandCytokinesCytokineMacrophagesChemotactic and activaAdjacent cysteinesLymphocytesGenesCCR2CCL19AntibodiesGeneCCL4KinaseReceptorsInflammationInflammatoryEosinophilsTumorLeukocyteInterleukinDendritic cellsResiduesCharacterizationCCL3Adhesion moleculesMediatesRenalAbundantly expressedBiomarkersCellsChemotaxisPotentSubfamilyFibroblastsInfiltrationFunctionalImmuneRecruitmentRhoATherapeuticCCR5ScreeningDysfunctionExpressionAmino acidHuman
CCL27
  • Background Chemokine ligand 2 (CCL2), also called monocyte chemoattractant proteins-1 (MCP-1), is one of the CC chemokine family members that is from the disease position and final results of osteoarthritis (OA). (careersfromscience.org)
  • Monocyte chemoattractant proteins 1 (MCP-1)/chemokine ligand 2 (CCL2), a ligand of CCR2, can be chemotactic for monocyte/macrophages and turned on T cells [10], [11]. (careersfromscience.org)
  • The outcomes display that CCL2 activates the CCR2 receptor which activates proteins kinase C (PKC), p38MAPK, and AP-1 signaling pathway, resulting in the upregulation of VCAM-1 manifestation. (careersfromscience.org)
  • The improved VCAM-1 manifestation correlates with improved adhesion of monocytes to CCL2-activated OASFs. (careersfromscience.org)
  • The chemokine CCL2 participates in multiple neuroinflammatory processes, mainly through the recruitment of glial cells. (mdpi.com)
  • Untreated M0 macrophages have low levels of monocyte chemoattractant protein-1/C-C motif chemokine ligand 2 (MCP-CCL2) and interleukin (IL)-6. (news-medical.net)
  • CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
Ligand2
  • Human CCL4 Recombinant Protein is purified chemokine ligand 4 (CCL4, MIP-1 beta) produced in yeast. (immunochemistry.com)
  • Chemokine ligand 4 (CCL4) is a small chemotactic cytokine belonging to the CC chemokine family that is also known as macrophage inflammatory protein-1β (MIP-1 beta). (immunochemistry.com)
Cytokines9
  • response to macrophage-derived proinflammatory cytokines such WIN 48098 as for example interleukin (IL)-1 and tumor necrosis aspect- WIN 48098 (TNF-), OA synovial fibroblasts (OASFs) generate chemokines that promote irritation, neovascularization, and cartilage degradation via activation of matrix-degrading enzymes such as for example matrix metalloproteinases (MMPs) [1], [2]. (careersfromscience.org)
  • Even though the jobs of cytokines and adhesion substances in polymorphonuclear cells adhesion to endothelial cells have already been described at length, little is well known about the systems underlying the conversation between monocytes and human being OASFs. (careersfromscience.org)
  • Since the discovery that adipocytes may secrete a variety of bioactive molecules (hormones, chemokines, and cytokines), an endocrine and paracrine role for white adipose tissue (WAT) in the regulation of energy balance and other physiological processes has been established, particularly with regard to brain and muscle. (unige.ch)
  • Factor(s) responsible for the conditioned medium-induced steatosis were screened by a battery of blocking antibodies against different cytokines/chemokines shown to be secreted by WAT. (unige.ch)
  • Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. (creativebiomart.net)
  • The CC cytokines are proteins characterized by two adjacent cysteines. (creativebiomart.net)
  • In paper I, a possible role of plasma cytokines or proteins associated with immune response or inflammation, as biomarkers for the survival of HNC patients was investigated. (diva-portal.org)
  • This results in a complex microenvironment within the periodontium, consisting of immune surveillance response, cellular damage and repair, and the production of cytokines, chemokines and other inflammatory mediators 10 . (bvsalud.org)
  • In general, the host response to bacterial stimuli leads to a cascade of inflammatory mediators such as cytokines (TNF-α), chemokines (IL-8) as well as prostaglandins and leukotrienes, which are metabolites from arachidonic acid. (bvsalud.org)
Cytokine3
  • The small chemotactic cytokine CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. (immunochemistry.com)
  • The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. (creativebiomart.net)
  • Fractalkine, also known as CX3CL1, is a cytokine protein containing a CX3C chemokine motif atop a mucin stalk. (irvinesci.com)
Macrophages4
  • CONCLUSION: The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes. (unige.ch)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. (peprotech.com)
  • CCR5 is known to play a decisive role as a chemotactic receptor abundantly expressed on monocytes, macrophages and T-cells and its heterozygous mutation-related deficiency implies impaired memory CD4 + T-cell response [ 5 ]. (biomedcentral.com)
Chemotactic and activa2
  • Chemokines of the alpha, beta-subclass inhibit human basophils' responsiveness to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. (musc.edu)
  • Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. (ac.ir)
Adjacent cysteines1
Lymphocytes3
Genes3
  • Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
  • The majority of the strongly induced mRNAs as analyzed by microarray hybridization were chemokine genes. (aai.org)
  • This chemokine is encoded by multiple genes. (lookformedical.com)
CCR22
  • Aim: We aimed to investigate the expression of monocyte chemoattractant proteins (MCPs) and their cognate receptor CC chemokine receptor 2 (CCR2) in aortas of apolipoprotein E-null (apoE -/- ) mice during atherogenesis as well as the possible transcription pathway involved in the early induction of MCP-1 in vascular smooth muscle cells (VSMCs) in vivo . (go.jp)
  • It binds to CCR2 and prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2. (creativebiolabs.net)
CCL192
  • This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. (wikipedia.org)
  • CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
Antibodies2
  • Incubation of conditioned medium with antimonocyte chemoattractant protein-1 antibodies prevented triglyceride accumulation. (unige.ch)
  • Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
Gene6
  • C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. (wikipedia.org)
  • Protein-protein interactions play important functional roles in almost all biological activities, including, but not restricted to, signal transduction, gene regulation, catalytic enzymatic activities and structural roles [ 1 ]. (biomedcentral.com)
  • This gene expression was specific because other chemokines were not induced by anti-Ly-49D receptors. (aai.org)
  • Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. (ac.ir)
  • Monocyte Chemoattractant Protein-1 in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis: Biomarker Potential and Association with Polymorphisms in the MCP-1 and the CC Chemokine Receptor-2 Gene. (cdc.gov)
CCL42
  • CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. (immunochemistry.com)
  • The Human CCL4/MIP-1 beta protein can be used in cell culture, as a CCL4/MIP-1 beta ELISA Standard, and as a Western Blot Control. (immunochemistry.com)
Kinase2
  • This effect was found to depend on the Ca 2+ increase mediated by the phospholipase C-β (PLC-β) and protein kinase C (PKC) pathways, as well as by the reverse activity of the Na + /Ca 2+ exchanger. (molvis.org)
  • 3D three-dimensional, BMSC bone marrow-derived stromal cell, CCR chemokine (C motif) receptor, GPCR G protein-coupled receptor, MCP-1 monocyte chemoattractant protein 1, PI3K PI3 kinase. (figshare.com)
Receptors11
  • These Ly-49 inhibitory receptors, as well as inhibitory KIRs, contain cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs) that are phosphorylated upon stimulation, leading to the recruitment of Src homology 2 domain-containing protein tyrosine phosphatase (SHP-1) and attenuation of intracellular signals ( 1 , 4 , 5 ). (aai.org)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
Inflammation1
Inflammatory7
  • RNA-seq results showed that transcription factors and macrophage inflammatory proteins were significantly downregulated in the DNMT3A mutant clones. (frontiersin.org)
  • Resistin significantly promoted the expression of inflammatory proteins in AML cells. (frontiersin.org)
  • The macrophage inflammatory proteins -1 alpha and -1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. (rndsystems.com)
  • Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
  • RNase protection assays and chemokine protein production analysis validated the microarray results, as cross-linking the Ly-49D mouse NK receptor induced high levels of IFN-γ, lymphotactin, macrophage-inflammatory protein (MIP)1α, and MIP1β. (aai.org)
  • Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
  • Chemokines: therapeutic targets for autoimmune and inflammatory renal disease. (ac.ir)
Eosinophils1
Tumor3
  • Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
  • In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
  • Higher levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) were detected in plasma of the patients compared with the levels in the controls. (diva-portal.org)
Leukocyte2
  • Chemokines are low molecular pounds secretory proteins that may regulate the chemotaxis and metabolic activity of particular leukocyte subsets. (careersfromscience.org)
  • The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
Interleukin1
  • In contrast to interleukin-8 and interleukin-6, the monocyte chemoattractant protein-1 was capable of inducing steatosis in hepatocytes in a time-dependent manner at concentrations similar to those found in conditioned medium. (unige.ch)
Dendritic cells2
Residues4
  • Rat CCL3 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. (goldbio.com)
  • The Rhotekin-RBD protein supplied in this kit contains Rhotekin residues 7-89 and is in the form of a GST fusion protein, which allows one to "pull-down" the Rhotekin-RBD/Rho-GTP complex with brightly colored glutathione affinity beads. (cytoskeleton.com)
  • Recombinant Murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. (peprotech.com)
  • At the center of protein-protein interactions are the binding surfaces, or interfacial residues which form contacts between binding partners and stabilize protein complexes. (biomedcentral.com)
Characterization1
  • Characterization and classification of protein-protein interactions would allow us to organize information in protein-protein interaction networks, to make predictions on their function, as well as to facilitate drug design targeted at interfering with those disease-associated protein-protein interactions. (biomedcentral.com)
CCL31
  • Activation of CCR5 through CCL3 activates a G-protein pathway through GNAI2 and a tyrosine phosphorylation through JAK2. (goldbio.com)
Adhesion molecules2
  • Anti-VEGF failed to inhibit T cell activation responses in vivo, but inhibited intragraft expression of several endothelial cell adhesion molecules and chemokines, including IP-10. (jci.org)
  • This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
Mediates1
  • The transmembrane chemokine receptor CX3CR1 mediates the adhesive and chemoattractant functions of fractalkine. (irvinesci.com)
Renal3
  • Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus. (ac.ir)
  • Glomerular expression of monocyte chemoattractant protein-1is predictive of poor renal prognosis in paediatric lupus nephritis. (ac.ir)
  • 15. Dai C, Liu Z, Zhou H, Li L. Monocyte chemoattractant protein-1 expression in renal tissue is associated with monocyte recruitment and tubulo-interstitial lesions in patients with lupus nephritis. (ac.ir)
Abundantly expressed1
  • In addition, the study suggested that chemokines, such as monocyte chemoattractant protein-1 (MCP-1), associated with monocyte/macrophage influx and activation, are abundantly expressed in postinjured muscle, and they might play a role in traumatic muscle injury/recovery processes. (cdc.gov)
Biomarkers2
  • On diagnostic grounds of AD C-reactive protein, pentraxins, collapsin response mediator protein-2, and growth-associated protein-43 represent the future of new possible biomarkers for diagnosing AD. (benthamscience.com)
  • Urine chemokines as biomarkers of human systemic lupus erythematosus activity. (ac.ir)
Cells3
  • MIP-1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP-1 alpha has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo . (rndsystems.com)
  • Soluble fractalkine functions as a chemoattractant for T cells and monocytes. (irvinesci.com)
  • MONOCYTES and a variety of other immune cells. (lookformedical.com)
Chemotaxis1
Potent1
  • In vitro, we found that VEGF enhanced endothelial cell expression of the chemokines monocyte chemoattractant protein 1 and IL-8, and in combination with IFN-γ synergistically induced endothelial cell production of the potent T cell chemoattractant IFN-inducible protein-10 (IP-10). (jci.org)
Subfamily1
Fibroblasts1
Infiltration2
  • Treatment of huSCID mice with anti-human VEGF inhibited both CD3 + T cell ( f ) and CD68 + monocyte macrophage ( i ) infiltration of skin. (jci.org)
  • Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)
Functional2
  • Structural comparison of protein-protein interfaces provides valuable insights into the functional relationship between proteins, which may not solely arise from shared evolutionary origin. (biomedcentral.com)
  • developed I2I-SiteEngine [ 12 ] to compare the physicochemical properties of the functional groups forming protein-protein interfaces, which uses an algorithm similar to pharmacophore mapping. (biomedcentral.com)
Immune2
  • Previous studies have not addressed the impact of vitamin A supplementation on the production of monocyte chemoattractant protein 1 (MCP-1), an essential chemokine involved in pathogen-specific mucosal immune response. (nih.gov)
  • A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
Recruitment1
RhoA3
  • The fact that many Rho family effector proteins will specifically recognize the GTP bound form of the protein has been exploited experimentally to develop a powerful affinity purification assay that monitors RhoA protein activation. (cytoskeleton.com)
  • His-tagged RhoA protein (Cat. (cytoskeleton.com)
  • The RhoA activation assay was tested by loading the RhoA protein in cell lysates with either GTPγS or GDP. (cytoskeleton.com)
Therapeutic1
  • Here, we reviewed the physiological/pathological roles and therapeutic significance of nearly all the proteins associated with AD that addresses putative as well as probable targets for developing effective anti-AD therapies. (benthamscience.com)
CCR51
  • First, we were interested in elucidating the potential impact of CCR5 delta32 (CD195), a near-loss-of-function mutant of the C-C chemokine receptor type 5 on the COVID-19 clinical course. (biomedcentral.com)
Screening1
  • Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy. (peprotech.com)
Dysfunction1
  • Disturbed expression of these proteins results in synaptic dysfunction, cognitive impairment, memory loss, and neuronal degradation. (benthamscience.com)
Expression1
  • Expression of monocyte chemoattractant protein-1 and lupus nephritis. (ac.ir)
Amino acid1
  • The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. (peprotech.com)
Human1
  • These cDNAs all code for the same human protein that is a homologue of the murine MIP-1 alpha. (rndsystems.com)