AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
AtherosclerosisChemokinesChemokines, CXCArteriosclerosisChemokines, CCApolipoproteins ECarotid Artery DiseasesDiet, AtherogenicReceptors, ChemokineAortaAortic DiseasesChemokine CCL2Coronary Artery DiseaseCarotid ArteriesTunica IntimaChemokine CCL5Tunica MediaMice, KnockoutCholesterolInflammationMice, Inbred C57BLChemokine CXCL10MacrophagesPlaque, AtheroscleroticRisk FactorsChemokine CXCL9Chemokines, CMacrophage Inflammatory ProteinsChemokine CXCL1CytokinesLipoproteins, LDLChemokine CCL3Chemokine CCL4Intracranial ArteriosclerosisReceptors, LDLEndothelium, VascularDisease Models, AnimalCells, CulturedLipidsChemokines, CX3CCarotid Intima-Media ThicknessHypercholesterolemiaFoam CellsChemokine CXCL11Cholesterol, DietaryCarotid Artery, CommonChemokine CCL7CalcinosisChemotaxis, LeukocyteMonocyte Chemoattractant ProteinsDisease ProgressionBiological MarkersMonocytesInflammation MediatorsInterleukin-8LipoproteinsReceptors, Interleukin-8BCoronary VesselsHyperlipidemiasReceptors, CCR2Chemokine CXCL2RNA, MessengerChemokine CXCL5Receptors, CXCR3Aorta, ThoracicDuffy Blood-Group SystemChlamydophila pneumoniaeCholesterol, HDLCell MovementCzechoslovakiaChemotactic FactorsVascular Cell Adhesion Molecule-1Muscle, Smooth, VascularCholesterol, LDLSignal TransductionEndothelial CellsGene Expression RegulationChemokine CCL19Chemokine CCL21ChemotaxisTriglyceridesLeukocytesAorta, AbdominalChemokine CCL17Receptors, CCR1ArteriesChemokine CCL8Time FactorsRabbitsC-Reactive ProteinChemokine CXCL12Chemokine CCL11Cardiovascular DiseasesUp-RegulationMonokinesChemokine CX3CL1Prospective StudiesLipid MetabolismTumor Necrosis Factor-alphaVasculitis
CytokinesReceptorsDevelopment of atherosclerosisInflammationCCL2RheumatoidLigandMotif chemokine 11ProteinsProcess of atherosclerosisPathogenesisMonocytesReceptor familyMechanismsVascularMyocardial infarctionCoronaryInflammatory diseasePotential therapeutic targetChronicCytokineEndothelialBindsChemotaxisInitiationSubfamilyProteinDiabeticCCR7PharmacologicalMacrophageBroad-spectrumImmuneCholesterolTissueDiabetes
Cytokines10
  • Chemokines are secretory cytokines able to attract migratory cells. (europa.eu)
  • The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
  • Platelets interact with leukocytes through both adhesive mechanisms as well as release of cytokines/chemokines. (comprehensivephysiology.com)
  • These benefits occurred independently of glycaemic control or BP, and were associated with downregulation of a range of pro-inflammatory cytokines, adhesion molecules, chemokines and various extracellular matrix proteins. (monash.edu)
  • We profiled the cellular constituents and concentrations of 40 cytokines, chemokines and cellular factors (collectively "soluble factors") involved in inflammatory and immune signalling pathways in pleural effusion samples from 50 mesothelioma patients. (iospress.com)
  • Typically tumor cells secrete a complex milieu of growth factors, cytokines and chemokines, some of which are pro-tumorogenic [ 7 , 8 , 9 ]. (iospress.com)
  • There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
  • Rheumatoid arthritis causes damage mediated by cytokines, chemokines, and metalloproteases. (msdmanuals.com)
  • This results in a complex microenvironment within the periodontium, consisting of immune surveillance response, cellular damage and repair, and the production of cytokines, chemokines and other inflammatory mediators 10 . (bvsalud.org)
  • In general, the host response to bacterial stimuli leads to a cascade of inflammatory mediators such as cytokines (TNF-α), chemokines (IL-8) as well as prostaglandins and leukotrienes, which are metabolites from arachidonic acid. (bvsalud.org)
Receptors18
  • Information on how arrestins and RGS act on chemokine receptors and signalling is scarce, and reports are incomplete and/or controversial. (europa.eu)
  • This project aims to study the desensitisation of the chemokine receptors CCR2 and CCR5 in hematopoietic cells using a multidisciplinary approach. (europa.eu)
  • These class A G-protein coupled receptors (GPCRs) are involved in mammalian signaling pathways and control cell migration toward endogenous CC chemokine ligands, named for the adjacent cysteine motif on their N terminus. (iasp-pain.org)
  • Chemokine receptors and their associated ligands are involved in a wide range of diseases and thus have become important drug targets. (iasp-pain.org)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
  • The projects A2 and A3, in which the BernhagenLab is involved, address the roles of chemokines and their receptors in atherosclerosis and seek to identify novel therapeutic target candidates. (isd-research.de)
  • It binds to chemokine receptors CCR2 and CCR4. (affbiotech.cn)
  • We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. (lu.se)
Development of atherosclerosis2
Inflammation5
  • Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • Monocyte chemoattractant protein-1 (MCP-1, also called chemokine (C-C motif) ligand 2, CCL2) is a chemokine that recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. (quanterix.com)
  • Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)
  • The physiopathological process of ACS is the atherosclerosis where MIF operates as a major regulator of inflammation. (hindawi.com)
CCL22
  • Chemokine ccl2. (lookformedical.com)
  • RESULTS: DYNT treatment reduced the size of the atherosclerotic plaques, alleviated the necrotic core, lowered the lipid retention, mitigated the macrophagic burden and decreased the expression of proatherogenic chemokine Ccl2 in the atherosclerotic lesions. (bvsalud.org)
Rheumatoid4
  • Expression of IP-10 is seen in many Th1-type human inflammatory diseases, including skin diseases (e.g., psoriasis), multiple sclerosis, atherosclerosis, rheumatoid arthritis, transplant rejection, and inflammatory bowel disease. (quanterix.com)
  • MCP-1 is implicated in pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. (quanterix.com)
  • Proinflammatory actions of MIF have been reported in various inflammatory diseases such as sepsis, rheumatoid arthritis, and atherosclerosis [ 16 , 17 ]. (hindawi.com)
  • It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. (affbiotech.cn)
Ligand3
  • MIP-3β (macrophage inflammatory protein-3-beta ), also known as (Chemokine (C-C motif) ligand 19 (CCL19) and EBI1 ligand chemokine (ELC) is a small cytokine belonging to the CC chemokine family. (quanterix.com)
  • Sept-Oct 2022 - Congratulations to Yuan Tian and Markus Brandhofer, who successfully completed their doctoral theses entitled "Modulation of neuroinflammation and stroke outcome by the COP9 signalosome" and "Interactions between MIF-family proteins and the classical chemokine ligand/receptor network", respectively. (isd-research.de)
  • Acts as a ligand for C-C chemokine receptor CCR2. (affbiotech.cn)
Motif chemokine 111
  • Interferon-inducible T-cell alpha chemoattractant (ITAC), also known as CXCL11 (C-X-C motif chemokine 11), is a protein found in several organs including the pancreas, liver, thymus, spleen, and lung. (quanterix.com)
Proteins1
  • Aim: We aimed to investigate the expression of monocyte chemoattractant proteins (MCPs) and their cognate receptor CC chemokine receptor 2 (CCR2) in aortas of apolipoprotein E-null (apoE -/- ) mice during atherogenesis as well as the possible transcription pathway involved in the early induction of MCP-1 in vascular smooth muscle cells (VSMCs) in vivo . (go.jp)
Process of atherosclerosis1
Pathogenesis3
Monocytes7
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
  • A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. (lookformedical.com)
  • Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils. (lookformedical.com)
  • A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. (lookformedical.com)
  • Monocyte chemoattractant protein (MCP- 1) is an essential chemokine involved in monocyte rrafficking, together with its receptor CCR2, and a major chemoattractant for monocytes to inflamed endothelial cells. (wearecellix.com)
  • Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
Receptor family2
  • The CX3CR1 receptor is part of the G-protein chemokine receptor family with the metabotropic function. (wikipedia.org)
  • CC chemokine receptor 2 (CCR2) is a part of the chemokine receptor family, an important class of therapeutic targets. (iasp-pain.org)
Mechanisms2
  • The Collaborative Research Center CRC1123 "Atherosclerosis - Mechanisms and Networks of Novel Therapeutic Targets" (Speaker: Christian Weber, IPEK, LMU) was awarded a third funding period from the DFG for the years 2022-2026. (isd-research.de)
  • It is the aim of the multidisciplinary basic and clinical research projects in CRC1123 to elucidate the mechanisms and molecular networks driving atherosclerosis and to further the identification of potential therapeutic target candidates. (isd-research.de)
Vascular2
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
Myocardial infarction1
  • Chemokine receptor 5 polymorphism in myocardial infarction patients from Luxembourg. (cdc.gov)
Coronary2
Inflammatory disease1
  • Atherosclerosis is an inflammatory disease that accounts for nearly 50% of deaths in western societies [ 1 ]. (biomedcentral.com)
Potential therapeutic target1
  • Lentiviral 35K gene transfer is a promising experimental strategy to reduce atherosclerosis progression, and demonstrates the potential of long-term CC-chemokine inhibition as a potential therapeutic target in atherosclerosis. (ox.ac.uk)
Chronic4
  • However, atherosclerosis is a chronic condition where short-term effects, while demonstrating proof-of-principle, are unlikely to provide maximum therapeutic benefit. (ox.ac.uk)
  • According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury. (medscape.com)
  • The physiopathological process of ACS is the atherosclerosis, the build-up of an atherosclerotic plaque starts at lesion-prone areas in large- and medium-sized arteries where the endothelium is dysfunctional, induced by cardiovascular risk factors like chronic smoking, hypertension, and permeation of macromolecules such as lipoproteins to the intima layer [ 6 , 7 ]. (hindawi.com)
  • Atherosclerosis is defined as a chronic progressive disease of the arterial wall having a long asymptomatic phase. (bmrat.org)
Cytokine1
Endothelial2
  • endothelial surface, an essential step prior to transmigration towards the inflamed tissue.Chemokines cause surface integrins to switch from a low-affinity state to a high- affinity state. (wearecellix.com)
  • Infections and inflammatory conditions also contribute to endothelial injury and atherosclerosis. (medscape.com)
Binds1
  • As the name suggests, this receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in humans). (wikipedia.org)
Chemotaxis1
  • The shedded form carries out typical function of conventional chemokines, the chemotaxis, while the membrane-bound protein behaves as adhesion molecule for facilitation of diapedesis. (wikipedia.org)
Initiation1
Subfamily1
  • CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family and the only known member of the CX3C chemokine receptor subfamily. (wikipedia.org)
Protein1
  • IFN-γ-inducible protein 10 (IP-10, CXCL10) is a 10 kDa chemokine secreted from cells stimulated with type I and II interferons (IFNs) and lipopolysaccharide (LPS). (quanterix.com)
Diabetic1
CCR71
  • It is expressed at high levels in the lymph nodes, thymus and appendix, and elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. (quanterix.com)
Pharmacological2
  • The aim of this study was to investigate the role of AT 2 R in diabetes-associated atherosclerosis using pharmacological blockade and genetic deficiency. (monash.edu)
  • MATERIALS AND METHODS: Histological, immunohistochemical, molecular biological approaches were adopted to investigate the pharmacological impact of DYNT treatment on atherosclerosis and associated pathophysiological alterations in the high fat diet (HFD)-fed ApoE gene deficient (ApoE-/-) mice. (bvsalud.org)
Macrophage1
Broad-spectrum1
  • To investigate the effects of prolonged broad-spectrum chemokine inhibition on atherosclerosis, lenti35K, or lentiGFP or PBS were delivered to 6-week-old ApoE knockout (ApoE-KO) mice by hydrodynamic injection. (ox.ac.uk)
Immune1
  • Numerous animal studies as well as observational and clinical trials have shown that atherosclerosis arises from immune activation, with several cell-type specific pathways involved. (bmrat.org)
Cholesterol3
Tissue2
Diabetes2
  • Atherosclerosis (AS) is one of the most common complications of diabetes. (wjgnet.com)
  • Conclusions/interpretation: This study provides evidence for AT 2 R playing a role in the development of diabetes-associated atherosclerosis. (monash.edu)