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  • viral
  • Chemokines are involved in the attraction and activation of mononuclear and polymorphonuclear leukocytes to sites of inflammatory responses, bacterial or viral infections, allergy, cardiovascular diseases and wound healing. (knowcancer.com)
  • pulmonary
  • Regulation of pulmonary fibrosis by chemokine receptor CXCR3. (ebi.ac.uk)
  • In vivo, hG31P was significantly effective in blocking the pathology associated with airway endotoxemia, aspiration pneumonia, and intestinal ischemia and reperfusion injury, including neutrophil recruitment (70-95% reduction) into, and activation within, the airways or gut, chemokine or cytokine expression, and pulmonary vascular complications. (usask.ca)
  • ELR-CXC Chemokine Antagonism Considerably Lowers Airway Neutrophil Recruitment and Ameliorates Pulmonary Level Swelling ELR-CXC chemokine antagonists play a highly effective part in airway neutrophil recruitment and exert an inflammatory actions. (cancercurehere.com)
  • residues
  • Four major chemokine subfamilies are distinguished based on the arrangement of conserved cystein residues within the amino acid sequences. (ahajournals.org)
  • Fibroblasts
  • Using this novel technology, we did comparative analyses of gene expression for ∼23,000 transcripts in normal human fibroblasts and found that low-dose X-rays up-regulated a distinct set of chemokines that have not been shown to be associated with radiation. (aacrjournals.org)
  • degradation
  • By combining J8-DT with an inactive form of the streptococcal CXC protease, S. pyogenes cell envelope proteinase, we developed a combination vaccine that is highly effective in blocking CXC chemokine degradation and permits opsonic Abs to kill the bacteria. (jimmunol.org)
  • It controls chemokine levels and localization via highaffinity chemokine binding that is uncoupled from classic liganddriven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. (bioportfolio.com)
  • Similarity
  • Sequence and phylogenetic analyses of all chicken CXC chemokines present in the recently published chicken genome revealed that vIL-8 shares the highest amino acid similarity with the CXCL13L1 variant. (uni-muenchen.de)
  • The results revealed that BS CXC has a high gene similarity and tertiary structure similarity with piscine and mammalian CXC chemokines, both ELR - CXC and ELR + CXC, although it has a lower identity with ELR - CXC, compared with ELR + CXC chemokines. (beds.ac.uk)
  • motif
  • 4 These PMN chemoattractants contain a conserved Glu-Leu-Arg (ELR) motif proximal to the CXC sequence, which is critical in cognate receptor binding and activation, 5 as well as PMN chemotaxis. (bloodjournal.org)
  • Like other piscine IL-8, BS CXC has only an incomplete ELR motif, which is essential for the mammalian ELR + CXC ability to attract granulocytes. (beds.ac.uk)
  • lung
  • Reports have suggested that several types of cancer, such as breast, ovary, prostate, kidney, brain, lung, and thyroid, expressed the chemokine receptor and used the chemokines to metastasize to the target organ as in the homing of hematopoietic cells. (knowcancer.com)
  • inflammatory
  • These coinduced chemokines may cooperate to attract leukocytes to the site of infection, thereby enhancing the outcome of an inflammatory response. (aspetjournals.org)
  • We propose that the macrophage, specifically through MMP-12, assists in orchestrating the regulation of acute inflammatory responses by precise proteolysis of ELR + CXC and CC chemokines. (bloodjournal.org)
  • significantly
  • A S. typhimurium sipAsopABDE2 mutant complemented with sipA or a strain carrying a chromosomal copy of sipA (sopABDE2 mutant) activated chemokines at significantly higher levels than a S. typhimurium sipAsopABDE2 mutant. (nih.gov)