Chemokine receptor cxcr6. Medical search. Frequent questions

Interestingly, receptors which expression declines during NK cell differentiation (CCR5, CCR7, and CXCR3) are commonly associated with adaptive T cell responses to viruses, whereas receptors that are upregulated along the differentiation axis (CXCR1, CXCR2, CX3CR1, CMKLR1) are typical for neutrophils and macrophages as a part of the innate immune response. (confex.com)
Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians. (cdc.gov)
He found that individuals carrying this risk factor display reduced levels of chemokine receptors, namely CCR3, CCR5, and CXCR6. (ua-magazine.com)
Immuno-phenotyping of liver showed that, liver was enriched with T cells expressing the chemokine receptors CCR2, CCR5, CXCR3, and CXCR6. (edu.au)
Th1 and Th2 cells has been distinctively defined based on chemokine receptor expression on the surface CCR5 CXCR3 and CXCR6 and CCR3 CCR4 CCR7 CCR8 CRTh2 and CXCR5 respectively (Mosmann et CC-4047 al. (biospraysehatalami.com)

Conversely, CD69INTCD4+ T cells represented a more heterogenous population containing cells with a more activated phenotype, a distinct chemokine receptor profile (CX3CR1+CXCR3+CXCR1+) and a bias towards interleukin-4 production. (ucl.ac.uk)
PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)

The receptor N-terminus is external and contributes to ligand binding while the carboxy terminus (COOH) allows for interaction with signaling molecules and downstream signaling. (biolegend.com)
Distinct receptor-ligand interactions and distinct cytokine milieus lead to the generation of antigen-specific memory NK cells. (nature.com)
These studies have identified LY49H as the MCMV-specific activating NK cell receptor and m157 as the cognate viral ligand recognized by LY49H. (nature.com)
This study aimed to determine the effects of the CXC chemokine ligand 16 (CXCL16)/CXC chemokine receptor 6 (CXCR6) pathway on cholesterol accumulation in the radial arteries of end-stage renal disease (ESRD) patients with concomitant microinflammation and to further investigate the potential effects of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R). (medsci.org)
The genes listed here can be expressed on NK cells, feeder cells, or tumor cells to study individual NK cell signaling pathways, strengths of activation of different receptor-ligand interactions, and whether certain NK cells are more or less resistant to inhibitory cues from cancer cells. (freegenes.org)
CXCL16, the cell surface ligand for CXCR6, is expressed on sinusoidal endothelial cells, and CXCR6 deficiency resulted in reduced survival, but not in altered speed or pattern of patrolling of NKT cells. (ox.ac.uk)
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. (fabgennix.com)
Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. (fabgennix.com)
Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
[7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)

Expression of cytokine/chemokine receptors, MHC class I and class II are modulated by PD-1 Ab, HBI-8000, or their combination. (biomedcentral.com)
2001 Despite overlapping expression of chemokine receptors the classification of Th1/Th2 cells can be based on the representative marker expression of CXCR3+ and CCR4- and the validity was confirmed with cytokine profile of each subset (Kim et al. (biospraysehatalami.com)
Regardless of these limitations, we conclude that analysis of systemic chemokine/cytokine profiles can reflect critical clinical characteristics and, as a result, is definitely an crucial scientific tool which will be used as a component of future clinical studies to determine clinically relevant biomarkers. (5htreceptor.com)

G chemoattractant and C-C chemokine receptor 2 (CCR2) Val64Ile polymorphisms and multiple sclerosis in a Tunisian population. (cdc.gov)
Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region. (cdc.gov)

CXCL16/CXCR6 pathway-related protein expression, P2X7R protein expression and the expression of monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-α (TNF-α), and CD68 were detected by immunohistochemical and immunofluorescence staining. (medsci.org)
Further analysis showed that protein expression of CXCL16, CXCR6, disintegrin and metalloproteinase-10 (ADAM10) in the radial arteries of the inflamed group was significantly increased. (medsci.org)
Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. (medsci.org)
CXCL16, which was originally described as a scavenger receptor for phosphatidylserine and oxidized low-density lipoprotein (SR-PSOX), is one of the few scavenger receptors that has two distinct forms: membrane-bound and soluble. (medsci.org)
The membrane-bound form of CXCL16 binds and internalizes oxidative low-density lipoprotein (oxLDL) and promotes adhesion of cells expressing its cognate receptor, CXCR6 [ 6 , 7 ] . (medsci.org)
CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. (peprotech.com)
The chemokine domain of CXCL16 contains six cysteine residues, including the four highly conserved cysteine residues characteristic of CXC chemokines. (peprotech.com)
The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal mucin-like stalk sequence. (peprotech.com)
The objective of this study was to determine the role of CXCR6/CXCL16 in NKT cell-DC interactions. (aai.org)
These results suggest that CXCR6/CXCL16 is required for full NKT cell and dendritic cell activation/maturation. (aai.org)
CXCR receptors that are specific for CHEMOKINE CXCL16. (bvsalud.org)

The human NK cell repertoire is functionally diversified through a tightly regulated differentiation process characterized by an early transition from CD56bright to CD56dim NK cells, followed by coordinated changes in expression of inhibitory receptors, including NKG2A and killer cell immunoglobulin-like receptors (KIR). (confex.com)
The activating or inhibitory receptors can similarly be transduced or transfected into NK cells to perturb their behavior. (freegenes.org)
Additionally, impaired differentiation and trafficking of CD8+ T cells is known to be associated with immune escape and exhaustion of CTLs, but the timing and mechanisms and expression patterns of inhibitory receptors as wells as impairments in differentiation during primary HCV infection remains unclear. (edu.au)

This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. (cancerindex.org)
Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. (cdc.gov)
The NK cell research toolkit product contains three classes of genes: ligands, surface receptors, and transcription factors. (freegenes.org)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
RESULTS: CD8 T cells from lungs of i.n. immunized mice expressed a large number of chemokines chemotactic for resting and activated T cells as well as activation and survival genes. (ox.ac.uk)
The sustained expression of chemokines and activation genes enables CD8 T cells to remain in the lungs for extended periods after i.n. immunization. (ox.ac.uk)
Phenotypic validation of target genes revealed a previously unrecognized complexity of the CD4 + T RM compartment in the lungs, as the expression of VLA-1, CXCR6 and the inhibitory 2B4 did not strictly associate to any of the conventional T RM phenotypes. (keystonesymposia.org)

Among several homing chemokines, an antibody array revealed that expression of eotaxin-3 (but not eotxin-1 and -2) was highly enhanced in MSCs treated with PC-3-conditioned medium. (cancerindex.org)

These chemokines also have a more diverse range of functions compared to inflammatory chemokines. (biolegend.com)
In the event of infection, injury, or tissue damage, inflammatory chemokines are often released to address the problem. (biolegend.com)
Many inflammatory chemokines attract a wide variety of cells in both the innate and adaptive arms of immunity. (biolegend.com)
approximately 50 human chemokines and 20 receptors happen to be identified (Table 1) [12], and they could be classified either on the basis of (i) the molecular structure, i.e., the pattern of cysteine residues within the ligands or (ii) their functional qualities, as inducible or inflammatory chemokines and constitutively expressed homeostatic chemokines [33]. (5htreceptor.com)
The complexity from the chemokine system is noticed at the receptor level, exactly where specially inflammatory chemokines frequently bind several receptors and vice versa [34], and acute myeloid leukemia (AML) cells normally show constitutive release of numerous chemokines and express several chemokine receptors [20]. (5htreceptor.com)

Interestingly, CCR1 and CXCR6 were expressed mainly on less differentiated NKG2A+ CD56dim NK cells (B). Next, we stratified the chemokine receptor expression on mature KIR+ NK cells based on the expression of self (educated) or non-self KIR (uneducated). (confex.com)

CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field. (wikipedia.org)
Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. (southernbiotech.com)

Homeostatic chemokines are constitutively expressed in particular organs or tissues. (biolegend.com)

A gene expression array showed significantly increased expression of CCR3, a receptor of eotaxin-3, in PC-3. (cancerindex.org)

Due to their function of targeting cells to specific organs, homeostatic chemokines can also be involved in cancer and metastasis. (biolegend.com)

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene. (wikipedia.org)
Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
G protein-coupled receptor clas. (gsea-msigdb.org)
We examined the in vivo behavior of liver natural killer T cells (NKT cells) by intravital fluorescence microscopic imaging of mice in which a green fluorescent protein cDNA was used to replace the gene encoding the chemokine receptor CXCR6. (ox.ac.uk)
Comprehensive proteomic screening of chemokines in the blister fluids of DEB-affected mice was conducted to define the inflammatory and immune activities, thus providing potential to examine local biological mechanisms and define the protein signature within lesional skin as a potential marker of disease activity. (biomedcentral.com)
Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. (fabgennix.com)

Chemokines are a class of cytokines that induce chemotaxis (migration) of target cells. (biolegend.com)
Once at the site of injury, immune cells can react by releasing additional cytokines and chemokines, bringing more cells into the fold. (biolegend.com)
[ 5 ] confirmed that inflammatory cytokines contribute to foam cell formation by modifying cholesterol-mediated LDL receptor regulation in mesangial cells. (medsci.org)
throughout leukemogenesis, chemokines interact with other cytokines, especially hematopoietic growth variables and angioregulatory components [357], but in addition using the matrix metalloprotease (MMP) technique that seems to become directly involved in leukemogenesis and causes proteolytic cleavage and, thereby, activation of chemokines [38]. (5htreceptor.com)
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)

Lessons learned from the study of NK cell memory could help with the design of better expansion protocols for adoptive NK cell therapy, for the manufacturing of chimeric antigen receptor (CAR)-engineered NK cells and for improving NK cell-based therapies that rely on antibody-dependent cellular cytotoxicity (ADCC). (nature.com)
NKT cells, which account for most CXCR6(+) cells in liver, were found to crawl within hepatic sinusoids at 10-20 microm/min and to stop upon T cell antigen receptor activation. (ox.ac.uk)

The present results show that peripheral blood NK cell chemokine receptor profile changes in a coordinated fashion during NK cell differentiation and is further influenced by the expression of self-specific KIR. (confex.com)
We have characterized the T cell composition and chemokine profile in paired intervillous and peripheral blood samples from healthy mothers giving birth following term pregnancies. (frontiersin.org)
The levels of several chemokines were significantly higher in intervillous compared to peripheral blood, including macrophage migration inhibitory factor (MIF), CXCL10, and CCL25, whereas CCL21, CCL27 and CXCL12 were lower. (frontiersin.org)

Using an orthotopic head and neck tumor model, CXCR6 expression on tumor-infiltrating Trm induced by i.n. immunization has also been reported. (aacrjournals.org)
In addition, we showed that Cxcr6-deficiency impairs mice survival in a prophylactic and therapeutic i.n. vaccination settings in various mucosal tumor models. (aacrjournals.org)
In this Cxcr6-deficient mouse model, the loss of vaccine-induced protection against tumor graft correlates with a clear reduction of Trm infiltration in tumor. (aacrjournals.org)
To conclude, we have identified CXCR6 as a required parameter to recruit the crucial anti-tumor Trm in mucosal tumor. (aacrjournals.org)
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. (peprotech.com)
The NK Cell Research Toolkit enables researchers to examine the effects of distinct molecules on NK cells' targeting and eradication of discrete tumor cell types, and to design novel chimeric antigen receptors to modify endogenous signaling pathways. (freegenes.org)

Click on the receptor to sort the ligands to the top. (biolegend.com)

While some chemotaxis is induced by inflammation or damaged cells, other chemokines function in homeostasis. (biolegend.com)
The key mechanism that regulates recruitment of leukocytes and progenitor stem cells to distal anatomical tissues affected with disease is chemotaxis, which depends on the signaling molecules, chemokines, and acts primarily as part of the host defense and repair mechanism. (biomedcentral.com)

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. (wikipedia.org)
Attracted cells move toward areas of higher concentrations of the chemokine. (biolegend.com)
Upon sensing the inflammatory chemokine, cells will extravasate from the blood vessel and follow the gradient to its source. (biolegend.com)
define NK cell differentiation states based on their education via NKG2a and expression of CD16 (FcγRIII), an activating Fc receptor that mediates antibody-dependent cell-mediated cytotoxicity (ADCC) 8 , and demonstrate that nonpathogenic SIVagm infection in African green monkeys (AGMs) imprints the maturation of NK cells inducing terminally differentiated NKG2a low CD16 + NK cells, which express high levels of interleukin (IL)−21R. (nature.com)
Based on a transcriptomic analysis, we have identified a chemokine receptor, CXCR6, highly expressed by these specific Trm CD8+ T-cells, induced by the i.n. vaccination. (aacrjournals.org)
To understand the role of CXCR6 in vaccination efficacy, we have set up a body of experiments using heterozygous Cxcr6gfp/+ mice, where GFP reflects CXCR6 expression and homozygous Cxcr6-deficient mice Cxcr6gfp/gfp.We have then confirmed CXCR6 expression on specific Trm CD8+ T-cells induced by i.n. vaccination in lung mucosa. (aacrjournals.org)
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. (peprotech.com)
This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. (cancerindex.org)
We found that the chemokine-induced migration capability of NK cells correlated closely with the expression level of corresponding chemokine receptor, leading to subset specific responses to various chemokine gradients (D). (confex.com)
Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4 + T cells. (southernbiotech.com)
8. Iwasaki M, Nagata K, Takano S, Takahashi K, Ishii N, Ikezawa Z. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. (southernbiotech.com)
The variant identified by researchers is generally connected with severe COVID-19 and is situated on chromosome 3, specifically in an area that leads to the production of chemokine receptors (receptors for a type of small soluble proteins released from cells that affect the immune system). (ua-magazine.com)
Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A. (ox.ac.uk)
Lung lymphocytes from i.n. immunized mice also express the chemokine receptor gene Cxcr6, which is thought to aid long-term retention of antigen-responding T cells in the lungs. (ox.ac.uk)
Expression of CXCR6 on CD8 T cells was confirmed by flow cytometry. (ox.ac.uk)
CXCR6-deficient mice exhibited a selective and severe reduction of CD1d-reactive NKT cells in the liver and decreased susceptibility to T-cell-dependent hepatitis. (ox.ac.uk)
Thus, NKT cells patrol liver sinusoids to provide intravascular immune surveillance, and CXCR6 contributes to liver-based immune responses by regulating their abundance. (ox.ac.uk)
CD69HICD4+ cells were identified as tissue-resident CD4+ T cells on the basis of their exclusion from the circulation, phenotypical profile (CXCR6+CD49a+S1PR1−PD-1+) and long-term persistence within the pool of donor-derived leukcoocytes in HLA-disparate liver allografts. (ucl.ac.uk)

Allograft renal rejection and chemokine polymorphism. (cdc.gov)

Chemokines and their receptors are involved inside the improvement of a number of disorders, including autoimmune diseases, cancer, also as vascular ailments [34], and systemic (serum or plasma) PLD Inhibitor custom synthesis chemokine levels may consequently serve as biomarkers for illness development or reflect disease activity, also as treatment responses. (5htreceptor.com)

We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
In order to delineate the homing patterns of distinct NK cell subsets, we used high-dimensional flow cytometry combined with functional assays to map the NK cell chemokine receptor expression and migratory behavior. (confex.com)
To determine whether the observed differences in chemokine receptor expression translate into altered chemokine responsiveness between the subsets, we combined the transwell system with multicolor flow cytometry. (confex.com)
Interestingly, lesser expression of these receptors has been correlated with a reduced prevalence of HIV. (ua-magazine.com)

The non-phospho-D2 receptor antibody is directed against the third intracellular loop of mouse, rat and human D2 dopamine receptor. (7tmantibodies.com)

This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). (cancerindex.org)

CXCR6 has also recently been designated CD186 (cluster of differentiation 186). (wikipedia.org)

The dopamine D2 receptor belongs to the D2-like subfamily of dopamine receptors. (7tmantibodies.com)

It serves on purinergic G2RX7 receptors on DCs that in convert activate the NLRP3/ASC/caspase-1 inflammasome, finally ending in the release of interleukin (IL-) IL-18 and IL-1 (56). (rawveronica.com)

Assessment of blister fluid-derived chemokines showed a persistent presence of several chemotactic molecules, including CXCL1 + 2 and CXCL5. (biomedcentral.com)

We performed targeted transcriptomics and T-cell receptor sequencing in a restricted subset of samples evaluated in relationship with HIV status. (imperial.ac.uk)

A strong correlation exists between the therapeutic effects of antipsychotics and blockade of the D2 dopamine receptor. (7tmantibodies.com)

CD4 + T RM expressed unique sets of chemokine receptors and adhesion molecules necessary for tissue homing. (keystonesymposia.org)

The spacing between the first two cysteines determines the type of chemokine. (biolegend.com)
GABA type A receptor associated. (gsea-msigdb.org)
Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
[8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)

Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. (fabgennix.com)

Chemokines work through concentration gradients. (biolegend.com)

Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)

Anatomy39

Organisms12

Diseases12

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes41

Disciplines and Occupations1

Information Science3

CCR55

CXCR32

Ligand12

Cytokine3

CCR22

CXCL1611

Inhibitory receptors3

Genes7

Several homing che1

Inflammatory chemokines5

CCR11

BONZO2

Constitutively expressed1

CCR31

Homeostatic chemokines1

Protein9

Cytokines5

Antigen receptor2

Peripheral blood3

Tumor6

Ligands1

Chemotaxis2

Cells18

Polymorphism1

Biomarkers1

Expression4

Antibody1

Binds1

Differentiation1

Subfamily1

Purinergic1

Chemotactic1

Cell receptor1

Blockade1

Adhesion1

Type4

Acts1

Gradients1

Tissues1