Chemokine macrophage inflammatory chemokines. Medical search. Frequent questions

We assessed the levels of 17 cytokines and chemokines associated with innate and adaptive (T- and B-cell) responses in CSF of patients with meningoradiculoneuritis, PFP/meningitis, or suspected LNB. (cdc.gov)
Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. (aspetjournals.org)
The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
BZK induced a significant increase in the severity of the clinical score, infiltration of inflammatory cells, local expression of inflammatory cytokines in subcutaneous tissue, and total serum immunoglobulin (Ig) E. PVP-I increased the clinical score, number of mast cells, and production of inflammatory cytokines, and total serum IgE. (medsci.org)

The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha). (wikipedia.org)
This chemokine receptor is special because it binds only one chemokine ligand CCL20 in compare to other chemokine receptors. (wikipedia.org)
MIP-3β (macrophage inflammatory protein-3-beta ), also known as (Chemokine (C-C motif) ligand 19 (CCL19) and EBI1 ligand chemokine (ELC) is a small cytokine belonging to the CC chemokine family. (quanterix.com)
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
Astrocyte-derived chemokine C-C motif ligand 20 (CCL20) was identified using cytokine arrays, and its role in glioblastoma development was evaluated in orthotopic xenografts. (cancerindex.org)
Human CCL4 Recombinant Protein is purified chemokine ligand 4 (CCL4, MIP-1 beta) produced in yeast. (immunochemistry.com)
Chemokine ligand 4 (CCL4) is a small chemotactic cytokine belonging to the CC chemokine family that is also known as macrophage inflammatory protein-1β (MIP-1 beta). (immunochemistry.com)

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)

Severe COVID-19 is associated with profound changes in the myeloid compartment, including expansion of dysfunctional, pro-inflammatory monocytes during the first weeks after SARS-CoV-2 infection 6 , 7 . (nature.com)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Our data extended prior observations of Sia + IgG on DC function and showed that Sia + IgG was able to differentially modulate multiple pathways in monocytes and macrophages. (scirp.org)
CC chemokines induce the migration of monocytes and other cell types such as NK cells and dendritic cells. (immunochemistry.com)

Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. (nature.com)
Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)

CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ) is a 7.8 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). (rndsystems.com)
CCL4 is involved in several inflammatory and autoimmune diseases including viral infection such as HIV-1/AIDS. (immunochemistry.com)

The end products of its enzymatic activity possess anti-oxidative, anti-apoptotic and anti-inflammatory properties. (springer.com)
This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of ACD. (aspetjournals.org)

In the current study, we used LPS to mimic aspects of central or systemic infection and the ME7 model of murine prion disease to model chronic neurodegeneration to address the hypothesis that microglial cells, activated by chronic neurodegeneration, are primed to produce greater proinflammatory responses to subsequent central and systemic inflammatory challenges. (jneurosci.org)
To achieve this, we assessed proinflammatory cytokine expression, inflammatory cell infiltration, and expression of effector enzymes such as cyclooxygenase 2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) after intracerebral and intraperitoneal LPS challenges. (jneurosci.org)

By studying transcriptome- and lipid mediator profiles in MDM of convalescent SARS-CoV-2-infected individuals with previous mild disease, we show that inflammatory gene expression and eicosanoid profiles as well as altered responsiveness to inflammatory cues are maintained at 3-5 months post infection as well as throughout macrophage differentiation. (nature.com)
This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. (wikipedia.org)
We have previously shown that the sialic acid-containing (Sia + ) fraction of intravenous immune globulin (IVIG) influences cell surface marker expression and cytokine/ chemokine secretion during the differentiation and maturation of human dendritic cells (DC). (scirp.org)

Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
According to the function and immune phenotype, macrophages can be divided into two types: Classically activated (M1) and alternatively activated (M2) macrophages. (frontiersin.org)

Stimulation with SARS-CoV-2 spike protein or LPS triggered exaggerated prostanoid-, type I IFN-, and chemokine responses in post COVID-19 MDM. (nature.com)
However, these inflammatory cells are "primed" to produce exaggerated inflammatory responses to subsequent lipopolysaccharide (LPS) challenges. (jneurosci.org)
Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)
MIP-3β and plays a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation, migration and homing. (quanterix.com)
In the setting of cancer, instead of eliciting effector pathways that would lead to tumor elimination, these antibodies might promote down-regulation of the cellular inflammatory responses to the tumor. (scirp.org)
This may to a certain degree explain why this type of CoV triggers severe inflammatory responses and immune damage and its associated complications. (spandidos-publications.com)

After the co-culture, the increase in pro-inflammatory cytokine expression in the mutant cells was significantly lower than that in the control group, while that in immunosuppressive factors was not significantly different. (frontiersin.org)

Resident and recruited macrophages in the lung produce high levels of cysteinyl LTs (cysLTs) and leukotriene B 4 (LTB 4 ), thereby promoting granulocyte infiltration, airway inflammation and tissue remodeling 8 . (nature.com)
Abundant macrophage infiltration of solid cancers commonly correlates with poor prognosis. (aacrjournals.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)

Thus, SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19. (nature.com)

Pro-inflammatory 5-LOX metabolites were selectively increased in post COVID-19 MDM, suggesting that SARS-CoV-2 infection drives a pro-inflammatory eicosanoid reprogramming that contributes to long-term alterations in innate immune cell function. (nature.com)

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. (wikipedia.org)

KEGG enrichment and gene set enrichment analysis (GSEA) showed that a large number of genes were enriched in inflammatory immune-related pathways, such as the toll-like receptor signaling pathway. (frontiersin.org)
It is expressed at high levels in the lymph nodes, thymus and appendix, and elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. (quanterix.com)
Cannabinoid type-2 (CB 2 ) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). (aspetjournals.org)

RNA-seq results showed that transcription factors and macrophage inflammatory proteins were significantly downregulated in the DNMT3A mutant clones. (frontiersin.org)
Resistin significantly promoted the expression of inflammatory proteins in AML cells. (frontiersin.org)

and, hence, although they show some evidence of inflammation, they do not exhibit an inflammatory response that can be a response to neurodegeneration. (jneurosci.org)
Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)
The prominence of perivenular round cell inflammation in either illness is a feature that is shared with many forms of encephalitis, but patchy demyelination with preservation of axon cylinders and the prominence of microglial cells in the inflammatory exudate are not. (medscape.com)
2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)
Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)

Characterization of active disaggregated chemokine variants. (expasy.org)

however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)

These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)

The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases. (jneurosci.org)

Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
In xenografts, the tumor volumes in the experimental group were significantly larger than those in the control group, and the proportion of M2 macrophages was significantly higher. (frontiersin.org)

It can regulate immune response in inflammatory tissue. (wikipedia.org)
It relieved the inhibitory effect of DNMT3A mutation, promoted the phenotypic recovery of the co-cultured macrophages, eliminated resistance, and regulated the immune microenvironment. (frontiersin.org)
Macrophages are the most abundant white blood cells in the immune microenvironment and have a high degree of heterogeneity. (frontiersin.org)
Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately affects the white matter of the brain and spinal cord. (medscape.com)

Whole genome analysis of lung, sampled 24 hours after challenge, showed expression changes of not only genes belonging to several Gene Ontology groups with up-regulation of inflammatory-associated genes and those associated with lung remodeling but also genes involved in downsizing these processes. (cdc.gov)

Viral macrophage inflammatory protein-II (vMIP) is a highly basic protein and human chemokine analog encoded by human herpesvirus-8. (drugbank.com)

This report reviews the emerging literature describing a novel class of proteolytic targets, leukocyte chemoattractants, and, in particular, chemerin, a dendritic cell and macrophage chemoattractant activated by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (nih.gov)
B) Hierarchical clustering analysis (Euclidian distance) of inflammatory mediators and CSF leukocyte counts. (cdc.gov)

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)

Heat map analysis of inflammatory mediators in CSF stratified by clinical presentation of LNB among patients with Lyme neuroborreliosis treated in Ljubljana, Slovenia, during 2006-2013. (cdc.gov)
A) Levels of inflammatory mediators stratified by LNB manifestation. (cdc.gov)

2002). considered to be an inflammatory disorder. (cdc.gov)

Unsensitized animals challenged with TMA exhibited also an increased number of macrophages in BAL, but gene expression in the above-mentioned gene pathways was unchanged or down-regulated. (cdc.gov)

Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. (expasy.org)
The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)

The DNMT3A-mutated AML cells attenuated M1 macrophage polarization and resisted its killing effect in vitro and in vivo . (frontiersin.org)
Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)

Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T-cells (Treg). (wikipedia.org)
Therefore, we co-cultured AML cells with macrophages. (frontiersin.org)
Et-OH increased the clinical score and number of inflammatory cells, but showed no effect on serum IgE levels. (medsci.org)

In co-cultivated supernatants, the concentration of inflammatory factors in the experimental group was significantly lower than that in the control group, while that of immunosuppressive factors was significantly higher. (frontiersin.org)

Allergic contact dermatitis (ACD), a form of delayed-type hypersensitivity, is a typical T-cell-mediated skin inflammatory response that occurs after cutaneous exposure to an allergen. (aspetjournals.org)
Metal allergy is an inflammatory disease categorized as a delayed-type hypersensitivity (DTH) reaction. (mdpi.com)

There isno alteration in macrophage function after BNNT exposure with all purity grades. (cdc.gov)

Despite that macrophages have low affinity for nonoxidized LDL, reducing LDL levels prevents oxidation, as recognized by European and American cardiac societies in their guidelines [ 11 ]. (hindawi.com)

MDM from convalescent SARS-CoV-2-infected individuals showed a downregulation of pro-resolving factors and an increased production of pro-inflammatory eicosanoids, particularly 5-lipoxygenase-derived leukotrienes. (nature.com)

Here we report that MDM from SARS-CoV-2-infected individuals with mild disease show an inflammatory transcriptional and metabolic imprint that lasts for at least 5 months after SARS-CoV-2 infection. (nature.com)
Most cases of ADEM possibly occur as the result of an inflammatory response provoked by pre-pubertal infection with a virus, vaccine, or other infectious agent. (medscape.com)

The material from each step isscreened using acellular and in vitro assays for evaluating general toxicity, mechanisms of toxicity, and macrophage function. (cdc.gov)

Anatomy46

Organisms13

Diseases8

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Cytokines6

Ligand7

Receptors1

Monocytes6

Monocyte-derived2

CCL42

Anti-inflammatory properties2

Proinflammatory2

Differentiation3

Phenotype2

Responses6

Cytokine expression1

Infiltration3

Effector1

Innate1

CCR61

Receptor3

Proteins2

Inflammation6

Characterization1

Neutrophils1

CCL21

Systemic1

Tumor2

Immune5

Genes1

Viral1

Leukocyte2

Oxidative1

Mediators2

20021

Pathways1

Human2

Polarization2

Cells3

Significantly1

Hypersensitivity2

Exposure1

Levels1

Production1

Infection2

Function1