ReceptorCytokinesCXCL1LigandCXCR2ChemotacticGenesCXCL8ChemoattractantCCL2Constitutively expressedChemotaxisSeven transmembraneFIBROBLASTSHomeostatic chemokinesInflammatory chemokinesCytokineReceptors are involvedCysteinesCXCL16ProteinCCL21CCL8LYMPHOCYTESBindRecombinantAminoCXCRSubfamilyHomeostasisConstitutiveMONOCYTESCellsSpecificityVivoTumorigenesisThymusCalciumPlateletMeasurementAcuteExpression
Receptor9
- Use this table to quickly identify the chemokines that bind to each receptor. (biolegend.com)
- We selected most pathways CCL3L3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. (creativebiomart.net)
- The receptor usage of the CXC chemokine granulocyte chemotactic protein-2 (GCP-2) was compared with that of interleukin-8 (IL-8) and epithelial-cell-derived neutrophil attractant-78 (ENA-78). (tau.ac.il)
- Chemokine activities were evaluated by measurement of intracellular calcium increase and by chemotasis and binding assays, using CXC chemokine receptor (CXCR)-transfected cell lines. (tau.ac.il)
- The differential receptor usage of the structurally related ELR + CXC chemokines GCP-2 and ENA-78 is indicative of a different role in inflammatory reactions. (tau.ac.il)
- CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. (umassmed.edu)
- Table 1 CXC- C- CX3C- and CC-chemokine and receptor families As the CXC-chemokines CXCL1 and GW788388 CXCL8 have been associated with tumour growth metastasis and angiogenesis I concentrate on these important chemokines. (cancerrealitycheck.com)
- The complexity from the chemokine system is noticed at the receptor level, exactly where specially inflammatory chemokines frequently bind several receptors and vice versa [34], and acute myeloid leukemia (AML) cells normally show constitutive release of numerous chemokines and express several chemokine receptors [20]. (5htreceptor.com)
- PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
Cytokines7
- Chemokines are a class of cytokines that induce chemotaxis (migration) of target cells. (biolegend.com)
- Once at the site of injury, immune cells can react by releasing additional cytokines and chemokines, bringing more cells into the fold. (biolegend.com)
- Inherited genetic variants such as single-nucleotide polymorphisms (SNPs) of candidate genes, encoding various cytokines, chemokines, and inflammatory regulators, have become a subject of interest of genetic studies searching for independent predictors of GVHD development and HSCT outcome [ 4 - 7 ]. (hindawi.com)
- The inflammatory response is mediated by a family of chemotactic cytokines, designated chemokines. (tau.ac.il)
- of transcription of genes that encode cytokines chemokines adhesion factors and inhibitors of apoptosis. (cancerrealitycheck.com)
- throughout leukemogenesis, chemokines interact with other cytokines, especially hematopoietic growth variables and angioregulatory components [357], but in addition using the matrix metalloprotease (MMP) technique that seems to become directly involved in leukemogenesis and causes proteolytic cleavage and, thereby, activation of chemokines [38]. (5htreceptor.com)
- Multiple pro-inflammatory cytokines such as IL-1β, TNF-α, IL-6 and chemokines (IL-8 and others) are produced by activated chondrocytes in OA [ 3 - 6 ]. (biomedcentral.com)
CXCL14
- The data presented here describe the cellular pharmacology of the acid and ester forms of the nicotinamide glycolate pharmacophore, a potent antagonist of CXCR2 signaling by the chemokines CXCL1 and CXCL8. (aspetjournals.org)
- CXCL8 and CXCL6 bind to the chemokine receptors CXCR1 and CXCR2 whereas CXCL1 and other CXC-chemokines that have a Glu-Leu-Arg (ELR) motif at their amino terminus (CXCL2 -3 and-5) bind to and activate CXCR2 only2. (cancerrealitycheck.com)
- The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). (wikidoc.org)
- [8] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. (wikidoc.org)
Ligand1
- Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). (wikipedia.org)
CXCR22
- It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. (wikipedia.org)
- IL-8 signals through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. (bio-techne.com)
Chemotactic1
- A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. (lookformedical.com)
Genes6
- The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes. (wikipedia.org)
- This chemokine is encoded by multiple genes. (lookformedical.com)
- The transcription of chemokine genes is often inhibited by transforming growth factor-β (TGF-β) and glucocorticoids1. (cancerrealitycheck.com)
- This constitutive expression of chemokines occurs due to transcriptional activation of the encoding genes. (cancerrealitycheck.com)
- In part the endogenous transcription of chemokine genes in melanoma cells is due to altered NF-κB activation. (cancerrealitycheck.com)
- Tumour angiogenesis growth and metastasis are facilitated by the NF-κB-modulated transcription of chemokine genes. (cancerrealitycheck.com)
CXCL83
- In normal cartilage, CXCL6 and CXCL8 are present within the cartilage matrix. (qmul.ac.uk)
- CXCL8 is bound to heparan sulphate proteoglycans, whilst CXCL6 is sequestered by an as of yet unidentified alternative matrix interaction, contributing to the determination of the chemokine signalling domain. (qmul.ac.uk)
- Interleukin-8 (IL-8), also known as CXCL8, is a chemokine that is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. (bio-techne.com)
Chemoattractant3
- As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. (wikipedia.org)
- Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. (genome.jp)
- A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
CCL21
- CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
Constitutively expressed3
- Homeostatic chemokines are constitutively expressed in particular organs or tissues. (biolegend.com)
- Dermal fibroblasts constitutively expressed distinct sets of chemokine mRNA. (pdgfrinhibitors.com)
- approximately 50 human chemokines and 20 receptors happen to be identified (Table 1) [12], and they could be classified either on the basis of (i) the molecular structure, i.e., the pattern of cysteine residues within the ligands or (ii) their functional qualities, as inducible or inflammatory chemokines and constitutively expressed homeostatic chemokines [33]. (5htreceptor.com)
Chemotaxis1
- While some chemotaxis is induced by inflammation or damaged cells, other chemokines function in homeostasis. (biolegend.com)
Seven transmembrane2
- Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
- The biological functions of chemokines are mediated through seven-transmembrane G-protein-coupled receptors. (cancerrealitycheck.com)
FIBROBLASTS1
- affected the release of chemokines CCL8, CCL13, CXCL4 and CXCL6 by fibroblasts. (pdgfrinhibitors.com)
Homeostatic chemokines1
- Due to their function of targeting cells to specific organs, homeostatic chemokines can also be involved in cancer and metastasis. (biolegend.com)
Inflammatory chemokines3
- These chemokines also have a more diverse range of functions compared to inflammatory chemokines. (biolegend.com)
- In the event of infection, injury, or tissue damage, inflammatory chemokines are often released to address the problem. (biolegend.com)
- Many inflammatory chemokines attract a wide variety of cells in both the innate and adaptive arms of immunity. (biolegend.com)
Cytokine1
- Regardless of these limitations, we conclude that analysis of systemic chemokine/cytokine profiles can reflect critical clinical characteristics and, as a result, is definitely an crucial scientific tool which will be used as a component of future clinical studies to determine clinically relevant biomarkers. (5htreceptor.com)
Receptors are involved1
- Chemokines and their receptors are involved inside the improvement of a number of disorders, including autoimmune diseases, cancer, also as vascular ailments [34], and systemic (serum or plasma) PLD Inhibitor custom synthesis chemokine levels may consequently serve as biomarkers for illness development or reflect disease activity, also as treatment responses. (5htreceptor.com)
Cysteines5
- Chemokines contain several (usually four) cysteines in conserved positions. (biolegend.com)
- These cysteines provide tertiary structure for the chemokine through disulfide bonds. (biolegend.com)
- The spacing between the first two cysteines determines the type of chemokine. (biolegend.com)
- Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils. (lookformedical.com)
- Group of chemokines with paired cysteines separated by a different amino acid. (umassmed.edu)
CXCL161
- In this study we demonstrate that IR markedly enhanced the secretion by mouse and human breast cancer cells of CXCL16, a chemokine that binds to CXCR6 on Th1 and activated CD8 effector T cells, and plays an important role in their recruitment to sites of inflammation. (ox.ac.uk)
Protein3
- The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
- Negative expression of CXCL6 protein in RH-30 cells is consistent with the predicted expression pattern. (cellsignal.com)
- The Ferret CXCL6 Do-It-Yourself ELISA contains capture antibody, recombinant protein standard, and detection antibody for development of a Ferret CXCL6 ELISA. (kingfisherbiotech.com)
CCL211
- CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
CCL81
- Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
LYMPHOCYTES2
- A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. (lookformedical.com)
- Recruitment of CD8+ lymphocytes can also be regulated by IL-2 and chemokines released by the CD4+ Helper T-lymphocytes. (glucagon-receptor.com)
Bind1
- Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
Recombinant1
- Recombinant human CXCL6/GCP-2 (Val40-Asn114) fused with N-GST tag was expressed in E. coli. (creativebiomart.net)
Amino1
- Chemokines regulate the transport activation and sometimes proliferation of several cell types including myeloid lymphoid GW788388 endothelial and epithelial cells1 2 There are four chemokine subfamilies - CXC C CX3C and CC - based on the positions of conserved cysteine residues near the amino terminus of the proteins1 (TABLE 1). (cancerrealitycheck.com)
CXCR1
- Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
Subfamily1
- We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH. (statsignaling.com)
Homeostasis1
- ELR+ CXC chemokine signalling in cartilage homeostasis. (qmul.ac.uk)
Constitutive1
- VPF In this review I discuss the factors that lie upstream of the NF-κB cascade that are activated during tumorigenesis and the role of the putative NF-κB enhanceosome in constitutive chemokine gene transcription during tumorigenesis. (cancerrealitycheck.com)
MONOCYTES1
- CXC chemokines are chemoattractants for neutrophils but not monocytes. (umassmed.edu)
Cells6
- Attracted cells move toward areas of higher concentrations of the chemokine. (biolegend.com)
- Upon sensing the inflammatory chemokine, cells will extravasate from the blood vessel and follow the gradient to its source. (biolegend.com)
- In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (genome.jp)
- Western blot analysis of extracts from Caki-1 and RH-30 cells using CXCL6 (E6V8D) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). (cellsignal.com)
- Confocal immunofluorescent analysis of Caki-1 cells (left, positive) or RH-30 cells (right, negative) using CXCL6 (E6V8D) Rabbit mAb (green), DyLight 650 Phalloidin #12956 (red), and DAPI #4083 (blue). (cellsignal.com)
- Recruitment of effector T cells to inflamed peripheral tissues is regulated by chemokines and their receptors, but the factors regulating recruitment to tumors remain largely undefined. (ox.ac.uk)
Specificity5
- A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
- A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
- A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
- CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
- CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
Vivo1
- Healthy articular chondrocytes also express CXC chemokines and chemokine receptors, however their purpose within cartilage is unclear because chondrocytes are encased within a dense avascular extracellular matrix and are not known to migrate in vivo. (qmul.ac.uk)
Tumorigenesis1
- In this review I explore the mechanisms by which constitutively activated kinases that GW788388 function upstream of the NF-κB cascade facilitate chemokine-mediated tumorigenesis. (cancerrealitycheck.com)
Thymus1
- Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)
Calcium1
- Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. (genome.jp)
Platelet1
- This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules. (wikidoc.org)
Measurement1
- Measurement of Ferret CXCL6 in an ELISA. (kingfisherbiotech.com)
Acute1
- Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. (umassmed.edu)
Expression1
- Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. (umassmed.edu)