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  • CXCR2
  • CXCL8 (otherwise known as interleukin-8) and CXCL6 can both bind CXCR1 in humans, while all other ELR-positive chemokines, such as CXCL1 to CXCL7 bind only CXCR2. (wikipedia.org)
  • lymph nodes
  • Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
  • Their homeostatic function in homing is best exemplified by the chemokines CCL19 and CCL21 (expressed within lymph nodes and on lymphatic endothelial cells) and their receptor CCR7 (expressed on cells destined for homing in cells to these organs). (wikipedia.org)
  • SDF1
  • Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8). (manchester.ac.uk)
  • However, in breast cancer where SDF1/CXCL12 is also expressed by the cancer cells themselves along with CXCR4, CXCL12 expression is positively correlated with disease free (metastasis free) survival. (wikipedia.org)
  • chemoattractants
  • Inflammatory chemokines function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or tissue damage. (wikipedia.org)
  • stimulation
  • In the field of oncology, melanoma associated fibroblasts are stimulated by stimulation of the A2B adenosine receptor followed by stimulation of fibroblast growth factor and increased expression of CXCL12. (wikipedia.org)
  • vivo
  • To assess the impact of CXCL12 signaling on the vasculature and its ability to recruit progenitor cells, we combined a fluorescent chimeric mouse model and in vivo imaging to capture the chronological interactions among tumor cells (RFP), circulating BMDCs (GFP) and the cerebral vessels (FITC dextran) during tumor growth. (aacrjournals.org)
  • pathological conditions
  • This chemokine system has been shown to play important roles in brain plasticity processes occurring during development but also in the physiology of the brain in normal and pathological conditions. (frontiersin.org)
  • CXCL12 plays a role in myofibroblast-mediated ECM remodeling in pathological conditions. (upstate.edu)
  • mesenchymal
  • Integration with a microfluidics chip enables engineering of a "TM-on-a chip" platform to perform studies under dynamic flow conditions, and investigating CXCL12-mediated chemoattraction for mesenchymal stem cell therapy of high-pressure glaucoma. (upstate.edu)
  • immune
  • Overall, this chemokine system could be one of the key players of the neuro-immune interface that participates in shaping the brain in response to changes in the environment. (frontiersin.org)
  • Humans
  • In humans, CXCL12 has been implicated in a wide variety of biomedical conditions involving several organ systems. (wikipedia.org)