MotifReceptorNeutrophilsMonocyte chemoattractant proteinCCL2MRNA expressionCytokine and chemokineLymphocytesEosinophilsMonocytesGenesReceptorsChemotaxisProteinCytokinesINFLAMMATIONCCL17ThymicPathogenesisProteinsPotentSignaling pathwayCCR8PlateletLeukocyteCellsInflammatoryGeneMobilizationPlays a roleSmall
Motif3
- Chemokine (C-C motif) ligand 1 (CCL1) is also known as small inducible cytokine A1 and I-309 in humans. (wikipedia.org)
- Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
- The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). (wikidoc.org)
Receptor11
- CCL1 binds to the chemokine receptor CCR8 and induces Ca2+ influx, chemotaxis and regulate apoptosis. (wikipedia.org)
- Because CCL1 binds to the CCR8 receptor, some diseases can be caused by dysregulation and dysfunction of this receptor. (wikipedia.org)
- Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. (cusabio.com)
- Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis. (cusabio.com)
- The chemokine receptor is expressed on the cell surface and is a 7-pass transmembrane protein coupled to the G protein. (creative-proteomics.com)
- The chemokine is to transmit cell signals after binding to the receptor. (creative-proteomics.com)
- PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
- However, potential associations between chemokine and chemokine receptor polymorphisms and BD have been fundamentally understudied. (psychiatryinvestigation.org)
- To identify participation of chemokines in BD pathogenesis, we examined genetic variants of several chemokine and chemokine receptor genes. (psychiatryinvestigation.org)
- Our findings indicate an association between genetic variants of certain chemokine and chemokine receptor (especially MCP-1) genes and BD. (psychiatryinvestigation.org)
- 1 By contrast, potential associations between chemokine and chemokine receptor polymorphisms and BD have been fundamen tally understudied and only MCP-1 gene polymorphisms have been investigated in patients with BD. (psychiatryinvestigation.org)
Neutrophils2
- Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils. (lookformedical.com)
- As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (wikidoc.org)
Monocyte chemoattractant protein1
- A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
CCL22
- In addition to other chemokines, such as CCL2, CCL3, and CCL4, the presence of CCL1 has been reported in the development of brain abscesses, most likely leading to an influx of lymphocytes and monocytes and thus to an adaptive immune response. (wikipedia.org)
- CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
MRNA expression3
- For example, CCL1 and CCR8 mRNA expression has been detected in the CNS of mice with experimental autoimmune encephalomyelitis (EAE). (wikipedia.org)
- Changes in ST mitogen-activated protein kinase (MAPK) activation were assessed by immunoblotting and mRNA expression levels of selected cytokine and chemokines in primary ST bound by iRBC were determined using real-time, reverse transcription PCR. (biomedcentral.com)
- Among the results was evidence that there was differential chemokine mRNA expression by the papilloma tissues, which suggested that the virus might be able to polarize the patients' innate immune responses. (biomedcentral.com)
Cytokine and chemokine2
- In addition, secreted cytokine and chemokine proteins were assayed by standard ELISA, and chemotaxis of PBMC was assessed using a two-chamber assay system. (biomedcentral.com)
- A pharmacological inhibitor of TLR3 considerably reduced cytokine and chemokine production by CD4 + and CD8 + T cells but not by CD14 + monocytes, highlighting divergent signaling pathways of immune cells in response to COVID-19 plasma exosomes. (wphobby.com)
Lymphocytes5
- CCL1 is secreted by activated monocytes/macrophages, T lymphocytes and endothelial cells. (wikipedia.org)
- Thus, CCL1 mainly acts as a chemoattractant for monocytes/macrophages, T lymphocytes, specially Th2-differentiated T cells and a subset of T regulatory cells in vitro into inflammatory siter. (wikipedia.org)
- A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. (lookformedical.com)
- A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. (lookformedical.com)
- Additionally, the MIP-1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP-1 alpha and MIP-1 beta preferentially attracting CD8 + and CD4 + T cells, respectively. (rndsystems.com)
Eosinophils2
- Chemoattractant for eosinophils and basophils. (cusabio.com)
- It is a potent chemoattractant for EOSINOPHILS. (lookformedical.com)
Monocytes2
- CCL1 stimulates a transient increase in the concentration of cytoplasmic free calcium in monocytes but not in other type of cells. (wikipedia.org)
- A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
Genes4
- CCL1 is encoded by CCL1 gene which is one of the several chemokine genes clustered on the chromosome 17q11.2-q12 in humans. (wikipedia.org)
- CCL is the first human CCL chemokine that was identified by molecular cloning during searching for genes expressed by T cells. (wikipedia.org)
- This chemokine is encoded by multiple genes. (lookformedical.com)
- [8] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. (wikidoc.org)
Receptors14
- A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
- A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
- A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
- CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
- CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
- Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
- Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
- A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
- CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
- After activating G protein through chemokine receptors, phospholipase C (PLC) is activated immediately. (creative-proteomics.com)
- This pathway highlights the different classes of chemokines, their receptors, and how chemokine signaling activates JAK/Stat, Ras, ERK, and Akt pathways.Chemokines are classified into four groups based on the pattern of their cysteine residues, namely CXC (α chemokines), CC (β chemokines), CX3C and C. Their receptors are class A GPCRs, however not all receptors are selective for a single ligand. (creative-proteomics.com)
- A chemokine may therefore bind a number of receptors and exhibit agonist behavior with some and antagonist behavior with others. (creative-proteomics.com)
- The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (creative-proteomics.com)
- In previous studies, expression levels of several chemokine and chemokine receptors have been examined in patients with BD. (psychiatryinvestigation.org)
Chemotaxis2
- Chemokines also use this mechanism to induce targeted chemotaxis in response cells. (creative-proteomics.com)
- Despite their well-known involvement in neuroimmunologic processes, the pathogenic significance of chemokines, which are small signaling proteins with the ability to induce chemotaxis, has been relatively understudied in BD as compared with other immune system components. (psychiatryinvestigation.org)
Protein1
- For example, CCL1 transcription was increased in primary human CD4+ T cells expressing T cell immunoglobulin and protein 3 containing the mucin domain (TIM-3) and was identified as a differentially transcribed gene in CD4+ cells T cells expressing TIM-3 that play a role in the regulation anti-tumor immunity. (wikipedia.org)
Cytokines2
- Chemokines are a class of cytokines with small molecular weights, whose main role is to recruit white blood cell subpopulations under steady-state and pathological conditions. (creative-proteomics.com)
- Here, we report that plasma exosomes of COVID-19 patients contain SARS-CoV-2 double stranded RNA (dsRNA) and stimulate robust production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and other inflammatory cytokines and chemokines by human peripheral mononuclear cells. (wphobby.com)
INFLAMMATION2
- Chemokines main function is to attract immune system cells at sites of inflammation. (creative-proteomics.com)
- This chemokine plays a role in accumulation of leukocytes during inflammation. (creativebiomart.net)
CCL171
- In this study, we have characterized the T H 2-like chemokine profile (CCL17, CCL18, CCL20, CCL22) in patients with RRP and asked whether it was modulated in patients who had achieved significant clinical improvement. (biomedcentral.com)
Thymic1
- Furthermore, CCL1 inhibits apoptosis in thymic cell lines by the RAS/MAPK pathway but can prevent dexamethasone-induced apoptosis in cultured murine thymic lymphoma cells. (wikipedia.org)
Pathogenesis1
- Due to these facts, the dysregulation of CCL1 can leads in pathogenesis of several diseases. (wikipedia.org)
Proteins1
- The MIP‑1 proteins are members of the beta (C-C) subfamily of chemokines. (rndsystems.com)
Potent2
- Thus, CCl1 has also been studied as a possible potent inhibitor of fusion of cells and cells mediated by HIV-1 envelope and viral infection. (wikipedia.org)
- To suppress the apoptotic activity of CCL1, removing three amino acids from the C-terminus of CCL1 reduces CCR8 binding but converts CCL1 to a more potent CCR8 agonist, leading to increased intracellular calcium release and increased antiapoptotic activity. (wikipedia.org)
Signaling pathway2
- Based on Luminex technology platform, Creative Proteomics provides analysis services for key targets of Chemokine signaling pathway. (creative-proteomics.com)
- We provide Luminex technology for Chemokine signaling pathway analysis. (creative-proteomics.com)
CCR81
- CCL1 is also overexpressed in ATL cells and mediates an autocrine antiapoptotic loop along CCR8 for in vivo growth and survival of leukemic cells. (wikipedia.org)
Platelet1
- This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules. (wikidoc.org)
Leukocyte1
- CCL1 is involved in inflammatory processes through leukocyte recruitment and could play a crucial role in angiogenesis and other viral and tumoral processes. (wikipedia.org)
Cells2
- In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (creative-proteomics.com)
- Chemokine signaling pathways are widely used to regulate the excessive biological processes of hematopoietic cells, leading to cell activation, differentiation and survival, and providing directional clues for cell transportation, which are essential for protective host responses. (creative-proteomics.com)
Inflammatory1
- Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
Gene1
- Some single nucleotide polymorphisms (SNPs) in the CCL1 gene are associated with exacerbations of chronic obstructive pulmonary disease (COPD). (wikipedia.org)
Mobilization1
- Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. (creative-proteomics.com)
Plays a role1
- CCL1 plays a role in various CNS functions and could be associated with some neuroinflammatory disorders. (wikipedia.org)
Small2
- CCL1 is a small glycoprotein that belongs to the CC chemokine family. (wikipedia.org)
- CCL1 is a small glycoprotein with a molecular weight of approximately 15-16 kDa. (wikipedia.org)