• 15. Dai C, Liu Z, Zhou H, Li L. Monocyte chemoattractant protein-1 expression in renal tissue is associated with monocyte recruitment and tubulo-interstitial lesions in patients with lupus nephritis. (ac.ir)
  • Most neutrophil chemoattractant receptors are expressed also by mononuclear phagocytes, the free fatty acid receptor 2 (FFAR2) being an exception. (chalmers.se)
  • The recent construction of G beta null mutants (g beta-) in Dictyostelium provides a unique opportunity to study the role of beta gamma dimers in signaling processes mediated by chemoattractant receptors. (rupress.org)
  • These results show that in vivo G beta links chemoattractant receptors to effectors and is therefore essential in many chemoattractant-mediated processes. (rupress.org)
  • Gene transcription through activation of G-protein-coupled chemoattractant receptors. (elsevierpure.com)
  • Receptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte functions such as chemotaxis, degranulation, and the release of superoxide anions. (elsevierpure.com)
  • Chemoattractants stimulate the expression of several inflammatory cytokines and chemokines, which in turn may activate their respective receptors and initiate an autocrine regulatory mechanism for persistent cytokine and chemokine gene expression. (elsevierpure.com)
  • Dive into the research topics of 'Gene transcription through activation of G-protein-coupled chemoattractant receptors. (elsevierpure.com)
  • Both dimethyl sulfoxide and dibutyryl cAMP induced expression of receptors for the N-formylated oligopeptide chemoattractants in U937 cells. (duke.edu)
  • Treatment of U937 cells with dibutyryl cAMP resulted in the most reproducible and rapid increase in the number of chemoattractant receptors as well as in chemotactic responsiveness. (duke.edu)
  • The receptors on dibutyryl cAMP-treated cells and on dimethyl sulfoxide-treated cells initiated chemotaxis and lysosomal enzyme secretion in response to chemoattractants, but not the formation of superoxide anion. (duke.edu)
  • Previous studies demonstrated that oligopeptide chemoattractant receptors on PMN and macrophages exist in high and low affinity states which are interconvertible by guanosine di- and triphosphates. (psu.edu)
  • For example, the Slit protein that mediates axonal chemorepulsion has also been shown to inhibit the directed migration of leukocytes in response to chemoattractants. (wikipedia.org)
  • This report reviews the emerging literature describing a novel class of proteolytic targets, leukocyte chemoattractants, and, in particular, chemerin, a dendritic cell and macrophage chemoattractant activated by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (nih.gov)
  • Thus, chemoattractant mRNA expression correlated with the development of renal failure in Cy/Cy and Cy/+ rats. (fujita-hu.ac.jp)
  • The biphasic nature of the light-scattering responses to chemoattractants, moreover, correlates with the dual regulation of the chemotactic and secretory responses of leukocytes. (jci.org)
  • We investigated the production of the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1) using sera, synovial fluid, synovial tissue, as well as macrophages and fibroblasts isolated from synovial tissues from 80 arthritic patients. (northwestern.edu)
  • Chemokines of the alpha, beta-subclass inhibit human basophils' responsiveness to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. (musc.edu)
  • The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. (rupress.org)
  • Scholars@Duke publication: Induction of selective biological responses to chemoattractants in a human monocyte-like cell line. (duke.edu)
  • Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. (ac.ir)
  • In contrast to interleukin-8 and interleukin-6, the monocyte chemoattractant protein-1 was capable of inducing steatosis in hepatocytes in a time-dependent manner at concentrations similar to those found in conditioned medium. (unige.ch)
  • Incubation of conditioned medium with antimonocyte chemoattractant protein-1 antibodies prevented triglyceride accumulation. (unige.ch)
  • CONCLUSION: The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes. (unige.ch)
  • Relation between serum monocyte chemoattractant protein-1 and coronary collateral development. (gazi.edu.tr)
  • In animal studies monocyte chemoattractant protein-1 (MCP-1) has been found to be related to collateral vessel development. (gazi.edu.tr)
  • Monocyte chemoattractant protein-1 is critical for monocyte recruitment to the lungs in response to bacterial infection. (lsu.edu)
  • Leissinger, Mary Katherine, "The role of monocyte chemoattractant protein-1 in innate immunity against methicillin resistant Staphylococcus aureus pneumonia" (2014). (lsu.edu)
  • To examine the mechanisms for increased monocyte/macrophage recruitment in IPF and nonIPF interstitial lung diseases (nonIPF) the localization of monocyte chemoattractant protein-1 (MCP-1) was investigated in 14 cases of IPF, seven cases of nonIPF, and seven normal control lungs (CTRL) by immunohistochemistry using a specific anti-MCP-1 monoclonal antibody, F9. (elsevierpure.com)
  • Monocyte chemoattractant protein-1 production by epithelial cells in IPF may be caused by the metaplastic nature of the epithelial cells and may be one of the key factors inducing the irreversible progression of IPF. (elsevierpure.com)
  • Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). (erdogan.edu.tr)
  • Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus. (ac.ir)
  • Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas (lpr) mice. (ac.ir)
  • Expression of monocyte chemoattractant protein-1 and lupus nephritis. (ac.ir)
  • Glomerular expression of monocyte chemoattractant protein-1is predictive of poor renal prognosis in paediatric lupus nephritis. (ac.ir)
  • Monocyte chemoattractant protein-1 (MCP-1/CCL2) is reported to contribute to tumor progression and is regulated by the renin-angiotensin system in hypertensive disease. (elsevierpure.com)
  • Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 ( MCP-1 ) gene and the risk of tuberculosis (TB). (geneticsmr.com)
  • To examine the relationship between proinflammatory chemoattractants and the development of interstitial inflammation and ultimately renal failure in ADPKD, we evaluated monocyte chemoattractant protein-1 (MCP-1) and osteopontin mRNAs and proteins in kidneys from Han:SRPD rats. (fujita-hu.ac.jp)
  • Jeon, SM , Lee, KM & Cho, HJ 2009, ' Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain ', Brain research , vol. 1251, pp. 103-111. (johnshopkins.edu)
  • This conclusion is based on the findings that inactivation of an N protein of 41,000 m.w. by Bordetella pertussis toxin (PT) treatment abolishes monocyte responsiveness to chemoattractants but not to lectins, PMA, or the Ca 2+ ionophore A23187. (psu.edu)
  • Therefore, a PT-sensitive N protein plays an important role in the activation of monocytes by chemoattractants. (psu.edu)
  • We found that physiological and pharmacological levels of E2 (10(-12) M-10(-6) M) have no effect on the release of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), or monocyte chemoattractant protein-1 (MCP-1). (cdc.gov)
  • Specific binding proteins for the chemoattractants were identified by covalent affinity labeling on the differentiated U937 cells as well as on normal human monocytes. (duke.edu)
  • 3 kDa) soluble chemoattractants released by growing P. gingivalis, and show that these are selective for neutrophils. (chalmers.se)
  • As chemoattractants are critical for both systemic leukocyte positioning by triggering integrin activation and subsequent recruitment from circulation, and local intratissue leukocyte positioning via chemotaxis, modulation of attractant activities by proteases may have profound effects on the immune response. (nih.gov)
  • Balatskaya N.V., Filatova I.A., Kulikova I.G., Denisyuk V.O. Features of the systemic production of pro-inflammatory and chemoattractant mediators in patients with persisting chronic post-traumatic uveitis. (hnj.science)
  • The typical GTP-regulated high affinity chemoattractant-binding sites are lost in g beta- cells and membranes. (rupress.org)
  • It should be noted that we detected the pro-inflammatory cytokines IL-18, IL-8, and inducible chemoattractant GRO-α, which were absent in the control group blood samples, in almost one third of patients with chronic post-traumatic uveitis. (hnj.science)
  • Increased expression of chemoattractants was associated with the accumulation of ED-1 positive cells (macrophages) in the interstitium of cystic kidneys. (fujita-hu.ac.jp)
  • The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration. (umassmed.edu)
  • The fact that neutrophils are the dominating cell type in the gingival pocket suggests that neutrophil-specific chemoattractants are released by subgingival bacteria, but characterization of chemoattractants released by subgingival biofilm species remains incomplete. (chalmers.se)
  • Neutrophil migration from blood to tissue-residing microbes is governed by a series of chemoattractant gradients of both endogenous and microbial origin. (chalmers.se)
  • Initiation of the slow (40 +/- 5 s) peak required 10-fold higher amounts of chemoattractants, and the dose-response curve correlated with the induction of lysosomal enzyme secretion and superoxide anion production. (jci.org)
  • Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants. (jci.org)
  • The addition of chemoattractants to polymorphonuclear leukocyte suspensions evoked a single wave of increased light transmission, whereas the perpendicular scattering measurement demonstrated a previously unrecognized biphasic response. (jci.org)
  • The g beta- cells do not display chemoattractant-stimulated adenylyl cyclase or guanylyl cyclase activity. (rupress.org)
  • Transcription factors, such as NF kappa B and AP-1, are activated upon stimulation of the cells with several chemoattractants at physiologically relevant concentrations. (elsevierpure.com)
  • Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review. (ox.ac.uk)
  • Cells exposed to conditioned medium responded chemotactically, secreted lysosomal enzymes, and formed superoxide anion when incubated with the chemoattractant. (duke.edu)
  • Bioassay-guided fractionation was employed to isolate the chemoattractant, yielding a single pure, fully active compound after reversed-phase and size-exclusion high-performance liquid chromatography. (biologists.com)
  • The rapid perpendicular light-scattering response of polymorphonuclear leukocytes to chemoattractants appears to record an initial event in the stimulus-response coupling, and its measurement should provide a useful new tool for the study of leukocyte function. (jci.org)
  • The dose-response curve of chemoattractants for inducing the rapid (10 +/- 1 s) perpendicular scattering peak corresponded to that which initiated chemotaxis. (jci.org)