Loading...
  • steric
  • Pascal begins with the assumption that terminal aryl substitution on the enediyne will both (a) inhibit the C 1 -C 6 cyclization due to steric interactions and (b) the C 1 -C 5 cyclization should be enhanced due to stabilization of the radical by the neighboring aryl group. (comporgchem.com)
  • reductive
  • Here, the authors show a folding cascade strategy to convert linear substrates into polycyclic compounds with multiple stereocentres by combining the reductive chemistry of SmI 2 with 1,5-hydrogen atom transfer. (nature.com)
  • peptide
  • The cyclic peptide libraries screened with these methods are generated by altering in a combinatorial fashion the amino acid sequence of the peptides, the number of amino acids in the macrocycle rings, and the cyclization chemistry. (epfl.ch)
  • Then, we examine peptide cyclization with perfluoroaryl-cysteine SNAr chemistry to improve the stability and delivery of peptide-ASO conjugates. (mit.edu)
  • Consequently, we demonstrate that peptide cyclization with perfluoroaryl-cysteine SNAr chemistry enhances the ability of peptides to cross the BBB. (mit.edu)
  • In celebration of this decade of excellence, we sat down together with one of the microwave pioneers, Professor Adolf Gogoll at Uppsala University, for a chat on microwaves, peptide chemistry and exploding glass vials. (biotage.com)
  • polymerization
  • Here, the authors report membraneless compartments can enhance RNA chemistries, affecting template directed RNA polymerization and stimulating nucleic acid enzymes. (nature.com)
  • Biochemistry
  • After postdoctoral research on RNA biochemistry with Thomas Cech at the University of Colorado at Boulder, he joined the University of Illinois in 2000, where he is currently Professor of Chemistry. (rsc.org)
  • Despite
  • Despite the diverse chemistry, we demonstrate that the proteins are evolutionarily related and that only a limited set of amino acid changes in the active sites are responsible for the switch in chemistry. (pnas.org)
  • Despite more energetically favorable cyclization barriers for the b 5 structures, the b 4 ions experimental data show more clear evidence of cyclization and sequence scrambling before fragmentation. (springer.com)
  • medicinal chemistry
  • Julia Eckhoff handles manuscripts on chemical biology and medicinal chemistry. (nature.com)
  • To receive news and publication updates for International Journal of Medicinal Chemistry, enter your email address in the box below. (hindawi.com)
  • The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an active area of intensive investigation in medicinal chemistry. (hindawi.com)
  • sequence
  • There is compelling experimental and theoretical evidence for formation of nondirect sequence ions via cyclization/reopening chemistry in the CID spectra of the b tons when the His residue is near the C-terminus. (springer.com)
  • aliphatic
  • This indicates less active cyclization/reopening followed by fragmentation of common structures for b n ions containing His than for sequences of solely aliphatic residues. (springer.com)
  • Innovation in Chemistry
  • From 2005-12, MP Led the EPSRC/HEFCE Science & Innovation project DICE, Driving Innovation in Chemistry & Engineering, which is promoting research collaboration between chemists and chemical engineers at Nottingham and beyond, www.nottingham.ac.uk/dice . (nottingham.ac.uk)
  • 1991
  • He received his BS in chemistry from UCLA in 1991, working with Christopher Foote on photooxygenation mechanisms. (rsc.org)
  • ligands
  • Alkynoic acids derived from salicylic acid and analogues undergo arylative cyclization with arenediazonium salts promoted by gold in the absence of external ligands. (rsc.org)
  • molecular structure
  • The marine polycyclic ether toxins, associated with the massive fish kills and human food poisoning from red tides and dinoflagellates have attracted much attention in the chemistry community for their intriguing molecular structure and biological activity. (nii.ac.jp)