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Compounds2022EvaluationTotal synthesisCharacterizationReactivityAntimicrobialSpectroscopicGreen chemistryPyrroleHalidesMolecularInorganicAcidsMedicinal Chemistry LettersLigandsReactionsSchiffPropertiesActivityMoleculesDepartmentPotentQuercetinReactionJournalAcidSyntheticChemicalStudiesEnzymeBioorganicStructuresMechanismThesisUnusualBiomedicalCyclization
Compounds9
  • Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells. (amrita.edu)
  • A convenient and new method for the synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives starting from 1,3,-dicarbonyl compounds through acid catalyzed cyclization reaction is described. (metu.edu.tr)
  • This paper examines the synthesis of \gamma-butyrolactone compounds 2, 3, 4, 5, and 9, and their potential antimicrobial nature and ability. (tubitak.gov.tr)
  • This thesis covers two broad areas of work under the general theme of the synthesis of bioactive and/or synthetically useful compounds based on natural products or deriving from the chiral pool. (vuw.ac.nz)
  • The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry . (wikipedia.org)
  • Berzelius also contended that compounds could be distinguished by whether they required any organisms in their synthesis (organic compounds) or whether they did not ( inorganic compounds ). (wikipedia.org)
  • The percentage cell viability following exposure to Quercetin and its derivatives (Compounds 1-5 ) were measured. (thescipub.com)
  • The designed compounds were further subjected for synthesis and biological evaluation. (duke.edu)
  • This category presents the methods for the synthesis of organic compounds organized according to the functional group or groups prepared in the product. (thieme.de)
20222
Evaluation9
  • Crich, D. Synthesis and Evaluation of 1,5-Dithia-D-laminaribiose, Triose and Tetraose as Truncated β-(1→3)-Glucan Mimetics. (uga.edu)
  • Crich, D. Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics. (uga.edu)
  • Crich, D. Synthesis and evaluation of 1,5-dithialaminaribiose and -triose tetravalent constructs. (uga.edu)
  • Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
  • Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Cocaine Addiction. (acs.org)
  • Synthesis and biological evaluation of Glycosylphosphatidylinositols from Trypanasoma brucei. (mpg.de)
  • 2014. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies . (ub.edu)
  • 2005. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease . (ub.edu)
  • In vitro evaluation of some derivatives of the carcinogen butter yellow: Implications for environmental screening. (cdc.gov)
Total synthesis3
  • In this review, the progress of cytisine and its derivatives in regard to bioactivities, total synthesis, structural modifications focusing on their N-12 position and lactam ring is reported. (nih.gov)
  • total synthesis. (nih.gov)
  • A synthetic program with the aim of devising a total synthesis was initiated at Victoria University of Wellington after peloruside A's discovery in 1999. (vuw.ac.nz)
Characterization2
  • 3. Rather, MY, Ara KZG, Nordberg Karlsson E, Adlercreutz P. ( 2015 ) Characterization of cyclodextrin glycosyltransferases (CGTases) and their application for synthesis of alkyl glycosides with oligomeric head group. (lu.se)
  • 8. von Schantz L, Schagerlöf H, Nordberg-Karlsson E, Ohlin M. ( 2014 ) Characterization of the substitution pattern of cellulose derivatives using carbohydrate-binding modules. (lu.se)
Reactivity3
  • Insertion of carbon fragments into P(III)-N bonds in aminophosphines and aminobis(phosphines): synthesis, reactivity, and coordination chemistry of resulting phosphine oxide derivatives. (unboundmedicine.com)
  • Materials chemistry seeks to understand how composition, reactivity, and structure are related to function from a molecular perspective. (mcgill.ca)
  • OBJECTIVES: This study was aimed at evaluating the use of whole cells of Escherichia coli carrying recombinant Pseudomonas fluorescens benzaldehyde lyase as biocatalysts for 5-HMF carboligation, recovery of the C 12 derivatives DHMF and BHMF, and testing the reactivity of the carbonyl groups for hydrazone formation for potential use as cross-linking agents in surface coatings. (lu.se)
Antimicrobial4
  • In search of effective antimicrobial and cytotoxic agents, a series of indole hybridized diazenyl derivatives ( DS-1 to DS-21 ) was efficiently prepared by condensation of diazotized p -aminoacetophenone with indole or nitroindole followed by reaction with different aromatic/heteroaromatic amines of biological significance. (biomedcentral.com)
  • The active antimicrobial derivatives were further evaluated for cytotoxicity against human lung carcinoma cell line (HCT-116), breast cancer cell line (MDAMB231), leukemic cancer cell line (K562), and normal cell line (HEK293) by MTT assay using doxorubicin as the standard drug. (biomedcentral.com)
  • The derivatives DS-14 and DS-20 have shown potential against Gram-negative bacteria and breast cancer cell line and can be used as a lead for rational drug designing of the antimicrobial and cytotoxic agents. (biomedcentral.com)
  • The Synthesis and Antimicrobial Activity of \\\\gamma-Butyrolactone De" by SLOBODAN SUKDOLAK, SLAVICA SOLUJIC-SUKDOLAK et al. (tubitak.gov.tr)
Spectroscopic1
  • The synthesized derivatives were characterized by various spectroscopic techniques. (biomedcentral.com)
Green chemistry1
  • The new process meets the essential requirements of green chemistry by diminishing waste products and eliminating organic solvents, while maximizing the use of the involved reagents. (agri.gov.il)
Pyrrole1
  • Porphobilinogen (PBG) is a pyrrole derivative and an essential component of the heme synthesis pathway. (medscape.com)
Halides1
  • Allylic halides [ 5 ] reacted with Fe 3 (CO) 12 in benzene to give a mixture of three products including 1,5-hexadiene derivatives [ 7 ]. (go.jp)
Molecular2
  • The test derivatives were additionally docked for the B-subunit of enzyme DNA gyrase from E. coli at the ATPase binding site to study the molecular interactions using Schrodinger maestro v11.5 software. (biomedcentral.com)
  • 1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)
Inorganic3
  • Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. (nottingham.ac.uk)
  • Inorganic Chemistry , 42 (4), 1272-81. (unboundmedicine.com)
  • Reaxys is a system for searching the world's most extensive collection of organic, organo-metallic, and inorganic chemistry data, includes toxicology data. (lu.se)
Acids2
  • More precisely, it is a derivative of 2-aryl propanoic acids, which is an important class of nonsteroidal anti-inflammatory drugs including flurbiprofen, ibuprofen, naproxen and fenoprofen. (biomedcentral.com)
  • Synthesis of α-(Trifluoromethyl)styrenes and 1,3-Di(trifluoromethyl)indanes via Electrophilic Activation of TMS Ethers of (Trifluoromethyl)benzyl Alcohols in Brønsted Acids. (acs.org)
Medicinal Chemistry Letters1
  • Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer ACS Medicinal Chemistry Letters. (nottingham.ac.uk)
Ligands1
  • The phosphine oxide derivatives act as bidentate ligands and form chelate complexes with Co(II), Mo(VI), Th(IV), and U(VI) derivatives. (unboundmedicine.com)
Reactions4
  • The Corey-Winter olefin synthesis (also known as Corey-Winter-Eastwood olefination) is a series of chemical reactions for converting 1,2-diols into olefins. (wikipedia.org)
  • Reactions of N-aryl and N-alicyclic derivatives of aminophosphines with paraformaldehyde lead to methylene insertion into P-N bond followed by oxidation of phosphorus from the P(III) to P(V) state. (unboundmedicine.com)
  • The research interests of the members of the Chemical Physics Thematic Research Group are diverse, with groups focusing on high-end laser and NMR spectroscopies, kinetics and modelling of atmospheric chemical reactions, experimental and theoretical biophysical chemistry, polymers at interfaces, and statistical and quantum mechanics. (mcgill.ca)
  • SciFinder-N provides access to the world's most comprehensive and authoritative source of references, substances and reactions in chemistry, chemical engineering, food, biomedicine and related sciences. (lu.se)
Schiff1
  • A series of modified polysaccharide polymers were prepared via a solvent-free synthesis involving heterogeneous Schiff base reaction of carboxymethyl chitosan (CMCS) with diverse aldehydes: hexanal, citral, benzaldehyde, 4-methoxybenzaldehyde, 4-chlorobenzaldehyde, and trans-cinnamaldehyde. (agri.gov.il)
Properties8
  • Witczak, Z. J. Synthesis and Biological Properties of Monothiosaccharides. (uga.edu)
  • The prepared CMCS derivatives were extensively studied in terms of their physicochemical, mechanical and morphologic properties. (agri.gov.il)
  • The properties of products prepared by the new method and traditional solvent-based synthesis were compared. (agri.gov.il)
  • We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)
  • Synthesis and properties of some heterocyclic derivatives of naphthalene - 1,8 - dicarboxylic acid. (bl.uk)
  • The synthesis and basic properties of 2-ethylhexanol based innovative nonionic surfactants are described in this paper. (springer.com)
  • The synthesis and properties of a series of unsymmetrical thienopentalenes are explored, including both monoareno and diareno derivatives. (researchgate.net)
  • The photophysical properties of various 1,8-naphthalimide derivatives are also discussed. (tcd.ie)
Activity6
  • Additionally, the structure-activity relationships of cytisine and its derivatives are also discussed. (nih.gov)
  • Most of the synthesized derivatives have shown high activity against Gram-negative bacteria particularly E. coli and K. pneumonia with MIC ranging from 1.95 to 7.81 μg/ml. (biomedcentral.com)
  • The derivatives have demonstrated very less activity against tested Gram positive bacterial and fungal strains. (biomedcentral.com)
  • The recent advances in QSAR and computer science have provided a systematic approach to design a structure of any compound and further, the biological activity of the compound can be predicted before synthesis. (duke.edu)
  • The DPPH assay has showed the powerful antioxidant activity of nitro and bromo derivatives, while the nitro derivative showed the significant reduction potential towards FRAP assay. (bvsalud.org)
  • however, the chloro-derivative exhibited the more potent hypoglycaemic activity showing about 43% reduction in the mean blood glucose levels of the treated animals . (bvsalud.org)
Molecules1
  • The synthesis of the designed molecules started from easily accessible and versatile gem -difluoro propargylic derivatives. (biomedcentral.com)
Department1
  • The chemistry department offers a vibrant undergraduate research experience. (sru.edu)
Potent1
Quercetin1
  • This study involves the synthesis of new Quercetin derivatives and the investigation their effects against MDA-MB231 cell lines. (thescipub.com)
Reaction3
  • A new and general strategy for highly functional furo[3,4- c ]coumarins and related furyl coumarin derivatives has been developed, which is based on an extraordinarily facile intramolecular Wittig reaction , starting from α , β -unsaturated ketones , tributylphosphine , and acyl chlorides . (rsc.org)
  • For the synthesis of monoareno pentalenes, a carbopalladation cascade reaction between alkynes and gem-dibromoolefins was applied. (researchgate.net)
  • However, the reaction of [ 1 ] with the Fe 3 (CO) 12 -pyridine N -oxide (PyNO) reagent system selectively afforded 1,2-diphenylethane derivatives [ 2 ]. (go.jp)
Journal8
Acid4
  • First, two phenylpropionic acid derivatives A1 (as a non-fluorinated reference) and the corresponding gem -difluoro derivative A2 were proposed as analogues of fenoprofen and ketoprofen. (biomedcentral.com)
  • On the other hand, three other derivatives A3 , A4 , and A5 were designed as simplified benzoic acid-type derivatives, with three different substituents in meta position on the second aromatic ring (Scheme 1 ). (biomedcentral.com)
  • Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. (nottingham.ac.uk)
  • The Chemical Biology Thematic Research Group is engaged in a diverse range of research topics, which span structural biology, enzymology, nucleic acid research, signalling pathways, single-molecule biophysics, and biophysical chemistry of living tissues. (mcgill.ca)
Synthetic1
  • GRAPHIC] Two independent synthetic routes, starting from 1,3-cyclohexadione, toward the 4-hydroxy bicyclo[2.2.2]octane-2,6-dione derivative 3 are described. (lu.se)
Chemical3
  • We offer two emphases within the American Chemical Society, one of the largest scientific societies in the country: ACS Chemistry and ACS Environmental Chemistry. (uwgb.edu)
  • In the area of atmospheric chemistry, the chemical transformation of the atmosphere is being modelled both experimentally and theoretically to understand how these processes are currently affecting and driving climate change. (mcgill.ca)
  • In chemistry , many authors consider an organic compound to be any chemical compound that contains carbon-hydrogen or carbon-carbon bonds , however, some authors consider an organic compound to be any chemical compound that contains carbon. (wikipedia.org)
Studies1
  • The 3D-QSAR studies for the set of 4-hydroxy-N'-(1,3-thiazoldin- 2-yldene)benzohydrazide and their derivatives were carried out by using V-life MDS (3.50). (duke.edu)
Enzyme2
  • In the field of biophysical chemistry, single molecule spectroscopy is being used to probe enzyme function as well as DNA recombination and repair. (mcgill.ca)
  • However, in patients with inherited deficiencies in the enzyme porphobilinogen deaminase, provoking factors such as alcohol use, hormonal effects, or medications drive heme synthesis and overwhelm the limited enzyme capacity. (medscape.com)
Bioorganic2
  • Thioglycosides and thiasugars both have a long history in bioorganic and medicinal chemistry 1-7 but it is widely considered that they are less "active" than the parent sugars. (uga.edu)
  • Bioorganic & Medicinal Chemistry 01. (uit.no)
Structures1
  • Varela, O. Non-Conventional Glycosidic Linkages: Syntheses and Structures of Thiooligosaccharides and Carbohydrates with Three-Bond Glycosidic Connections. (uga.edu)
Mechanism1
  • These unusual isocournarin derivatives were characterized and their mechanism of formation is discussed. (metu.edu.tr)
Thesis1
  • In this thesis, the synthesis of the C-3 to C-7 fragment is described. (vuw.ac.nz)
Unusual1
  • The synthesis of unusual isocoumarin der. (metu.edu.tr)
Biomedical1
  • Our collective research has direct implications in fields such as materials, environmental, and biomedical chemistry. (mcgill.ca)
Cyclization1