SynthesisGlycosidesToxicologySaponinsMitragynineEuropean Journal of PharmacologyBiologyIndole AlkaloidsIsoquinoline AlkaloidsKratom alkaloidsPharmacologicalAbstractDepartment of ChemisBiosynthesisSecondary metabolitesIsolationVincaBiosynthetic pathwaysPharmacologically activeConstituentsAntimicrobialAnaloguesExtractBioorganicMedicinalComputational ChemistryAnticancerBiochemistryOpioid1975PlantInorganic ChemistryPharmacyNaturallyStructuralNicotinicDrugsPhysical ChemistryClassificationVitro1987MoleculesFoundPROFESSOR
Synthesis6
- 1 Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, China. (nih.gov)
- Synthesis of pyrrole and carbazole alkaloids. (novapublishers.com)
- H. J (ed) Alkaloid synthesis. (novapublishers.com)
- Medicinal Chemistry: Structure, nomenclature, classification, synthesis, SAR and metabolism of the following category of drugs, which are official in Indian Pharmacopoeia and British Pharmacopoeia. (firstranker.com)
- Over 45 papers in the fields of heterocyclic chemistry, multicomponent reactions and natural product synthesis. (combichem.net)
- Vinca alkaloids act on the G and S phases of mitosis, inhibiting microtubule formation and inhibiting DNA/RNA synthesis. (medscape.com)
Glycosides1
- Phytochemical and biological investigations were undertaken on ethanolic extracts of the leaves and root bark of Justica adhatoda L. Alkaloids, cardiac glycosides, tannins, steroids and saponins were detected in extracts from both parts of the title plant. (arjournals.org)
Toxicology2
- Pyrrolizidine alkaloids: Chemistry, pharmacology, toxicology and food safety. (hsilgroup.com)
- Pharmacology: General pharmacological principles including Toxicology. (firstranker.com)
Saponins1
- The phytochemical screening detected the presence of saponins, alkaloids, reducing sugars and coumarins. (researchgate.net)
Mitragynine14
- Mitragynine kratom alkaloid is a compound found in the leaves of the Mitrgyna speciosa tree. (guidancepa.com)
- Recently, Mitragynine kratom alkaloid is gaining popularity as an effective psychoactive herbal product. (guidancepa.com)
- Mitragynine kratom alkaloid is used as a reference point for measuring the potency of different kratom strains . (guidancepa.com)
- Mitragynine is typically the predominant alkaloid in kratom. (guidancepa.com)
- Mitragynine kratom alkaloid has been the subject of research exploring its potential benefits in various areas. (guidancepa.com)
- Mitragynine alkaloid has attracted attention mainly because of its potential as a pain reliever. (guidancepa.com)
- Mitragynine kratom alkaloid has been reported to lower blood pressure. (guidancepa.com)
- Mitragynine alkaloids regulate blood sugar levels and improve glucose metabolism. (guidancepa.com)
- Mitragynine is a natural alkaloid that interacts with receptors in the brain. (guidancepa.com)
- Mitragynine kratom alkaloid is consumed as a syrup pill. (guidancepa.com)
- Mitragynine is a corynanthe-type indole alkaloid representing the major psychoactive constituent of Mitragyna speciosa (also known as ?kratom? (grantome.com)
- Despite the initial intent by the DEA to place two alkaloids of this plant, mitragynine and 7-hydroxymitragynine (7OH), into Schedule I of the Control Substance Act, the DEA eventually withdrew this action following dramatic opposition from the public. (grantome.com)
- The proposed research addresses an urgent need for a systematic examination of mitragynine alkaloids and builds on extensive preliminary results generated by the PIs. (grantome.com)
- We propose to systematically investigate two key kratom alkaloids, mitragynine and 7-hydroxymitragynine, in terms of synthetic methods, chemical biology, and pharmacology in vitro and in mice. (grantome.com)
European Journal of Pharmacology1
- European Journal of Pharmacology. (unibo.it)
Biology5
- The Chemistry and Biology of Isoquinoline Alkaloids. (wikipedia.org)
- Buxus steroidal alkaloids: chemistry and biology. (novapublishers.com)
- Chemistry and Biology. (simplelists.com)
- As the esteemed, leading reference in the field of alkaloid chemistry, this series covers all aspects of alkaloids, including their chemistry, biology and pharmacology. (elsevier.com)
- This database will also serve researchers working in the field of synthetic biology, as developing medicinally important alkaloids using synthetic process are one of important challenges. (biomedcentral.com)
Indole Alkaloids2
- Ten indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. (nih.gov)
- Indole Alkaloids,) "Heterocyclic Chemistry. (combichem.net)
Isoquinoline Alkaloids1
- β-Phenylethylamines and the isoquinoline alkaloids. (novapublishers.com)
Kratom alkaloids2
- It's like the very first step of any kind of discovery effort, which is basically going backward from the point we've reached already with kratom alkaloids, which is now up to animal studies," said Kruegel. (healthline.com)
- Really there's nothing out there approved that's substantially similar to the kratom alkaloids," added Kruegel. (healthline.com)
Pharmacological3
- Recent trends in pharmacological activity of alkaloids in animal colitis: potential use for inflammatory bowel disease. (novapublishers.com)
- Pharmacological activity of alkaloids: a review. (novapublishers.com)
- Overall, these anti-viral effects of alkaloids point to a high degree of specificity, implying that they could serve as effective and safe antiviral medicines if further pursued in medicinal and pharmacological investigations. (edu.sa)
Abstract1
- abstract = "Alkaloids are a diverse group of natural phytochemicals. (edu.sa)
Department of Chemis4
- What they are effectively doing is using computer modeling, which is a very preliminary method in drug discovery," Andrew Kruegel, PhD, an associate research scientist in the department of chemistry at Columbia University in New York, told Healthline. (healthline.com)
- Muhammad Shahid Department of Chemistry and Biochemistry, University of Agriculture Faisalabad, Pakistan. (arjournals.org)
- 4 Department of Chemistry, Federal University of Piauí, Brazil. (researchgate.net)
- After returning to Poland, Andrzej started his research on the structure-activity relationships of opioid peptides at the Department of Chemistry of Warsaw University. (inrcworld.org)
Biosynthesis1
- Erysodienone is a key precursor in the biosynthesis of many Erythrina-produced alkaloids. (wikipedia.org)
Secondary metabolites1
- Alkaloids are naturally occurring secondary metabolites, low molecular weight, and nitrogen containing compounds that are found in more than 20% of plant species [ 1 ]. (biomedcentral.com)
Isolation1
- There are various extraction and isolation methods, available to obtain alkaloids in a smooth manner, where some are common and some are specific. (novapublishers.com)
Vinca2
- Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
- A vinca alkaloid with a cytotoxic effect (as a result of causing mitotic arrest), vinblastine binds to a specific site on tubulin, prevents polymerization of tubulin dimers, and inhibits microtubule formation. (medscape.com)
Biosynthetic pathways2
- Early work was done by Derek Barton and co-workers to illustrate the biosynthetic pathways towards erythrina alkaloids. (wikipedia.org)
- Alkaloids can be classified on the basis of biological activities, chemical structure and biosynthetic pathways. (biomedcentral.com)
Pharmacologically active2
- In general, many alkaloids are pharmacologically active and possess various physiological activities in humans and animals. (novapublishers.com)
- Alkaloids belonging to this class are found to be pharmacologically active and show potential therapeutic properties. (biomedcentral.com)
Constituents1
- The active constituents of Sceletium tortuosum are alkaloids, including mesembrine, mesembrenone, mesembrenone and tortuosamine. (medicoherbs.com)
Antimicrobial1
- and Bhagwat AM. Antimicrobial activity of alkaloids extract from Adhatoda vasica. (arjournals.org)
Analogues1
- He started his career in Professor Stefania Drabarek s group in the Chemistry Department working on oxytocin analogues. (inrcworld.org)
Extract2
- Lemon juice is sometimes added to extract the alkaloids. (guidancepa.com)
- We extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. (biomedcentral.com)
Bioorganic1
- Nowadays, non-natural alkaloids are growing rapidly as a result of bioorganic and stereochemistry research. (biomedcentral.com)
Medicinal7
- Because of the medicinal use of alkaloids, proper identification is needed for safety purposes for which, a number of identification tests are available. (novapublishers.com)
- Numerous of these alkaloids have a variety of biological effects, and some have even been developed into medications with different medicinal properties. (edu.sa)
- related tetraamines bearing a 11-Acetyl-5,11-Dyhidro-6h-Pyrido[2,3-B] [1,4]-Benzodiazepin-6-One Moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines, Journal of Medicinal Chemistry, 37, 3363-3372, 1994. (unibo.it)
- Medicinal Chemistry) from UOW. (edu.au)
- This paper gives a brief historical overview of the role of natural products in the history and development of medicinal chemistry and experimental pharmacology, particularly with respect to the development of psychopharmacology and the discovery of CNS-active agents. (erowid.org)
- Tetrandrine (TET) is a bis-benzylisoquinoline alkaloid, which is identified as an active ingredient in Radix Stephanae tetrandrae (a Chinese medicinal herb). (biomedcentral.com)
- Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer ACS Medicinal Chemistry Letters. (nottingham.ac.uk)
Computational Chemistry1
- These goals will be accomplished by an interdisciplinary team with significant experience in synthetic and computational chemistry, opioid receptor signaling, and in vitro and in vivo pharmacology. (grantome.com)
Anticancer1
- Human serum albumin (HSA) binding of anticancer plant alkaloid ellipticine has been studied in conjunction with assessing its association to serum a1-acid-glycoprotein (AAG). (jascoinc.com)
Biochemistry1
- 2 Department of Biochemistry and Pharmacology, Federal University of Piauí, Brazil. (researchgate.net)
Opioid2
- Andrzej, from the beginning of his research in the opioid field, was committed to searching for new molecules, particularly peptides, that could be employed in the clinic as analgesics with fewer adverse effects and liabilities compared with traditional opioid alkaloids. (inrcworld.org)
- In order to better understand the problems associated with opioid pharmacology Andrzej joined for a few months, in 1983, Albert Herz s group at the Max Planck Institute for Psychiatry (Munich, Germany). (inrcworld.org)
19752
Plant2
- The plant contains the water soluble alkaloids, Hyoscyamine and Scopolamine. (shaman-australis.com)
- In 1971 military institute started exploring alkaloids in this plant and in 1972 work was started on discovering a new antimalarial drug. (howmed.net)
Inorganic Chemistry1
- Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. (nottingham.ac.uk)
Pharmacy1
- In African Journal of Pharmacy and Pharmacology (Vol. 5, Issue 10, pp. 1258-1262). (usim.edu.my)
Naturally2
- This review aims to provide a broad overview of the numerous naturally occurring alkaloids (isolated from both terrestrial and aquatic species) along with synthetically produced alkaloid compounds having prominent antiviral properties. (edu.sa)
- Many of them are naturally occurring alkaloids. (bvsalud.org)
Structural1
- Alkaloids as drug leads-a predictive structural and biodiversity based analysis. (novapublishers.com)
Nicotinic1
- Alkaloids such as trigocoumarin, nicotinic acid, trimethyl coumarin and trigonelline are present in stem. (brmi.online)
Drugs2
- These alkaloids repressed and targeted various important stages of viral infection at non-toxic doses while some of the alkaloids reported here also exhibited comparable inhibitory activities to commercially used drugs. (edu.sa)
- Pharmacology of drugs acting on Central nervous system, Cardiovascular system, Autonomic nervous system, Gastro intestinal system and Respiratory system. (firstranker.com)
Physical Chemistry1
- For example, one of the molecules will go to physical chemistry students who will study how the molecule's structure affects the rate of its reactions and then report back to sophomore students. (indstate.edu)
Classification2
- The widespread distribution of alkaloids and their wide array of structures makes their classification often difficult, hence, there are different classification methods are been reported for better understanding. (novapublishers.com)
- Herein, this work is a comprehensive revision of the web of knowledge on the introductory sight of alkaloids, their classification, extraction techniques, identification tests and pharmaceutical applications. (novapublishers.com)
Vitro1
- We reviewed here several antiviral alkaloids that have been described in the literature in different investigational environments i.e. (in-vivo, in-ovo, in-vitro, and in-silico), and found that these alkaloid compounds have significant antiviral properties against several infectious viruses. (edu.sa)
19871
- 1987) in chemistry from the University of Warsaw. (inrcworld.org)
Molecules1
- The NSF grant allows Fitch to hire a post-doctoral fellow and undergraduate students to chemically prepare the frog alkaloid and related molecules, evaluating its detailed pharmacology. (indstate.edu)
Found2
- Even LSD, for many psychopharmacologists the prototype hallucinogen, is not itself a natural compound but rather is a semisynthetic analogue of alkaloids found in plants and fungi. (erowid.org)
- Fitch's current research focuses on a specific alkaloid called phantasmidine, found in the Ecuadorian frog in trace amounts. (indstate.edu)
PROFESSOR1
- An Indiana State University chemistry professor recently received two grants totaling more than $330,000 from the National Science Foundation. (indstate.edu)