• GC/MS analysis allows separation of compounds based on their retention time within a chromatography column and identification of each compound by the characteristic fragments into which a given chemical is broken following ionization of the compound. (medscape.com)
  • He did say the industry is phasing out some of the chemical compounds, but added the health impact of substitute chemical options remains unclear. (drugs.com)
  • For more than a century, most catalysts were prepared using chemical compounds called phosphines," said Guy Bertrand, the lead author of the study and Distinguished Professor of chemistry. (redorbit.com)
  • Dr Mark Matfield, scientific co-ordinator of the Association for International Cancer Research pointed out that several highly effective cancer drugs were first discovered as natural compounds. (earthtimes.org)
  • Despite the evident analogy with scheduled compounds, research chemicals fall into a legal grey area under U.S. law. (drugs-forum.com)
  • The wide range of compounds encompassed under the term ' research chemical ' are summarized in the figure below. (drugs-forum.com)
  • For pairs of proteins sharing a common ligand, we use protein and chemical superimpositions combined with fast structural compatibility screens to predict whether additional compounds bound by one protein would bind the other. (plos.org)
  • This includes organic compounds, pharmaceuticals, and chemicals commonly found in metropolitan water supplies. (aquasana.com)
  • Researchers were also able to trigger false positive results for marijuana with common hospital gel soap and several other products, which led them to discover that two specific chemical compounds can completely confound commonly used immunoassay drug tests and produce false positives for marijuana. (rawstory.com)
  • The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. (mdpi.com)
  • The request should generally be limited to four items or drugs/compounds per order to avoid delay. (drugabuse.gov)
  • Although legislators have outlawed specific compounds, drug manufacturers have tweaked the chemical composition just enough to where it falls outside the arm of the law. (smokymountainnews.com)
  • One consequence of these compounds not having been evaluated as legitimate drugs is that they do not have trivial names, so rather than use the full chemical name they become known by abbreviations assigned usually by the laboratory that first detected them. (drugs-forum.com)
  • Using in vitro experiments with human liver cells , the team found that minor chemical modifications can affect the stability of drug compounds as these alter the generation of reactive metabolites. (phys.org)
  • Many other compounds with small chemical changes were also synthesised and evaluated for their potential to cause toxicity and how they may be metabolised differently in liver cells. (phys.org)
  • Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds, Chemical Research in Toxicology (2016). (phys.org)
  • Structure-toxicity relationship and structure-activity relationship study of 2-phenylaminophenylacetic acid derived compounds, Food and Chemical Toxicology (2014). (phys.org)
  • The demand for new antibiotics continues to grow due to the rapid emergence of antibiotic resistant pathogens causing life threatening infections in spite of considerable progress in the fields of chemical synthesis and engineered biosynthesis of antimicrobial compounds. (ijpsonline.com)
  • To work towards the development of photo-sensitive drugs, we must enhance the photochemical response of the compounds and be able to stimulate them at visible wavelengths. (nanowerk.com)
  • Inside Science) -- With many a daily flush of a toilet, a dilute cocktail of chemical compounds we excrete, from hormones to antidepressants to caffeine to nicotine, are sluiced into the sewers of American life, eventually making their way into municipal wastewater treatment plants. (insidescience.org)
  • In studying less commonly used pharmaceuticals, the scientists found elevated levels of as many as 33 pharmaceuticals in the treated water of plants receiving waste from drug manufacturers out of the 200 compounds they tested. (insidescience.org)
  • The change effectively acts as a switch causing a redistribution of electrons within the compounds chemical backbone. (qmul.ac.uk)
  • Whereas historically drugs such as heroin and cocaine have been considered the "dangerous" drugs, in recent years, prescription drug abuse has far surpassed "illegal" drugs as agents of lethal drug toxicity. (medscape.com)
  • Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of alcohol to alter the toxicity of chemical pollutants and drugs in animal models and humans. (routledge.com)
  • Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (medindia.net)
  • We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. (frontiersin.org)
  • We describe three case studies of complementary multi-scale computational modeling approaches to understand perturbation of toxicity pathways in the human liver as a result of exposure to environmental contaminants and specific drugs. (frontiersin.org)
  • Central to this vision is the idea of "toxicity pathways" - innate cellular signaling pathways that are perturbed by chemicals and pharmaceuticals, and the determination of chemical concentration ranges where those perturbations are likely to be excessive, thereby leading to adverse health effects if present for a prolonged duration in an organism. (frontiersin.org)
  • In 2009, the U.S. Environmental Protection Agency published its Strategic Plan for Evaluating the Toxicity of Chemicals ( U.S.EPA, 2009 ), which also envisions dynamic mathematical modeling as a key component of risk assessment linking toxicity pathways to dose-response. (frontiersin.org)
  • Derivatives of lumiracoxib were synthesised to understand the contribution of different chemical groups to toxicity. (phys.org)
  • Changes to compound stability (via formation of oxidised products, -OH), chemical reactivity, and metabolite formation were observed and they allude to the mechanism for causing toxicity. (phys.org)
  • A research team led by Prof HO Han Kiat from the Department of Pharmacy, NUS has discovered the mechanisms involved when minor chemical modifications such as a single substitution of a small halogen or alkyl group (functional groups in chemical structures) of pharmaceutical drugs alters the toxicity profile of the drugs. (phys.org)
  • By understanding the specific mechanisms contributing to the toxicity, pharmaceutical scientists can modify the chemical structure so as to develop drugs which are more effective and safe. (phys.org)
  • As part of the research, the team used a pair of anti-inflammatory drugs, diclofenac and lumiracoxib, that differ minimally in terms of structure, but exhibit profound differences in terms of toxicity. (phys.org)
  • RIVERSIDE, Calif. "" Aug. 18, 2005 "" Chemists at the University of California, Riverside have synthesized a new class of carbenes "" molecules that have unusual carbon atoms "" that is expected to have wide applications in the pharmaceutical industry, ultimately resulting in a reduction in the price of drugs. (redorbit.com)
  • All of this can dramatically reduce the cost of manufacturing drugs, given that pharmaceutical companies are increasingly using carbene-supported catalysts for their chemical reactions. (redorbit.com)
  • Gary D. Strahan uses physico-chemical techniques to understand biological systems relevant to pharmaceutical discovery and agricultural and natural product analyses. (wiley.com)
  • More specifically, the aim of the Conference is to address the most advanced directions and new achievements in physical chemistry methods which underlie almost all instrumental techniques used in the research processes in drug discovery and pharmaceutical development. (rsc.org)
  • Lunbeck sold its rights to the drug at the end of 2011 to Akorn, another pharmaceutical company. (rt.com)
  • The chemical industry is already accustomed to tight controls over the smaller-volume domestic trade in pharmaceutical precursors, or chemical intermediates. (joc.com)
  • Affymax and its Japanese partner Takeda Pharmaceutical have voluntarily recalled the anemia drug Omontys after about a year on the U.S. market. (acs.org)
  • In a reverse of the usual big pharma-biotech relationship, the New York City-based biotech firm Ovid Therapeutics will help develop a Takeda Pharmaceutical drug for rare pediatric epilepsy. (acs.org)
  • From 2007 to 2013 she was responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company Apoteka "Beograd" in Belgrade, and in 2013 she was appointed Director of the Production Department in the same company. (springer.com)
  • is designed for pharmaceutical scientists working in industry and academia, as well as younger researchers exploring the world of drug delivery via this route. (springer.com)
  • NUS pharmaceutical scientists have discovered the mechanisms involved when small chemical modifications to certain pharmaceutical drugs may cause harm instead of improving treatment. (phys.org)
  • Prof Ho Han Kiat with his research team investigating the mechanisms involved when small chemical modifications are made to pharmaceutical drugs. (phys.org)
  • Prof Ho said, "The research findings show that it is important to examine the potential toxicological impact when making minor chemical changes to pharmaceutical drugs . (phys.org)
  • Pharmaceutical drugs are broken down by enzymes in the liver into their metabolites, which are subsequently excreted in the faeces and urine. (phys.org)
  • G-protein coupled receptors (GPCRs) represent one of the most important families of drug targets in pharmaceutical development. (biomedsearch.com)
  • In the last 15 years, there have been numerous reports in the United States about pharmaceutical chemicals found in waterways and drinking water supplies. (insidescience.org)
  • While levels were not quite as elevated as in India, the USGS study found "pretty hefty concentrations" of pharmaceutical chemicals coming from manufacturers, he said. (insidescience.org)
  • Of those seven common pharmaceutical chemicals, only bupropion, the active ingredient in an antidepressant drug known as Wellbutrin, was found at high concentrations in the treated discharge coming from plants receiving waste from pharmaceutical manufacturers. (insidescience.org)
  • Global Neuromyelitis Optica Drug Sales Market Report 2017 Industry. (mynewsdesk.com)
  • MARCH 11, 2016 SIDLEY UPDATE China Reforms Its Chemical Drug Classification System On March 4, 2016, China Food and Drug Administration (CFDA) issued the Work Plan for Reforming Chemical Drugs Registration Classification System (the New Classification), which took effect on the same day. (lexology.com)
  • In this report, the Global Neuromyelitis Optica Drug Market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (mynewsdesk.com)
  • Credit: Ho Han Kiat, published in Chemical Research in Toxicology , 2016. (phys.org)
  • In May 2016, The New York Times reported that a number of countries use chemical castration on sex offenders, often in return for reduced sentences. (wikipedia.org)
  • The research, Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design, is published by Nature Communications . (eurekalert.org)
  • Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. (rsc.org)
  • Describe two chemical properties of Vinblastine (anticancer drug) and one benefit to society? (enotes.com)
  • The DEA already had banned the substances for a year, but with that period soon to expire, the DEA announced it will file a notice in the Federal Register on Thursday that will mean the chemicals will continue to be illegal. (cnn.com)
  • The substances used to make the fake pot products are: JWH-018, JWH-073, JWH-200, CP-47,497 (that's all one chemical CP-47,497) and cannabicyclohexanol. (cnn.com)
  • The DEA's emergency action means the chemicals are designated as Schedule 1 substances, the most restrictive category of drugs under the Controlled Substances Act. (cnn.com)
  • Schedule 1 substances are reserved for those substances with a high potential for abuse, no currently accepted medical use in treatment in the United States and a lack of accepted safety for use of the drug under medical supervision," according to a DEA press release. (cnn.com)
  • Discussions of common classes of drugs and other poisonous substances can be found at Medscape Reference, as listed in the Further Reading section. (medscape.com)
  • Widely used manmade chemicals called perfluoroalkyl substances (PFAS) may undermine dieters' attempts to maintain weight loss by slowing down the body's metabolism, the new study suggests. (drugs.com)
  • it is intended for laboratory personnel involved in the manufacture of chemicals, but it contains information that will be useful for anyone who handles or is exposed to chemicals or who is interested in action and effects of chemical substances. (wiley.com)
  • To obtain research chemicals and controlled substances from the NIDA DSP, all research investigators will need to prepare a Request Package. (drugabuse.gov)
  • For radio-labeled drugs or chemical substances, indicate the address to which such materials will be shipped. (drugabuse.gov)
  • Calculate required amount of drugs or chemical substances for your project and submit your request well in advance of your planned experiments or tasks, or 6‑8 weeks prior to depletion of stock on hand for ongoing studies/tasks. (drugabuse.gov)
  • Hollingsed sent a letter to business owners around Waynesville in early April telling them about the drugs and asking those who sell the substances to stop. (smokymountainnews.com)
  • Blood carries chemical, toxins, drugs, and other harmful substances to the filtration systems of the liver and kidneys. (totalhealthinstitute.com)
  • Describe the properties of chemical substances with different types of bonds. (enotes.com)
  • A CONVICTED drug runner busted speeding on a major Queensland highway with $85,000 of dangerous substances - including a notorious date rape drug - wants his jail term lowered. (gympietimes.com.au)
  • It was alleged Lambert was a drug runner and that he was transporting the substances across the Queensland and NSW borders. (gympietimes.com.au)
  • Pectin helps to release heavy metals, chemicals and other substances into the blood stream, where it binds to them and flushes them from the body. (naturalnews.com)
  • Called cyclic alkyl amino carbenes or CAACs, the molecules attach themselves to metals, such as palladium, to form highly efficient catalysts that allow chemical transformations otherwise considered impossible. (redorbit.com)
  • 5z)-7-oxozeaenol (5ZO), a preclinical drug that targets transforming growth factor-β-activated kinase 1 (TAK1), was more effective at blocking SF activation across all contexts than the approved drug tofacitinib, which supports the development of molecules similar to 5ZO for use as RA therapeutics. (nature.com)
  • Molecules found in deep sea organisms are used in research into a number of diseases, including malaria and cancer, but the particular sea sponge under investigation by the Imperial College team naturally contains the chemical psammaplin A. This is reported to be a powerful blocker of several components of the processing machinery in cancer cells that prevents them from growing and dividing. (earthtimes.org)
  • Often scientists can improve upon Nature's handiwork by tweaking the chemical structure of these molecules, just as Dr Fuchter has discovered with psammaplin A. (earthtimes.org)
  • She said: "Your water is now somewhat contaminated with chemical molecules which derive from the complex transformation which has taken place, so pouring it down the drain is not environmentally friendly. (nottingham.ac.uk)
  • Because sulfuryl fluoride has been shown to be a useful chemical to build fluorosulfates, a type of chemical group that can be used in applications ranging from polymer chemistry to building new molecules to studying the biology of diseases. (pfizer.com)
  • The process of drug design to improve therapeutic activities involves making small chemical changes to drug molecules. (phys.org)
  • Building drug molecules that activate only a certain type of response might allow us to dial out undesired side effects, but that's just a hope at this point. (healthcanal.com)
  • To date, much of the focus on drug development has concerned the external features of signaling molecules, which directly contact a receptor, Gellman says. (healthcanal.com)
  • For our purposes here, systems biology means an approach to biology that looks at networks of molecular interactions (including gene products, endogenous small molecules and drugs) and processes these using qualitative graphical models or quantitative mathematical modeling [ 8 ]. (pubmedcentralcanada.ca)
  • Based on the results of chemical screening, the pigment was tentatively identified as group of sugar containing molecules. (ijpsonline.com)
  • A team of UTHSC medicinal chemists then used the results to synthesize related molecules for pre-clinical testing, and a chemical called DJ-V-159 was found to be highly potent in stimulating insulin secretion and lowering sugar levels in mice. (medicalxpress.com)
  • Alcohol Interactions with Drugs and Chemicals will be a valuable reference tool for environmental scientists, toxicologists, epidemiologists, and alcohol researchers studying the interactions of alcohol with drugs and chemical pollutants. (routledge.com)
  • Researchers at the University of Warwick found that when the chemical, Sodium Formate, is used in combination with a metal-based cancer treatment it can greatly increase its ability to shut down cancer cells. (eurekalert.org)
  • The Warwick researchers developed a novel method for binding Sodium Formate with JS07 to form a more potent form of the drug. (eurekalert.org)
  • To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. (ucsd.edu)
  • First, researchers generate RNAi drugs with a sequence that corresponds to the gene blueprint for the disease protein and then delivers them into cells. (ucsd.edu)
  • The discovery also allows the researchers to make variations of the psammaplin A chemical and to use these variants to further understand the anti-cancer activity of this natural product. (earthtimes.org)
  • Researchers have been looking at the effects of drugs on fish over the course of several years, and the results show evidence that the drugs humans use are harming fish. (aquasana.com)
  • Swedish researchers tested an anti-anxiety drug called oxazepam (found in water sources) on perch in the lab. (aquasana.com)
  • Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment - called environmental estrogens - can produce infertility , abnormal reproductive development, including "precocious puberty ," and promote breast cancer. (medicalnewstoday.com)
  • They found that by combining data about structural disturbances from many structures with activity profiles of their ligands (the estrogenic chemicals), researchers can identify the sub-ångström details that determine endocrine disruption. (medicalnewstoday.com)
  • Researchers at the University of North Carolina began testing soaps after local nurses noticed an unusual uptick in positive drug tests on infants. (rawstory.com)
  • Researchers added that less than 0.1 mililiters of these chemicals in a drug test sample could contaminate the results. (rawstory.com)
  • That problem in the brain may be corrected by low doses of drugs used to treat anxiety and epileptic seizures, researchers from the University of Washington say. (medicaldaily.com)
  • As the researchers call for immediate clinical trials, Astra-Zeneca has begun testing benzodiazepines and newer such drugs on people with autism. (medicaldaily.com)
  • The researchers also found much higher concentrations of some pharmaceuticals in the discharge from plants receiving wastewater from drug manufacturers than from plants with no wastewater coming from these sources. (insidescience.org)
  • Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. (wiley.com)
  • Several medical examiners' offices that routinely test for alcohol and drugs of abuse report finding some substance on toxicologic analysis in at least 50% of their cases. (medscape.com)
  • Alcohol and other drug abuse is estimated to cost the nation over $160 billion per year in lost productivity, health care costs, and crime. (druglibrary.org)
  • There are constant reminders in the news media of the ever-present effects of alcohol and other drug abuse. (druglibrary.org)
  • Health care professionals witness the effects of alcohol and other drug use on the health of the population every day. (druglibrary.org)
  • Outpatient alcohol and drug treatment serving Crow Wing County and surrounding areas. (brainerd.com)
  • Alcohol is a drug, and when a person consumes alcohol, it has an effect on many body systems. (antiessays.com)
  • Extreme use of alcohol and other drugs can damage the brain and can sometimes cause hallucinations or other symptoms of a mental disorder but is only usually caused by excessive use of alcohol and drugs. (antiessays.com)
  • Alcohol is a Drug? (bradfordhealth.com)
  • As the most widely used and accepted drug, alcohol has wrecked havoc on millions of families. (bradfordhealth.com)
  • Millions of people affected by drugs and alcohol continue to endure the damages of addiction because they don't think they can afford to get help. (bradfordhealth.com)
  • SB-1247 Vessels: operation under the influence of alcohol or drugs: chemical testing. (ca.gov)
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • The book systematically assesses interactions according to general chemical classes of inorganic and organic agents. (routledge.com)
  • Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra , the only comprehensive book written about this topic. (wiley.com)
  • Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions. (nih.gov)
  • Here we use this principle to suggest new protein-chemical interactions via the network derived from three-dimensional structures. (plos.org)
  • Predicting drug-target interactions is a hot topic, and many efforts have been undertaken to do this, many using large interaction networks. (plos.org)
  • We take a novel approach using protein-chemical interactions derived from 3D structures. (plos.org)
  • We use protein and chemical superimpositions and physical tests of chemical-protein compatibility to identify the most likely candidates among the nearly one million potential interactions. (plos.org)
  • We make thousands of confident predictions, including structures for known protein-drug interactions lacking a structure (e.g. topoisomerase-2/radicicol) and many new interactions. (plos.org)
  • Large biological networks have been used previously to suggest protein-protein interactions [1] , phosphorylation events [2] and most recently drug-protein interactions. (plos.org)
  • The network contains many thousands of protein-protein and protein-chemical interactions, of which several hundred involve drugs. (plos.org)
  • In this paper we explored this large network systematically to predict new potential protein-chemical interactions. (plos.org)
  • Considering protein-chemical interactions alone would lead to many thousands of predictions including mostly false positives. (plos.org)
  • This process is more complex if the person takes other drugs and has other diseases, because drug-drug and drug-disease interactions are possible. (antiessays.com)
  • New approaches to predicting ligand similarity and protein interactions can explain unexpected observations of drug inefficacy or side-effects. (pubmedcentralcanada.ca)
  • Such tools will most certainly include emerging information about protein-protein interactions, signaling pathways, and pathways of drug action and metabolism. (pubmedcentralcanada.ca)
  • these include both intoxication from abuse of illicit drugs and deaths resulting from a consequence of medication taken as medical therapy. (medscape.com)
  • A coalition of U.S. chemical companies is negotiating with Congress and the Drug Enforcement Administration on ways to control domestic and international trade in chemicals used to manufacture illicit drugs. (joc.com)
  • The ad hoc group of chemical manufacturers and distributors expects to reach an agreement soon with the drug-enforcement agency and the House Judiciary Committee's subcommittee on crime to regulate a dozen or more chemicals used by illicit drugmakers.The subcommittee, chaired by Rep. William Hughes, D-N.J., seeks a workable means of allowing the DEA to track these chemicals. (joc.com)
  • It also includes chemicals that are essential in illicit drug manufacturing, such as the solvent acetone and acetic anhydride, used to make aspirin. (joc.com)
  • The prevalence of marijuana, use is highest of the illicit drugs being tested. (druglibrary.org)
  • The result of controlling BZP is that we now have an ever-expanding illicit pharmacopoeia of chemicals never before used as drugs being sold to vulnerable youngsters by unscrupulous vendors with neither understanding the risks they are taking. (drugs-forum.com)
  • While others have envisioned a causal role for psychotropic drugs in idiopathic autism, we were astonished to find evidence that this might occur at very low dosages, such as those found in aquatic systems," said lead scientist Dr Michael Thomas. (prisonplanet.com)
  • The Waynesville Police Department receives about a dozen calls a week related to synthetic drugs, which in essence are plants that have been sprayed with a number of unknown chemicals and psychotropic drugs, Hollingsed said. (smokymountainnews.com)
  • Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways! (routledge.com)
  • CRISPR/Cas9-based screens, which are largely limited to a gene's loss of function, have already been very successful in identifying drug targets and pathways related to the drug's mode of action. (nih.gov)
  • After exposing fish to two different anti-depressant drugs, Prozac and venlafaxine, and a seizure-controlling drug called carbamazepine, experts from the University of Idaho were 'astonished' after observing changes in the genetic pathways of the fish. (prisonplanet.com)
  • Some adverse events are predictable consequences of the known mechanism of a drug, but others are not predicted and seem to result from 'off-target' pathways. (pubmedcentralcanada.ca)
  • When developing novel chemical entities (NCEs) for a therapeutic application, knowledge of binding partners and affected biological pathways is useful for predicting both efficacy and side-effects. (pubmedcentralcanada.ca)
  • It is not surprising that evolutionary relationships might lead to shared drug-binding capabilities in protein paralogs found across a wide range of cell types and biological pathways. (pubmedcentralcanada.ca)
  • Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver! (routledge.com)
  • We are confident that our results will lead to the development of a new, highly selective generation of Alzheimer's drugs," explained Demuth. (eurekalert.org)
  • The team's preliminary results indicate that these psammaplin A variants are more potent than the natural product and that they could well form the basis of new selective drugs in the future. (earthtimes.org)
  • The sheer volume of trade in some of these chemicals, such as acetone, of which 4 billion pounds a year are produced by 10 major global companies, will complicate a reporting requirement that is not selective. (joc.com)
  • Currently, the best treatments for skin lesions associated with psoriasis are topical steroids, but the problem with those drugs is that they're not selective for the disease-causing cells. (innovations-report.com)
  • urine is the primary body fluid used for drug screening. (medscape.com)
  • Our bodies absorb some of the drugs we take, but residual amounts pass through us (in our urine or stool) and are flushed down the toilet, although these amounts are very small in comparison. (aquasana.com)
  • In other words, it would not be surprising to find trace amounts of these products in urine, saliva or hair follicles - putting a huge question mark on the validity of less expensive drug tests conducted by employers and law enforcement agencies around the nation. (rawstory.com)
  • Only in an environment of criminal drug prohibition can people judged solely on the contents of their urine, rather than on their behavior and performance. (rawstory.com)
  • Figure 6: Inferring the likely targets of 5ZO on the basis of experiments in SFs and current understanding of the drug. (nature.com)
  • This chemogenomic approach combined with latest sequencing technologies allows deconvolution of drug targets and characterization of drug-target binding interfaces at amino acid resolution, therefore nicely complementing existing biochemical approaches. (nih.gov)
  • Kalinina OV, Wichmann O, Apic G, Russell RB (2011) Combinations of Protein-Chemical Complex Structures Reveal New Targets for Established Drugs. (plos.org)
  • To compound the problem, protein-ligand studies have found that a single drug can bind targets with vastly different pharmacology and that about 35% of known drugs have two or more targets [ 5 ]. (pubmedcentralcanada.ca)
  • These complexities, however, create new opportunities for therapeutic strategies involving the concerted use of drugs with multiple targets to achieve an increased specificity in effect. (pubmedcentralcanada.ca)
  • To identify new targets for individualized diagnosis or therapeutic intervention, we performed a kinase centric chemical proteomics screen and quantified 146 kinases across 34 head and neck squamous cell carcinoma (HNSCC) cell lines using intensity-based label-free mass spectrometry. (mcponline.org)
  • Importantly, the strategy employed in this study is generic and therefore also of more general utility for the identification of novel drug targets and molecular pathway markers in tumors. (mcponline.org)
  • A separate and special population of modern health-hazardous chemicals is a group of agents which selectively suppress protein synthesis in mammalian cells and tissues due to the direct effect on the translation machinery elements or on the messenger RNA processing steps. (biomedsearch.com)
  • Stanczyk, J., Ospelt, C. & Gay, S. Is there a future for small molecule drugs in the treatment of rheumatic diseases? (nature.com)
  • This research method could also be used to speed up the discovery of new drugs for breast cancer and many other diseases, added study senior author Kendall Nettles, associate professor at TSRI. (medicalnewstoday.com)
  • The drug, a small molecule called TAK-935, inhibits the enzyme cholesterol 24-hydroxylase, which may have a role in central nervous system diseases such as epilepsy. (acs.org)
  • Drugs and Human Diseases. (wiley.com)
  • Also, these chemicals may be industrial hazards promoting the origin and development of various occupational diseases. (biomedsearch.com)
  • A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. (mdibl.org)
  • At present, resistance to the drugs used in the treatment of many infectious diseases is increasing, while microbial infections are being found to be responsible for more life threatening diseases than previously thought. (ijpsonline.com)
  • This changing pattern of diseases and the emergence of resistant bacterial strains to currently used antibiotics continuously puts demand on the drug discovery scientists to search for novel antibiotics [ 2 ]. (ijpsonline.com)
  • Many myths, theories, and speculations exist as to the exact etiology of the diseases, drugs, and chemicals that affected the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. (healthyplace.com)
  • Diseases, drugs, and chemicals may have influenced their creativity and productivity. (healthyplace.com)
  • Dr Fuchter points out that the new chemical routes toward the natural product psammaplin A were developed with the particular view to preparing diverse variants for biological assessment. (earthtimes.org)
  • Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. (mdpi.com)
  • As for the solving of this task, it may be reached only in the case of successful fundamental studies of mechanisms of toxic action of different classes of chemicals performed at different biological levels (systemic, organ/tissue, cellular and molecular levels of research). (biomedsearch.com)
  • It provides interaction data between GPCRs and their ligands, along with chemical information on the ligands, as well as biological information regarding GPCRs. (biomedsearch.com)
  • These data are connected with each other in a relational database, allowing users in the field of Chemical Genomics research to easily retrieve such information from either biological or chemical starting points. (biomedsearch.com)
  • Wouter Basson , who headed a controversial chemical and biological weapons program in the 1980s and 1990s, saw an end to a six-year inquiry by The Health Professions Council of South Africa after the group made their verdict. (pakalertpress.com)
  • The study, appearing in the Journal of Biological Chemistry , investigated how the drug nifurtimox works to kill off the trypanosome. (qmul.ac.uk)
  • Co-author of the study, Dr Shane Wilkinson from Queen Mary's School of Biological and Chemical Sciences, said: "Hopefully our research will lead to the development of anti-parasitic medicines which have fewer side effects than Nifurtimox and are more effective. (qmul.ac.uk)
  • Dr Wilkinson and his colleagues Dr Belinda Hall and Mr Christopher Bot from Queen Mary's School of Biological and Chemical Sciences focused their research on the characterisation of the breakdown product from nifurtimox. (qmul.ac.uk)
  • Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication. (wikipedia.org)
  • This category lists articles that have a second identifier in {{Infobox drug}} , introducing a second chemical substance. (wikipedia.org)
  • Mix drugs with an undesirable substance, such as cat litter or used coffee grounds. (aquasana.com)
  • And [two], standard drug tests provide society with very little useful information regarding whether someone actually used a particular substance, when they last used a particular substance, or whether they were impaired at the time they were tested. (rawstory.com)
  • The way the drugs are made and sold one can never be sure what type of chemicals the substance contains, he added. (smokymountainnews.com)
  • The police receive calls either when parents find the substance among their children's possessions or a child has grown suddenly violent or passed out as a result of ingesting synthetic drugs. (smokymountainnews.com)
  • Click chemistry for drug development and diverse chemical-biology applications. (nih.gov)
  • The study was published online ahead of print in the journal Cell Chemical Biology . (medicalnewstoday.com)
  • Pathway mapping and modeling based on network biology concepts are a key component of the vision laid out in this report for a more biologically based analysis of dose-response behavior and the safety of chemicals and drugs. (frontiersin.org)
  • The biology of autism spectrum disorder may be as simple as the "chemical imbalance" illustrated by cartoon blobs in Pfizer's classic 2002 commercial spot for Zoloft. (medicaldaily.com)
  • Chemical systems biology, or the application of systemwide tools to the analysis of pharmacological responses, can help address the lack of efficacy and undesired off-target effects [ 3 ]. (pubmedcentralcanada.ca)
  • 7 ]) have used a chemical systems biology approach to explain the serious side-effects of a drug that was being trialed for prevention of cardiovascular disease. (pubmedcentralcanada.ca)
  • Dr. Devi and her team are currently working with co-author Marta Filizola, PhD, Associate Professor of Structural and Chemical Biology at Mount Sinai, to learn how CYM51010 binds to the protein complex. (bio-medicine.org)
  • The drug discovery journey is not only an expensive venture but often it can take a decade or more to deliver a medicine for widespread clinical use to a public in desperate need of treatment. (acs.org)
  • One such example is using artificial intelligence technology and novel approaches in targeted protein degradation, which has the potential to transform the way medicinal chemistry and drug discovery is carried out. (acs.org)
  • Are You Looking For A Faster Horse In Drug Discovery? (acs.org)
  • Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones? (acs.org)
  • Drugs: Discovery and Development. (wiley.com)
  • These results emphasize that marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery. (mdpi.com)
  • But the real excitement of the discovery is the potential impact on a large class of peptide drugs, Gellman says. (healthcanal.com)
  • GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update. (biomedsearch.com)
  • We hope that it will prove very useful for Chemical Genomics research and GPCR-related drug discovery. (biomedsearch.com)
  • This new approach to diabetes drug discovery has been published in PLOS One , a peer-reviewed open access scientific journal. (medicalxpress.com)
  • A battle with chemical dependency may feel hopeless, but there is help available! (brainerd.com)
  • The Brainerd Lakes Area is home to several programs for rehabilitation and chemical dependency care including medical care, counseling, and in patient treatment program. (brainerd.com)
  • The chemical dependency team and addiction recovery services at Essentia Health-St. Joseph's Medical. (brainerd.com)
  • Several relapse warning signs appear before you fall completely back into chemical dependency. (bradfordhealth.com)
  • The congressional subcommittee's list includes chemical precursors, such as ephedrine and pseudoephedrine, which are used widely to make non- prescription pharmaceuticals. (joc.com)
  • Chemicals in pharmaceuticals such as anti-seizure medications and anti-depressants may also contribute, since they mimic estrogen. (aquasana.com)
  • Drugs and Pharmaceuticals: Safety Considerations. (wiley.com)
  • The USGS scientists tested the treated discharge coming from each of 20 wastewater treatment plants in nine states across the U.S. and Puerto Rico over a 24-hour period once a year from 2012 to 2014, for 200 pharmaceuticals, nonpharmaceuticals and other chemicals of concern. (insidescience.org)
  • The team selected their study sites based on nearby manufacturing of seven commonly used pharmaceuticals, including an antidepressant, an opioid, an antibiotic, an anticonvulsant, a synthetic estrogen, a breast cancer drug and an immunosuppressant. (insidescience.org)
  • Once inside, cellular machinery converts these disguised drug precursors - called siRNNs - into active RNAi drugs. (ucsd.edu)
  • Developed by Warwick's Department of Chemistry, the drug, a compound of the metal ruthenium called JS07, is capable of exploiting a cancer cell's natural weaknesses and disrupts its energy generation mechanism. (eurekalert.org)
  • Innovative drug is defined as a chemical compound with new and clearly defined structure, pharmacological property(ies) and apparent clinical value. (lexology.com)
  • In a study published online Dec. 3 in the Journal of Pharmacology and Experimental Therapeutics, scientists from the University of Michigan report that a compound called benzodiazepine-423 (Bz-423)---a chemical cousin of the anti-anxiety drugs Valiumâ and Xanaxâ---suppresses cell growth in a model of psoriasis. (innovations-report.com)
  • However, there is no way to know the exact chemical make-up of a compound unless it is tested. (smokymountainnews.com)
  • Chemical compound shows promise as alternative to opioid pain. (bio-medicine.org)
  • Jeremy Smith, Governor's Chair for Molecular Biophysics at the University of Tennessee, Knoxville, and director of the Center for Molecular Biophysics at Oak Ridge National Laboratory, has worked with a research team from the UT Health Science Center to discover a chemical compound that could lower sugar levels as effectively as the diabetes drug metformin but with a lower dose. (medicalxpress.com)
  • This chemical compound lowers sugar levels in mice as effectively as metformin, but with a 30-times lower dose," Smith said. (medicalxpress.com)
  • Many current approaches use nanoparticles to deliver RNAi drugs into cells," said Steven F. Dowdy, PhD, professor in the Department of Cellular and Molecular Medicine and the study's principal investigator. (ucsd.edu)
  • While nanotechnology protects the RNAi drug, from a molecular perspective nanoparticles are huge, some 5,000 times larger than the RNAi drug itself. (ucsd.edu)
  • Nettles and his colleagues reasoned that they could use a similar approach with x-ray crystallography to compare molecular snapshots, or structures, and better understand how estrogenic chemicals control receptor activity. (medicalnewstoday.com)
  • Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel," Molecular Cancer Therapeutics , vol. 5, no. 4, pp. 853-867, 2006. (hindawi.com)
  • By analyzing the correlation patterns between GPCRs and ligands, we can gain more detailed knowledge about their conserved molecular recognition patterns and improve drug design efforts by focusing on inferred candidates for GPCR-specific drugs. (biomedsearch.com)
  • All drugs can be dangerous toxic chemicals when not used appropriately. (madinamerica.com)
  • Edward was diagnosed as suffering from severe Aplastic Anaemia in April 1986 following exposure to a number of toxic chemicals at his workplace and, although it was not recognised by us at the time, he also suffered several of the documented symptoms of chemical poisoning (memory loss, jaundice, extreme fatigue etc.) in the weeks and months before diagnosis. (whale.to)
  • A predictive physiological model (DILIsym™) to understand drug-induced liver injury (DILI), the most common adverse event leading to termination of clinical development programs and regulatory actions on drugs, is also described. (frontiersin.org)
  • The chemical reactivity of as-anodized porous silicon is shown to have an adverse effect on a model drug (Lansoprazole) loaded into the pores. (springer.com)
  • Chemical modifications can cause the drug to have both beneficial and adverse effects on patients. (phys.org)
  • Drug-related adverse events affect approximately 2 million patients in the United States each year, resulting in about 100,000 deaths [ 1 ]. (pubmedcentralcanada.ca)
  • For example, highly publicized cases of severe adverse reactions recently resulted in a US Food and Drug Administration advisory panel suggesting that the popular pain relievers Percocet and Vicodin be banned [ 2 ]. (pubmedcentralcanada.ca)
  • Adverse side-effects and lack of efficacy are the two most important reasons a drug will fail clinical trials, each accounting for around 30% of failures [ 3 ]. (pubmedcentralcanada.ca)
  • The laboratory assays currently used to evaluate potential adverse drug effects can be costly and time-consuming. (pubmedcentralcanada.ca)
  • My contention, of course, is that the drugs don't work, in the sense that any putative short-term benefits are far outweighed by the long-term adverse effects. (madinamerica.com)
  • The research recorded a continuation of this more positive behaviour after the administration of the drug had ended with no evidence of adverse side effects and recommended medroxyprogesterone acetate along with counselling as a successful method of treatment for serial sex offenders. (wikipedia.org)
  • We used interaction multiple linear regression to quantify therapeutic and countertherapeutic drug effects across activators and donors and found that the ability of drugs to block SF activation was strongly dependent on the identity of the activating cytokine. (nature.com)
  • Think of delivering a package into your house by having an 18-wheeler truck drive it through your living room wall - that's nanoparticles carrying standard RNAi drugs. (ucsd.edu)
  • Shahbazi MA, Herranz B, Santos HA (2012) Nanostructured porous Si-based nanoparticles for targeted drug delivery. (springer.com)
  • Research chemicals have not been through clinical trials and are therefore not approved as safe for human consumption. (drugs-forum.com)
  • A study (PDF) featured in the June 2012 print edition of the medical journal Clinical Biochemistry claims that tiny traces of certain baby soaps and shampoos can trigger drug test results showing the presence of marijuana , which can in some cases cause state authorities to remove a child from parental custody. (rawstory.com)
  • This announcement is especially disappointing because preladenant was already relatively far along the drug development pipeline, and the clinical results to date had been quite encouraging, explains Maurizio Facheris , MD, MSc, associate director of research programs at The Michael J. Fox Foundation (MJFF). (michaeljfox.org)
  • Interestingly, psammaplin A and our man-made variants show high selectivity in lab-based experiments, which is an important feature for the design and manufacture of future drugs. (earthtimes.org)
  • They specifically highlighted the ingredients polyquaternium 11 and cocamidopropyl betaine as "showing strong reactivity" with chemicals in less expensive drug tests, producing the positive result for marijuana. (rawstory.com)
  • Sailor MJ (2014) Chemical reactivity and surface chemistry of porous silicon. (springer.com)
  • It has been used to synthesize Musk 105 , 10-hydroxy-2-decylenic acid (queen acid) , as the intermediates of new drug for resistance to senile dementia -idebenone, and other medicine ,etc. (alibaba.com)
  • Masamichi Tsuboi studies DNA and RNA structures, drug-DNA interaction, protein conformation, protein-nucleic acid recognition, and virus structure using a variety of physicochemical and biomedical techniques including X-ray diffraction, UV-Visible, IR/Raman , and NMR spectroscopy. (wiley.com)
  • By inducing single nucleotide changes using an alkylating reagent, it is possible to generate amino acid changes that perturb the interaction between a drug and its direct target, resulting in drug resistance. (nih.gov)
  • The number of confident predictions grows faster than the number of known structures, suggesting that this approach will play a key role in completing the protein-chemical interaction repertoire. (plos.org)
  • the study of the rates of chemical reactions. (drugs.com)
  • In their paper, the UCR chemists discuss a set of chemical reactions involving the use of catalysts other than those that are CAAC-based. (redorbit.com)
  • Now it mostly appears when it's unintentionally produced from chemical reactions at industrial sites. (healthline.com)
  • Experts from the University of Nottingham have created a self-sustaining circuit of reactions which is a greener and more efficient method of chemical production. (nottingham.ac.uk)
  • In their paper Self-sustaining closed-loop multienzyme mediated conversion of amines into alcohols in continuous reactions , published in Nature Catalysis , Drs Francesca Paradisi and Martina Contente of the University of Nottingham produce chemicals more efficiently through a looped set of reactions using enzymes in flow. (nottingham.ac.uk)
  • Dr Paradisi, Associate Professor in Biocatalysis and Enzyme Engineering in the School of Chemistry, explained that water is often used as the medium in which enzyme mediated chemical reactions can take place but there is an issue in disposing of the waste at the end of the process. (nottingham.ac.uk)
  • We also discovered that working in this way meant the yields of some "tricky to make" high-value products are also much higher than for traditional chemical reactions - by over 20-fold. (nottingham.ac.uk)
  • Royalty free and rights managed images of allergic reactions of drugs and other chemicals. (sciencephoto.com)
  • David Paul Lambert was sentenced to eight years and two months in prison at the start of 2019 on numerous offences including possession of a range of dangerous drugs. (gympietimes.com.au)
  • Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. (rsc.org)
  • Finally, because the stereochemistry of the principal metabolite of cimetidine and (S)-nicotine in small experimental animals is distinct from that observed in humans, it is likely that species variation in predominant FMO isoforms exist and this may have important consequences for the choice of experimental animals in human preclinical drug design and development programs. (nih.gov)
  • MeSH contains thousands of chemicals, so it is likely that the specific chemical in a given article can be found by searching the MeSH Browser. (nih.gov)
  • For example, the drug Propranolol can be readily found using either method. (nih.gov)
  • The Introduction and Epidemiology sections have both mentioned that drugs are found in 50% of forensic autopsies (when tested) and that drugs or medications are responsible for causing or contributing to death in over 20% of deaths unrelated to natural causes in the United States. (medscape.com)
  • The study can't prove cause-and-effect, but "found that individuals with higher blood levels of these chemicals had more difficulties of maintaining weight loss after dieting," said study lead author Dr. Qi Sun. "This pattern is primarily observed in women. (drugs.com)
  • There, Dowdy's team found that siRNNs were significantly more effective at blocking target protein production than typical RNAi drugs - demonstrating that once siRNNs get inside a cell they can do a better job. (ucsd.edu)
  • A report in a recent edition of Organic & Biomolecular Chemistry , the journal of the Royal Society of Chemistry, described how a young scientist from Imperial College London had been awarded a grant of £106,079 to investigate naturally occurring chemicals found in sea sponges in an effort to find out more about anti-cancer drugs. (earthtimes.org)
  • More detailed information on specific chemicals and families of chemicals can be found in their respective articles. (drugs-forum.com)
  • While there are a number of possible causes of autism, some research has shown that anti-depressants and other chemicals found in the water supply could be helping to surge autism rates, specifically 'idiopathic' autism spectrum disorders. (prisonplanet.com)
  • They found that just traces of common medications and other chemicals in the water were enough to bring about autism. (prisonplanet.com)
  • Studies found that the effect of another brain chemical called glutamate, which when perturbed is thought to cause dyskinesias, was also inhibited through by this drug. (michaeljfox.org)
  • Police, local radio RPP said, found drug making chemicals and supplies, including 620 kilograms of sulfuric acid, 720 kilograms of kerosene, 600 kilograms of formic acid, 100 kilograms of calcium oxide, and 10 kilograms of baking soda. (livinginperu.com)
  • A South African doctor that rose to infamy during the period of a partheid for his production of chemical weapons and drugs was found guilty this week of unprofessional conduct. (pakalertpress.com)
  • Smith's computations found several chemicals that might activate the protein, and the Quarles laboratory at UTHSC tested each. (medicalxpress.com)
  • In conjunction with asymmetric chemical syntheses and spectral, chiroptical, chromatographic and stereochemical correlation methods, we have developed procedures for the quantification of sulfoxide enantiomers and tertiary amine N-oxide diastereomer metabolites arising from the action of the adult human liver and other flavin-containing monooxygenases (FMOs). (nih.gov)
  • Given their ubiquitous existence in the environment and our consumer products, it is challenging to entirely avoid exposures to these chemicals, although choosing products that are free of PFAS can help reduce the exposure," Sun said. (drugs.com)
  • 4) Drug exposure to the nursing infant may be minimized by having the mother take the medication just after she has breast-fed the infant and/or just before the infant is due to have a lengthy sleep period. (aappublications.org)
  • The new research shows how high-resolution imaging techniques could give scientists a window into how exposure to these chemicals may impact public health. (medicalnewstoday.com)
  • Exposure to a wide variety of chemicals and drugs has become common in industrial, laboratory, and even household environments. (wiley.com)
  • Drug and Chemical Toxicology is a quarterly peer-reviewed medical journal that publishes full-length research papers, review articles, and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. (wikipedia.org)
  • During our investigations it became increasingly obvious that serious and often fatal blood disorders resulting from exposure to drugs, chemicals and radiation - with implications that these conditions are pre-cancerous - could often be avoided with public awareness. (whale.to)
  • The announcement follows the massive recall of angiotensin II receptor blockers (ARBs) used for blood pressure and ranitidine drugs - commonly known under the brand name Zantac and used for heartburn - that took place earlier this year due to concerning levels of NDMA. (healthline.com)
  • Leuprolide acetate is an LHRH agonist that is most commonly used in chemical castration today. (wikipedia.org)
  • He reflected that without this financial backing he would not have been able to do the research and without it the work to design new drugs with the potential to enable people to survive cancer would not have been possible. (earthtimes.org)
  • This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy. (mdpi.com)
  • This book details the fundamental principles of drug design and formulations to penetrate the skin. (springer.com)
  • Traditional drug design has relied heavily on the one drug-one target paradigm [ 3 ], but this may overlook system-wide effects that cause the drug to be unsuccessful. (pubmedcentralcanada.ca)
  • The UTHSC team verified its potency and used this starting point to design an even more effective chemical . (medicalxpress.com)
  • Now scientists are taking a new tack that could finally yield promising treatments, according to a story in Chemical & Engineering News (C&EN) that was produced in collaboration with the American Chemical Society's open-access journal ACS Central Science . (acs.org)
  • Like other animal model research, scientists theorize that unwanted drugs getting into our water supplies may also have negative health effects on humans, but without extensive studies, this is conjecture. (aquasana.com)
  • Scientists from the U.S. Geological Survey recently visited 13 wastewater treatment plants in nine states and Puerto Rico, to learn if the drug manufacturers themselves are a major source for contamination in waterways. (insidescience.org)
  • Scientists have uncovered the mechanisms behind a drug used to treat African sleeping sickness and Chagas disease, infections caused by trypanosome parasites which result in 60,000 deaths each year. (qmul.ac.uk)
  • The basic premise is that two proteins sharing a common bound chemical will likely share others. (plos.org)
  • We show for a benchmark that known protein-chemical structures are reconstructed with good accuracy and sometimes via very different proteins and chemicals. (plos.org)
  • We exploited the basic premise that if two proteins in the network share one bound chemical they are likely to share others. (plos.org)
  • A single prediction candidate ( Figure 1 ) involves combining three protein-chemical complex structures, two of which involve two distinct proteins (P 1 and P 2 ) binding a common ligand (L a ) and a third where one protein (P 1 ) binds another ligand (L b ). (plos.org)
  • Traditionally, the oral route cannot be employed for the delivery of macromolecular drugs such as proteins and peptides due, in large part, to limited transport across the epithelial membrane. (springer.com)
  • Unfortunately, due to their size and negatively charged chemical groups (phosphates) on their backbone, RNAi drugs are repelled by the cellular membrane and cannot be delivered into cells without a special delivery agent. (ucsd.edu)
  • Potentially, the "alter-the-backbone" strategy could allow oral dosing of the rather fragile peptide drugs, which today must be injected to avoid destruction in the stomach and small intestine. (healthcanal.com)
  • The backbone of nifurtimox contains a chemical group called a nitro linked to a ring structure called a furan," Dr Wilkinson explained. (qmul.ac.uk)
  • Late king of Pop Michael Jackson had a "chemical castration" drug to suppress his sexual urges towards under-age boys, if reports are to be believed. (medindia.net)
  • Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. (wikipedia.org)
  • Unlike surgical castration, where the gonads are removed through an incision in the body, chemical castration does not remove organs, nor is it a form of sterilization. (wikipedia.org)
  • Chemical castration is generally considered reversible when treatment is discontinued,[citation needed] although permanent effects in body chemistry can sometimes be seen, as in the case of bone density loss increasing with length of use of DMPA. (wikipedia.org)
  • full development is less common unless chemical castration is combined with feminizing oestrogen therapy. (wikipedia.org)
  • The first use of chemical castration occurred in 1944, when diethylstilbestrol was used with the purpose of lowering men's testosterone. (wikipedia.org)
  • Chemical castration was often seen as an easier alternative to life imprisonment or the death penalty because it allowed the release of the convicted. (wikipedia.org)
  • Psychotherapy has also recently been used in conjunction with chemical castration in order to maximize and prolong the beneficial results. (wikipedia.org)
  • Chemical castration therapy reduces an individual's libido which then makes some offenders more responsive to the introduction of psychotherapy. (wikipedia.org)
  • One hypothesis is that men who accept the negative effects of hormonal treatment in exchange for shorter prison sentence are distinct in that they value freedom from incarceration higher than men who rather stay in prison for a longer time than face the side effects of chemical castration. (wikipedia.org)
  • Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. (springer.com)
  • In addition to research pinpointing anti-depressants and other chemicals in the water as possible causes of autism, there are a number of other likely and possible causes. (prisonplanet.com)
  • The indexer can also go to the MeSH Browser, type the name of the chemical, and search for the exact term. (nih.gov)
  • Entire textbooks have been written on forensic toxicology and individual drugs and chemicals that can cause death. (medscape.com)
  • He is also the editor of Toxicology of Pesticides in Animals, and author of Safety Evaluation of Environmental Chemicals. (wiley.com)
  • This year Conference is accompanied by a satellite summer school:5th International Summer School on Drug Development (ISSDD-5) Participants are encouraged to present their work either as oral or poster presentation. (rsc.org)
  • This change may incentivize multinational companies wishing to bring innovative drugs to China to start their product development in China earlier in the process than before in order to realize marketing advantages. (lexology.com)
  • Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. (mdpi.com)
  • The combination of drugs with external devices to control light may contribute to the development of personalized medicine in which treatments can be adapted to each patient, limiting the time given regions are treated, thus markedly reducing unwanted effects. (nanowerk.com)
  • It therefore is a good starting point for the development of a new and effective drug to fight diabetes. (medicalxpress.com)
  • His work has emphasized spectroscopic methods, NMR, and computational modeling to determine the structures and properties of multistranded DNA, drug-DNA complexes, carbohydrates, and other biomolecules, as well as metabonomic and chemometric studies. (wiley.com)
  • The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. (springer.com)
  • EGFR inhibition by the small molecule inhibitors lapatinib, gefitinib, and erlotinib as well as siRNA led to strong reduction of viability in high but not low expressing lines, confirming EGFR as a drug target in 10-20% of HNSCC cell lines. (mcponline.org)
  • The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential. (mdpi.com)
  • 3) If there is a possibility that a drug may present a risk to the infant, consideration should be given to measurement of blood concentrations in the nursing infant. (aappublications.org)
  • What's more, the drug concentrations were comparable with the highest estimated environmental levels. (prisonplanet.com)
  • This research lends even more concern for pregnant mothers who drink water with trace concentrations, who run the risk of passing along these drugs and other chemicals in the water to their unborn children. (prisonplanet.com)
  • By protecting the drugs from degrading enzymes, the new approach could also help sustain higher drug concentrations in the bloodstream. (healthcanal.com)
  • Some of them produce effects similar to illegal drugs. (drugs-forum.com)
  • A number of drugs without psychoactive effects, including synthetic anabolic steroids, and derivatives of the erectile dysfunction medication sildenafil, have also been marketed as research chemicals for similar legal reasons. (drugs-forum.com)
  • Until we have conclusive studies analyzing the effects of unwanted drugs in our water, it is best to be safe and install a water filter. (aquasana.com)
  • A new drug candidate previously shown to reduce harmful side effects of the autoimmune disease lupus also may be useful in treating psoriasis. (innovations-report.com)
  • There are also protein drugs approved for use in treating psoriasis, but those drugs are injected instead of applied topically, which makes them more costly, less convenient and more likely to cause side effects since they are delivered throughout the body. (innovations-report.com)
  • The Waynesville Police Department, in cooperation with residents, schools and other law enforcement agencies, has started hosting meetings around Haywood County to generate greater awareness of synthetic drugs and their side effects. (smokymountainnews.com)
  • A study was commissioned to investigate the consequences of the use of BZP as a recreational drug but it was abandoned because of the unpleasant side effects reported by volunteers. (drugs-forum.com)
  • it] is far from one-sided, and argues that rather than discarding drugs we should use them properly and concentrate on their effects rather than upon traditional but ultimately unscientific assumptions. (palgrave.com)
  • And certain research focusing on the positive effects of coffee may be directly related to the adenosine chemical as well. (michaeljfox.org)
  • Finally, the numerous side effects of multiple new drugs may serve as causes of a number of different health disorders. (biomedsearch.com)
  • Informative guides on ecstasy, ecstasy effects, ecstasy pills, ecstasy dangers, ecstasy drug tests, mixing ecstasy with other drugs and the legality of ecstacy. (thegooddrugsguide.com)
  • Learn the risks and effects of abusing inhaled chemicals. (thegooddrugsguide.com)
  • Know the basics about ketamine, as well as understand ketamine effects, ketamine addiction, ketamine dangers, ketamine drug tests, and the results of ketamine mixing with other drugs. (thegooddrugsguide.com)
  • Effects of Drugs and Chemicals on the Brain and Body Ashley Schreij General Psychology 1030 - F01 Bob Zimmerman March 17, 2013 Effects of Drugs and Chemicals on the Brain and Body Drug abuse is something many people are familiar with. (antiessays.com)
  • As with most illegal drugs, heroin use has both short-term and long-term effects. (antiessays.com)
  • Effects of age: Infants and older people particularly have problems with drug response. (antiessays.com)
  • A systems view of the body's responses to a drug threatens the simplicity of the one drug-one target paradigm, but could provide a framework for considering all effects, and not just those that are targeted. (pubmedcentralcanada.ca)
  • A drug targeting a protein complex containing two different types of opioid receptors may be an effective alternative to morphine and other opioid pain medications, without any of the side effects or risk of dependence, according to research led by the Icahn School of Medicine at Mount Sinai. (bio-medicine.org)
  • The AUL model ensures that women considering a drug-induced abortion receives comprehensive information on abortion-inducing drugs, including the potential to reverse the effects of the drugs should she change her mind. (aul.org)
  • This drug has been observed as having higher rates of success in reducing abnormal sexual urges and fantasies, but is often reserved for those offenders who are at a high risk of reoffending due to the drug's intense effects. (wikipedia.org)
  • Blood is also the way we get rid of waste products of cellular metabolism (endogenous toxins), and chemicals, drugs and toxins from exogenous sources. (totalhealthinstitute.com)
  • The Food and Drug Administration (FDA) announced it's currently testing the widely used diabetes drug metformin for a cancer-causing contaminant known as N-nitrosodimethylamine (NDMA). (healthline.com)
  • Today, no medical therapy for autism has been approved by the Food and Drug Administration, as Americans continue to turn to homeopathic remedies, alternative diets free of dairy or gluten, invasive treatments, and - now - an aversion to MSG. (medicaldaily.com)
  • Paprocki observed: "Women are being sold 'medication' abortions as a means of convenience, but the real convenience is for the abortion industry which can make more money with less overhead especially under the recently compromised Food and Drug Administration (FDA) administration protocol. (aul.org)
  • The Industrial Guide to Chemical and Drug Safety covers not only current standards, but also a wealth of information on toxins to help regulatory bodies develop new protocols. (wiley.com)
  • We need to cleanse our blood through detoxification to keep it from circulating toxins, chemicals and drugs. (totalhealthinstitute.com)
  • In fact, changes to even a single atom in a chemical or endocrine therapy drug can often drive widely divergent outcomes, but the resolution of the typical crystal structure does not allow visualization of these small changes. (medicalnewstoday.com)
  • The growth rate of confident predictions is twice that of experimental complexes, meaning that a complete structural drug-protein repertoire will be available at least ten years earlier than by X-ray and NMR techniques alone. (plos.org)
  • Despite decades of deceptive assurances to the contrary, no psychiatric drug has the effect of correcting a functional or structural pathology within the organism. (madinamerica.com)
  • It may contaminate the products during the manufacturing process or through how the drugs are stored or packed. (healthline.com)
  • The New Classification changes the current chemical drug classification system and sets forth new registration requirements for applicants. (lexology.com)
  • Under the New Classification, chemical drugs are classified into five categories: 1. (lexology.com)
  • The New Classification further defines the originator's drug as the drug that was first approved in the world, supported with complete and sufficient safety and efficacy data for marketing approval. (lexology.com)
  • Drug applications under the New Classification will continue to follow the existing procedures defined by the CFDA. (lexology.com)
  • In cities and towns that use wastewater treatment plants, prescription and over-the-counter drugs are poured down the sink or flushed down the toilet, pass through the treatment system, and then may enter rivers and lakes. (aquasana.com)
  • Drug-Rehab.org will place you in contact with a trained advisor from one of our sponsoring treatment providers. (drug-rehab.org)
  • It is a concise, powerful, well-referenced and well-constructed critique of psychiatric drug treatment. (palgrave.com)
  • This means that these drugs, modified to enhance treatment, may instead be undesirable for the patient. (phys.org)
  • Vinblastine is an antimicrotubule drug used in the treatment of various kinds of cancer. (enotes.com)
  • These are very exciting results because they suggest that existing drugs - called benzodiazepines - might be useful in treatment of the core deficits in autism," senior study leader William Catterall said in a statement . (medicaldaily.com)
  • drugs chemicals for' seller' in Psycholinguistic treatment. (windhover.org)
  • Metformin, a drug that lowers the liver's production of sugar and decreases risk of mortality, is currently recommended as a first-line treatment. (medicalxpress.com)
  • Wastewater treatment plants are a well-known source for the discharge of these chemicals into the environment. (insidescience.org)
  • The DEA says the products are made of plant material coated with chemicals that claim to mimic THC, the key ingredient in marijuana. (cnn.com)
  • The prevalence of drug use is reiterated here to emphasize the vital role that toxicologic analysis plays in autopsy pathology. (medscape.com)
  • The results presented here emphasize the importance of understanding enhancer mechanism and uncover a zwitterionic surfactant capable of safely and effectively achieving intraepithelial drug delivery in vitro . (springer.com)
  • While such reports tend to emphasize the seriousness of the drug abuse problem, they do not actually estimate the prevalence of drug use in the workplace. (druglibrary.org)
  • By initially dosing any new batch in the mid-microgram range (200-600µg, 0.2-0.6mg), even the most potent research chemical should still be physiologically tolerable. (drugs-forum.com)
  • Neurospecific translation control and the problem of potent danger of drugs and chemicals: a caution. (biomedsearch.com)
  • This means that any chemical substantially similar to those drugs was also deemed illegal, and police could arrest people in possession of them. (smokymountainnews.com)
  • The chemical diversity varied substantially between the two temperatures for the tested species, ranging from 31% similarity for C. furcellatus and P. glacialis to 81% similarity for A. longicornis . (mdpi.com)
  • This means that the substantially increased use of abortion drugs are happening when the risk of complications is higher and the ability to care for women is lowered. (aul.org)
  • GLIDA is a public GPCR-related Chemical Genomics database that is primarily focused on the integration of information between GPCRs and their ligands. (biomedsearch.com)
  • This particular challenge can potentially be addressed through the use of chemical permeation enhancers, which affect transcellular and/or paracellular transport routes. (springer.com)
  • Understanding gained from enhancer mechanisms enabled the deduction of structure-function relationships for hydrophilic and hydrophobic permeation enhancers as well as the identification of a transcellular enhancer, 0.01% ( w / v ) palmityldimethyl ammonio propane sulfonate, which enabled the non-cytotoxic intracellular delivery of a model drug. (springer.com)
  • The chemicals that would be covered include such common solvents as acetone and toluene, which represent 80 percent of the chemicals used to refine cocaine in South America, Mr. Patterson said. (joc.com)
  • A recent review by Giordano and Petrelli, for example, describes their approach to developing multi-target drugs for cancer therapy while avoiding drug resistance by targeting multiple tyrosine kinase receptors [ 6 ]. (pubmedcentralcanada.ca)
  • Many research chemicals are structurally similar to scheduled chemicals, and could be considered to be analogues. (drugs-forum.com)
  • This article is a general overview of research chemicals. (drugs-forum.com)
  • Schematic higlighting the major families and subfamilies of research chemicals, and some of their most prominent members. (drugs-forum.com)
  • In the absence of independent analysis, some of the risks of consuming an unknown batch of a research chemicals can be offset by starting with extremely cautious doses, and systematically working up towards the active dose. (drugs-forum.com)
  • This minimizes the risks associated with misrepresented research chemicals, as was the case in the Haupt incident. (drugs-forum.com)
  • Working upwards from this point over the course of several weeks (allowing time for tolerance to diminish between doses) until the active dose is reached is the safest approach for testing a new batch of research chemicals if analysis cannot be performed. (drugs-forum.com)