MoleculesCarbohydrates2020VaccinesBiologyInhibitorsGlycanHealth and DisMonosaccharideBiosynthesisCharacterizationGlycosylphosphatidylinositolOligosaccharides2000StructuralCarbohydrateMethodologiesTissuesPolysaccharidesChemistrySyntheticEnzymaticMolecularSensitivityEnzymesGlycoproteins2016DrugsCompositionAcidCandidatesMechanismsDiseaseMassNovotny2022BacterialAgentsScience2021Functions
Molecules5
- These organic molecules include active forms of carcinogenic polycyclic aromatic hydrocarbons (PAHs), DNA-cleaving natural products, and glycoconjugate molecules. (umich.edu)
- Chemical synthesis of these compounds, stable isotope-labeled derivatives, and their analogs/inhibitors is an integral part of our overall studies of these biologically intriguing organic molecules. (umich.edu)
- In the first instance, an overview of some key earlier published works has been provided, followed by a review of subsequent methodological improvements, which made the synthesis of this group of biologically interesting glycoconjugate molecules practical and efficient. (elsevierpure.com)
- This research will focus on the production of bioactive target molecules (e.g., non-natural amino-acids, glycoconjugates and mimetics, flavonoids, steroids) and chiral precursors of enantiopure pharmaceuticals. (cost.eu)
- We show single-molecule analysis of glycoconjugates by direct imaging of individual glycoconjugate molecules using low-temperature scanning tunneling microscopy. (bvsalud.org)
Carbohydrates5
- Professor Lindhorst's research interests include the biological chemistry of carbohydrates and glycoconjugates, the synthesis of carbohydrates, peptides, and dendrimers, as well as ligand-receptor interactions and conformational switches. (chemistryviews.org)
- University scientists have described the first chip- based chemical strategy for rapidly screening carbohydrates for biologically useful activity. (genomicglossaries.com)
- Chemical method makes further investigation of carbohydrates possible, Univ. (genomicglossaries.com)
- Chemical analyses of the membraneless granule fractin revealed the presence of a heterogeneous mixture of complex carbohydrates. (rupress.org)
- GLYCOVAX is based on a profound interaction between the academic and industrial sectors, involving 9 academic groups and 2 industrial partners with complementary expertise in chemical/enzymatic synthesis of carbohydrates, conjugation techniques, high throughput screening technology, structural glycobiology, vaccinology and immunology. (com.hr)
20201
- Journal of the American Chemical Society 2020 , 142 (47) , 19809-19813. (acs.org)
Vaccines4
- Glycoconjugate vaccines are important additions to the existing means for prevention of diseases caused by bacterial and viral pathogens. (bvsalud.org)
- The project aims at the education of promising young scientists who learn how to rationally design well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and tackle unmet medical needs. (com.hr)
- Glycoconjugate vaccines represent the key for success of vaccination in children. (com.hr)
- By combining the beneficiaries' expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX is creating a multidisciplinary environment where 14 young researchers are contributing to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. (com.hr)
Biology9
- 22 is the third offering of a biennial international conference series focused on the growing intersection of Chemical Biology and Physiology. (ohsu.edu)
- The interaction of Chemical Biology and Physiology is based on the need for new tools that are applicable in complex systems and provides innovative opportunities for drug target discovery and novel therapeutic concepts. (ohsu.edu)
- Bob Ignacio, Ph.D. candidate in chemical biology at Radboud University in The Netherlands, explains his research to Beth Habecker, Ph.D., professor of chemical physiology and biochemistry, medicine, and anesthesia and perioperative medicine, OHSU School of Medicine, during the poster session that he won. (ohsu.edu)
- Gretchen Fujimura, a bachelor's of science student at Oregon State University, came to the OHSU Chemical Biology and Physiology Conference to trade ideas. (ohsu.edu)
- Kathrine Rush, Ph.D., postdoc in the lab of Ninian Blackburn, OHSU School of Medicine, gives a short talk at the Chemical Biology and Physiology Conference. (ohsu.edu)
- Ever since Bob Ignacio became a graduate student in chemical biology at Radboud University in The Netherlands, he's wanted to attend a conference in a place far away. (ohsu.edu)
- He said he'd imagined some tropical location with a poster session beneath the palm trees, but when he came across the April 28 - May 1 Chemical Biology and Physiology Conference at OHSU, he knew this would do. (ohsu.edu)
- Carsten Schultz, Ph.D., professor and chair of chemical physiology and biochemistry, OHSU School of Medicine, together with his colleagues from University of Oregon, Oregon State University and OHSU, conceived of the conference - the third in a series - to further catalyze the growing synergy between the fields of chemical biology and physiology. (ohsu.edu)
- The interaction of chemical biology and physiology is based on the need for new tools that are applicable in complex systems and provides innovative opportunities for drug target discovery and novel therapeutic concepts and to infuse new chemical technology into biomedical research. (ohsu.edu)
Inhibitors1
- Treatment of cells with inhibitors of these enzymes results in the production of glycans or glycoconjugates containing missing or altered glycan chains. (go.jp)
Glycan1
- Current analytical strategies for these glycan-decorated biomolecules, termed glycoconjugates, rely on ensemble-averaged methods that do not provide a full view of positions and structures of glycans attached at individual sites in a given molecule, especially for glycoproteins. (bvsalud.org)
Health and Dis1
- This approach is highly useful for examining the potential functional role(s) of glycans and glycoconjugates in cells or tissues, and in biological processes of health and disease. (go.jp)
Monosaccharide1
- Stu Borman, Chemical and Engineering News, Dec. 16, 2002 lists as highlights of 2002 http://pubs.acs.org/cen/coverstory/8050/8050chemhighlights5.html with references to the literature on polysaccharide and glycoconjugate microarrays, monosaccharide chips, natural and synthetic oligosaccharide arrays, and synthetic oligosaccharides in microtiter plate format. (genomicglossaries.com)
Biosynthesis1
- This review highlights recent developments in chemical regulation of glycosylation processes with specific targets including: inhibition of (1) N -glycosylation, (2) O -glycosylation, (3) O -linked GlcNAc glycosylation, (4) proteoglycan biosynthesis, (5) glycolipid biosynthesis, and (6) terminal glycosylation. (go.jp)
Characterization1
- This study shows that the MP technique is a promising alternative to methods developed earlier for monitoring glycoconjugation reactions and characterization of glycoconjugates. (bvsalud.org)
Glycosylphosphatidylinositol1
- Immunological evaluation of synthetic glycosylphosphatidylinositol glycoconjugates as vaccine candidates against malaria. (mpg.de)
Oligosaccharides1
- The structural complexity of glycans poses a serious challenge in the chemical synthesis of glycosides, oligosaccharides and glycoconjugates. (bvsalud.org)
20001
- I studied chemistry at the University of Padova (Italy) where I received the MChem Degree in Inorganic and Physical Chemistry in 2000 and, subsequently, the PhD in Chemical Sciences in 2004. (universityofgalway.ie)
Structural2
- Currently, deep structural insight to understand the rapidly advancing discoveries of new and varied functions of glycoconjugates in biological systems is often missing. (ttu.edu)
- This chapter describes typical examples of recent chemical syntheses of lipid A analogues including both natural types corresponding to those obtained from bacterial cells and several artificial structural analogues related to the former. (elsevierpure.com)
Carbohydrate2
- Where my research was focused on the biomimetic total Synthesis of complex natural products mainly bioactive lactones from carbohydrate scaffolds and Artemisinic acid glycoconjugates synthesis. (utu.fi)
- Eva Nordberg Karlsson works within the fields of enzymology and microbiology, with a focus on production and biomolecular development of carbohydrate-modifying enzymes for hydrolysis (oligo- and monosaccharides) and trans-glycosylation reactions (for glycoconjugates such as surfactants and antioxidants), using the carbohydrate polymers of the biomass as the starting material. (lu.se)
Methodologies1
- In this highly multidisciplinary environment 14 Early Stage Researchers (ESRs) are trained in the growing field of glycoscience and vaccinology, enriching their skills and combining different state-of-the-art methodologies for the rational design of innovative glycoconjugates. (com.hr)
Tissues1
- Deficiency of acid β -galactosidase results in the accumulation of glycoconjugates in body tissues and their excretion in urine. (medscape.com)
Polysaccharides1
- On the basis of the chemical structure of the capsular polysaccharides, H. influenzae are divided into 6 serotypes (a, b, c, d, e, and f), and unencapsulated strains lacking the cap gene are referred to as nontypeable ( 1 ). (cdc.gov)
Chemistry4
- This year's topics of focus include Bioinorganic Chemistry, Chemical Physiology, Imaging and Biosensors, Immune Response in Cancer, Molecular Switches, and Protein Chemistry. (ohsu.edu)
- Multiple sponsors stepped forward, including Poster Sponsor ThermoFisher Scientific, and Gold level sponsors Advion, Royal Chemical Society, and Cascade Chemistry. (ohsu.edu)
- I returned to Italy in late 2007 and, after a short period as Senior Researcher, in April 2008 I was appointed Assistant Professor of Inorganic Chemistry at the Department of Chemical Sciences of the University of Padova. (universityofgalway.ie)
- In February 2013, I was appointed Lecturer in Inorganic Chemistry at the School of Biological and Chemical Sciences (formerly School of Chemistry) of the University of Galway (Formerly NUI Galway). (universityofgalway.ie)
Synthetic2
- Therefore, this COST Action (acronym "CASCAT") aims to enhance the synthetic potential of biocatalysis by coupling biotransformations one to another and integrating them with chemical steps to increase the product purity and yields close to quantitative values. (cost.eu)
- We report herein the encapsulation of a semisynthetic glycoconjugate (GC) composed of a synthetic tetrasaccharide mimicking theS. (univ-nantes.fr)
Enzymatic1
- We cater for the chemical and biotech industries, as well the agri-food and health sectors, with a view to: validating an enzymatic assay method, improving the physico-chemical and rheological properties of an industrial product, and creating a functioning extraction process. (capacites.fr)
Molecular2
- Traditional mass spectrometry techniques, such as MALDI-TOF and SELDI-TOF, have difficulties in detecting glycoconjugates with high molecular masses. (bvsalud.org)
- Three different glycoconjugates were prepared from carrier protein BSA, and one from a large protein complex, a virus capsid with 3.74 MDa molecular mass. (bvsalud.org)
Sensitivity2
- Chemical isotope labelling LC-MS analysis methods have been developed for most other phytohormones, enhancing their LC separations and quantitative sensitivity. (unboundmedicine.com)
- The developed method demonstrated enhanced sensitivity, as the CKs and their glycoconjugates could be analysed with LODs within the range of 0.62-25.9 pg/mL. (unboundmedicine.com)
Enzymes2
- Les interactions sucres/protéines (enzymes, lectines) sont au cœur de la communication cellulaire tant extracellulaire (interactions cellule-cellule, cellule-matrice, hôte-pathogène) qu'intracellulaire (GlcNAcylation en tant que modification post-traductionnelle). (univ-nantes.fr)
- From an industrial perspective, one well-designed enzyme or system of enzymes can be very attractive, as the final processing does not involve complete cells and can therefore be adapted relatively easily for use within the traditional chemical industry. (lu.se)
Glycoproteins1
- Many of these minor bands are accounted for by glycoproteins, as revealed by their binding of 125I-concanavalin A, and two of these are also stained blue by the stains-all procedure, a reaction specific for acidic glycoconjugates. (rupress.org)
20161
- Professor Thisbe K. Lindhorst, Christian-Albrechts-University of Kiel , Germany, has been elected President of the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society) for 2016 and 2017. (chemistryviews.org)
Drugs2
- Understanding its biological and chemical nature helps us to understand the effects of exercise, vitamins and supplements, and drugs used for cancer therapies. (benthamscience.com)
- and 4) synthesis of oligo-saccharides and drug-glycoconjugates (these drugs include antitumor agents such as camptothecin, taxol, and etoposide) for targeted drug delivery. (umich.edu)
Composition1
- Our research elucidated chemical composition and structure of WSNP, WSAP-1 and WSAP-2. (springeropen.com)
Acid1
- Acid β -galactosidase is a lysosomal hydrolase that catalyzes the removal of the terminal β -linked galactose from glycoconjugates (eg, G M1 ganglioside), generating G M2 ganglioside. (medscape.com)
Candidates1
- A significant number of membrane-bound glycosyltransferases (GTs) and transporters play pivotal roles in forming the complex glycoconjugates and are targeted by the first-line anti-TB drug and potent drug candidates. (bvsalud.org)
Mechanisms1
- The objective of this study was to characterize chemical properties of water-soluble extract (WSE) obtained from yeast cell wall, and study its antibacterial activity and antimicrobial mechanisms against E. coli . (springeropen.com)
Disease1
- Den återstående sjukdomar beskrivs som "Disease X" och som representeras av kunskapen att en allvarlig internationell epidemi kan orsakas av ett smittämne som för närvarande är okänt som sjukdomsframkallande hos människor. (umu.se)
Mass1
- The chemical structure of the new molecule was fully characterized by proton nuclear magnetic resonance ( 1 H-NMR), carbon-13 nuclear magnetic resonance ( 13 C-NMR), heteronuclear single quantum coherence (HSQC), correlation spectroscopy ( 1 H- 1 H-COSY), distortionless enhancement by polarization transfer (DEPT), mass spectrometry, Fourier-transform infrared (FTIR), and ultraviolet (UV) spectroscopies. (mdpi.com)
Novotny1
- In 1986, Novotny was given the Award in Chromatography from the American Chemical Society. (wikipedia.org)
20221
- ACS Chemical Neuroscience 2022 , 13 (18) , 2766-2777. (acs.org)
Bacterial3
- The important role of chemical synthesis is to supply preparations completely free from any contaminants of bacterial origin and labeled or modified derivatives to be used as tracers or probes for biological investigations or spectroscopic conformational analyses. (elsevierpure.com)
- Dive into the research topics of 'Chemical synthesis of bacterial lipid A'. Together they form a unique fingerprint. (elsevierpure.com)
- Chemical synthesis of bacterial lipid A . In Microbial Glycobiology: Structures, Relevance and Applications (pp. 413-427). (elsevierpure.com)
Agents1
- i ) metal-based anticancer and imaging agents targeting specific biomarkers up-regulated in tumor cells for the targeted chemotherapy and diagnosis, and ( ii ) metal-glycoconjugates as antiviral agents against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). (universityofgalway.ie)
Science2
- I received my Ph.D. in chemical science from the CSIR-National Chemical Laboratory, Pune, India. (utu.fi)
- Les glycosciences forment un domaine de recherche en plein essor qui étudie la science et la technologie des glucides qui sont les molécules biologiques les plus abondantes sur Terre, faisant partie de la biologie de tous les organismes vivants. (univ-nantes.fr)
20212
Functions1
- It also functions to degrade other β -galactose-containing glycoconjugates, such as keratan sulfate. (medscape.com)