GlucoseGlucuronic acidMercapturic acidsBiomassPolymersNitricYieldsPathwayFermentationBeta-glucuronidaseCalcium salt formNaturallyLiverTitersByproductEscherichiaToxinsToxicPrecursorCAGR2021EnzymesUrinaryHazardousFruits and vegetablesReactionsBiosynthesisProcessesFormulationFatty AcidKombuchaCombinesDetoxificationNorth AmericaProductionGenesIngredientsCerevisiaeExposureColiEstrogenNewlyKalionWater solubleProduced from petroleumProducts2017MarketFoundSyntheticGlobalOdor
Glucose12
- We then constructed the biosynthesis pathway of d -glucaric acid in S. cerevisiae INVSc1 opi1Δ and obtained two engineered strains, LGA-1 and LGA-C, producing record-breaking titers of d -glucaric acid: 9.53 ± 0.46 g/L and 11.21 ± 0.63 g/L d -glucaric acid from 30 g/L glucose and 10.8 g/L myo -inositol in fed-batch fermentation mode, respectively. (biomedcentral.com)
- Conventionally, d -glucaric acid is produced via nitric acid oxidation of d -glucose. (biomedcentral.com)
- A biosynthesis route from d -glucose to d -glucaric acid involving three heterologous genes was constructed in recombinant Escherichia coli by Moon et al. (biomedcentral.com)
- Hence, a synthetic scaffold was used to increase MIOX stability and the efficiency of the biosynthesis route, leading to a titer of 2.5 g/L d -glucaric acid from 10 g/L d -glucose [ 7 ]. (biomedcentral.com)
- Glucaric acid also known as saccharic acid, is a six-carbon dicarboxylic acid sugar, natural endogenous end-catabolite of UDP-glucose that is made by oxidizing a sugar like glucose with nitric acid. (witenrepreneur.com)
- Irene works with the microbe Escherichia coli to help facilitate solutions based on biotechnology for glucaric acid production from glucose. (greentalents.de)
- For the past four years, Irene has been working with the microbe Escherichia coli, commonly referred to as E.coli, in order to help facilitate a solution based on biotechnology for glucaric acid production from glucose in the industrial sector. (greentalents.de)
- Building on a pathway for producing glucaric acid from glucose previously developed by a former student of the MIT lab, Irene has further been able to control the degradation of the E.coli enzyme phosphofructokinase - a key enzyme for improving yields of glucaric acid. (greentalents.de)
- Applying protein engineering and gene bioprospecting to improve glucaric acid production from glucose in E. coli and S. cerevisiae . (mit.edu)
- The general structure of glucose and many other aldohexoses was established by simple chemical reactions. (vivalitealimentos.com)
- Glucaronic acid: an acid, C6H10O7, formed by the oxidation of glucose, found combined with other products of metabolism in the blood and urine. (wikidoc.org)
- 2014 . "Engineering E. coli for the biosynthesis of 3-hydroxy-γ-butyrolactone (3HBL) as a value added chemical from glucose as a sole carbon source. (mit.edu)
Glucuronic acid7
- Such exposures induce the glucuronic acid enzymatic pathway and production of D-glucaric acid, thus urinary D-glucaric acid is an indirect byproduct of chemical exposure and phase I detoxification reactions. (nordicvms.com)
- One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by attaching glucuronic acid to them in the liver and then excreting the complex in the bile. (medindex.am)
- Glucuronide: a glycoside that yields glucuronic acid upon hydrolysis. (wikidoc.org)
- A healthy liver combines estrogen with glucuronic acid ("sugar acid") to make it water-soluble for elimination. (healyourselfathome.com)
- Prevents the liver from attaching glucuronic acid to estrogen , and so increases the body's retention of estrogen , which in turn impairs the thyroid gland's ability to secrete thyroid hormone. (healyourselfathome.com)
- also glucuronic acid tends to inhibit the intracellular release of estrogen by beta-glucuronidase. (healyourselfathome.com)
- Glucuronidase - converts water-soluble estrogen glucuro nides into oil-soluble forms by attaching glucuronic acid. (healyourselfathome.com)
Mercapturic acids4
- Urinary mercapturic acids are excreted end products of Phase II detoxification. (iclabs.ca)
- The urinary level of mercapturic acids indicates quantitatively the degree of activity or capability of phase II detoxification. (nordicvms.com)
- Mercapturic acids are the final excretory products of detoxification and include a variety of functionalized xenobiotics that have been conjugated with glutathione or L-cysteine prior to excretion. (nordicvms.com)
- Low levels of mercapturic acids are consistent with insufficient levels of glutathione and/or cysteine. (nordicvms.com)
Biomass6
- Glucaric acid was identified as a "Top Value Added Chemicals from Biomass" and multi-billion dollar markets for use glucaric are limited by cost (2004 DOE report). (gust.com)
- Biomass by virtue of its nature is comprised of various recalcitrant polymers and cellulose is one of them, which can be used for the generation of various platform chemicals. (intechopen.com)
- Biorefineries are facilities that convert renewable biomass into biofuels, chemicals, and materials such as plastics and polymers [ 2 ]. (intechopen.com)
- The biomanufacturing of d -glucaric acid has attracted increasing interest because it is one of the top value-added chemicals produced from biomass. (biomedcentral.com)
- The employment of glucaric acid - a biopolymer building block currently derived from oxidizing a sugar with a nitric acid - is beneficial, as it can be produced from biomass and can decrease the use of chemical products derived from petroleum. (greentalents.de)
- D-Glucaric acid (GA) is a value-added chemical produced from biomass, and has potential applications as a versatile platform chemical, food additive, metal sequestering agent, and therapeutic agent. (bvsalud.org)
Polymers3
- Start with highest value product, glucaric acid, then address high $$ polymers. (gust.com)
- Glucaric acid and its related compounds enhance sustainability as well as improve the chemical properties of products ranging from water treatment, polymers & textiles, coatings, detergents and pharmaceuticals. (bostonharborangels.com)
- Furthermore, the growing application of glucaric acid in the formation of certain polymers like nylon is expected to enhance the product demand. (witenrepreneur.com)
Nitric1
- Slightly stronger oxidation because of the dilute nitric acidic gave the brand new diacid, glucaric acid, giving support to the suggestion out of a half a dozen-carbon dioxide chain. (vivalitealimentos.com)
Yields1
- Hydrolysis of cyanohydrine and reduction of acid obtained with hydrogen iodide yields heptanoic acid. (sureden.com)
Pathway1
- Aside from improving inherent peroxisomal essential fatty acids β-oxidation cycle, a novel heterologous cytosolic essential fatty acids β-oxidation pathway ended up being built, and this led to a heightened output of MK by simply 2-fold. (bcl-2protein.com)
Fermentation2
- Kalion is an early stage industrial biotech company that will transform the traditional chemical industry by providing low-cost access to glucaric acid using traditional, green, fermentation technology. (gust.com)
- 2022-11-25T14:00:11-05:00 The industrial biotech start-up Kalion says it has collected several tons of glucaric acid from its first full-scale fermentation, conducted by Evonik Industries. (bostonharborangels.com)
Beta-glucuronidase1
- When beta-glucuronidase breaks the bond, it prolongs the stay of the hormone or toxic chemical in the body. (medindex.am)
Calcium salt form2
- The calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. (medindex.am)
- Calcium D-glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. (gasparsbest.com)
Naturally3
- Calcium D-Glucarate is a chemical which is similar to a naturally occurring chemical called Glucaric Acid. (fabricheminc.com)
- Calcium D-glucarate supplement combines the benefits of calcium with the benefits of glucaric acid, a chemical that is naturally produced in the body and found in a number of fruits and vegetables. (amazingnutrition.com)
- Calcium D-Glucarate is the calcium salt of D-Glucaric acid, produced naturally in apples. (lifetropics.com)
Liver1
- The body continually attempts to eliminate chemical toxins through enzymatic processes in the liver. (iclabs.ca)
Titers2
- Two engineered S. cerevisiae strains, LGA-1 and LGA-C, with high titers of d -glucaric acid were obtained. (biomedcentral.com)
- 2014. "Functional screening and in vitro analysis reveals thioesterases with enhanced substrate specificity profiles that improve medium-chain fatty acid production titers in Escherichia coli . (mit.edu)
Byproduct1
- Urinary D-glucaric acid, a byproduct of Phase I detoxification, is an indicator of chemical exposure to over 200 chemicals. (iclabs.ca)
Escherichia2
- In 2009, her team created a glucaric acid from Escherichia coli which contained enzymes from three organisms. (wikipedia.org)
- 2020. "Production of D-glyceric acid from D-galacturonate in Escherichia coli. (wikipedia.org)
Toxins6
- The DetoxiCleanse Detoxification Nutritional Drink Mix contains a variety of supportive nutrients, including N-acetyl cysteine, alpha-lipoic acid, green tea extract, milk thistle and broccoli powder, which work to support detoxification pathways, eliminate toxins from the body and protect cells from oxidative stress. (photentialhealth.ca)
- The production, use and disposal of toxic chemicals and synthetic materials have increased the risk of exposure to health-threatening toxins. (nordicvms.com)
- We live in a world of environmental toxins, foods loaded with Soy filler, and hazardous chemicals infusing the air we breathe. (naturalscience.com)
- With the increase in air pollution, chemicals in your food, and chemicals in the cleaning materials and cosmetics you use, you are being exposed to more and more toxins on a daily basis. (camformulas.com)
- Glucuronidation removes several toxic and potentially toxic chemicals from our system, such as polycyclic aromatic hydrocarbons, steroid hormones, some nitrosamines, heterocyclic amines, some fungal toxins, and aromatic amines. (wikidoc.org)
- After being nagged for a while by my dear husband about the chemicals and toxins I was slathering all over my face/body/hair on a daily basis I have broken down and started researching and making my own. (inspiralcoaching.com)
Toxic3
- Causal relationships between toxic chemicals and diseases have been well established. (nordicvms.com)
- A reliable biomarker for exposure to toxic chemicals is urinary D-glucaric acid. (nordicvms.com)
- It contains glucaric acid that binds to toxic substances and helps to remove them from the body through the urinary tract. (xzensupplements.com)
Precursor2
- Her newly developed E.coli strain has tested well with higher production of myo-inositol, a precursor of glucaric acid. (greentalents.de)
- But first the company had to make the hydrogen peroxide as a precursor chemical, Hunt said. (our-source.com)
CAGR1
- The global glucaric acid market was valued at USD 12.56 Million in 2021 and is projected to reach USD 18.67 Million by 2029, expanding at a CAGR of 5.2% during the forecast period. (blueskytccaalibaba.com)
20211
- As the global economy recovers in 2021 and the supply of the industrial chain improves, the Glucaric Acid market will undergo major changes. (blueskytccaalibaba.com)
Enzymes1
- Elevated levels of D-glucaric acid indicate induction of cytochrome P-450 enzymes (phase I) as a result of exposure to many xenobiotics, including pesticides, fungicides, petrochemicals, drugs, toluene, formaldehyde, styrenes and more. (nordicvms.com)
Urinary1
- As urinary screens, they are noninvasve and apble on a large scale with current labo techniques For short-term esue, glucaric acid, thloetbers, and mug tests are usefl. (cdc.gov)
Hazardous1
- Applying engineered passivation films in aqueous systems provides corrosion protection in a different way than phosphate- or zinc-based systems, while simultaneously eliminating excess biological nutrients-such as phosphorus, heavy metals like zinc (which is an EPA priority pollutant) and hazardous acids-that cause strain on the cooling systems themselves and waste treatment operations. (hydrocarbonprocessing.com)
Fruits and vegetables1
- Glucaric Acid is found in our bodies as well as in fruits and vegetables such as oranges, apples, brussels sprouts, broccoli, and cabbage. (fabricheminc.com)
Reactions1
- This allowed her to produce drugs with biological processes rather than chemical reactions. (wikipedia.org)
Biosynthesis3
- 2013. "Integrating the protein and metabolic engineering toolkits for next-generation chemical biosynthesis. (mit.edu)
- Microorganisms dependent biosynthesis signifies an alternate course regarding creation of these types of generally non-renewable primarily based chemical substances. (bcl-2protein.com)
- To boost as well as fluxes to methyl ketone, the provision regarding precursors ended up being increased simply by executive fat metabolic process, including helping the intracellular biosynthesis associated with acyl-CoAs, worsening the intake of acyl-CoAs regarding fats storage area, as well as reinforcing account activation of free of charge Immunohistochemistry Kits essential fatty acids to acyl-CoAs. (bcl-2protein.com)
Processes2
- This means that more chemical companies are refining their production processes and the strategies they use to become more competitive on price. (bostonharborangels.com)
- Our food supplements also use 2 types of vegan-friendly capsules: HPMC vegetarian capsules and Pullulan capsules (which are untouched by any chemical processes! (lifetropics.com)
Formulation1
- Calcium-d-glucarate is a patented formulation of glucaric acid that is used to help to promote and support healthy detoxification. (camformulas.com)
Fatty Acid2
- The researchers also found that the longer they ate omega-3 fatty acid-containing foods, the more their symptoms improved. (xzensupplements.com)
- These final results show that executive MCV can be a probable technique to boost the performance involving microbe mobile producers throughout business functions.Methyl ketones (MK) are usually highly important fatty acid types along with wide apps. (bcl-2protein.com)
Kombucha1
- Another reason to choose glass bottles is that those stored in stainless steel or plastic can leech nasty chemicals into the Kombucha. (nuferm.com)
Combines1
- Calcium D-Glucarate combines calcium and glucaric acid, which can be more readily used by the human body (13). (bodybuildingnewshubb.com)
Detoxification2
- Thus, there is a great demand for noninvasive laboratory tests that can provide timely assessment of chemical exposure and the capability of hepatic detoxification. (nordicvms.com)
- Some women have estrogen dominance throughout their life for various reasons, such as low thyroid, high cortisol, exposure to environmental estrogen-like chemicals, or impaired detoxification pathways for estrogen. (naturalscience.com)
North America1
- Among these, North America accounts for a significant share of the glucaric acid market. (witenrepreneur.com)
Production19
- 2022-11-25T14:02:28-05:00 Kalion Inc. has been awarded a National Science Foundation (NSF) Phase II Small Business Research (SBIR) grant for $746,822 to conduct research and development work improving the bio-based production of glucaric acid. (bostonharborangels.com)
- Part of the Agile BioFoundry (ABF) consortium, these projects will leverage National Laboratory capabilities to address challenges in biomanufacturing - Kalion, Inc, of Milton, MA, will use machine learning and artificial intelligence to lower growth media production costs, increase productivity, and increase the overall commercial feasibility of biomanufacturing, with glucaric acid. (bostonharborangels.com)
- Rapid industrialization has led to development of various platform chemicals and fossil fuel refinery is one of the mainstreams for their production. (intechopen.com)
- Saccharomyces cerevisiae is regarded as an excellent host for d- glucaric acid production. (biomedcentral.com)
- The opi1 gene was knocked out because of its negative regulation on myo -inositol synthesis, which is the limiting step of d -glucaric acid production by S. cerevisiae . (biomedcentral.com)
- There have been no reports on d -glucaric acid production from lignocellulose. (biomedcentral.com)
- This indicated that S. cerevisiae INVSc1 is an excellent host for d -glucaric acid production. (biomedcentral.com)
- Further work should be done to improve the efficiency of this microbial consortium for d -glucaric acid production from lignocellulose. (biomedcentral.com)
- Biological production of d -glucaric acid has attracted increased interest due to its potential as a cheaper and more environmentally friendly process that avoids costly catalysts and harsh reaction conditions [ 3 , 4 ]. (biomedcentral.com)
- Moreover, an N-terminal small ubiquitin-related modifier (SUMO) fusion to MIOX gave rise to a 75% increase in d -glucaric acid production from myo -inositol. (biomedcentral.com)
- With the need for renewable energy sources, Irene's research focuses on strategies to engineer microorganisms for renewable chemical production to help reduce greenhouse gas emissions. (greentalents.de)
- With the need for renewable energy sources and the current prices of petroleum on the rise, Irene Brockman has taken on the challenge of developing strategies to engineer microorganisms for renewable chemical production, in order to help reduce greenhouse gas emissions. (greentalents.de)
- As Irene says, "I have focused on bringing tools that were developed for fundamental biological research and applying them to a system that is relevant for sustainable chemical production. (greentalents.de)
- The young researcher is looking forward to continuing her biological research on sustainable chemical production with international collaborations formed at the Green Talents Forum. (greentalents.de)
- The jury was impressed by Irene's ability to link chemical production alternatives with sustainability initiatives in order to create efficient alternatives for the industrial sector. (greentalents.de)
- If Solugen can get its high-value chemical into commercial production, the company can follow the path that sustainable tech companies like Tesla have mastered - moving from a pricy specialty product into the mass market. (our-source.com)
- Solugen still intends to raise more capital, the company just wanted to wait until its latest production plant for the acid came online, according to Hunt. (our-source.com)
- 2014. "Improving D-glucaric acid production from myo-inositol in E. coli by increasing MIOX stability and myo -inositol transport. (mit.edu)
- Shilajit contains fulvic acid, dibenzo-α-pyrone, and other humic substances which have shown to increase adenosine triphosphate (ATP) availability and increased sex hormone production (20)(21). (bodybuildingnewshubb.com)
Genes1
- I was can not verify the particular SNPs inside applicant family genes formerly considered to be Hydrotropic Agents chemical associated with adhesive capsulitis although i was in a position to verify medical personnel most formerly noted SNPs associated with Dupuytren ailment. (bcl-2protein.com)
Ingredients2
- Startups including Geltor , Impossible Foods , Ginkgo Bioworks , Lygos , Novomer and Perfect Day have all raised significant amounts of capital to reduce the environmental footprint of food, chemicals, ingredients and plastics through synthetic biology. (our-source.com)
- Some of these companies are seeing early success in food replacements and ingredients, but the promise of biologically based chemicals have been elusive - until now. (our-source.com)
Cerevisiae1
- Within Saccharomyces cerevisiae, MCV ended up being improved simply by decreasing ROS deposition using 2nd codon executive in order to fine-tune ceramide synthase (lag1), leading to glucaric chemical p creation as much as Being unfaithful.55 grams L-1 with its output Zero.057 h L-1·h-1. (bcl-2protein.com)
Exposure2
- 1997. TLVs and BEIs: Threshold limit values for chemical substances and physical agents biological exposure indices. (cdc.gov)
- Exposure to a potential fetal health hazard can be estimated through ecological assessment (e.g., testing the community water supply), questionnaires (e.g., classifying residents accord- ing to whether they drink bottled or tap water), or biological markers (e.g., testing for exposures to chemicals or solvents found in tap water). (cdc.gov)
Coli1
- Up to 4.85 g/L of d -glucaric acid was produced from 10.8 g/L myo -inositol in recombinant E. coli [ 4 ]. (biomedcentral.com)
Estrogen2
- As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhancing the potential for greater antioxidant activity. (gasparsbest.com)
- Glucuronidation plays many roles in the body, not just that of binding estrogen, thus one may have low or normal levels of glucaronic acid along with low, normal or high levels of estrogen. (wikidoc.org)
Newly1
- Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. (scialert.net)
Kalion3
- Kalion Inc. uses machine learning to accelerate the development of high-purity, low-cost glucaric acid. (bostonharborangels.com)
- Kalion based in Massachusetts is using glucaric acid to provide the low cost molecule in. (bostonharborangels.com)
- The major players in the market are The Archer-Daniels-Midland Company, Kalion Inc., Chemos GmbH & CokG, Cayman Chemical, among others. (witenrepreneur.com)
Water soluble1
- The combinatorial screening programs employed by the pharmaceutical companies identified that about 40% of active New Chemical Entities (NCEs) are poorly water soluble. (scialert.net)
Produced from petroleum1
- Till date most platform chemicals were produced from petroleum refinery where crude oil is converted into fuels and chemicals that provide multiple products and revenue streams but depletion of fossil fuels and global warming are the two major concerns in chemical manufacturing. (intechopen.com)
Products7
- The Global Glucaric Acid Market Price , Share, Trends, Growth, Report and Forecast 2023-2028', gives an in-depth analysis of the global glucaric acid market, assessing the market based on its segments like products, applications, and major regions. (witenrepreneur.com)
- The extractive industry doesn't just produce fuel, but also the chemicals that make up most of the products that defined consumer goods in the twentieth century. (our-source.com)
- Given the continuing tensions between the two countries, the U.S. is looking to make more high-value products - including chemicals - domestically, and Solugen's technology is a good way forward to have home-grown supplies of critical materials. (our-source.com)
- Solugen's co-founder sees the path that his company is on as one that other startups working in the synthetic biology space will pursue to bring profitable products to market at the higher end before competing with more sustainable versions of commodity chemicals. (our-source.com)
- The major players in the market are Lubrizol Corporation, Imerial-Oel Import Handelsges mbH, Nippon Fine Chemicals Co. Ltd., Lanotec Australia Pty Ltd, Croda International Plc, Rolex Lanolin Products Limited and among others. (holyhellions.com)
- This testosterone support product stands above many commercial sports nutrition products that are potentially contaminated with banned substances or dangerous chemicals (2)(3)(4). (bodybuildingnewshubb.com)
- We are Currently offering a few dozens of specialized products in three major areas including water treatment chemicals, food / feed grade additives and special chemicals for oil and other industries. (dubichem.com)
20172
- Prather was a reviewer for the ACS synthetic biology in 2016 and 2018 and for the Journal of the American Chemical Society in 2016 in 2017. (wikipedia.org)
- The two co-founders, Hunt and Gaurab Chakrabarti, first realized they could potentially use the technology they'd developed to make specialty chemicals back in 2017, according to Hunt. (our-source.com)
Market4
- The global Glucaric Acid industry report provides top-notch qualitative and quantitative information including: Market size (2018-2022 value and 2023 forecast). (blueskytccaalibaba.com)
- Taking into account previous growth patterns, growth drivers, and current and future trends, we also forecast the overall growth of the global Glucaric Acid market during the next few years. (blueskytccaalibaba.com)
- The glucaric acid market is being driven by the thriving detergents industry. (witenrepreneur.com)
- The rising awareness about the negative impact of non-biodegradable chemicals is likely to aid the market as the product is an eco-friendly biodegradable chemical. (witenrepreneur.com)
Found1
- The popularity of glucaric acid for household and laundry cleaning is significantly increasing as it acts as a builder, capturing magnesium and calcium found in hard water and prevents the formation of soap scum. (witenrepreneur.com)
Synthetic2
- Late last year, Solugen , a startup using synthetic biology to take hydrocarbons out of the chemicals industry, decided against pursuing a new round of funding that would have valued the company at over $1 billion, TechCrunch has learned. (our-source.com)
- The journal encourages research related to applied sciences like Forensic chemistry, Computational chemistry, Phytochemistry, Synthetic Drug chemistry, Chemical Engineering and Chemical Physics. (rroij.com)
Global1
- As the world looks to move away from oil and its byproducts to reduce greenhouse gas emissions and slow down or reverse global climate change, the chemicals industry is in the crosshairs as a huge target for disruption. (our-source.com)
Odor2
- Odor as an aid to chemical safety: Odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. (cdc.gov)
- Glutaraldehyde is a colorless, oily, liquid-chemical with a pungent odor. (dubichem.com)