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  • compounds
  • The Millward Laboratory is using directed evolution, chemical biology and metabolomics to design novel compounds that can be directly integrated into optical, nuclear and MR-based imaging platforms. (mdanderson.org)
  • It starts with the final, desired product and then uses natural selection to produce a series of specialized enzymes that can make the final product out of a chain of chemical reactions that begin with simple, commonly available compounds. (eurekalert.org)
  • In the present study, we used the paper wasp social parasite-host system Polistes sulcifer (Zimmerman)- Polistes dominulus (Christ) to evaluate the relative importance of the CHCs and polar compounds in two different steps of the host exploitation process: host nest detection by the pre-usurping parasite and parasite chemical integration into the host colony. (biologists.org)
  • Our results show that nest polar compounds neither are used by the parasite to detect the host's nest nor play a role in parasite chemical integration into the host colony. (biologists.org)
  • chemistry and biology
  • These programs give the Institute its research identity at the interface of chemistry and biology in the United States and worldwide. (scripps.edu)
  • For example, an initiative in RNA chemistry and biology is focused on understanding the structure and function of these key molecules of life that will ultimately lead to new therapeutic agents. (scripps.edu)
  • Marletta obtained an A.B. in chemistry and biology from the State University of New York at Fredonia, a Ph.D. from UCSF under George Kenyon and, after a postdoctoral appointment at MIT under Chris Walsh, began his independent career. (elifesciences.org)
  • Behavior
  • Pathway mapping and modeling based on network biology concepts are a key component of the vision laid out in this report for a more biologically based analysis of dose-response behavior and the safety of chemicals and drugs. (frontiersin.org)
  • bioinformatics
  • Current Research and Scholarly Interests The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, CRISPR libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and tissue renegeneration, with a particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity. (stanford.edu)
  • biotechnological
  • Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. (wiley.com)
  • evolutionary
  • The goal is to achieve an integrated, interdisciplinary understanding of the chemical, physiological and evolutionary principles that have shaped chemical communication across insect societies of different evolutionary and ecological history. (lu.se)
  • I am also grateful to Janusz Petkowski (MIT, MA, USA) for many helpful comments, to Sara Seager (MIT, MA, USA) for her unfailing and generous support in this and other work, and to Pierre Pontarotti (Ai-Marseilles University, France) and the staff and attendees of the 19th Evolutionary Biology Meeting (Marseilles, France, September 2015) for encouraging me to order my thoughts on why any of us are here at all. (springer.com)
  • protein
  • Recent advancements in genetic engineering, most notably directed evolution, have allowed for the stepwise manipulation of the properties of living organisms, promoting the expansion of protein-based devices in nanotechnology. (royalsocietypublishing.org)
  • The integration and unique interplay between protein engineering and biology can transform a number of scientific disciplines, as well as biologically inspired technologies. (royalsocietypublishing.org)
  • Department
  • Lumineszenz-Resonanzenergietransfer zu Konformationsänderungen in Membranproteinen in Säugerzellen exprimiert Studieren Drew M. Dolino 1 , Swarna S. Ramaswamy 1 , Vasanthi Jayaraman 1 1 Center for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Wir beschreiben hier eine verbesserte Lumineszenz-Resonanz-Energie-Transfer (LRET) Verfahren, wo wir eine Protease-Schnittstelle zwischen dem Spender und Akzeptor-Fluorophor Stellen einzuführen. (jove.com)
  • hypothesis
  • Bachmann got the idea of applying natural selection in reverse from the retro-evolution hypothesis proposed in 1945 by the late Caltech geneticist Norman Horowitz. (eurekalert.org)
  • These results support the hypothesis that physical attributes of jelly coats can account for a significant portion of their contribution to fertilization, and may help to explain why coats and other accessory structures are often substantially larger than expected from the nature of chemical interactions between egg and sperm. (biologists.org)
  • As an alternative to the conventional view of accessory structures as primarily chemical in their action, here I test the hypothesis that accessory structures around free-spawned eggs can enhance fertilization success through a change in physical target size. (biologists.org)
  • interactions
  • As in many other insect-insect interactions, chemical signals are known or can be assumed to play an important role for the ability of the parasite to invade the host. (lu.se)
  • In addition to mediating chemical interactions, however, accessory structures can also alter the egg as a physical target for sperm. (biologists.org)
  • approach
  • We really need a green alternative to the traditional approach to making chemicals. (eurekalert.org)
  • A key element of the proposed approach is the use of computational systems biology models as a tool to generate hypotheses about cellular level dose-response based on existing data sets, and to identify data and knowledge gaps that can help guide the design of in vitro assays, focused animal studies, and improved in vitro - in vivo extrapolation (IVIVE) methods. (frontiersin.org)
  • gene
  • This research adds a fundamental new layer of gene regulation vital for post-transcriptional gene expression, organismal development, and evolution. (nih.gov)
  • peptides
  • They are using mRNA display in conjunction with chemical modification to select for high-affinity, modification-resistant peptides in ex vivo and in vivo systems. (mdanderson.org)
  • insect
  • Insect social life is governed by chemicals. (biologists.org)
  • Insect social life is mainly governed by chemicals, and about 30 years of research has provided overwhelming evidence that the blend of lipids present on the cuticle of social insects (mainly hydrocarbons, hereafter CHCs) plays a pivotal role in intra- and inter-specific communication ( Howard and Blomquist, 2005 ). (biologists.org)
  • influence
  • Most research on the role of these structures in fertilization has focused on chemical constituents and their influence on sperm-egg interaction. (biologists.org)
  • reactions
  • I agree this is all a result of evolution based on a gradual change in DNA coding, but that is the strength of an planet like earth being able to perform a conservative estimate of two trillion, quadrillion, quadrillion, quadrillion chemical reactions over a time span of about 4 billion years. (sciforums.com)
  • But if you start counting chemical reactions and time spans in universal terms, it seems that the probability for the development of other life forms somewhere in this vast universe is not only high, but may well be an imperative. (sciforums.com)
  • research
  • The research group of Steven Millward, Ph.D. is working at the chemistry-biology interface to develop new molecular imaging agents to visualize the hallmarks of cancer in living systems. (mdanderson.org)
  • The goal of the Skaggs Institute is to maintain itself as a model for research in chemical biology and to provide a nurturing environment for the next generation of scientists. (scripps.edu)
  • It is increasingly difficult to choose between those research accomplishments that capture the thrill of discovery in biology and the ingenuity of invention in chemistry. (scripps.edu)
  • most research on their role in fertilization has focused on chemical constituents and their effects on sperm-egg interaction. (biologists.org)
  • parental
  • It is not surprising, therefore, that social parasites, specialized in exploiting the costly parental care provided by host workers, exploit the host chemical communication system too. (biologists.org)
  • species
  • In this environment, imagine that one of the species finds a use for the complex chemical compound A that gives it a competitive advantage. (eurekalert.org)
  • biochemical
  • Most in vitro evolution studies involve a powerful but laborious process in which a population of molecules is first challenged to perform a biochemical task, segregated on the basis of whether or not the molecules performed the task, and then amplified to produce "progeny" molecules that resemble but are not identical to their parents. (scripps.edu)