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  • genomic
  • Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. (springer.com)
  • Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer. (nih.gov)
  • Brca1
  • The carboxyterminal BRCT domain of BRCA1 corresponds precisely to the recently identified minimal transcription activation domain of this protein, indicating one such function. (epfl.ch)
  • targets
  • Therefore, we have looked for sets of evolutionary conserved, functionally related genes that are direct targets of pRb/E2F proteins. (embopress.org)
  • This review focusses on the unusual cell cycles of Plasmodium , which may present a rich source of novel drug targets as well as a topic of fundamental biological interest. (springer.com)
  • Furthermore, the parasite possesses two organelles of bacterial origin, the apicoplast and mitochondrion, both of which carry their own genomes and may harbour distinct drug targets in the form of prokaryotic-type replication proteins (apicoplast replication was recently well-reviewed [ 7 ], so this article focusses only on nuclear replication). (springer.com)
  • OMIM
  • 2016 ). Hypomorphic mutations in the ATR gene are associated with a rare autosomal recessive disorder, Seckel syndrome (OMIM #210600), characterized by intrauterine growth retardation, dwarfism, microcephaly, and mental retardation (Ogi et al. (springer.com)
  • CHK1
  • In addition, this study implicates ATR as a direct upstream activator of Chk1 in human cells. (asm.org)
  • Promoters
  • In the primary feedback loop, three basic helix-loop-helix (bHLH)/PAS domain-containing transcription factors, Clock , Npas2 and Bmal1 , activate the transcription of two period genes ( Per1 and Per2 ) and two cryptochrome (Cry) genes ( Cry1 and Cry2 ) by binding to the E-box cis elements in the promoters of these genes. (biomedsearch.com)
  • regulates
  • Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development. (nih.gov)
  • Title: The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition. (nih.gov)
  • Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. (uniprot.org)
  • embryonic
  • Unlike ATM , deletion of ATR in mice results in an embryonic lethal phenotype indicating that ATR is an essential gene ( 6 , 17 ). (asm.org)
  • We show that these cells have an increased ability to form tumorspheres, a characteristic of stem cells, and that they express embryonic stem cell markers associated with pluripotency. (mdpi.com)
  • Finally, analyzing the clock-controlled cell cycle genes p21, c-Myc, Cyclin D1 and p27, we found that the relative phases between p21 and Cyclin D expression profiles have been changed significantly in these Per2 allele mutant mouse embryonic fibroblasts. (biomedsearch.com)
  • MMR-deficient HCT116 cells or embryonic fibroblasts from MLH1 knockout mice also demonstrated classic DNA damage tolerance responses after 6-TG exposure. (biomedsearch.com)
  • NCBI
  • This database is built by NCBI, and, provides only a single record for each gene/transcript. (origene.com)
  • Regulation
  • May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. (genecards.org)
  • The circadian regulation extends beyond clock genes to involve various clock-controlled genes (CCGs) including various cell cycle genes. (jcircadianrhythms.com)
  • Phenotypic characterization of uvsB mutants shows that they possess defects in additional aspects of the DNA damage response besides checkpoint control, including inhibition of septum formation, regulation of gene expression, and induced mutagenesis. (genetics.org)
  • ataxia
  • The ATM gene is mutated in the human genetic disorder ataxia telangiectasia ( 58 ). (asm.org)
  • Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. (jax.org)
  • proliferation
  • Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. (pnas.org)
  • Because wound healing defects were also seen in multiple circadian clock-deficient mouse lines, our results therefore suggest that coupling of the cell cycle to the circadian clock via NONO may be useful to segregate in temporal fashion cell proliferation from tissue organization. (pnas.org)
  • Finally, transcription factors within the nucleus must initiate the transcription of genes involved in cell proliferation. (britannica.com)
  • Elevated NANOS levels promote proliferation and survival of pRb‐deficient cells, as well as homeostasis of RBF1‐depleted tissues. (embopress.org)
  • polymerase
  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. (genecards.org)
  • Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). (genecards.org)
  • organisms
  • Thus, the BRCT domain is likely to perform critical, yet uncharacterized, functions in the cell cycle control of organisms from bacteria to humans. (epfl.ch)
  • Each cell within eukaryotic organisms has built‐in safeguards that limit the tumorigenic potential of cells that lose their normal controls. (embopress.org)
  • Circadian oscillation and cell cycle progression are the two most essential rhythmic events present in almost all organisms. (biomedsearch.com)
  • Circadian gated cell divisions are observed in nearly all organisms. (biomedsearch.com)
  • Here, we collate what is known about the various cell cycle events and their regulators throughout the Plasmodium life-cycle, highlighting the differences between Plasmodium , model organisms and other apicomplexan parasites and identifying areas where further study is required. (springer.com)
  • amino
  • The BRCT domain consists of approximately 95 amino acid residues and occurs as a tandem repeat at the carboxyl terminus of numerous proteins, but has been observed also as a tandem repeat at the amino terminus or as a single copy. (epfl.ch)
  • mice
  • Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound healing in mice. (pnas.org)
  • Specifically, although fibroblasts from NONO-deficient mice showed approximately normal circadian cycles, they displayed elevated cell doubling and lower cellular senescence. (pnas.org)