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  • immune
  • Abstract A97: A high-throughput RNAi screen unravels new immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes. (aacrjournals.org)
  • Biomarkers such as programmed death receptor 1 ligand (PD-L1) expression, tumor mutational burden (TMB), and high microsatellite instability are potentially applicable to predict the efficacy of immune checkpoint blockade (ICB). (aacrjournals.org)
  • Here we identify co-mutations in the DNA damage response (DDR) pathways of homologous recombination repair and mismatch repair (HRR-MMR) or HRR and base excision repair (HRR-BER) (defined as co-mut+) that are associated with increased TMB and neoantigen load and increased levels of immune gene expression signatures. (aacrjournals.org)
  • The data that will be presented at the Immuno-Oncology Congress demonstrate the unique potential of duvelisib, as a dual inhibitor of PI3K-delta and PI3K-gamma, to enhance the efficacy of immune checkpoint and co-stimulatory antibodies in preclinical models of both hematological malignancies and solid tumors," said Dr. Pachter. (corporate-ir.net)
  • Inhibition
  • Overall, at the moment the data are extremely preliminary, but they do demonstrate the potential of the use of checkpoint inhibition in this disease, particularly in the post-transplant setting," Dr Sweetenham said in his presentation. (mtolympusthemepark.com)
  • cell
  • Upon activation, checkpoints interface with cyclin-Cdk complexes to block cell cycle progression or alternatively to induce cell death. (asm.org)
  • The efficiency with which telomeres are hidden from checkpoint and repair processes is illustrated by the fact that a haploid budding yeast cell that has 64 telomeres enters mitosis without delay or `repair' of the chromosome ends. (biologists.org)
  • Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. (proteinlounge.com)
  • In budding yeast, physiological perturbations that inhibit cell-cycle progression do so through checkpoints whose primary effect is thought to be maintenance of high mitotic CDK activity. (biomedcentral.com)
  • study
  • They believe that their study shows how reoviruses might enhance a type of immunotherapy called checkpoint therapy for cancers that start in the brain or spread to the brain from another part of the body. (medicalnewstoday.com)
  • highly
  • Indeed Dia2 is definitely highly stabilized when the checkpoint is definitely activated in the presence of MMS (Kile and Koepp 2010). (exposed-skin-care.net)
  • It is not a spontaneous process that just happens when building blocks (nutrients) are available, but rather a highly regulated, plastic process controlled by TOR-dependent signaling pathways. (rockefeller.edu)
  • major
  • In particular, genetic analysis in C. elegans has identified components of major signaling pathways that underlie diseases of aging such as cancer and Alzheimer's disease, and revealed. (ellisonfoundation.org)
  • effects
  • These effects were associated with intrinsic apoptosis pathway and disrupted NF-κB signaling. (mdpi.com)