Checkpoint Kinase 2Cell Cycle ProteinsCell CycleProtein KinasesProtein-Serine-Threonine KinasesDNA DamageG2 PhaseGenes, cdcAtaxia Telangiectasia Mutated ProteinsS PhaseMitosiscdc25 PhosphatasesCell Cycle CheckpointsPhosphorylationDNA ReplicationM Phase Cell Cycle CheckpointsTumor Suppressor ProteinsDNA-Binding ProteinsHydroxyureaSpindle ApparatusG2 Phase Cell Cycle CheckpointsDNA RepairSchizosaccharomycesSchizosaccharomyces pombe ProteinsNuclear ProteinsSaccharomyces cerevisiae ProteinsMutationCDC2 Protein KinaseTumor Suppressor Protein p53G1 PhaseSaccharomyces cerevisiaeIntracellular Signaling Peptides and ProteinsRadiation, IonizingProtein Kinase InhibitorsGamma RaysCell LineS Phase Cell Cycle CheckpointsUltraviolet RaysFungal ProteinsSignal TransductionCell Line, TumorPhosphatidylinositol 3-KinasesHeLa CellsKinetochoresCyclin BApoptosisNocodazoleMolecular Sequence DataGenomic InstabilityMAP Kinase Signaling SystemCell DivisionDNA Breaks, Double-StrandedCyclin-Dependent Kinase Inhibitor p21DNA, FungalProtein BindingChromosomal InstabilityEnzyme ActivationCyclin-Dependent KinasesModels, BiologicalAtaxia TelangiectasiaRadiation ToleranceMethyl MethanesulfonateCyclinsHistonesRNA, Small InterferingGenes, FungalAmino Acid SequenceProtein-Tyrosine KinasesMad2 ProteinsCdc20 ProteinsFibroblastsGene DeletionCyclin B1Cell NucleusCalcium-Calmodulin-Dependent Protein KinasesCell SurvivalBase SequenceChromosome SegregationAurora KinasesRNA InterferenceBlotting, WesternCyclin-Dependent Kinase 2G1 Phase Cell Cycle CheckpointsCDC2-CDC28 KinasesSerineDNACell ProliferationFlow CytometryTumor Cells, Culturedsrc-Family KinasesProtein Structure, TertiaryBRCA1 ProteinStaurosporineReplication Protein ACaffeineNucleic Acid Synthesis InhibitorsTransfectionHCT116 CellsRepressor ProteinsChromosomal Proteins, Non-Histone