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  • telomere
  • The telomere is a special DNA-protein complex at the end of eukaryotic chromosomes that caps the ends of chromosomes to stop them being recognised by DNA repair and checkpoint complexes. (ncl.ac.uk)
  • embryonic
  • The murine embryonic cells homozygous for truncated Brca2 show a severe proliferative defect and are more susceptible to X-rays and other genotoxins, despite normal enforcement of checkpoints activated by DNA damage. (beds.ac.uk)
  • eukaryotic
  • In addition to their checkpoint function, several observations suggest that the ATM kinases regulate additional facets of the eukaryotic DDR. (genetics.org)
  • mutants
  • Although recombination is variably affected in the gsg1 and mum mutants, we hypothesize that these mutants define genes important for aspects of meiosis not directly related to recombination. (genetics.org)
  • Malignant
  • Pellagatti A, Jadersten M, Forsblom AM et al (2007) Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients. (springer.com)
  • progression
  • Cdk4/6-cyclin D, Cdk2-cyclin E, and the transcription complex that includes pRb and E2F are pivotal in controlling progression through the late G 1 restriction point ( 9 ). (aacrjournals.org)
  • Transcription
  • The E2F family is a group of genes encoding for transcription factors E2F-1, E2F-2 and E2F-3 , which are downstream targets of the RB family. (springer.com)
  • cDNA
  • Thus, confirmation of primer specificity, one or more invariant endogenous controls, RNA and cDNA quality, as well as real-time PCR amplification efficiencies and linearity calculations from individual slopes or R 2 -values must be included in each study. (mdpi.com)