We are at the forefront when it comes to exposure/emission characterization with advanced state-of-the-art online and offline instrumentation, such as time-of-flight aerosol mass spectrometry and electron microscopy. (lu.se)
Nucleolar proteome2
Paper IV provides a complete characterization of the nucleolar proteome. (kth.se)
Using the protein location data from Paper I and Paper II, Paper III presents an image-based characterization of the nucleolar proteome. (kth.se)
Phosphoproteome2
2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. (phosphosite.org)
System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation. (mpg.de)
Proteins11
Paper I of this thesis presents a subcellular map of the human proteome, where the spatial distribution of 12,003 human proteins was mapped into 30 subcellular structures, half of which were not previously localized. (kth.se)
Here, we presented the first proteome-wide spatiotemporal analysis of the nucleolus with its sub-compartments, and identified 69 nucleolar proteins that relocated to the chromosomes periphery during mitosis. (kth.se)
Children develop rapidly during the first years of life, and understanding the sources and associated levels of variation in the serum proteome is important when using serum proteins as markers for childhood diseases. (aalto.fi)
A breakthrough for the identification of the proteome of the presynaptic active zone was the successful employment of antibodies directed against a cytosolic epitope of membrane integral synaptic vesicle proteins for the immunopurification of synaptic vesicles docked to the presynaptic plasma membrane. (mdpi.com)
Employing human proteome arrays, we profiled the antibodies extracted from explanted SAH, alcoholic cirrhosis (AC), nonalcoholic steatohepatitis (NASH), primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), hepatitis B virus (HBV), hepatitis C virus (HCV) and HD livers and found that antibodies of IgG and IgA isotypes were highly accumulated in SAH and recognized a unique set of human proteins as autoantigens. (elifesciences.org)
Proteome Profiler™ Antibody Arrays allow for the measurement of up to 119 proteins in a single sample. (rndsystems.com)
2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. (phosphosite.org)
The identification and characterization of protein modifications is particularly challenging for low-abundance proteins, which are often detected only after enrichment. (genengnews.com)
Apart from enabling exploration of the organellar proteomes, we conclude that half of the human proteins localize to multiple compartments, and that almost one fifth display cell-to-cell variations in terms of protein expression. (kth.se)
Paper IV presents a systematic dissection of the variable proteome drafted in Paper I. We show evidence for 539 proteins being correlated to cell cycle variations, of which a minority are also cycling at a transcriptional level, suggesting protein regulation at a translational or post-translational level. (kth.se)
Mitochondrial3
As many as 20% of the mitochondrial proteome showed variations in their expression pattern at the single cell level, most often independent of the cell cycle. (kth.se)
2] "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues. (tcdb.org)
[17] The mitochondrial proteome is thocht tae be dynamically regulatit. (wikipedia.org)
Quantitative proteomics1
Quantitative proteomics strategies such as SILAC and iTRAQ have been widely applied to study the dynamics of proteome. (genengnews.com)
Prediction2
We introduce FpClass, a data mining-based method for proteome-wide PPI prediction. (nature.com)
Interpreting functional effects of coding variants: challenges in proteome-scale prediction, annotation and assessment. (ncbs.res.in)
Protein1
Therefore, spatial mapping of the human proteome is essential to understand protein function in health and disease. (kth.se)
Characterize1
Therefore, our objective was to characterize the liver proteome in cows experiencing either NEB or positive energy balance (PEB). (agri.gov.il)
Transcriptome1
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)
Systematic1
Systematic characterization of polar and lipid metabolome of a wide range of complex biological matrices (tissues/cell lysates, biofluids, etc.) derived from different model systems analyzed on a regular basis at our platform. (unil.ch)
Assays2
Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. (elifesciences.org)
Both Proteome Profiler™ Antibody Arrays and Luminex ® -based Flow Cytometry Assays are optimized for maximum specificity and sensitivity of analyte detection. (rndsystems.com)
We also use on- and off-line methods for detailed characterization of particle properties. (lu.se)
Characterization of scanning mobility particle sizers for use with nanoaerosols. (cdc.gov)
Metabolic1
SIGNIFICANCE: Our manuscript describes the associations of negative energy balance with the liver proteome in early lactation dairy cows, when metabolic stress and the incidence of diseases is increased. (agri.gov.il)
Characterization of adults with a self-diagnosis of nonceliac gluten sensitivity. (medscape.com)
Fluid1
This study showed that the gingival crevicular fluid human proteome and metaproteome could reflect the characteristics of periodontitis . (bvsalud.org)
Liver2
The liver proteome was characterized using label-free quantitative shotgun proteomics and Ingenuity Pathway Analysis used to identify key affected canonical pathways. (agri.gov.il)
The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). (elifesciences.org)
Biology2
In conclusion, this thesis unravels the spatiotemporal proteome organization of the human cell over the course of a cell cycle and offers a valuable starting point for a better understanding of human cell biology in health and disease. (kth.se)
While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. (nih.gov)
Study1
The aim of this study was to establish a reference model for the evolution of a healthy serum proteome during early childhood. (aalto.fi)
Details1
These data provide important details on the maturing serum proteome during early life, and evaluate how patterns detected in cord blood are conserved in the first years of life. (aalto.fi)
Cancer1
Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II. (buffalo.edu)
Paper III1
In Paper III and IV , we spatiotemporally characterized the proteomes of these two organelles, mitochondria and nucleoli, in greater detail. (kth.se)
Identification1
Discover workhorse versatility from confident proteomic and small-molecule identification and quantitation to biopharmaceutical characterization and in-depth sample-profiling. (thermofisher.com)
Data1
Supporting Information: LC-MS characterization of GSH-MDI reaction products, Tables of peptides matched to albumin or modified albumin, and MS/MS data on the GSH-MDI modified albumin peptide containing residues 411-428. (cdc.gov)