Loading...
  • nucleus
  • The interaction and disassembly of import receptor: cargo complexes is reliant on the differential localisation of nucleotide bound Ran across the envelope, maintained in its low affinity, GDP-bound form in the cytoplasm, and its high affinity, GTP-bound form in the nucleus. (edu.au)
  • import receptor
  • This study provides a detailed account of the binding mechanism enabling Prp20 interaction with the nuclear import receptor, and additional new information for the interaction between IMP alpha and cargo. (edu.au)
  • cellular
  • To uncover the cellular localization of plant PHGPx, we first investigated RsPHGPx's intracellular distribution. (deepdyve.com)
  • Despite its abundant use as a household protein, little is known about its exact cellular localization and dynamics. (embl-heidelberg.de)
  • As VIP1 is not an abundant protein, representing one of the limiting factors for transformation, Agrobacterium may have evolved to produce and export to the host cells its own virulence protein that at least partially complements the cellular VIP1 function necessary for the T‐DNA nuclear import and subsequent expression within the infected cell. (deepdyve.com)
  • An FQ, Compitello N, Horwitz E, Sramkoski M, Knudsen ES, Renne R (2005) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells fromp16 INK4A-induced cell cycle arrest. (springer.com)
  • NS5A
  • These results suggest that the endoplasmic reticulum-associated NS5A is able to transduce signals into the nucleoplasm via UBF hyperphosphorylation leading to rRNA transcription activation. (aacrjournals.org)
  • The effects of NS5A on interferon signalling, and the regulation of cell growth and apoptosis are highlighted, demonstrating that this protein is indeed of critical importance for HCV and is worthy of further investigation. (microbiologyresearch.org)
  • amino
  • Deletion of the N-terminal 34 amino acids or selective mutation of the nonapeptide (25)RRTALRPRR(33), located in the N-terminal region of HSV-1 TK, resulted in the loss of the specific nuclear localization of HSV-1 TK. (ox.ac.uk)
  • We found that the sites containing the amino acids R236-R237 and K317-R318 are absolutely required for specific nuclear targeting of HSV-1 TK. (ox.ac.uk)
  • molecules
  • The activating signals are transduced by signaling cascades that converge on the IκB kinases (IKKs) that phosphorylate the NF-κB inhibitory molecules, including members of the IκB family and inhibitory domains of NF-κB precursors, leading to their ubiquitination and subsequent degradation by the proteasome. (biologists.org)
  • persistence
  • Ballestas ME, Chatis PA, Kaye KM (1999) Efficient persistence of extrachromosomal KSHVDNAmediated by latency-associated nuclear antigen. (springer.com)
  • interacts
  • In addition to binding plant karyopherin α, VirE3 interacts with VirE2, a major bacterial protein that directly associates with the T‐DNA and facilitates its nuclear import. (deepdyve.com)
  • These results suggest that LSM8 nuclear import involves an unidentified nuclear-import signal that is only present when LSM8 interacts with other LSM2-8 subunits. (biologists.org)
  • presence
  • Our findings indicate that TcRPA31-EGFP alters its nuclear presence from concentrated nucleolar localization in exponentially growing epimastigotes to a dispersed granular distribution in the nucleoplasm of stationary epimastigotes and metacyclic trypomastigotes. (readbyqxmd.com)