• Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer. (biomedcentral.com)
  • Regions coding for tumor suppressor genes are often deleted and regions harboring oncogenes may be amplified. (biomedcentral.com)
  • The 'cancer platform' concept proposes that most oncogenic molecules also have the inherent ability to activate tumor suppressor genes or pathways through oncogene-induced apoptosis or senescence, thus limiting their oncogenic effects in a homeostatic fashion. (biomedcentral.com)
  • Branched chain amino acid transaminase 1 is a protein that in humans is encoded by the BCAT1 gene. (wikipedia.org)
  • But the RNA we found is important for maintaining MYC attached to its protein and RNA accessories in order to act asa carcinogenic unit. (ridefordad.ca)
  • Effect of PRP on endometrial cell proliferation and on the expression of genes [prostaglandin-endoperoxide synthase 2 ( COX2 ), tumor protein p53 ( TP53 ), oestrogen receptors ( ER-α and ER-β ), progesterone receptor ( PR ) and c-Myc ] involved in the regulation of oestrus cycle and fetal-maternal interaction were evaluated. (biomedcentral.com)
  • The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
  • What does this gene/protein do? (cancerindex.org)
  • MYC is a transcription factor regulating global gene expression through heterodimerization with the protein myc-associated factor X (MAX) [ 1 - 3 ]. (oncotarget.com)
  • For instance, the stability of MYC protein modulated by phosphorylation is regulated by promyelocytic leukemia zinc finger ( PLZF ) protein and long noncoding RNA PVT1 [ 9 , 10 ]. (oncotarget.com)
  • Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and consequent loss of function of in particular cytotoxic T and NK cells. (biomedcentral.com)
  • Given that we previously defined the viral np9 gene, which is aberrantly activated in human leukemia, as a potent oncogene [ 1 ], we next attempted to search for cellular homologs of the viral oncogene np9 in NCBI database by performing alignment using Np9 protein sequence. (aging-us.com)
  • Following this, the differentially expressed genes (DEGs) were included in Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein‑protein interaction network and survival analyses. (cancerindex.org)
  • Publications] Kaibuchi,K.: 'Molecular cloning and characterization of the stimulatory GDP/GTP exchange protein(GDS)for smg p21s,ras p21ーlike small GTPーbinding proteins. (nii.ac.jp)
  • In the X-linked recessive form, the gene defect lies in the DKC1 gene (located at Xq28), which encodes for the protein dyskerin. (medscape.com)
  • In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
  • N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
  • T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
  • A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
  • N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
  • After conducting an in-depth characterization of changes at various levels-transcriptome, genome, and clonality-in relation to cell differentiation status, the researchers identified distinct correlation patterns within genetic subtypes. (ascopost.com)
  • The dynamic changes in gene expression associated with multiple myeloma throughout the differentiation process pointed to genes potentially related to disease progression. (ascopost.com)
  • Through the genome-wide regulation of gene expression, MYC is involved in diverse cellular processes including cell growth, cell cycle, apoptosis, angiogenesis, cell differentiation and genomic instability [ 4 ]. (oncotarget.com)
  • Although previous studies have reported such heterogeneity, this study further uncovers that intratumoral heterogeneity may extend to established myeloma-related genes such as CCND1 , CD38 , BCMA , LAMP5 , and MYC -some of which have been targeted in clinical trials. (ascopost.com)
  • Once stabilized, β-catenin accumulates and translocates to the nucleus, where it complexes with TCF/LEF to activate transcription of target genes, such as MYC and CCND1 . (plos.org)
  • Furthermore, there was a positive correlation between MYC (also known as c-MYC) level and HN1 level, mechanism analysis suggested HN1 promoted the expression of MYC and its targeted genes like CDK4, CCND1, p21, CAV1, and SFRP1. (biomedcentral.com)
  • MYC combines with other proteins and a special type of molecule called RNA. (ridefordad.ca)
  • RNA is traditionally known as a messenger that transmits information in genes to make proteins. (ridefordad.ca)
  • Numerous cellular proteins detect DNA damage and induce senescence , a permanent change of state characterized by morphological and gene expression changes. (massgenomics.org)
  • The MYC family of proteins, which function in transcription, are dysregulated in most human cancers, including hepatoblastoma. (uwinhealth.com)
  • For example - how do genome structural aberrations and changes in copy number, a result of increased genome instability in cancer, affect the expression of genes and other functional elements such as miRNA, and how do the latter changes affect the function of related proteins. (biomedcentral.com)
  • all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
  • Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Kipps TJ (2010) B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. (springer.com)
  • It is necessary to explore further the effects of genes derived from genomic instability on the progression of LUAD. (biomedcentral.com)
  • The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
  • The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. (oncotarget.com)
  • Immunohistochemical Detection of P21 'ras' and P110 'myc' Oncogene Expression in Regenerating Rat Liver. (epa.gov)
  • Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and predominantly present in Hominoidea. (aging-us.com)
  • DKC1 has been found to be a direct target of the c- myc oncogene, strengthening the connection between DKC and malignancy. (medscape.com)
  • In addition, the effect of the genes related to genomic instability in LUAD on individualized treatment of LUAD is unknown. (biomedcentral.com)
  • This study confirms that genes related to genomic instability can affect the prognosis and immune status of LUAD patients. (biomedcentral.com)
  • analyzed the gene expression profiles of 48 breast cancer specimens and identified 12 genes characterized by genomic instability [ 8 ]. (biomedcentral.com)
  • established a gene tag of seven genes associated with genomic instability that could predict the prognosis of patients with LUAD [ 9 ]. (biomedcentral.com)
  • In this study, we have identified and characterized a novel cellular homolog of HERV-K np9 gene, which encodes a nuclear oncoprotein of 17kDa associated with human leukemia and is referred to as np17 gene. (aging-us.com)
  • As expected, we identified a cellular homolog of the viral np9 gene from Homo sapiens cDNA FLJ26472 fis containing an intact open reading frame (ORF) (450bp) ( Supplementary Figure 1 ). (aging-us.com)
  • They performed a genome-wide CRISPR-Cas9 screen to identify essential genes required for tumor cell survival. (uwinhealth.com)
  • 2006). Covalent Attachment of Low Molecular Weight Poly(ethylene imine) Improves Tat Peptide Mediated Gene Delivery. (igem.org)
  • Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53 and c-Myc as Alternative Mechanisms of Carcinogenesis. (rochester.edu)
  • Computational biologists focusing on cancer develop methods for the genome scale characterization of tumors, on various levels of the molecular process. (biomedcentral.com)
  • Moreover, we observed molecular changes in cell cycle, MYC and mTOR signaling in both HSCs, and progenitor subsets. (lu.se)
  • Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)
  • T. Okuda and H. Kondoh, "Identification of New Genes ndr2 and ndr3 Which Are Related to Ndr1/RTP/Drg1 but Show Distinct Tissue Specificity and Response to Nmyc," Biochemical and Biophysical Research Communications, Vol. 266, No. 1, 1999, pp. 208-215. (scirp.org)
  • The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. (oncotarget.com)
  • Here, we report the identification and structural characterization of two GSK homologs named TaSK1 and TaSK2 in the hexaploid wheat genome as well as a widespread phylogenetic analysis of land plant GSKs. (biomedcentral.com)
  • These genes overlapped to a large extent with published gene sets associated with key aspects of HSC function, demonstrating the potential of this data set as a resource for identification of novel HSC regulators. (lu.se)
  • The assay revealed that HMGCS2 is a direct target of c-Myc, which represses HMGCS2 transcriptional activity. (aacrjournals.org)
  • Hepatoblastoma is known to have a high level of transcriptional heterogeneity, meaning cells within a tumor express genes at different levels and at different times. (uwinhealth.com)
  • Recently, many studies have revealed versatile functions of lncRNAs in gene expression modulation through various routes such as transcriptional, posttranscriptional, posttranslational and epigenetic regulation [ 10 , 11 ]. (oncotarget.com)
  • Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. (nature.com)
  • This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. (wikipedia.org)
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. (cancerindex.org)
  • Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). (oncotarget.com)
  • To determine whether HN1 regulates MYC, we used quantitative real-time PCR and Western blot analysis to assess the expression of MYC and their targeted genes to determine the phenotype caused by knockdown of MYC in breast cancer cell with HN1 overexpression. (biomedcentral.com)
  • Quantitative trait loci (QTL) for age of puberty, nipple number and ovulation rate have been identified in Meishan crosses on pig chromosome 10q (SSC10) near the telomere, which is homologous to human chromosome 10p15 and contains an aldo-keto reductase (AKR) gene cluster with at least six family members. (biomedcentral.com)
  • In the human, an aldo-keto reductase (AKR) gene family (AKR1C) has been identified near the telomere on chromosome 10p15 that contains at least six aldo-keto reductase family 1, member C genes [ 11 ]. (biomedcentral.com)
  • The homologous region on mouse chromosome 13 contains a cluster of eight or nine AKR1C genes [ 12 ]. (biomedcentral.com)
  • Genomic and cDNA sequence alignments as well as chromosome localization using nullisomic-tetrasomic lines provided strong evidence for three expressed gene copies located on homoeolog chromosomes for TaSK1 as well as for TaSK2 . (biomedcentral.com)
  • This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. (cancerindex.org)
  • The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)
  • In addition, posttranscriptional regulation of MYC also contributes on the overexpression of MYC in cancer. (oncotarget.com)
  • Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. (biomedcentral.com)
  • 1989). Immortalization of murine microglial cells by a v-raf/ v-myc carrying retrovirus. (igem.org)
  • For triterpene saponin biosynthesis, we found the genes in MVA and non-MVA pathways were differentially expressed among three examined tissues, indicating the parallel but compartmentally separated biosynthesis pathways of IPP and DMAPP in A. mongolicus . (biomedcentral.com)
  • Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. (edu.au)
  • Other specific computational needs of cancer research are related to epigenetic changes, somatic evolution, definition of gene sets in the context of specific cancer types, and to drugs and data that measures the effects of drugs. (biomedcentral.com)
  • All GS-2 iPSC clones displayed a normal karyotype (46XX or 46XY) and were shown to express the same RAB27A gene mutation that was present in the original somatic donor cells. (biomedcentral.com)
  • In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
  • Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
  • In addition, it is also down-regulated in 80% of small intestine Myc-independent tumors. (aacrjournals.org)
  • Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)
  • The viral Np9 transcript, a small regulatory gene of HERV-K type 1, was reported to be exclusively present in tumors and the transformed cells [ 24 ]. (aging-us.com)
  • MYC is primarily overexpressed and/or amplified in numerous types of cancer through various mechanisms such as retroviral transduction and MYC translocation [ 4 , 5 , 8 ]. (oncotarget.com)
  • The journal of gene medicine 2023 9 e3600. (cdc.gov)
  • Induced pluripotent stem cells (iPSC) express genes associated with pluripotency, have the capacity for infinite expansion, and can differentiate into cells from all three germ layers. (biomedcentral.com)
  • Interestingly, most mRNAs involved in lipid metabolism are overexpressed after hatching (FASN, SCD1, ACOX1), whereas genes implicated in carbohydrate metabolism (HK1, GAPDH, GLUT1) and development (HGF, IGF, FGFR2) are predominantly overexpressed from E12 to E20. (biomedcentral.com)
  • Therefore, a global transcriptome analysis on A. mongolicus tissues was performed to identify the genes essential for the metabolism and to profile their expression patterns in greater details. (biomedcentral.com)
  • 1990). Characterization and Expression of the Gene for the Human Fc Receptor γ Subunit. (igem.org)
  • Nevertheless, NDRG1 sequencing assay disclosed no mutations in the gene. (scirp.org)
  • Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
  • The oncogenic transcription factor Myc is frequently reported to drive BCAT1 expression. (wikipedia.org)
  • This MHC phenotype is dominantly enhanced by removal of rok or of other members of the PCP effector gene family. (uni-wuerzburg.de)
  • HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
  • I am very interested in making gene therapies through viral vectors (AAV, lentivirus, adenovirus) available, affordable, and reliable. (researchgate.net)
  • Therefore, the aim of the present study was to analyze a wide range of genes involved in liver development, cell stress, lipid and carbohydrate metabolisms throughout embryogenesis in mule ducks to better understand the ontogeny of pathways related to liver fattening. (biomedcentral.com)
  • The specific effects that lead to inactivation of these pro-apoptotic or senescence pathways may impinge on major known tumor suppressors such as p53, but may also be due to effects on other genes and molecules within the p53 or other tumor suppressor pathways [ 5 ]. (biomedcentral.com)
  • Because of their location in the swine genome and their implication in reproductive physiology, this gene cluster was characterized and evaluated for effects on reproductive traits in swine. (biomedcentral.com)
  • In contrast to the human genome that contains two genes, plant GSKs are encoded by a multigene family. (biomedcentral.com)
  • The analyzed gene datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database. (cancerindex.org)
  • explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
  • The National Cancer Institute's 'Therapeutically Applicable Research to Generate Effective Treatments' (TARGET) initiative seeks to identify therapeutic targets for high-risk paediatric tumours through comprehensive characterization and integrative analyses ( http://ocg.cancer.gov/programs/target ). (nature.com)
  • Integrative analysis of cuproptosis-associated genes for predicting immunotherapy response in single-cell and multi-cohort studies. (cdc.gov)
  • Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. (cancerindex.org)
  • In vitro , 5 % PRP at passage 5 increased proliferation rate and induced a significant increase in the expression of all studied genes. (biomedcentral.com)
  • Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
  • These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis. (edu.au)
  • K. Kokame, H. Kato and T. Miyata, "Homocysteine-Respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis. (scirp.org)
  • MYC is a master-regulator that directs other genes needed to multiply a cell to become many cells. (ridefordad.ca)
  • 2009). Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. (igem.org)
  • Expression of housekeeping genes varies depending on mevalonate pathway inhibition in cancer cells. (rochester.edu)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)
  • c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)
  • Increased levels of pup licking/grooming by rat mothers in the first week of life alter DNA structure at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. (deepdyve.com)
  • By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6. (oncotarget.com)
  • utilizes a combination of high-resolution comparative genomic hybridization, short hairpin RNA inhibition of target genes at the locations of focal genomic deletions, and a primed cell mosaic mouse model to identify novel tumor suppressors in hepatocellular carcinoma. (biomedcentral.com)
  • Six variants (all identified by WGS) involved MLLT1 , a gene not previously reported to be involved in WT. (nature.com)
  • Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
  • The top 14 hub genes were subsequently confirmed by reverse transcription‑quantitative polymerase chain reaction in ACC and adrenocortical adenoma samples. (cancerindex.org)
  • Interestingly, carbohydrate-related genes appear to be highly expressed at the start of kinetics, while most lipid-related genes are overexpress after hatching, revealing greater sensitivity to the food transition that occurs at this stage. (biomedcentral.com)
  • Comparison of sequence data with the porcine BAC fingerprint map show that the cluster of genes resides in a 300 kb region. (biomedcentral.com)
  • These duplicated genes maintain a high degree of sequence similarity, but differ greatly in their substrate specificity and tissue expression patterns. (biomedcentral.com)
  • The majority of MYC studies focus on its function in cancer due to the critical role of MYC in human cancer [ 5 ]. (oncotarget.com)
  • However, in the absence of human leukocyte antigen (HLA)-compatible donors, no other curative treatment options are available, and therefore, new treatment strategies, such as gene therapy, should be explored. (biomedcentral.com)
  • Amazingly, the first human cancer gene was cloned only thirty years ago. (jcancer.org)
  • Without doubt, the first human transforming gene, and more broadly, oncogenes and anti-oncogenes, had been previously theorized by Theodor Boveri. (jcancer.org)
  • NAC can protect liver tissue against Cd by elevating antioxidants capacity, mitigating oxidative stress and inflammation, as well as down-regulating of apoptotic genes. (springer.com)
  • To this end, a kinetic study was designed to determine the level of expression of selected genes involved in steatosis-related liver functions throughout embryogenesis. (biomedcentral.com)
  • Since liver sampling was only possible from the 12th day of embryogenesis (E12), we analyzed hepatic gene expression at 7 sampling points every 4 days from this point up to 4 days post-hatch (D4) and revealed different patterns of expression depending on the cellular pathway. (biomedcentral.com)
  • These MLLT1 mutations were associated with changes in binding to H3K9ac, evidence of HOX and MYC (MYC-C) expression dysregulation, and were often accompanied by CTNNB1 mutations and evidence of Wnt pathway activation. (nature.com)
  • MYC is a notorious gene that causes aggressive prostate cancer. (ridefordad.ca)
  • Understanding how MYC acts will give us clues about how to approach new molecule-based methods to detect growing cancer and potentially create new drugs to stop MYC. (ridefordad.ca)
  • MYC has also been found to be implicated in various biological phenomena and diseases such as healthy life span, Alzheimer's disease, Huntington disease, Parkinson disease and cancer [ 5 - 7 ]. (oncotarget.com)
  • The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)
  • Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)